Gene

KWMTBOMO05571  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006754

Annotation

pelota-like_protein_[Bombyx_mori]

Location

Bomo_Chr10(+):5267822-5270793      View in EpiBrowser

Full name

Protein pelota homolog       + More
Protein pelota      

Location in the cell

Cytoplasmic   Reliability : 2.03 Nuclear   Reliability : 1.529

CDS

ATGAAACTCGTTCACAAAAACATTGAGAAAGATGACTCCGGGAGTATTGGGCTCATACCGGAGGAACCCGAGGACATGTGGCATGCGTATAATCTAATCACAGAAGGCGATGCTGTAACTGCATCAACTGTTCGGAAAGTTCAAACAGAATCTTCGACCGGGTCTTCCACTAGCAGTAGAGTTAGGACTACGCTCACCATTACTGTAGAAAACATTGACTTTGATACCCAAGCATGTGTGTTAAGGTTGAAAGGTCGTAACATTGTGGAAAATCAATATGTTAAGATGGGTGCATATCACACATTGGATTTAGAACTGAATCGAAAGTTTATTCTGCAGAAGGTATTGTGGGATTCGGTAGCATTAGAACGCGTGGAAACTGCTTGTGATCCAGCAAGTAATGCTGATGTTGCAGCAGTTGTCATGCAGGAAGGACTGGCACATGTCTGTCTTATTACACCCTCAATGACACTTGTGAGGATTAAAATTGACATCACAATACCTAAAAAACGGAAAGGATTTGTACAACAGCATGAAAAGGGCTTAAACAAGTTTTATGAAGCGGTAATGCAAGGAATTCTCAGGCATATAGATTTTAACATTGTCAAGTGTGTAATCATTGCTTCACCTGGTTTTGTGAAGGATCAGTTCTTTGAGTATATGATGCAGCAGGCAATCAAAACAGATAATAAGCTACTTATAGATAACAGAAGTAAATTTTTACTGGTCAAAGCTTCATCTGGATTCAAACATTCTTTAAAAGAAGTTTTACAAGAACCTGCAGTAATGGCAAAAATATCAGATACGAAGGCTGCAAGTGAAGTAAAATTACTGGAAAGTTTTTACACAATGTTGCAGTTAGAGCCCTCAAAAGCGTTCTATGGAAAAAAACATGTAATGAGGGCTAATGAGGCCCTTGCAATTGAAACACTCATGATCTCAGATAAATTGTTCAGGTGTCAAGATACATTGAAGCGGAAAGAGTATGTTGCTCTTGTAGATTCTGTCCGAGAAAATGGTGGAGATGTTAGAATATTCTCTAGTATGCATGTGTCTGGGGAACAGCTAGATCAATTGACGGGTATAGCTGCAGTCCTGCGATTTCCTATGCCGGAACTTGAAGACAGTGATGCTGAAGAAGACAGCGAAAATGATTCTGATTAG

Protein

MKLVHKNIEKDDSGSIGLIPEEPEDMWHAYNLITEGDAVTASTVRKVQTESSTGSSTSSRVRTTLTITVENIDFDTQACVLRLKGRNIVENQYVKMGAYHTLDLELNRKFILQKVLWDSVALERVETACDPASNADVAAVVMQEGLAHVCLITPSMTLVRIKIDITIPKKRKGFVQQHEKGLNKFYEAVMQGILRHIDFNIVKCVIIASPGFVKDQFFEYMMQQAIKTDNKLLIDNRSKFLLVKASSGFKHSLKEVLQEPAVMAKISDTKAASEVKLLESFYTMLQLEPSKAFYGKKHVMRANEALAIETLMISDKLFRCQDTLKRKEYVALVDSVRENGGDVRIFSSMHVSGEQLDQLTGIAAVLRFPMPELEDSDAEEDSENDSD

Description

May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.
Required prior to the first meiotic division for spindle formation and nuclear envelope breakdown during spermatogenesis. It is also required for normal eye patterning and for mitotic divisions in the ovary. Required for ovarian germ line stem cell self-renewal. May play a role in regulating translation. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential).

Cofactor

a divalent metal cation

Similarity

Belongs to the eukaryotic release factor 1 family. Pelota subfamily.

Keywords

Cell cycle   Cell division   Complete proteome   Cytoplasm   Endonuclease   Hydrolase   Meiosis   Metal-binding   Mitosis   Nuclease   Nucleus   Reference proteome  

Feature

chain  Protein pelota

Uniprot

H9JB59   Q1HQ46   A0A194QRQ0   A0A194PF23   A0A2H1VHC0   A0A2A4K0F9   + More
A0A1C9EGK1   S4PGA8   A0A0L7L250   V5GPQ1   A0A1W4XI51   A0A1A9XDP3   A0A1A9VZM6   A0A1A9UMU1   A0A1A9ZJ48   D3TRE2   A0A0L0CFT4   A0A1Y1MVS7   A0A182L0Y9   A0A2J7QM97   A0A1S4GYG2   A0A182XL52   A0A182UNT0   A0A182ICH2   A0A1Q3F4Z8   U4TWH5   A0A182QYM9   A0A0K8SXT4   A0A0K8TRP8   A0A1B6KY61   T1PBR8   A0A224XRE3   A0A2M4AJB2   Q170N2   A0A182J8A1   A0A1B6EGQ4   A0A0P4VQJ8   K7IVK8   U5EV94   T1IFI8   B0WGL0   A0A1E1W1H7   A0A2M4CVA9   A0A232FL49   A0A067RQ81   A0A084W4V1   A0A182W6Q4   A0A2M4BR04   B4N1D3   A0A1I8NU07   Q29NB3   B4G7Y7   B3MUX7   B4NY68   E2AA79   A0A2M3ZHJ6   A0A1W4W8S6   B4KIE0   B4LQD1   W8CBU8   B4HW91   B3N8G8   D7ELJ7   A0A2M4CVT5   A0A1B0CSC3   Q7Q477   A0A3B0KIT5   B4Q7V3   A0A0A1XAE6   P48612   E2BMV0   A0A026WKW8   A0A2R5LKR8   A0A1W7R9Z6   A0A2A3EPQ7   A0A131XGK1   A0A088AVL4   A0A0M4E4Y8   A0A224Z559   A0A0K8W0Z8   A0A336LUU1   A0A293MWU4   A0A1L8DS72   G3MNJ2   A0A034WF72   L7MB26   A0A023GJD1   A0A131YNF6   B4JZG6   A0A1E1XFE2   A0A151I6M9   A0A0K8R5W8   A0A151X5M8   A0A158NRH7   A0A195BD03   A0A2I9LPF4   A0A182Y3H0   A0A2M4BQV0   A0A154PPD7   A0A195FSH5  

EC Number

3.1.-.-

Pubmed

19121390    26354079    23622113    26227816    20353571    26108605    + More
28004739    20966253    12364791    23537049    26369729    25315136    17510324    27129103    20075255    28648823    24845553    24438588    17994087    15632085    17550304    20798317    24495485    18362917    19820115    22936249    25830018    7588080    10731132    12537572    12537569    16280348    24508170    28049606    28797301    22216098    25348373    25576852    26830274    28503490    21347285    29248469    25244985   

EMBL

BABH01008636    DQ443206    ABF51295.1    KQ461198    KPJ06216.1    KQ459606    + More
KPI91623.1    ODYU01002558    SOQ40233.1    NWSH01000287    PCG77751.1    KX778610    AON96623.1    GAIX01003732    JAA88828.1    JTDY01003554    KOB69349.1    GALX01002367    JAB66099.1    EZ423994    ADD20270.1    JRES01000441    KNC31105.1    GEZM01025376    JAV87487.1    NEVH01013214    PNF29721.1    AAAB01008964    APCN01000799    GFDL01012404    JAV22641.1    KB630423    KB631761    ERL83596.1    ERL85914.1    AXCN02000788    GBRD01007719    JAG58102.1    GDAI01000566    JAI17037.1    GEBQ01023617    GEBQ01018900    GEBQ01010575    GEBQ01007811    JAT16360.1    JAT21077.1    JAT29402.1    JAT32166.1    KA646211    AFP60840.1    GFTR01005713    JAW10713.1    GGFK01007545    MBW40866.1    CH477471    EAT40419.1    GEDC01000199    JAS37099.1    GDKW01001308    JAI55287.1    GANO01001977    JAB57894.1    ACPB03005609    DS231927    EDS27039.1    GDQN01010209    JAT80845.1    GGFL01005017    MBW69195.1    NNAY01000064    OXU31385.1    KK852530    KDR21904.1    ATLV01020383    KE525299    KFB45245.1    GGFJ01006293    MBW55434.1    CH963920    EDW78106.1    CH379060    EAL33429.1    CH479180    EDW28485.1    CH902624    EDV33042.1    CM000157    EDW88670.1    GL438030    EFN69659.1    GGFM01007179    MBW27930.1    CH933807    EDW13437.1    CH940649    EDW63381.1    GAMC01004496    JAC02060.1    CH480818    EDW52286.1    CH954177    EDV58391.1    DS497871    EFA12200.1    GGFL01004770    MBW68948.1    AJWK01025894    AJWK01025895    AJWK01025896    AJWK01025897    AJWK01025898    EAA12313.4    OUUW01000010    SPP85676.1    CM000361    CM002910    EDX04385.1    KMY89301.1    GBXI01006416    JAD07876.1    U27197    AY058644    AE014134    GL449347    EFN82985.1    KK107167    EZA56316.1    GGLE01005781    MBY09907.1    GFAH01000421    JAV47968.1    KZ288198    PBC33697.1    GEFH01001937    JAP66644.1    CP012523    ALC39071.1    GFPF01011035    MAA22181.1    GDHF01007491    JAI44823.1    UFQT01000215    SSX21812.1    GFWV01018907    MAA43635.1    GFDF01004884    JAV09200.1    JO843443    AEO35060.1    GAKP01006177    JAC52775.1    GACK01004685    JAA60349.1    GBBM01001361    JAC34057.1    GEDV01007768    JAP80789.1    CH916379    EDV94088.1    GFAC01001319    JAT97869.1    KQ978465    KYM93754.1    GADI01007550    JAA66258.1    KQ982498    KYQ55687.1    ADTU01024042    KQ976511    KYM82451.1    GFWZ01000280    MBW20270.1    GGFJ01006298    MBW55439.1    KQ434998    KZC13304.1    KQ981280    KYN43391.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000037510    UP000192223    + More
UP000092443    UP000091820    UP000078200    UP000092445    UP000037069    UP000075882    UP000235965    UP000076407    UP000075903    UP000075840    UP000030742    UP000075886    UP000095301    UP000008820    UP000075880    UP000002358    UP000015103    UP000002320    UP000215335    UP000027135    UP000030765    UP000075920    UP000007798    UP000095300    UP000001819    UP000008744    UP000007801    UP000002282    UP000000311    UP000192221    UP000009192    UP000008792    UP000001292    UP000008711    UP000007266    UP000092461    UP000007062    UP000268350    UP000000304    UP000000803    UP000008237    UP000053097    UP000242457    UP000005203    UP000092553    UP000001070    UP000078542    UP000075809    UP000005205    UP000078540    UP000076408    UP000076502    UP000078541   

PRIDE

H9JB59    Q1HQ46    P48612   

Pfam

PF03464   eRF1_2        + More
PF03463   eRF1_1
PF03465   eRF1_3
PF00254   FKBP_C

Interpro

IPR005142   eRF1_3        + More
IPR004405   Transl-rel_pelota       
IPR005141   eRF1_2       
IPR005140   eRF1_1_Pelota       
IPR038069   Pelota/DOM34_N       
IPR029064   L30e-like       
IPR042226   eFR1_2_sf       
IPR001179   PPIase_FKBP_dom       

SUPFAM

SSF159065   SSF159065        + More
SSF55315   SSF55315       

Gene 3D

2.30.30.870     3.30.1330.30     3.30.420.60    

ProteinModelPortal

H9JB59   Q1HQ46   A0A194QRQ0   A0A194PF23   A0A2H1VHC0   A0A2A4K0F9   + More
A0A1C9EGK1   S4PGA8   A0A0L7L250   V5GPQ1   A0A1W4XI51   A0A1A9XDP3   A0A1A9VZM6   A0A1A9UMU1   A0A1A9ZJ48   D3TRE2   A0A0L0CFT4   A0A1Y1MVS7   A0A182L0Y9   A0A2J7QM97   A0A1S4GYG2   A0A182XL52   A0A182UNT0   A0A182ICH2   A0A1Q3F4Z8   U4TWH5   A0A182QYM9   A0A0K8SXT4   A0A0K8TRP8   A0A1B6KY61   T1PBR8   A0A224XRE3   A0A2M4AJB2   Q170N2   A0A182J8A1   A0A1B6EGQ4   A0A0P4VQJ8   K7IVK8   U5EV94   T1IFI8   B0WGL0   A0A1E1W1H7   A0A2M4CVA9   A0A232FL49   A0A067RQ81   A0A084W4V1   A0A182W6Q4   A0A2M4BR04   B4N1D3   A0A1I8NU07   Q29NB3   B4G7Y7   B3MUX7   B4NY68   E2AA79   A0A2M3ZHJ6   A0A1W4W8S6   B4KIE0   B4LQD1   W8CBU8   B4HW91   B3N8G8   D7ELJ7   A0A2M4CVT5   A0A1B0CSC3   Q7Q477   A0A3B0KIT5   B4Q7V3   A0A0A1XAE6   P48612   E2BMV0   A0A026WKW8   A0A2R5LKR8   A0A1W7R9Z6   A0A2A3EPQ7   A0A131XGK1   A0A088AVL4   A0A0M4E4Y8   A0A224Z559   A0A0K8W0Z8   A0A336LUU1   A0A293MWU4   A0A1L8DS72   G3MNJ2   A0A034WF72   L7MB26   A0A023GJD1   A0A131YNF6   B4JZG6   A0A1E1XFE2   A0A151I6M9   A0A0K8R5W8   A0A151X5M8   A0A158NRH7   A0A195BD03   A0A2I9LPF4   A0A182Y3H0   A0A2M4BQV0   A0A154PPD7   A0A195FSH5  

PDB

5LZZ     E-value=2.5446e-140,     Score=1278

KEGG

732920    K06965 protein pelota | (RefSeq) pelota-like protein

PATHWAY

03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)

GO

GO:0071025   GO:0004519   GO:0005634   GO:0046872   GO:0070481   GO:0005737   GO:0070966   GO:0051301   GO:0001745   GO:0048132   GO:0051078   GO:0016441   GO:0030718   GO:0000212   GO:1990533   GO:0048137   GO:0032790   GO:0043022   GO:0070651   GO:0007141   GO:0008315   GO:0051321  

PANTHER

PTHR10853  

Subcellular location

Nucleus  
Cytoplasm  

Length:

387

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.12553

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02870

outside

1  -  387

 

 

Pi

140.82228

Theta

171.797746

Tajima's D

-0.582069

CLR

12.377029

CSRT

0.217039148042598

Interpretation

Uncertain