Gene

KWMTBOMO05565  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006590

Annotation

PREDICTED:_syntaxin-1A_isoform_X6_[Bombyx_mori]

Location

Bomo_Chr10(-):5143803-5201541      View in EpiBrowser

Full name

Syntaxin-1A      

Alternative Name

dSynt1

Location in the cell

Nuclear   Reliability : 4.129

CDS

ATGATAGACAAGATTCAGGCGAACGTCGAAGAAGTGAAGAAAAAGCACAGTGCCATCTTATCAGCGCCACAGTCAGATGAAAAAACGAAGCATGAACTTGAGGATCTTATGGCTGATGTCAAGAAAACTGCCAACAAAGTCAGAGGAAAATTAAAACATATAGAACAGAACATCGAACAAGAGGAGCACTCGAACAAATCGTCGGCCGATCTCAGGATAAGAAAGACCCAACATTCAACTCTCTCCCGTAAGTTCGTCGAGGTGATGACCGAGTACAACCGCACGCAGACCGACTACAGAGATCGCTGCAAGAGCCGGATACAGAGACAACTCGAGATCACGGGCCGCGCCACCACCGACGATGAACTCGAGGAAATGCTCGAACAAGGCAACTCGGCCGTTTTCACTCAAGGGATTATCATGGAGACTCAACAGGCGAAGCAGACGCTTGCCGACATCGAAGCCCGACACGCCGACATCATCAAGCTGGAGACATCGATCCGTGAGCTCCACGACATGTTCATGGACATGGCGATGCTAGTCGAAAGCCAGGGTGAAATGATCGACCGCATTGAGTATCATGTAGAACATGCCGTGGACTATGTCCAAACTGCGACACAGGACACAAAGAAGGCACTAAAATATCAGAGCAAAGCTCGACGGAAGAAGATCATGATCTTAGTGTGCCTCCTCATTCTGGGCCTGGTCATCGTCGGCTACGTCTCCAGCTACTTTGTGTGA

Protein

MIDKIQANVEEVKKKHSAILSAPQSDEKTKHELEDLMADVKKTANKVRGKLKHIEQNIEQEEHSNKSSADLRIRKTQHSTLSRKFVEVMTEYNRTQTDYRDRCKSRIQRQLEITGRATTDDELEEMLEQGNSAVFTQGIIMETQQAKQTLADIEARHADIIKLETSIRELHDMFMDMAMLVESQGEMIDRIEYHVEHAVDYVQTATQDTKKALKYQSKARRKKIMILVCLLILGLVIVGYVSSYFV

Description

Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation (PubMed:7834751). Essential for embryonic viability and development (PubMed:7834751). Required for coordinated peristaltic contractions (PubMed:7834751). Recruited by Unc-13-4B to secretory lysosome-related organelles (SLs) that are essential for tracheal lumen fusion between previously separate tracheal branches (anastomosis). Possibly promotes the intracellular fusion of the extending tracheal stalk cell lumens in tracheal fusion cells (Fcs) by interacting with complementary SNAREs (such as Syb) present in the apical membrane of the FC-FC interface and the membranes of the separate tracheal stalk cells (PubMed:27323327).

Similarity

Belongs to the syntaxin family.

Keywords

Cell junction   Coiled coil   Complete proteome   Cytoplasmic vesicle   Lysosome   Membrane   Neurotransmitter transport   Phosphoprotein   Reference proteome   Synapse   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Syntaxin-1A

Uniprot

A0A3S2LJG4   H9JAP5   A0A1E1W6I1   A0A2A4K0Z1   A0A1Q3EU83   T1E282   + More
A0A194QMN3   A0A1C9EGJ5   A0A212EN85   A0A0K8TKQ6   A0A194PF28   A0A1B6LPN8   A0A1B6F298   A0A1Q3FUR0   A0A1B6D5G0   U5EM47   A0A158NPG6   A0A2S2R5C8   A0A023ENG8   V9IJK9   A0A336L6E0   Q16WA7   E0VCR8   A0A1L8DUM4   T1E373   A0A139WC42   A0A1L8DUN3   M9VAF8   T1DSY4   A0A2R7VND8   A0A2J7QJC6   A0A067QY92   A0A139WBV8   A0A0C9R8Y2   A0A0P5JJE4   J9JZS1   A0A1L8DUJ6   A0A195E586   W5JIN5   A0A0C9PTD1   A0A195CMZ0   A0A087ZW55   A0A1J1J5G8   E9HJP9   A0A0P5JDX2   A0A195EUY6   A0A2A3EL65   K7IZ27   A0A2H8TQ66   A0A1B0CMS6   A0A151WR80   A0A195B989   A0A154P512   A0A1Q3EUD4   A0A1I8PP34   A0A182I3V4   A0A0Q9VZS7   A0A2M4CUN6   A0A2M3Z3M9   A0A0P5APR5   A0A2M4AJ22   A0A1A9XRF7   A0A0P5W1T7   A0A182NHD2   A0A1I8MM75   A0A2M4CMM0   A0A1J1J838   T1PKN5   A0A1A9W815   B4K7D2   A0A1J1J9G0   A0A0K2VHB7   A0A0P5RKW9   T1E375   A0A1J1J5I0   V5GQZ3   A0A3L8E046   A0A0P5TXI8   A0A0P6IQI2   A0A0M4F624   Q5TX47   A0A0N8CUY7   A0A1B0G1M1   A0A0B4JCZ4   A0A0R1EBC6   A0A1B0BVW0   A0A1W4V491   B3MST1   A0A0R1E5Z6   A0A1A9UFP4   Q298K6   A0A126GV04   Q24547   A0A3B0JP83   A0A2M3ZGQ1   B4G427   A0A0Q9WT46   A0A2M4CTI3   A0A2M3Z420   A0A0K2VH59  

Pubmed

19121390    24330624    26354079    22118469    26369729    21347285    + More
24945155    17510324    20566863    18362917    19820115    24845553    20920257    23761445    21292972    20075255    17994087    25315136    30249741    12364791    14747013    17210077    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17550304    15632085    7834751    7609612    12537569    18327897    27323327   

EMBL

RSAL01000092    RVE47985.1    BABH01008628    BABH01008629    GDQN01008464    JAT82590.1    + More
NWSH01000287    PCG77729.1    GFDL01016171    JAV18874.1    GALA01000974    JAA93878.1    KQ461198    KPJ06220.1    KX778610    AON96620.1    AGBW02013697    OWR42948.1    GDAI01002885    JAI14718.1    KQ459606    KPI91628.1    GEBQ01014246    JAT25731.1    GECZ01025766    JAS44003.1    GFDL01003721    JAV31324.1    GEDC01016493    JAS20805.1    GANO01001151    JAB58720.1    ADTU01022517    ADTU01022518    ADTU01022519    ADTU01022520    ADTU01022521    ADTU01022522    ADTU01022523    ADTU01022524    GGMS01016008    MBY85211.1    GAPW01003148    JAC10450.1    JR049042    AEY60842.1    UFQS01002198    UFQT01002198    SSX13476.1    SSX32906.1    CH477572    EAT38843.1    DS235063    EEB11174.1    GFDF01003950    JAV10134.1    GALA01000094    JAA94758.1    KQ971372    KYB25401.1    GFDF01003944    JAV10140.1    KC161217    AGJ76545.1    GAMD01000010    JAB01581.1    KK854005    PTY09067.1    NEVH01013556    PNF28694.1    KK852824    KDR15446.1    KYB25402.1    GBYB01004630    JAG74397.1    GDIP01181143    GDIQ01223760    LRGB01000930    JAJ42259.1    JAK27965.1    KZS15081.1    ABLF02039236    GFDF01003973    JAV10111.1    KQ979608    KYN20323.1    ADMH02001403    ETN62659.1    GBYB01004633    JAG74400.1    KQ977574    KYN01832.1    CVRI01000073    CRL07648.1    GL732664    EFX68032.1    GDIP01149703    GDIQ01256237    GDIQ01201018    JAJ73699.1    JAK50707.1    KQ981965    KYN31694.1    KZ288215    PBC32450.1    GFXV01004480    MBW16285.1    AJWK01019146    AJWK01019147    AJWK01019148    AJWK01019149    AJWK01019150    KQ982807    KYQ50409.1    KQ976542    KYM81101.1    KQ434819    KZC06977.1    GFDL01016179    JAV18866.1    APCN01000225    CH940656    KRF78364.1    GGFL01004879    MBW69057.1    GGFM01002375    MBW23126.1    GDIP01195794    JAJ27608.1    GGFK01007287    MBW40608.1    GDIP01092194    JAM11521.1    GGFL01002399    MBW66577.1    CRL07646.1    KA648498    AFP63127.1    CH933806    EDW14256.2    CRL07649.1    HACA01032424    CDW49785.1    GDIQ01104652    JAL47074.1    GALA01000089    JAA94763.1    CRL07647.1    GALX01001902    JAB66564.1    QOIP01000002    RLU25843.1    GDIP01125157    JAL78557.1    GDIQ01018595    JAN76142.1    CP012526    ALC47437.1    AAAB01008807    EAL41719.2    EDO64509.1    GDIP01096351    JAM07364.1    CCAG010008577    AE014297    ADV37366.1    CM000160    KRK04602.1    JXJN01021495    CH902623    EDV30321.2    KRK04603.1    CM000070    EAL27950.3    ALI30636.1    L37732    AY061472    OUUW01000007    SPP82723.1    GGFM01006951    MBW27702.1    CH479179    EDW24438.1    CH964232    KRF99402.1    GGFL01004397    MBW68575.1    GGFM01002447    MBW23198.1    HACA01032423    CDW49784.1   

Proteomes

UP000283053    UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    + More
UP000005205    UP000008820    UP000009046    UP000007266    UP000235965    UP000027135    UP000076858    UP000007819    UP000078492    UP000000673    UP000078542    UP000005203    UP000183832    UP000000305    UP000078541    UP000242457    UP000002358    UP000092461    UP000075809    UP000078540    UP000076502    UP000095300    UP000075840    UP000008792    UP000092443    UP000075884    UP000095301    UP000091820    UP000009192    UP000279307    UP000092553    UP000007062    UP000092444    UP000000803    UP000002282    UP000092460    UP000192221    UP000007801    UP000078200    UP000001819    UP000268350    UP000008744    UP000007798   

PRIDE

H9JAP5    Q24547   

Pfam

PF05739   SNARE        + More
PF00804   Syntaxin
PF01652   IF4E

Interpro

IPR006011   Syntaxin_N        + More
IPR000727   T_SNARE_dom       
IPR010989   SNARE       
IPR028669   STX1       
IPR006012   Syntaxin/epimorphin_CS       
IPR023398   TIF_eIF4e-like       
IPR001040   TIF_eIF_4E       

SUPFAM

SSF47661   SSF47661        + More
SSF55418   SSF55418       

Gene 3D

3.30.760.10    

CDD

cd00179  SynN

ProteinModelPortal

A0A3S2LJG4   H9JAP5   A0A1E1W6I1   A0A2A4K0Z1   A0A1Q3EU83   T1E282   + More
A0A194QMN3   A0A1C9EGJ5   A0A212EN85   A0A0K8TKQ6   A0A194PF28   A0A1B6LPN8   A0A1B6F298   A0A1Q3FUR0   A0A1B6D5G0   U5EM47   A0A158NPG6   A0A2S2R5C8   A0A023ENG8   V9IJK9   A0A336L6E0   Q16WA7   E0VCR8   A0A1L8DUM4   T1E373   A0A139WC42   A0A1L8DUN3   M9VAF8   T1DSY4   A0A2R7VND8   A0A2J7QJC6   A0A067QY92   A0A139WBV8   A0A0C9R8Y2   A0A0P5JJE4   J9JZS1   A0A1L8DUJ6   A0A195E586   W5JIN5   A0A0C9PTD1   A0A195CMZ0   A0A087ZW55   A0A1J1J5G8   E9HJP9   A0A0P5JDX2   A0A195EUY6   A0A2A3EL65   K7IZ27   A0A2H8TQ66   A0A1B0CMS6   A0A151WR80   A0A195B989   A0A154P512   A0A1Q3EUD4   A0A1I8PP34   A0A182I3V4   A0A0Q9VZS7   A0A2M4CUN6   A0A2M3Z3M9   A0A0P5APR5   A0A2M4AJ22   A0A1A9XRF7   A0A0P5W1T7   A0A182NHD2   A0A1I8MM75   A0A2M4CMM0   A0A1J1J838   T1PKN5   A0A1A9W815   B4K7D2   A0A1J1J9G0   A0A0K2VHB7   A0A0P5RKW9   T1E375   A0A1J1J5I0   V5GQZ3   A0A3L8E046   A0A0P5TXI8   A0A0P6IQI2   A0A0M4F624   Q5TX47   A0A0N8CUY7   A0A1B0G1M1   A0A0B4JCZ4   A0A0R1EBC6   A0A1B0BVW0   A0A1W4V491   B3MST1   A0A0R1E5Z6   A0A1A9UFP4   Q298K6   A0A126GV04   Q24547   A0A3B0JP83   A0A2M3ZGQ1   B4G427   A0A0Q9WT46   A0A2M4CTI3   A0A2M3Z420   A0A0K2VH59  

PDB

3C98     E-value=3.40652e-71,     Score=679

KEGG

101737218    K04560 syntaxin 1A | (RefSeq) syntaxin-1A

PATHWAY

04130    SNARE interactions in vesicular transport - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0006886   GO:0017157   GO:0005623   GO:0000149   GO:0005484   GO:0016192   GO:0012505   GO:0031629   GO:0048787   GO:0006887   GO:0006906   GO:0031201   GO:0008021   GO:0048278   GO:0005886   GO:0042734   GO:0005737   GO:0003743   GO:0030672   GO:0016081   GO:0007269   GO:0007274   GO:0007482   GO:0007317   GO:0007349   GO:0030054   GO:0043195   GO:0005765   GO:0000281   GO:0016020   GO:0005515   GO:0006974   GO:0001664   GO:0005525   GO:0007264   GO:0003824  

PANTHER

PTHR19957:SF84  

Subcellular location

Cytoplasmic vesicle  
Secretory vesicle  
Synaptic vesicle membrane  
Lysosome membrane  

Length:

246

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

20.17839

Exp number, first 60 AAs:

0

Total prob of N-in:

0.97540

inside

1  -  223

TMhelix

224  -  241

outside

242  -  246

 

 

Pi

217.922162

Theta

179.790385

Tajima's D

0.358476

CLR

0.649954

CSRT

0.470926453677316

Interpretation

Uncertain