Gene

KWMTBOMO05541  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006603

Annotation

sarco/endoplasmic_reticulum_calcium_ATPase_[Bombyx_mori]

Location

Bomo_Chr10(-):4388734-4407837      View in EpiBrowser

Full name

Calcium-transporting ATPase       + More
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type      

Alternative Name

Calcium pump
Calcium ATPase at 60A

Location in the cell

PlasmaMembrane   Reliability : 2.976

CDS

ATGGAGGACGCTCACACGAAATCCGTGGAAGAAGTCTTAAAATATTTTGGCACAGACCCAGACAAAGGCCTTAGTCCAGACCAAATAAAAAGGAACCAAGAAAAATATGGACCCAATGAACTGCCTACGGAGGAAGGCAAAAGTATATGGCAGTTAGTCTTGGAACAATTCGACGACCTCTTAGTCAAGATTTTGCTGTTAGCTGCTATTATTTCATTCGTATTAGCTTTATTTGAAGAGCACGAAGATGCATTCTCAGCCTTCGTTGAACCTTTCGTTATTTTACTAATTCTTATTGCTAACGCTGTAGTAGGAGTATGGCAGGAAAGAAACGCCGAATCTGCCATCGAAGCTTTAAAAGAATACGAACCTGAAATGGGTAAAGTCATAAGAGGAGACAAATCTGGAGTACAAAAAATCCGTGCCAAGGAAATTGTTCCCGGGGACGTTGTTGAAGTGTCCGTTGGTGACAAGATCCCTGCTGACATTCGCCTTATCAAAATCTACTCCACCACAATCCGTATCGATCAGTCTATCCTGACTGGTGAATCTGTCTCGGTCATCAAACACACCGACCCCATTCCTGACCCCCGCGCCGTGAACCAAGACAAGAAGAACATTCTCTTCTCTGGTACTAATGTCGCAGCCGGTAAAGCTCGCGGTATCGTCATCGGTACTGGACTCAACACTGCCATCGGTAAGATCCGTACTGAAATGTCAGAAACCGAAGAAATCAAAACTCCTCTCCAACAGAAACTTGATGAGTTTGGTGAGCAGCTCTCTAAAGTAATCTCAGTTATCTGTGTCGCTGTGTGGGCTATTAACATCGGACACTTTAACGACCCCGCTCACGGTGGAAGTTGGATCAAGGGCGCCGTCTACTACTTCAAAATTGCCGTCGCTTTAGCCGTCGCTGCCATCCCTGAAGGTCTTCCGGCCGTCATCACCACTTGTCTCGCTTTGGGTACCAGAAGAATGGCTAAGAAAAACGCTATCGTAAGGTCTCTACCGTCAGTCGAAACCCTTGGCTGCACATCCGTCATCTGCTCCGACAAGACCGGCACACTGACCACTAACCAAATGTCCGTATCGCGCATGTTCATCTTTGAAAAGATCGAAGGTGGCGACAGCAGCTTCCTCGAGTTTGAAATCACTGGCTCAACTTATGAACCAATCGGCGACGTTTATCTGAAAGGACAGAAAGTTAAGGCTGCCGAATTTGATGCTCTTCACGAGATCGGTACCATCTGCGTAATGTGCAATGACTCCGCTATTGATTTCAACGAATTCAAACAGGCGTTCGAAAAGGTCGGCGAAGCTACCGAGACTGCTCTGATTGTTCTTGCTGAAAAAATGAATCCCTTCAATGTTCCTAAGACTGGCTTAGATCGCCGATCCTCTGCTATTGTTGTGCGTCAAGAAATTGAGACCAAGTGGAAGAAAGAATTCACTCTCGAGTTCTCTCGTGACAGGAAATCTATGTCGACATACTGCACACCCCTCAAACCCTCGCGCCTCGGCAACGGACCCAAACTATTTGTCAAGGGAGCACCCGAAGGTGTACTCGAACGTTGCACACACGCTCGCGTCGGCACCAGCAAGGTTCCTCTGACCACGACCCTGAAGAACCGCATCTTGGACCTGACCCGCCAGTACGGTACTGGTCGCGATACGCTGCGTTGCTTGGCCCTGGCCACGGCCGATAACCCCCTCAAACCCGACGAAATGGATCTTGGTGACTCCACCAAATTCTACACTTACGAAGTCAACCTTACGTTCGTCGGAGTCGTCGGCATGTTGGACCCCCCTCGTAAAGAAGTTTTCGACTCGATCGTTCGTTGTCGCGCTGCCGGTATTCGCGTAATCGTCATCACCGGTGACAACAAGTCCACTGCCGAAGCCATCTGCAGGCGTATCGGTGTATTCGGAGAGGACGAAGATACCACTGGCAAATCTTTCTCCGGTCGCGAGTTCGATGACCTGCCCATCGCCGAGCAGCGCAGCGCCTGCGCCAAGGCTCGCCTGTTCTCGCGCGTGGAGCCCGCGCACAAGTCTAAGATCGTAGAGTACCTGCAGAGCATGAACGAGATCTCCGCCATGACTGGTGACGGTGTGAATGACGCACCGGCTCTGAAGAAGGCCGAGATTGGTATTGCCATGGGATCCGGCACGGCCGTCGCGAAGTCCGCCGCCGAGATGGTGTTGGCCGACGACAACTTCTCCTCCATCGTCGCTGCTGTTGAGGAAGGTCGCGCCATTTACAACAACATGAAGCAGTTCATCCGCTATCTGATCTCATCCAACATCGGTGAGGTGGTCTCGATCTTCTTGACTGCCGCTCTGGGTCTGCCCGAAGCTCTGATCCCCGTCCAACTGCTGTGGGTGAACCTGGTCACTGACGGTCTGCCCGCTACCGCCCTCGGATTCAATCCTCCCGATCTCGACATCATGGACAAGCCCCCTCGCAAGGCTGACGAAGGTCTCATCTCCGGATGGCTGTTCTTCAGATACATGGCTATCGGTGGCTACGTAGGTGCGGCCACAGTCGGCGCTGCCTCCTGGTGGTTCATGTACTCCCCGTACGGACCTCAAATGACATACTGGCAACTCACTCATCACTTACAATGTATCAGCGGTGGTGATGAATTTAAGGGTGTTGACTGCAAAGTGTTCACTGACCCTCACCCGATGACGATGGCTCTCTCAGTGCTGGTCACAATCGAGATGTTAAACGCCATGAACAGCTTGTCTGAGAACCAGTCTCTGGTCACCATGCCGCCCTGGTCAAACTTGTGGCTCGTCGGCTCCATGGCGCTCTCCTTCACTCTTCATTTCGTCATCCTCTACGTCGAGGTTCTTTCGGCCGTGTTCCAAGTGACGCCGCTGTCGCTCGACGAGTGGGTAACCGTAATGAAGTTCTCAGTACCCGTGGTACTGCTGGATGAAGTGCTCAAATTCGTCGCGCGCAAGATCTCCGATGCGAACGATGTGGTCGTTGACAAGTGGTAA

Protein

MEDAHTKSVEEVLKYFGTDPDKGLSPDQIKRNQEKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEEHEDAFSAFVEPFVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVIRGDKSGVQKIRAKEIVPGDVVEVSVGDKIPADIRLIKIYSTTIRIDQSILTGESVSVIKHTDPIPDPRAVNQDKKNILFSGTNVAAGKARGIVIGTGLNTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFEKIEGGDSSFLEFEITGSTYEPIGDVYLKGQKVKAAEFDALHEIGTICVMCNDSAIDFNEFKQAFEKVGEATETALIVLAEKMNPFNVPKTGLDRRSSAIVVRQEIETKWKKEFTLEFSRDRKSMSTYCTPLKPSRLGNGPKLFVKGAPEGVLERCTHARVGTSKVPLTTTLKNRILDLTRQYGTGRDTLRCLALATADNPLKPDEMDLGDSTKFYTYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKSTAEAICRRIGVFGEDEDTTGKSFSGREFDDLPIAEQRSACAKARLFSRVEPAHKSKIVEYLQSMNEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDKPPRKADEGLISGWLFFRYMAIGGYVGAATVGAASWWFMYSPYGPQMTYWQLTHHLQCISGGDEFKGVDCKVFTDPHPMTMALSVLVTIEMLNAMNSLSENQSLVTMPPWSNLWLVGSMALSFTLHFVILYVEVLSAVFQVTPLSLDEWVTVMKFSVPVVLLDEVLKFVARKISDANDVVVDKW

Description

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.

Catalytic Activity

ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate

Subunit

Interacts with SclA and SclB.

Similarity

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.

Keywords

Alternative splicing   ATP-binding   Calcium   Calcium transport   Complete proteome   Endoplasmic reticulum   Ion transport   Magnesium   Membrane   Metal-binding   Nucleotide-binding   Phosphoprotein   Reference proteome   Sarcoplasmic reticulum   Translocase   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
splice variant  In isoform A.

Uniprot

C7AQP4   A0A2A4KA69   A0A3S2NIS6   A0A194QLJ6   O96696   A0A2A4KB22   + More
A0A2H1W1G5   A0A1L8DF78   H9JAQ8   A0A212EY66   A0A0C9QYZ2   A0A0C9R823   A0A1L8DF68   A0A1B6JB05   A0A1B6K2B5   A0A385MDB2   A0A1B6E9S2   A0A224X6B8   D6WZH8   K7IPT6   A0A1B6CRW6   A0A154PK50   A0A1B6EA81   A0A069DXH6   A0A1B0G7F1   A0A2J7R7V8   A0A151IYX4   A0A023F5T4   A0A195F7F3   A0A195ATM9   A0A158P1I0   A0A195CU94   A0A0P4VR76   A0A1S4FE53   Q175R5   Q175R4   A0A0L0CN78   A0A067REG0   A0A151X776   A0A1Y1N0V8   A0A1W4X7R1   A0A2J7R7U2   A0A0K8S6S5   A0A088ACZ9   A0A0A1X082   T1DHY9   Q175R3   A0A1A9XZK2   A0A1B0BYV5   A0A1A9W106   T1PE27   A0A2J7R7U7   A0A1A9ZUZ6   A0A026X1Y8   A0A0V0G6F0   A0A1W4XH71   A0A0L7RAA5   A0A0K8UMR7   A0A034VML4   A0A2J7R7U1   V9IA48   A0A1Y1N483   V9I895   Q7PPA5-3   A0A1A9VNL8   A0A1Y1N586   A0A1W4X7X2   Q7PPA5-2   A0A0A1XTC4   B4LNZ0   U5EVU1   A0A0A1X2W8   A0A336KD28   W8AZ56   A0A084WL52   A0A1I8QEW5   B3MCM7   E0W0H6   Q7PPA5   A0A1I8QEQ1   B4MRN4   A0A2M3YXR9   A0A2M4CSZ5   A0A2S2QCR1   A0A034VKP1   A0A0Q9W4D5   B4PAA1   A0A2M3ZZM7   W8BAL8   B4KMB9   P22700-2   W8AV60   B3NQ25   A0A2M3ZZP9   A0A0Q9W432   A0A0J9RK49   B4I8W7   A0A182YKV8   A0A1W4V0L4   A0A1Q3FL77  

EC Number

7.2.2.10

Pubmed

26354079    9528669    19121390    22118469    18362917    19820115    + More
20075255    26334808    25474469    21347285    27129103    17510324    26108605    24845553    28004739    26823975    25830018    24330624    24508170    30249741    25348373    12364791    17994087    24495485    24438588    20566863    17550304    2148477    10731132    12537572    12537569    2557235    18327897    23970561    18057021    22936249    25244985   

EMBL

FJ586237    ACU25861.1    NWSH01000001    PCG81121.1    RSAL01000081    RVE48605.1    + More
KQ461198    KPJ06244.1    AF115572    AAD09820.1    PCG81115.1    PCG81114.1    ODYU01005735    SOQ46877.1    GFDF01009090    JAV04994.1    BABH01008562    AGBW02011611    OWR46425.1    GBYB01007896    GBYB01009024    JAG77663.1    JAG78791.1    GBYB01009022    JAG78789.1    GFDF01009084    JAV05000.1    GECU01011379    GECU01000717    JAS96327.1    JAT06990.1    GECU01002138    GECU01001496    JAT05569.1    JAT06211.1    MG271936    AYA58203.1    GEDC01002653    JAS34645.1    GFTR01008430    JAW07996.1    KQ971372    EFA10430.1    GEDC01021233    JAS16065.1    KQ434943    KZC12236.1    GEDC01026479    GEDC01022485    GEDC01002459    JAS10819.1    JAS14813.1    JAS34839.1    GBGD01000289    JAC88600.1    CCAG010021567    NEVH01006727    PNF36906.1    KQ980735    KYN13754.1    GBBI01002172    JAC16540.1    KQ981756    KYN36112.1    KQ976741    KYM75583.1    ADTU01006654    ADTU01006655    ADTU01006656    ADTU01006657    KQ977305    KYN03709.1    GDKW01001061    JAI55534.1    CH477396    EAT41828.1    EAT41827.1    JRES01000153    KNC33775.1    KK852556    KDR21433.1    KQ982450    KYQ56223.1    GEZM01015647    GEZM01015646    JAV91494.1    PNF36909.1    GBRD01016953    GDHC01003390    JAG48874.1    JAQ15239.1    GBXI01012040    GBXI01009573    JAD02252.1    JAD04719.1    GALA01001251    JAA93601.1    EAT41829.1    JXJN01022846    KA647017    AFP61646.1    PNF36908.1    KK107024    QOIP01000004    EZA62297.1    RLU24058.1    GECL01002565    JAP03559.1    KQ414620    KOC67681.1    GDHF01024541    JAI27773.1    GAKP01015902    JAC43050.1    PNF36907.1    JR036722    JR036724    AEY57349.1    AEY57351.1    GEZM01015645    JAV91495.1    JR036721    JR036723    AEY57348.1    AEY57350.1    AAAB01008960    GEZM01015644    JAV91496.1    GBXI01000062    JAD14230.1    CH940648    EDW61159.2    GANO01000863    JAB59008.1    GBXI01009274    GBXI01005620    JAD05018.1    JAD08672.1    UFQS01000224    UFQT01000224    SSX01628.1    SSX22008.1    GAMC01016417    JAB90138.1    ATLV01024183    KE525350    KFB50946.1    CH902619    EDV36261.1    AAZO01006743    DS235860    EEB19132.1    CH963850    EDW74773.1    GGFM01000321    MBW21072.1    GGFL01004262    MBW68440.1    GGMS01006323    MBY75526.1    GAKP01015903    JAC43049.1    KRF79821.1    CM000158    EDW92427.1    GGFK01000628    MBW33949.1    GAMC01016419    JAB90136.1    CH933808    EDW09807.1    M62892    AE013599    AY058465    X17472    GAMC01016418    JAB90137.1    CH954179    EDV56898.1    GGFK01000631    MBW33952.1    KRF79820.1    CM002911    KMY96172.1    CH480824    EDW57042.1    GFDL01006802    JAV28243.1   

Proteomes

UP000218220    UP000283053    UP000053240    UP000005204    UP000007151    UP000007266    + More
UP000002358    UP000076502    UP000092444    UP000235965    UP000078492    UP000078541    UP000078540    UP000005205    UP000078542    UP000008820    UP000037069    UP000027135    UP000075809    UP000192223    UP000005203    UP000092443    UP000092460    UP000091820    UP000092445    UP000053097    UP000279307    UP000053825    UP000007062    UP000078200    UP000008792    UP000030765    UP000095300    UP000007801    UP000009046    UP000007798    UP000002282    UP000009192    UP000000803    UP000008711    UP000001292    UP000076408    UP000192221   

PRIDE

C7AQP4    O96696    H9JAQ8    Q7PPA5    P22700   

Pfam

PF00690   Cation_ATPase_N        + More
PF00689   Cation_ATPase_C

Interpro

IPR036412   HAD-like_sf        + More
IPR023214   HAD_sf       
IPR008250   ATPase_P-typ_transduc_dom_A_sf       
IPR006068   ATPase_P-typ_cation-transptr_C       
IPR023298   ATPase_P-typ_TM_dom_sf       
IPR001757   P_typ_ATPase       
IPR023299   ATPase_P-typ_cyto_dom_N       
IPR030332   SERCA1/2       
IPR005782   P-type_ATPase_IIA       
IPR004014   ATPase_P-typ_cation-transptr_N       
IPR018303   ATPase_P-typ_P_site       

SUPFAM

SSF81660   SSF81660        + More
SSF81665   SSF81665       
SSF81653   SSF81653       
SSF56784   SSF56784       

Gene 3D

3.40.1110.10     3.40.50.1000    

ProteinModelPortal

C7AQP4   A0A2A4KA69   A0A3S2NIS6   A0A194QLJ6   O96696   A0A2A4KB22   + More
A0A2H1W1G5   A0A1L8DF78   H9JAQ8   A0A212EY66   A0A0C9QYZ2   A0A0C9R823   A0A1L8DF68   A0A1B6JB05   A0A1B6K2B5   A0A385MDB2   A0A1B6E9S2   A0A224X6B8   D6WZH8   K7IPT6   A0A1B6CRW6   A0A154PK50   A0A1B6EA81   A0A069DXH6   A0A1B0G7F1   A0A2J7R7V8   A0A151IYX4   A0A023F5T4   A0A195F7F3   A0A195ATM9   A0A158P1I0   A0A195CU94   A0A0P4VR76   A0A1S4FE53   Q175R5   Q175R4   A0A0L0CN78   A0A067REG0   A0A151X776   A0A1Y1N0V8   A0A1W4X7R1   A0A2J7R7U2   A0A0K8S6S5   A0A088ACZ9   A0A0A1X082   T1DHY9   Q175R3   A0A1A9XZK2   A0A1B0BYV5   A0A1A9W106   T1PE27   A0A2J7R7U7   A0A1A9ZUZ6   A0A026X1Y8   A0A0V0G6F0   A0A1W4XH71   A0A0L7RAA5   A0A0K8UMR7   A0A034VML4   A0A2J7R7U1   V9IA48   A0A1Y1N483   V9I895   Q7PPA5-3   A0A1A9VNL8   A0A1Y1N586   A0A1W4X7X2   Q7PPA5-2   A0A0A1XTC4   B4LNZ0   U5EVU1   A0A0A1X2W8   A0A336KD28   W8AZ56   A0A084WL52   A0A1I8QEW5   B3MCM7   E0W0H6   Q7PPA5   A0A1I8QEQ1   B4MRN4   A0A2M3YXR9   A0A2M4CSZ5   A0A2S2QCR1   A0A034VKP1   A0A0Q9W4D5   B4PAA1   A0A2M3ZZM7   W8BAL8   B4KMB9   P22700-2   W8AV60   B3NQ25   A0A2M3ZZP9   A0A0Q9W432   A0A0J9RK49   B4I8W7   A0A182YKV8   A0A1W4V0L4   A0A1Q3FL77  

PDB

6HXB     E-value=0,     Score=3709

KEGG

100302733    K05853 P-type Ca2+ transporter type 2A [EC:7.2.2.10] | (RefSeq) sarco/endoplasmic reticulum calcium

GO

GO:0005388   GO:0016021   GO:0033017   GO:0005524   GO:0006816   GO:0070588   GO:0008553   GO:0006874   GO:0046872   GO:0007274   GO:0060047   GO:1903515   GO:0048863   GO:0005789   GO:0030322   GO:1901896   GO:0012505   GO:0006635   GO:1990845   GO:0005783   GO:0007629   GO:0030707   GO:0036335   GO:0051282   GO:0010884   GO:0008610   GO:0016529   GO:0000166   GO:0006974   GO:0001664   GO:0005525   GO:0007264   GO:0003824  

PANTHER

PTHR42861:SF18  

Subcellular location

Membrane  
Endoplasmic reticulum membrane  
Sarcoplasmic reticulum membrane  

Length:

1002

Number of predicted TMHs:

8

Exp number of AAs in TMHs:

161.22699

Exp number, first 60 AAs:

0.93101

Total prob of N-in:

0.94841

inside

1  -  59

TMhelix

60  -  78

outside

79  -  87

TMhelix

88  -  107

inside

108  -  259

TMhelix

260  -  279

outside

280  -  298

TMhelix

299  -  321

inside

322  -  759

TMhelix

760  -  782

outside

783  -  786

TMhelix

787  -  809

inside

810  -  832

TMhelix

833  -  855

outside

856  -  930

TMhelix

931  -  953

inside

954  -  1002

 

 

Pi

170.961071

Theta

179.042591

Tajima's D

-0.57074

CLR

11.509951

CSRT

0.226038698065097

Interpretation

Uncertain