SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO05526
Pre Gene Modal
BGIBMGA006609
Annotation
PREDICTED:_inositol_hexakisphosphate_and_diphosphoinositol-pentakisphosphate_kinase_isoform_X8_[Bombyx_mori]
Full name
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase      
Alternative Name
InsP6 and PP-IP5 kinase
Location in the cell
Nuclear   Reliability : 4.069
 

Sequence

CDS
ATGTGTGATATGTCATATACTGAGCTTGAACATGGGTATCAAGGATTGCGACAAGCTACTCAACCACAATTTTACGTTGGTGACGATGGAAATCTTGTTCCCATAAGATCTGGTGAATTGGATCTATGCGAATCATTAGACTGCGATGGCGGCGGAAAAAAAGTGGTGGTCGGCGTATGTGCCATGGCGAAGAAGTCACAATCGAAACCCATGAAGGAGATCCTGACGAGGCTCGACGAGTTCGAATACATCAAGATGCTGGTCTTCCCTGAGGAGGTTATCCTTAAGCAACCAGTGGAGGAGTGGCCTATCTGTGACTGTCTGATTTCATTTCACTCCAAAGGCTTCCCATTGGACAAAGCGATACAGTACGAGAAACTAAGGAAACCCTACGTGATAAATAATCTTCATATGCAATACGACATACAGGACCGTCGAAGAGTTTACGCCATACTGGAAGGGGAAGGTATAGAGATACCACGGTACGCGGTTCTGGATAGAGACTCACCAGATCCAAAACATCACGAGTTAGTTGAATCTGAAGACCACGTCGAAGTGAACGGGGTTGTGTTCAACAAGCCGTTCGTGGAGAAGCCCGTGTCCGCTGAGGACCACAATATATACATTTACTACCCGACGTCGGCTGGGGGAGGCAGTCAACGCCTGTTTAGGAAGATTGGAAGTCGCAGTAGTATATACTCGCCAGAGTCCAGAGTCAGAAAGACTGGATCCTTTATTTATGAAGATTTTATGCCGACCGATGGTACAGATGTAAAGGTGTACACGGTGGGCCCCGACTATGCACACGCCGAAGCCAGGAAGAGTCCAGCTCTAGACGGCAAAGTGGAGAGAGACTCTGAAGGCAAGGAAATCAGGTATCCAGTGATCCTGTCCAACCAGGAGAAATTGATCTCGAGGAAAGTGTGCCTGGCCTTCAAGCAAACCGTTTGTGGATTCGATTTGTTGAGAGCGAACGGCAAGTCCTTCGTGTGTGACGTGAACGGATTTTCGTTTGTGAAAAACTCGAATAAGTACTACGACGATTGCGCCAAGATACTCGGTAATATGATTTTGAGGGAATTGGCACCGACGCTGCACATACCGTGGTCGGTGCCCTTCCAGCTCGACGACCCCCCCATTGTTCCCACCACTTTTGGCAAGATGATGGAGCTCCGATGCGTCGTAGGCGTCATAAGGCACGGCGACAGAACTCCCAAACAGAAGATGAAGGTAGAAGTCAGACATCCGAGATTCTTCGAGATCTTTGAGAAATACGACGGCTACAAGCGCGGACACGTGAAGCTAAAGAAGCCGAAACAGCTCCAGGAGATACTGGACATCGCGCGCGCGCTGCTCGCCGACATACACACGAGGCACGCCGACCCGGAGATCGAGGAGAAGCAGGGGAAACTCGAACAGCTCAAAAGCGTTCTGGAAATGTACGGTCACTTCTCTGGGATCAACCGCAAGGTGCAGATGAAGTACCAGCCCCGCGGGCGGCCGCGCGGCTCCAGCTCCGACGACGGTAACGCGCCCCCCACGCACGGGTGCGCGGGCGAGCCGTCGCTGGTGCTGATCCTGAAGTGGGGCGGCGAGCTGACGCCGGCCGGCCGCATCCAGGCCGAGGAGCTCGGACGGATGTTTCGCTGTATGTACCCCGGCGGACAGGGGCGCCATATACCAGGTGAAGCCGGCACCCAAGGTCTCGGCCTTCTGCGTCTCCATTCGACTTTCCGTCACGACCTCAAGATTTATGCGTCCGACGAGGGGCGCGTGCAAATGACCGCCGCCGCCTTCGCGAAGGGACTGTTGGCGCTCGAGGGAGAACTCACGCCGATCCTCGTGCAGATGGTGAAGTCGGCCAACACCAACGGGCTGTTAGACAACGACTGCGACTCTTCGAAGGTTCAAAACATGGCGAAGGCTCGGCTGCACGAGGCGATGCAGGTGGACCGCGACTTCACGGACGAGGACCGGTGGCGCATCAACCCGTGCGGCTCGCTCAGCATCTCCACGGCTATGGAGTTCGTGAAGAACCCGGCGCGGTGCTGCGCGCACGTGCACGCGCTCATACACCACCTGCTGCGCATCGTGCTCGCCAAGCGGGACGACCCCAAGACCAAAGACACTATTCTATACCACGGCGAGACCTGGGAGCTGATGGGTCGACGCTGGGGTAAAATAGAAAAGGATTTCTGCACGAAAAACAAAACTTACGATATTTCGAAGATCCCCGACATATACGACTGCATCAAGTACGACCTCCAGCACAACCAGCACACGCTGCAGTTCGACTGCGCCGAGGAGCTTTACATATATGCTAAATATTTGGCGGACATCGTCATACCGCAGGAATATGGTTTGACGATGCAAGAAAAGTTAACAATTGGTCAAGGGATATGTACGCCATTGTTGAAAAAAATAAGAGCAGATTTGCAAAGAAATATAGAAGAATCCGGCGAAGAGACTGTTAATAGATTAAATCCTAGGTACAGTCACGGCGTGTCGAGCCCGGGCCGCCACGTGCGCACGCGACTGTACTTCACCAGCGAGAGCCACGTGCACTCCCTGCTCACCGTACTGAGGTTCGGAGGCCTGCTGGATGTGATGAAAGATGAGCAATGGCGTCGTGCGATGGAGTACGTTTCGATGGTGTCGGAATTGAACTACATGTCGCAGATTGTCGTTATGCTCTACGAAGATCCCACCAAAGATCCGTTTTCAGAAGAAAGATTCCACGTGGAGCTCCACTTCAGTCCCGGCGTGAACTGCTGCGTGCAGAAGAACCTGCCGCCCGGCCCCGGCTTCCGACCACACAGCCGGAATCATTCCACTACTAATAACTCGAGTTCATCGGACGAGGTGAAATGCATCGAAGAGGAAGGGGAAGATGACAACACAGCCAGTCAAGAAACTCTACAACCTGTGATGCATGACGATACGTTACAGGACGCGGCGGACGACTTCGACAGCGCCTTCTCGCCGAGACGCACCACCATGCTGAAGGCGTCCGATCCCATACCGATATGTAATTTACATCACACTGTAAGCGGACACGAGGCGTCCTCGCTGGCGGCGCGCCTCAACCACGAGCTGCGGGTGCGCACGCTCACCGACGACGACGCCGCGGCACAGATCGATCAGCAATCGTCTAAAGAAACGTCTGAAGAGCATCCGCCGCGGGCCCGAAGCTACGACCAACACAAGCAGAGCCATGACAACGGGCGGCGCCAGCGGCACAGCATCGCCGGCCAGATGAGCTACCTCAAGATGCTGGGACTCGGAGCGCGCGGCAAACTAGGCGCGGGACTCTTCAGTACGGCAGTCATCTCCGGATCCAGCTCTGCCCCTAATCTCCGCGTTATGATACCCTCCACGTCTGCTGCAAATGCGGCGCTGGAAGGTTTCGGCGGCGTGCCCGCGATCCGTCCGCTGGAGACGCTGCACAACGCGCTGTCGCTGCGCCAGCTCGACGCCTTCCTGGAGCGGGTGACGGCGGCGCCCGTGCTGCTGCAGCCGCCGCCGCCGCCGCCGCGGGTCAAGCCGCCTTCACCAACCAACAGTGTCGGTTGGAGTGGGCCTTCGTCGCTGATGTCTTCCTCGGGAGAATTGCCTAGCGGCCTCTCCTCTGCTGGGCCATCCTCACCTAACTCAAACTACGCTACAAATTCAGAAAACAAGAACTCTTCGGAAAGTAGCAATTGGAGTAAAAATGTGTCGAGCAAGCTCCCTCAGTGGGAGGGGGAGGTCGCCGCACTCTGCGCGCTCGAGCCCGCCCTGCGCGCCCTCTCGCACGCCCCTACTGCAGGTTCTTCTATTAGCGGCGACTTGACTCCGGTGTCGAACGCTTCGGAGCTGGAATTCAACAGCAACGAGGCGACGGCCGGCTCGATCACTGATCACGATCTAATGAGTGCAGAAGGAGAAGACGACGAAGAGACTCTGTCCATTGACGCGTACAGCTCCAGTTTGAAGATTATAAAGAACGATCTCAGCCCTCATTCCTTCGCTGGGGCGTCCACACTGAAGCCCGACATATACCAGCCATCAACAAGCAAAGCTTCAGATTTCTACGGTTTAAATTTCCAACAAACCAAGGAGAGCTTATTCAAAGACGTGCCATCCAGCAAAACCGGCGGAGGTAACAAGAATAATGAACTCTTAAATAACGGTAGCCGTAGATACAGCGACAGTAGCGCACAGAAGAGTAACGCGAATGCACAGTCCAACGTCTCGGGAACTAGATTCACGATGACTCTGGTAACCGAAGACTTGCTTAGGCCGAGCGACTCAAGTGAGAGCAAGTCCACCGACAACTCGGCCCTGTGCAAAAAGGATGTATCACAGCCGTTGGTGACGAAAGCCAACAACGCTAACATTAAACCGGGTTTCAAAGTTGCTGAAATTTGA
Protein
MCDMSYTELEHGYQGLRQATQPQFYVGDDGNLVPIRSGELDLCESLDCDGGGKKVVVGVCAMAKKSQSKPMKEILTRLDEFEYIKMLVFPEEVILKQPVEEWPICDCLISFHSKGFPLDKAIQYEKLRKPYVINNLHMQYDIQDRRRVYAILEGEGIEIPRYAVLDRDSPDPKHHELVESEDHVEVNGVVFNKPFVEKPVSAEDHNIYIYYPTSAGGGSQRLFRKIGSRSSIYSPESRVRKTGSFIYEDFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVILSNQEKLISRKVCLAFKQTVCGFDLLRANGKSFVCDVNGFSFVKNSNKYYDDCAKILGNMILRELAPTLHIPWSVPFQLDDPPIVPTTFGKMMELRCVVGVIRHGDRTPKQKMKVEVRHPRFFEIFEKYDGYKRGHVKLKKPKQLQEILDIARALLADIHTRHADPEIEEKQGKLEQLKSVLEMYGHFSGINRKVQMKYQPRGRPRGSSSDDGNAPPTHGCAGEPSLVLILKWGGELTPAGRIQAEELGRMFRCMYPGGQGRHIPGEAGTQGLGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANTNGLLDNDCDSSKVQNMAKARLHEAMQVDRDFTDEDRWRINPCGSLSISTAMEFVKNPARCCAHVHALIHHLLRIVLAKRDDPKTKDTILYHGETWELMGRRWGKIEKDFCTKNKTYDISKIPDIYDCIKYDLQHNQHTLQFDCAEELYIYAKYLADIVIPQEYGLTMQEKLTIGQGICTPLLKKIRADLQRNIEESGEETVNRLNPRYSHGVSSPGRHVRTRLYFTSESHVHSLLTVLRFGGLLDVMKDEQWRRAMEYVSMVSELNYMSQIVVMLYEDPTKDPFSEERFHVELHFSPGVNCCVQKNLPPGPGFRPHSRNHSTTNNSSSSDEVKCIEEEGEDDNTASQETLQPVMHDDTLQDAADDFDSAFSPRRTTMLKASDPIPICNLHHTVSGHEASSLAARLNHELRVRTLTDDDAAAQIDQQSSKETSEEHPPRARSYDQHKQSHDNGRRQRHSIAGQMSYLKMLGLGARGKLGAGLFSTAVISGSSSAPNLRVMIPSTSAANAALEGFGGVPAIRPLETLHNALSLRQLDAFLERVTAAPVLLQPPPPPPRVKPPSPTNSVGWSGPSSLMSSSGELPSGLSSAGPSSPNSNYATNSENKNSSESSNWSKNVSSKLPQWEGEVAALCALEPALRALSHAPTAGSSISGDLTPVSNASELEFNSNEATAGSITDHDLMSAEGEDDEETLSIDAYSSSLKIIKNDLSPHSFAGASTLKPDIYQPSTSKASDFYGLNFQQTKESLFKDVPSSKTGGGNKNNELLNNGSRRYSDSSAQKSNANAQSNVSGTRFTMTLVTEDLLRPSDSSESKSTDNSALCKKDVSQPLVTKANNANIKPGFKVAEI

Summary

Description
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.
Catalytic Activity
1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP
1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP
5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
Similarity
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Belongs to the histidine acid phosphatase family.
Keywords
Alternative splicing   ATP-binding   Complete proteome   Cytoplasm   Kinase   Nucleotide-binding   Phosphoprotein   Reference proteome   RNA editing   Transferase  
Feature
chain  Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
splice variant  In isoform H.
EC Number
2.7.4.21
2.7.4.24
EMBL
ODYU01005735    SOQ46890.1    BABH01008538    BABH01008539    KQ459606    KPI91667.1    + More
GFDF01000218    JAV13866.1    GFDL01008591    JAV26454.1    KQ976467    KYM84166.1    GFDL01008580    JAV26465.1    GFDL01008609    JAV26436.1    KA647103    AFP61732.1    GFDF01000234    JAV13850.1    GEZM01065606    GEZM01065605    JAV68418.1    DS232204    EDS37428.1    GAKP01005060    JAC53892.1    GFDF01000099    JAV13985.1    GEZM01065610    JAV68413.1    GEZM01065611    GEZM01065601    JAV68412.1    GFDF01000115    JAV13969.1    GEZM01065607    GEZM01065602    JAV68420.1    GEDC01006394    JAS30904.1    NNAY01000679    OXU27021.1    GAKP01005053    JAC53899.1    GEZM01065603    JAV68419.1    APCN01004701    APCN01004702    APCN01004703    APCN01004704    UFQS01000258    UFQT01000258    SSX02109.1    SSX22486.1    GL441452    EFN64795.1    CH379063    KRT05877.1    CH933815    EDW08067.2    SSX02108.1    SSX22485.1    KK107087    EZA59954.1    CH954180    EDV47656.2    CM000162    EDX03134.2    KQS30589.1    KRK07141.1    ADTU01007759    ADTU01007760    KRT05875.1    GECU01034690    JAS73016.1    AE014298    BT015295    BT030309    OUUW01000003    SPP77845.1    QOIP01000001    RLU26573.1    KQS30592.1    KQ414631    KOC67231.1    GECU01032760    JAS74946.1    KRT05876.1    KRT05869.1    GDHC01019385    JAP99243.1    KQ434931    KZC11838.1    AHN60005.1    KA646812    AFP61441.1    KRT05870.1    KQS30591.1    KRT05878.1    KRT05872.1    KRT05879.1    GL452320    EFN77525.1    KRK07143.1    KZ288288    PBC29326.1    KRT05871.1    EAL32343.3    CH964239    EDW82376.2    GDHC01006871    JAQ11758.1    LBMM01000847    KMQ97384.1    KQS30590.1    GAKP01005058    JAC53894.1    KRK07142.1    AHN60003.1    GDHC01007341    JAQ11288.1    KQ971354    KYB26507.1    GBXI01015805    JAC98486.1    GEZM01065609    GEZM01065608    JAV68415.1    GDHC01017312    JAQ01317.1    LJIG01009101    KRT83754.1   
Pfam
PF00328   His_Phos_2        + More
PF18086   PPIP5K2_N
PF00010   HLH
Interpro
IPR040557   VIP1_N        + More
IPR029033   His_PPase_superfam       
IPR033379   Acid_Pase_AS       
IPR000560   His_Pase_clade-2       
IPR037446   His_Pase_VIP1       
IPR011598   bHLH_dom       
IPR036638   HLH_DNA-bd_sf       
IPR016021   MIF4-like_sf       
SUPFAM
SSF53254   SSF53254        + More
SSF47459   SSF47459       
Gene 3D
PDB
5DGI     E-value=9.93946e-158,     Score=1434

Ontologies

Topology

Subcellular location
  
Length:
1469
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00338
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00001
outside
1  -  1469
 
 

Population Genetic Test Statistics

Pi
210.600692
Theta
175.441735
Tajima's D
0.456721
CLR
0.005512
CSRT
0.501924903754812
Interpretation
Possibly Positive selection
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