Gene

KWMTBOMO05512  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006725

Annotation

extracellular_regulated_MAP_kinase_[Bombyx_mori]

Location

Bomo_Chr10(+):3888343-3936898      View in EpiBrowser

Full name

Mitogen-activated protein kinase      

Location in the cell

Cytoplasmic   Reliability : 2.219

CDS

ATGAAAGACGTTTACATCGTTCAATGCTTGATGGAGACCGATCTTTACAAGCTGTTGAAGACCCAGAAATTAAGTAACGATCACATCTGCTACTTCCTGTATCAGATCCTTCGAGGACTGAAATATATTCACTCTGCAAACGTCCTCCATAGGGACTTGAAGCCTTCTAATTTACTACTTAATACCACGTGCGATTTGAAGATTTGCGACTTCGGTCTGGCGCGAGTTGCGGATCCTGATCACGACCACACCGGTTTCCTCACGGAATACGTAGCCACGCGCTGGTACCGTGCTCCTGAAATCATGCTCAACTCAAAGGGCTATACCAAATCAATAGATATTTGGTCAGTGGGATGTATTTTGGCGGAGATGCTGTCCAACAGACCTATATTCCCGGGCAAGCACTATTTGGATCAATTGAATCACATTTTGGGAGTGCTCGGTTCGCCGAGTCAGGAGGATCTTGATTGCATCATTAACGAAAAGGCTCGTGGTTACTTGGAGTCGTTGCCGTTCAAGCCTCGCGTGCCGTGGGTGGACCTCTTCCCCGGAGCGGACCCTCGCGCCTTGGACCTGCTCCATCGCATGCTGACTTTCAACCCTCACAAACGCATCACGGTCGAGGAAGCCCTAGCCCATCCGTACCTCGAGCAGTACTACGACCCGAATGATGAGCCCGTAGCCGAGGAGCCTTTCCGTTTCGCGATGGAGCTCGACGATCTCCCGAAGGAGACGCTCAAGAAATACATATTCGAGGAGACGTTGTTCTTTAAACAGCAGAACGAAGACGCGTAA

Protein

MKDVYIVQCLMETDLYKLLKTQKLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQEDLDCIINEKARGYLESLPFKPRVPWVDLFPGADPRALDLLHRMLTFNPHKRITVEEALAHPYLEQYYDPNDEPVAEEPFRFAMELDDLPKETLKKYIFEETLFFKQQNEDA

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mg(2+)

Similarity

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

Uniprot

Q3C2L4   H9JB30   A0A2H1WDP4   A0A194QI47   A0A345CI05   A0A2A4J871   + More
A0A1B0YY60   A0A1Y1K5A3   A0A1Y1K4F9   A0A1B6LW59   A0A2J7QM98   A0A1B6GNA8   R4WCW8   A0A0L7LF64   A0A1B6DKW0   A0A067RFT2   V5I8E7   A0A1I9WLG8   U5EVN2   A0A224XR06   A0A023FCL1   A0A069DYR7   S5TBX9   K9LM34   G8Z9H6   V5N6T9   A0A0A9WY65   A0A1J1I3C1   A0A0P6IXU9   T1IFJ4   A0A0P4VKF7   A0A182QR63   B0WDB3   G3GC05   Q16HR0   A0A1Q3G0K2   J9PCW7   A0A1A9W5C4   T1E242   C6L430   A7BHS4   A0A0P4W996   D0EKI4   A0A182IZZ6   A0A0M4M1D3   Q7PVR1   A0A1S4H175   A0A182I592   A0A2M4CWD2   A0A2M4CV60   A0A2M4AI56   A0A2M3ZKR3   A0A0L0CBJ2   E2BZZ2   A0A0K8TW32   A0A2K6VB43   T1E1K2   A0A1S3J4P5   A0A182Y9U8   A0A182RG65   A0A232F3U0   A0A034W3U1   A0A195ERA1   F4W648   A0A158P1W9   A0A195DMU6   A0A151I7W4   A0A0L7RJA8   A0A0U2DB09   A0A195AWA8   A0A154PD45   A0A026WAQ7   T1PAX6   A0A0A1X1V3   A0A0P5PHU9   A0A3L8DR75   Q16945   A0A0P5BRV5   A0A1B0A4T4   A0A3S3QDC1   J7FZ52   E1ZZM3   A0A293L4K2   A0A1B0G2A4   A0A1B0ANY6   A0A1A9XVU3   A0A1A9V2A9   D6X2Z2   A0A1L7H9J9   A0A2C9K4U6   A0A1I8P312   A0A2R5L8W0   A0A310SAP0   A0A0N8BWE0   R7V580   A0A151X0J9   A0A0M8ZPJ6   A0A1L6UW76   A0A2S2P210   A0A0P6JQZ7  

EC Number

2.7.11.24

Pubmed

16360949    19121390    26354079    28004739    23691247    26227816    + More
24845553    27538518    25474469    26334808    24084041    25401762    26823975    26999592    27129103    17510324    24330624    26846853    17681525    22394010    12364791    26108605    20798317    20920257    25244985    28648823    25348373    21719571    21347285    24508170    25315136    25830018    30249741    18362917    19820115    27765698    15562597    23254933    28012735   

EMBL

AB183869    BAE46741.1    BABH01008514    ODYU01007854    SOQ50992.1    KQ458793    + More
KPJ05069.1    MF797866    AXF67444.1    NWSH01002739    PCG67602.1    KU358552    RSAL01000201    ANO46362.1    RVE44434.1    GEZM01095789    JAV55350.1    GEZM01095790    JAV55348.1    GEBQ01012066    JAT27911.1    NEVH01013214    PNF29720.1    GECZ01015572    GECZ01005862    JAS54197.1    JAS63907.1    AK417233    BAN20448.1    JTDY01001350    KOB74107.1    GEDC01027332    GEDC01011048    JAS09966.1    JAS26250.1    KK852530    KDR21908.1    GALX01004815    JAB63651.1    KU932352    APA33988.1    GANO01003332    JAB56539.1    GFTR01005434    JAW10992.1    GBBI01000179    JAC18533.1    GBGD01001920    JAC86969.1    KC896761    AGS38337.1    JN035901    AFL70596.1    GU324353    GU324354    ADT80930.1    KC537791    AHA83424.1    GBHO01030187    GDHC01007988    JAG13417.1    JAQ10641.1    CVRI01000038    CRK94274.1    GDUN01000123    JAN95796.1    ACPB03005609    GDKW01001785    JAI54810.1    AXCN02000825    DS231895    EDS44348.1    JF830802    AEE81046.1    CH478148    EAT33794.1    GFDL01001728    JAV33317.1    GU002542    KP100030    ADF87942.1    AKO62680.1    GALA01001074    JAA93778.1    KU160504    AB478860    AME17868.1    BAH86598.1    AB277827    BAF75365.1    GDRN01076339    JAI62909.1    GQ847862    ACX32460.1    KR075869    ALE20588.1    AAAB01008984    EAA14714.5    APCN01003837    GGFL01004980    MBW69158.1    GGFL01004981    MBW69159.1    GGFK01007154    MBW40475.1    GGFM01008373    MBW29124.1    JRES01000648    KNC29602.1    GL451708    EFN78769.1    GDHF01034054    JAI18260.1    GALA01001589    JAA93263.1    NNAY01001066    OXU25262.1    GAKP01009568    JAC49384.1    KQ982021    KYN30409.1    GL887707    EGI70183.1    ADTU01006906    KQ980724    KYN14146.1    KQ978397    KYM94213.1    KQ414582    KOC70909.1    KP099006    AKO62652.1    KQ976731    KYM76320.1    KQ434874    KZC09743.1    KK107293    EZA53172.1    KA645305    AFP59934.1    GBXI01009185    JAD05107.1    GDIQ01138340    JAL13386.1    QOIP01000005    RLU22389.1    U40484    AAA83210.1    GDIP01181690    GDIQ01123541    JAJ41712.1    JAL28185.1    NCKU01003464    RWS07466.1    JX103496    AFP57674.1    GL435444    EFN73366.1    GFWV01001097    MAA25827.1    CCAG010004344    JXJN01001079    KQ971372    EFA10708.1    KU351558    APU52030.1    GGLE01001784    MBY05910.1    KQ766110    OAD53741.1    GDIQ01138339    JAL13387.1    AMQN01000736    AMQN01000737    KB295062    ELU13684.1    KQ982611    KYQ53901.1    KQ435922    KOX68500.1    KY283808    APS85777.1    GGMR01010841    MBY23460.1    GDIQ01011806    JAN82931.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000283053    UP000235965    UP000037510    + More
UP000027135    UP000183832    UP000015103    UP000075886    UP000002320    UP000008820    UP000091820    UP000075880    UP000007062    UP000075840    UP000037069    UP000008237    UP000085678    UP000076408    UP000075900    UP000215335    UP000078541    UP000007755    UP000005205    UP000078492    UP000078542    UP000053825    UP000078540    UP000076502    UP000053097    UP000095301    UP000279307    UP000092445    UP000285301    UP000000311    UP000092444    UP000092460    UP000092443    UP000078200    UP000007266    UP000076420    UP000095300    UP000014760    UP000075809    UP000053105   

PRIDE

Q3C2L4    H9JB30   

Pfam

PF00069   Pkinase

Interpro

IPR000719   Prot_kinase_dom        + More
IPR008349   MAPK_ERK1/2       
IPR003527   MAP_kinase_CS       
IPR017441   Protein_kinase_ATP_BS       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

Q3C2L4   H9JB30   A0A2H1WDP4   A0A194QI47   A0A345CI05   A0A2A4J871   + More
A0A1B0YY60   A0A1Y1K5A3   A0A1Y1K4F9   A0A1B6LW59   A0A2J7QM98   A0A1B6GNA8   R4WCW8   A0A0L7LF64   A0A1B6DKW0   A0A067RFT2   V5I8E7   A0A1I9WLG8   U5EVN2   A0A224XR06   A0A023FCL1   A0A069DYR7   S5TBX9   K9LM34   G8Z9H6   V5N6T9   A0A0A9WY65   A0A1J1I3C1   A0A0P6IXU9   T1IFJ4   A0A0P4VKF7   A0A182QR63   B0WDB3   G3GC05   Q16HR0   A0A1Q3G0K2   J9PCW7   A0A1A9W5C4   T1E242   C6L430   A7BHS4   A0A0P4W996   D0EKI4   A0A182IZZ6   A0A0M4M1D3   Q7PVR1   A0A1S4H175   A0A182I592   A0A2M4CWD2   A0A2M4CV60   A0A2M4AI56   A0A2M3ZKR3   A0A0L0CBJ2   E2BZZ2   A0A0K8TW32   A0A2K6VB43   T1E1K2   A0A1S3J4P5   A0A182Y9U8   A0A182RG65   A0A232F3U0   A0A034W3U1   A0A195ERA1   F4W648   A0A158P1W9   A0A195DMU6   A0A151I7W4   A0A0L7RJA8   A0A0U2DB09   A0A195AWA8   A0A154PD45   A0A026WAQ7   T1PAX6   A0A0A1X1V3   A0A0P5PHU9   A0A3L8DR75   Q16945   A0A0P5BRV5   A0A1B0A4T4   A0A3S3QDC1   J7FZ52   E1ZZM3   A0A293L4K2   A0A1B0G2A4   A0A1B0ANY6   A0A1A9XVU3   A0A1A9V2A9   D6X2Z2   A0A1L7H9J9   A0A2C9K4U6   A0A1I8P312   A0A2R5L8W0   A0A310SAP0   A0A0N8BWE0   R7V580   A0A151X0J9   A0A0M8ZPJ6   A0A1L6UW76   A0A2S2P210   A0A0P6JQZ7  

PDB

2ZOQ     E-value=2.01899e-134,     Score=1225

KEGG

692466    K04371 mitogen-activated protein kinase 1/3 [EC:2.7.11.24] | (RefSeq) Erk; extracellular regulated M

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04214    Apoptosis - fly - Bombyx mori (domestic silkworm)
04320    Dorso-ventral axis formation - Bombyx mori (domestic silkworm)
04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0004707   GO:0005524   GO:0005634   GO:0005737   GO:0035556   GO:0071310   GO:0010468   GO:0016301   GO:0004672   GO:0006468   GO:0031683   GO:0001664   GO:0005525   GO:0007264   GO:0003824  

Length:

264

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02396

Exp number, first 60 AAs:

0.01119

Total prob of N-in:

0.07168

outside

1  -  264

 

 

Pi

185.040927

Theta

183.70505

Tajima's D

0.027802

CLR

0.595672

CSRT

0.374031298435078

Interpretation

Uncertain