Gene

KWMTBOMO05511

Pre Gene Modal

BGIBMGA006616

Annotation

ORAI_calcium_release-activated_calcium_modulator_1_isoform_B_[Bombyx_mori]

Location

Bomo_Chr10(-):3878459-3883982      View in EpiBrowser

Full name

Calcium release-activated calcium channel protein 1      

Alternative Name

Protein orai
dOrai

Location in the cell

PlasmaMembrane   Reliability : 4.77

CDS

ATGTCGGGTGAGACGCCGATACAGTCGGGGGACGGGCTTCATACGCCGGCGTACCTCTCGTGGAGGAAGTTGCAGCTTAGTAGGGCGAAACTGAAGGCTTCCAGCAAAACATCTGCCCTACTTTCCGGTTTCGCTATGGTGGCTATGGTCGAAGTACAATTAAATCCAGCCCCCACTGCAGTACCAAAGGAGATGCTCGTCGCTTTCACGGTGTGCACAACACTCTTAGTCGCAGTCCACATGCTCGCGCTCATGATTAGCACCTGCATTTTGCCAAACATCGAAGCAGTCGGCAACTTGCATAGTATAGCGCTCGTCCATGAGTCGCCACACGAGAGACTCCACTGGTACATCGAAGTGGCTTGGGCTTTTTCGACCCTCTTAGGCTTAATCTTATTCTTGATAGAGATAGCTATACTATGTTGGGTTAAATTCTACGATTTGAGTCCGACGGCAGCTTGGTCGGCCTGTGTGGTCCTTATACCTGTTATGATTGTATTTTTGGCGTTCGCAATACATTTTTACATGTCCCTGGCGACGCACAAGTACGAAGTCACGGTGACAGGTATCAAAGAATTAGAATTGCTCAAAGAACAGATCGAAATGGGCGACCACGACGCCAGAATGAACAGCTTAACGTTGCTGGACCAAAGTCGGGTCGTCTGA

Protein

MSGETPIQSGDGLHTPAYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLNPAPTAVPKEMLVAFTVCTTLLVAVHMLALMISTCILPNIEAVGNLHSIALVHESPHERLHWYIEVAWAFSTLLGLILFLIEIAILCWVKFYDLSPTAAWSACVVLIPVMIVFLAFAIHFYMSLATHKYEVTVTGIKELELLKEQIEMGDHDARMNSLTLLDQSRVV

Description

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores. Regulates transcription factor NFAT nuclear import.

Miscellaneous

In Greek mythology, the 'Orai' are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace).

Similarity

Belongs to the Orai family.

Keywords

3D-structure   Alternative splicing   Calcium   Calcium channel   Calcium transport   Cell membrane   Complete proteome   Ion channel   Ion transport   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Calcium release-activated calcium channel protein 1
splice variant  In isoform E.

Uniprot

B5BRC4   B5BRC5   A0A2A4J677   A0A2A4J5M0   A0A2H4THI5   A0A2A4J4V7   + More
A0A2H1X1P9   A0A194RNY3   A0A194QHP9   A0A212FPV1   A0A0L7LFC4   A0A1E1W0N2   A0A2J7PD50   A0A1B6BWH1   A0A067RKQ5   A0A2A3E349   V9IMF7   A0A1B6DQT6   A0A1B6DJR3   A0A0C9S228   E0VCV9   A0A0Q9WFR7   E1ZXA4   B4KQU4   K7IRN4   A0A0N0BC83   A0A154PPF8   A0A0L7R8M8   A0A1B6DTE8   A0A195FT39   A0A195BD97   A0A195D4X5   A0A195DI95   A0A3L8E2D9   A0A026WLE9   B4LL00   A0A088A6F8   A0A158NQQ6   E2BPB3   A0A0Q9XLG5   F4WBV4   A0A151XB59   A0A0M4EFW8   A0A1J1IU05   E9IG63   A0A232F4J2   A0A023ENZ4   A0A182GIF4   A0A023EP20   Q1DGX6   A0A336MRH2   Q17KQ6   B3MHX0   A0A1B6M0F8   B4MYJ1   A0A0K8TMZ0   A0A034VVZ2   A0A1B6HJX2   A0A0A1X224   W8ARW0   A0A1B6K1W3   A0A1B6FRP5   A0A0P9AF78   A0A1B6L3M9   A0A1B6HEU3   A0A1B0CQE2   B3NLL3   W8AVR1   A0A1W4VCB4   A0A0K8V9V0   A0A034W048   A0A0J9RFF1   B4P522   A0A182FMR7   E2QCH2   Q9U6B8   A0A023F5K7   N6V920   A0A1B6FIK9   A0A0V0GBU1   A0A069DXE3   A0A1I8PVS4   B4J9K5   A0A224XSH1   A0A3B0J5I1   T1P9I5   D3TQ77   A0A0P4VLK6   U5EU49   A0A0Q5VSX6   Q9U6B8-3   B4HN91   B4QBS3   A0A1A9XNG8   A0A1B0B0A2   A0A1W4V019   A0A1A9WHE0   A0A1L8DFL5   A0A0R1DS50   T1HN87  

Pubmed

19740753    19121390    26354079    22118469    26227816    24845553    + More
20566863    17994087    20798317    20075255    30249741    24508170    21347285    21719571    21282665    28648823    24945155    26483478    17510324    18057021    26369729    25348373    25830018    24495485    22936249    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    16751269    12537569    16582901    16645049    25474469    15632085    23185243    26334808    20353571    27129103   

EMBL

AB425231    BAG69139.1    BABH01008506    AB425232    BAG69140.1    NWSH01002969    + More
PCG67178.1    PCG67179.1    KY174952    ATY75505.1    PCG67177.1    ODYU01012769    SOQ59241.1    KQ459984    KPJ19030.1    KQ458793    KPJ05068.1    AGBW02000411    OWR55776.1    JTDY01001350    KOB74110.1    GDQN01010509    JAT80545.1    NEVH01026394    PNF14257.1    GEDC01031667    JAS05631.1    KK852620    KDR20084.1    KZ288405    PBC26147.1    JR051951    AEY61594.1    GEDC01009261    JAS28037.1    GEDC01011362    JAS25936.1    GBYB01014931    JAG84698.1    DS235065    EEB11215.1    CH940648    KRF80244.1    GL435030    EFN74194.1    CH933808    EDW09293.2    KQ435922    KOX68562.1    KQ434998    KZC13324.1    KQ414632    KOC67183.1    GEDC01008357    JAS28941.1    KQ981280    KYN43467.1    KQ976511    KYM82533.1    KQ976885    KYN07479.1    KQ980824    KYN12557.1    QOIP01000001    RLU26864.1    KK107154    EZA56877.1    EDW61807.2    ADTU01023464    ADTU01023465    ADTU01023466    GL449574    EFN82468.1    KRG04579.1    GL888066    EGI68382.1    KQ982335    KYQ57584.1    CP012524    ALC42326.1    CVRI01000059    CRL03671.1    GL762910    EFZ20471.1    NNAY01001042    OXU25383.1    GAPW01002917    JAC10681.1    JXUM01066229    JXUM01066230    JXUM01066231    KQ562387    KXJ76013.1    GAPW01002893    JAC10705.1    CH900090    EAT32406.1    UFQS01001137    UFQT01001137    UFQT01001985    SSX09181.1    SSX32305.1    CH477222    EAT47248.1    CH902619    EDV36957.2    KPU76538.1    GEBQ01010607    GEBQ01007271    GEBQ01007103    GEBQ01003179    JAT29370.1    JAT32706.1    JAT32874.1    JAT36798.1    CH963894    EDW77180.2    GDAI01002080    JAI15523.1    GAKP01011441    GAKP01011440    GAKP01011439    JAC47511.1    GECU01032754    JAS74952.1    GBXI01009366    JAD04926.1    GAMC01017743    JAB88812.1    GECU01002281    JAT05426.1    GECZ01016911    JAS52858.1    KPU76537.1    GEBQ01021721    GEBQ01002336    JAT18256.1    JAT37641.1    GECU01034544    JAS73162.1    AJWK01023464    CH954179    EDV54988.1    KQS62052.1    GAMC01017742    JAB88813.1    GDHF01016701    GDHF01008376    JAI35613.1    JAI43938.1    GAKP01011442    JAC47510.1    CM002911    KMY94695.1    KMY94696.1    KMY94697.1    KMY94698.1    CM000158    EDW91723.1    KRK00046.1    KRK00047.1    AE013599    AAM68473.1    DQ503470    AF188634    AY071273    BT001876    BT003591    GBBI01002257    JAC16455.1    CM000071    ENO01906.2    KRT03044.1    GECZ01019723    JAS50046.1    GECL01000884    JAP05240.1    GBGD01002870    JAC86019.1    CH916367    EDW02512.1    GFTR01003658    JAW12768.1    OUUW01000001    SPP74922.1    KA645436    KA649240    AFP60065.1    EZ423579    ADD19855.1    GDKW01003274    JAI53321.1    GANO01002483    JAB57388.1    KQS62053.1    CH480816    EDW48373.1    CM000362    EDX07583.1    KMY94694.1    JXJN01006619    JXJN01006620    GFDF01008917    JAV05167.1    KRK00048.1    ACPB03020356   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000235965    UP000027135    UP000242457    UP000009046    UP000008792    UP000000311    UP000009192    UP000002358    UP000053105    UP000076502    UP000053825    UP000078541    UP000078540    UP000078542    UP000078492    UP000279307    UP000053097    UP000005203    UP000005205    UP000008237    UP000007755    UP000075809    UP000092553    UP000183832    UP000215335    UP000069940    UP000249989    UP000008820    UP000007801    UP000007798    UP000092461    UP000008711    UP000192221    UP000002282    UP000069272    UP000000803    UP000001819    UP000095300    UP000001070    UP000268350    UP000001292    UP000000304    UP000092443    UP000092460    UP000091820    UP000015103   

PRIDE

B5BRC4    B5BRC5    E2QCH2    Q9U6B8   

Pfam

PF07856   Orai-1

Interpro

IPR038350   Orai_sf        + More
IPR012446   CRAC_channel       

Gene 3D

1.20.140.140    

ProteinModelPortal

B5BRC4   B5BRC5   A0A2A4J677   A0A2A4J5M0   A0A2H4THI5   A0A2A4J4V7   + More
A0A2H1X1P9   A0A194RNY3   A0A194QHP9   A0A212FPV1   A0A0L7LFC4   A0A1E1W0N2   A0A2J7PD50   A0A1B6BWH1   A0A067RKQ5   A0A2A3E349   V9IMF7   A0A1B6DQT6   A0A1B6DJR3   A0A0C9S228   E0VCV9   A0A0Q9WFR7   E1ZXA4   B4KQU4   K7IRN4   A0A0N0BC83   A0A154PPF8   A0A0L7R8M8   A0A1B6DTE8   A0A195FT39   A0A195BD97   A0A195D4X5   A0A195DI95   A0A3L8E2D9   A0A026WLE9   B4LL00   A0A088A6F8   A0A158NQQ6   E2BPB3   A0A0Q9XLG5   F4WBV4   A0A151XB59   A0A0M4EFW8   A0A1J1IU05   E9IG63   A0A232F4J2   A0A023ENZ4   A0A182GIF4   A0A023EP20   Q1DGX6   A0A336MRH2   Q17KQ6   B3MHX0   A0A1B6M0F8   B4MYJ1   A0A0K8TMZ0   A0A034VVZ2   A0A1B6HJX2   A0A0A1X224   W8ARW0   A0A1B6K1W3   A0A1B6FRP5   A0A0P9AF78   A0A1B6L3M9   A0A1B6HEU3   A0A1B0CQE2   B3NLL3   W8AVR1   A0A1W4VCB4   A0A0K8V9V0   A0A034W048   A0A0J9RFF1   B4P522   A0A182FMR7   E2QCH2   Q9U6B8   A0A023F5K7   N6V920   A0A1B6FIK9   A0A0V0GBU1   A0A069DXE3   A0A1I8PVS4   B4J9K5   A0A224XSH1   A0A3B0J5I1   T1P9I5   D3TQ77   A0A0P4VLK6   U5EU49   A0A0Q5VSX6   Q9U6B8-3   B4HN91   B4QBS3   A0A1A9XNG8   A0A1B0B0A2   A0A1W4V019   A0A1A9WHE0   A0A1L8DFL5   A0A0R1DS50   T1HN87  

PDB

6BBG     E-value=5.01593e-64,     Score=617

KEGG

100188931    K16056 calcium release-activated calcium channel protein 1 | (RefSeq) Orai1; ORAI calcium release-ac

GO

GO:0016021   GO:0016787   GO:0051928   GO:0015279   GO:0005887   GO:0042802   GO:0002115   GO:0070886   GO:0007399   GO:0005886  

PANTHER

PTHR31501  

Subcellular location

Cell membrane  

Length:

221

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

77.94872

Exp number, first 60 AAs:

10.42785

Total prob of N-in:

0.65225

POSSIBLE N-term signal

sequence

outside

1  -  64

TMhelix

65  -  87

inside

88  -  119

TMhelix

120  -  142

outside

143  -  151

TMhelix

152  -  174

inside

175  -  221

 

 

Pi

200.451751

Theta

162.881095

Tajima's D

0.009993

CLR

345.342034

CSRT

0.372781360931953

Interpretation

Uncertain