Gene

KWMTBOMO05506

Pre Gene Modal

BGIBMGA006619

Annotation

dopamine_transporter_[Bombyx_mori]

Location

Bomo_Chr10(-):3807379-3836532      View in EpiBrowser

Full name

Transporter       + More
Sodium-dependent dopamine transporter      

Alternative Name

Protein fumin

Location in the cell

PlasmaMembrane   Reliability : 4.883

CDS

ATGGCGCTGAAGACCCCGACGCCGGGTGTTGTCGGCGAACGCGAGACCTGGGGCAAGAAGGTCGACTTCCTGCTCTCGGTCATCGGGTTCGCCGTCGACCTCGCCAACGTGTGGCGCTTCCCCTACCTCTGCTATAAGAATGGAGGGGGTGCGTTTTTGGTGCCATACTGCATCATGCTGGTAGTGGGTGGAATTCCACTTTTCTACATGGAGTTGGCGCTGGGACAATTTCACAGGAAGGGTGCCATCACCTGCTGGGGCAGGCTTGTCCCGCTTTTCAAAGGAATCGGTTATGCTGTCGTCCTGATCGCGTTCTACGTGGACTTTTACTACAACGTGATAATCGCTTGGGCGCTGCGTTTTTTCTTCGCCTCTTTCACGACCATGCTACCTTGGACCAACTGCGACAACGAATGGAACACACCTGCCTGCCGACCGTTCGAAGCCATTTGGGACGTTAACCGTACACGTATACGCAATACCACGTCCGCAAGTTTGGGAATCGCTCCGACAACACCGTACACTTCTGCTGCTTCGGAATATTTCAACCGCGCGATTTTAGAATTGCAAGGCAGCGAGGGGCTCCACGACCTTGGTTCTGTAAAATGGGATATGGCGCTGTGTTTATTGGCCGTCTACGTCATCTGCTACTTCTCCTTGTGGAAGGGAATCAGTACTTCTGGAAAAGTTGTTTGGTTCACAGCACTCTTTCCGTACGCTGTTCTTTTGATACTCTTGGTTCGTGGTATCACCCTCCCTGGATCGGCGACCGGAATCCAATACTATCTGAGTCCGAACTTTGAAGCTATAACTCAACCTCAGGTGTGGGTGGACGCCGCTACTCAAGTCTTCTTTTCTCTTGGACCGGGCTTTGGAGTGCTCTTGGCTTATGCATCGTACAACAAGTACCACAACAACGTGTACAAGGACGCCATTTTGACCAGCGTCATAAATTCCGCAACGTCTTTCGTCGCTGGTTTCGTGATCTTCAGCGTGCTCGGCTACATGGCGCACGCTTCGGGCAGAGACGTTCAGGATGTCGCAACCGAAGGCCCGGGACTAGTTTTCGTGGTGTACCCGGCGGCTATAGCTACGATGCCAGGATCAACGTTTTGGGCGCTTATATTCTTCATGATGCTGCTTACACTTGGGCTTGATAGTTCTTTTGGGGGTTCCGAAGCGATAATCACAGCTCTCAGTGACGAGTTCCCTCCTATCGGACGTCATCGCGAATTGTTCGTCGCCTGCCTCTTTACGTTGTATTTCTTCGTGGGACTGGCCTCTTGCACGAAAGGCGGATTTTACTTCTTCCAGCTCTTGGATCGCTATGCTGCGGGCTATTCTATTCTCATCGCTGTTTTCTTTGAGGCCATAGCTGTCTCCTGGATTTATGGCACGGAAAGATTTTGTGAGGACATTCGCGACATGATCGGCTTCAGACCTGGCCTGTACTGGCGCGTTTGTTGGCGTTTCGCGGCACCATCTTTTTTGCTCTTCATCACGGCATACGGACTCTTAGACTACGAACCTCTGCAATACGAGAACTACATCTATCCAGGCTGGGCCAACGCACTTGGCTGGGCCATTGCTGGATCCAGCGTCATGTGCATACCGACAGTGGCTATCTATAAACTGATTACAACTAAAGGATCGTTTTTGGAGCGTCTTCGCGTTTTAACAACCCCTTATGCAGACAGCGAACGTAATGGAACCGTGCACAACGGTATGATAGTGTCCGAGAGCGGCGGCGTTCGGCTGACGTCAGCGGTGCAAACCCCCACAACTCCACAGCAACCGATCGGAGCAAATATTCCAGCAGCCTCGGCTCCAACTCTCGCTTCATCTCCAGCGCTGGTCTGA

Protein

MALKTPTPGVVGERETWGKKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYCIMLVVGGIPLFYMELALGQFHRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWALRFFFASFTTMLPWTNCDNEWNTPACRPFEAIWDVNRTRIRNTTSASLGIAPTTPYTSAASEYFNRAILELQGSEGLHDLGSVKWDMALCLLAVYVICYFSLWKGISTSGKVVWFTALFPYAVLLILLVRGITLPGSATGIQYYLSPNFEAITQPQVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDAILTSVINSATSFVAGFVIFSVLGYMAHASGRDVQDVATEGPGLVFVVYPAAIATMPGSTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPPIGRHRELFVACLFTLYFFVGLASCTKGGFYFFQLLDRYAAGYSILIAVFFEAIAVSWIYGTERFCEDIRDMIGFRPGLYWRVCWRFAAPSFLLFITAYGLLDYEPLQYENYIYPGWANALGWAIAGSSVMCIPTVAIYKLITTKGSFLERLRVLTTPYADSERNGTVHNGMIVSESGGVRLTSAVQTPTTPQQPIGANIPAASAPTLASSPALV

Description

Sodium-dependent dopamine transporter which terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:11125028, PubMed:12606774, PubMed:24037379, PubMed:25970245). Also transports tyramine and norepinephrine, shows less efficient transport of octopamine and does not transport serotonin (PubMed:11125028, PubMed:12606774). Plays a role in the regulation of the rest/activity cycle (PubMed:16093388, PubMed:25232310).

Miscellaneous

10-fold less sensitive to cocaine than mammalian dopamine transporter SLC6A3.

Similarity

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.

Keywords

3D-structure   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Membrane   Metal-binding   Neurotransmitter transport   Reference proteome   Sodium   Symport   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Transporter

Uniprot

Q45VA3   A0A2A4IX52   Q86MC4   H9JAS4   A0A2H1WLW5   A0A212F0P2   + More
Q45VA2   A0A194RSJ2   A0A0G3VG04   A0A3S2NTV6   A0A194QHP4   A0A0L7LLJ2   Q16TV9   A0A1I8MCE3   A0A0V0GBJ2   A0A023F4F4   I2FKF4   A0A069DV82   A0A224X9N0   A0A2J7RJL9   A0A0L0BLL6   A0A182IX90   A0A1I8PFW0   A0A195FSP1   E1ZXA1   A0A084WN18   A0A182QPG6   A0A195D3J0   B4KSI5   A0A158NQQ9   A0A151WND3   A0A182UWK2   Q7QJ94   F4WBV1   A0A195BE92   A0A1A9WR92   A0A195DI93   W8C6P2   B4P656   W8BA44   B3NPH4   B4LMF2   B4HSZ4   B4J7H0   B4QI04   A0A0B4KEX2   Q7K4Y6   A0A1B0FKI7   A0A154P078   A0A026WMI7   A0A3L8E4C5   A0A1W4UKV4   A0A1B6MBJ9   A0A2A3EG39   A0A3B0JJ43   A0A0M9A3V3   A0A087ZQ28   B4MPH7   A0A0K8VN76   B9A0V7   A0A0K8U8S5   Q291U3   B4GA93   A0A336MNN5   A0A0M5IXL3   A0A1J1ICN7   A0A0A1X506   A0A2H8TLX0   A0A2S2PRA9   E9HBL2   B0WUE7   T1I1H1   A0A0P5IDE2   A0A0P6BYM5   E9IG58   A0A182UCW0   A0A182FDF5   A0A182PRE6   A0A226E682   A0A182NI32   A0A182XYN8   A0A182MIW2   A0A182WJF0   A0A1B0B3H9   A0A310SJT6   A0A0P5LUT0   A0A182I335   A0A0P5RJ52   A0A182X3Y4   A0A182JRM0   W5JIV4   A0A087T7C5   A0A182R7A4   B4K361   T1PKA4   A0A0N8ACY8   A0A164NRL7   A0A1B6HM80   A0A182SRQ8   A0A2R5LK72  

Pubmed

16310975    19121390    22118469    26354079    26227816    17510324    + More
25315136    25474469    26334808    26108605    20798317    24438588    17994087    21347285    12364791    21719571    24495485    17550304    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    11125028    12606774    12537569    16093388    17131045    25232310    24037379    25970245    25961798    24508170    30249741    15632085    25830018    21292972    21282665    25244985    20920257    23761445   

EMBL

DQ105979    AAZ17653.1    NWSH01004992    PCG64517.1    AY154398    AAN52844.2    + More
BABH01008498    BABH01008499    BABH01008500    ODYU01009490    SOQ53966.1    AGBW02011059    OWR47287.1    DQ105980    AAZ17654.1    KQ459984    KPJ19036.1    KP657644    AKL78869.1    RSAL01000201    RVE44440.1    KQ458793    KPJ05063.1    JTDY01000624    KOB76428.1    CH477638    EAT37969.1    GECL01000819    JAP05305.1    GBBI01002316    JAC16396.1    AB720744    BAM15639.1    GBGD01000916    JAC87973.1    GFTR01007359    JAW09067.1    NEVH01002992    PNF41019.1    JRES01001695    KNC20917.1    KQ981280    KYN43463.1    GL435030    EFN74191.1    ATLV01024553    KE525352    KFB51612.1    AXCN02000388    AXCN02000389    KQ976885    KYN07475.1    CH933808    EDW09490.2    ADTU01023469    ADTU01023470    ADTU01023471    KQ982911    KYQ49330.1    AAAB01008807    EAA04277.4    GL888066    EGI68379.1    KQ976511    KYM82529.1    KQ980824    KYN12561.1    GAMC01008426    JAB98129.1    CM000158    EDW91906.1    GAMC01008425    JAB98130.1    CH954179    EDV55741.1    CH940648    EDW62047.2    CH480816    EDW48158.1    CH916367    EDW01094.1    CM000362    CM002911    EDX07375.1    KMY94287.1    AE013599    AGB93558.1    AF260833    AF439752    AY051579    AAF76882.1    AAK93003.1    AAL32055.1    CCAG010001148    KQ434782    KZC04540.1    KK107154    EZA56881.1    QOIP01000001    RLU27541.1    GEBQ01006674    JAT33303.1    KZ288254    PBC30725.1    OUUW01000001    SPP73459.1    KQ435763    KOX75413.1    CH963849    EDW74016.1    GDHF01011983    JAI40331.1    AB370000    BAH22564.1    GDHF01029321    JAI22993.1    CM000071    EAL25019.2    CH479181    EDW31845.1    UFQS01001621    UFQT01001621    SSX11636.1    SSX31201.1    CP012524    ALC41674.1    CVRI01000043    CRK96201.1    GBXI01008487    JAD05805.1    GFXV01002857    MBW14662.1    GGMR01019255    MBY31874.1    GL732616    EFX70864.1    DS232104    EDS34926.1    ACPB03008045    GDIQ01216288    JAK35437.1    GDIP01007470    JAM96245.1    GL762910    EFZ20467.1    LNIX01000006    OXA52564.1    AXCM01001523    JXJN01007860    KQ761824    OAD56761.1    GDIQ01164868    JAK86857.1    APCN01000197    GDIQ01101821    JAL49905.1    ADMH02001280    ETN63223.1    KK113777    KFM61014.1    CH920905    EDW04524.1    KA649196    AFP63825.1    GDIP01159633    JAJ63769.1    LRGB01002836    KZS06180.1    GECU01031913    JAS75793.1    GGLE01005702    MBY09828.1   

Proteomes

UP000218220    UP000005204    UP000007151    UP000053240    UP000283053    UP000053268    + More
UP000037510    UP000008820    UP000095301    UP000235965    UP000037069    UP000075880    UP000095300    UP000078541    UP000000311    UP000030765    UP000075886    UP000078542    UP000009192    UP000005205    UP000075809    UP000075903    UP000007062    UP000007755    UP000078540    UP000091820    UP000078492    UP000002282    UP000008711    UP000008792    UP000001292    UP000001070    UP000000304    UP000000803    UP000092444    UP000076502    UP000053097    UP000279307    UP000192221    UP000242457    UP000268350    UP000053105    UP000005203    UP000007798    UP000001819    UP000008744    UP000092553    UP000183832    UP000000305    UP000002320    UP000015103    UP000075902    UP000069272    UP000075885    UP000198287    UP000075884    UP000076408    UP000075883    UP000075920    UP000092460    UP000075840    UP000075881    UP000000673    UP000054359    UP000075900    UP000076858    UP000075901   

PRIDE

Q45VA3    H9JAS4    Q7K4Y6   

Pfam

PF00209   SNF

Interpro

IPR037272   SNS_sf        + More
IPR000175   Na/ntran_symport       

SUPFAM

SSF161070   SSF161070       

ProteinModelPortal

Q45VA3   A0A2A4IX52   Q86MC4   H9JAS4   A0A2H1WLW5   A0A212F0P2   + More
Q45VA2   A0A194RSJ2   A0A0G3VG04   A0A3S2NTV6   A0A194QHP4   A0A0L7LLJ2   Q16TV9   A0A1I8MCE3   A0A0V0GBJ2   A0A023F4F4   I2FKF4   A0A069DV82   A0A224X9N0   A0A2J7RJL9   A0A0L0BLL6   A0A182IX90   A0A1I8PFW0   A0A195FSP1   E1ZXA1   A0A084WN18   A0A182QPG6   A0A195D3J0   B4KSI5   A0A158NQQ9   A0A151WND3   A0A182UWK2   Q7QJ94   F4WBV1   A0A195BE92   A0A1A9WR92   A0A195DI93   W8C6P2   B4P656   W8BA44   B3NPH4   B4LMF2   B4HSZ4   B4J7H0   B4QI04   A0A0B4KEX2   Q7K4Y6   A0A1B0FKI7   A0A154P078   A0A026WMI7   A0A3L8E4C5   A0A1W4UKV4   A0A1B6MBJ9   A0A2A3EG39   A0A3B0JJ43   A0A0M9A3V3   A0A087ZQ28   B4MPH7   A0A0K8VN76   B9A0V7   A0A0K8U8S5   Q291U3   B4GA93   A0A336MNN5   A0A0M5IXL3   A0A1J1ICN7   A0A0A1X506   A0A2H8TLX0   A0A2S2PRA9   E9HBL2   B0WUE7   T1I1H1   A0A0P5IDE2   A0A0P6BYM5   E9IG58   A0A182UCW0   A0A182FDF5   A0A182PRE6   A0A226E682   A0A182NI32   A0A182XYN8   A0A182MIW2   A0A182WJF0   A0A1B0B3H9   A0A310SJT6   A0A0P5LUT0   A0A182I335   A0A0P5RJ52   A0A182X3Y4   A0A182JRM0   W5JIV4   A0A087T7C5   A0A182R7A4   B4K361   T1PKA4   A0A0N8ACY8   A0A164NRL7   A0A1B6HM80   A0A182SRQ8   A0A2R5LK72  

PDB

4XPA     E-value=0,     Score=2216

KEGG

101744281    K05036 solute carrier family 6 (neurotransmitter transporter, dopamine) member 3 | (RefSeq) DAT; sod

GO

GO:0016021   GO:0005328   GO:0015293   GO:0015874   GO:0005330   GO:0042734   GO:0032809   GO:0051583   GO:0043005   GO:0005886   GO:0099509   GO:0030431   GO:0008344   GO:0046872   GO:1990834   GO:0042745   GO:0098793   GO:0019811   GO:0005887   GO:0015872   GO:0006836   GO:0006468   GO:0005524   GO:0031683   GO:0001664   GO:0005525   GO:0007264   GO:0003824  

PANTHER

PTHR11616  

Subcellular location

Cell membrane  

Length:

619

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

266.25967

Exp number, first 60 AAs:

26.62077

Total prob of N-in:

0.71042

POSSIBLE N-term signal

sequence

inside

1  -  22

TMhelix

23  -  42

outside

43  -  51

TMhelix

52  -  74

inside

75  -  94

TMhelix

95  -  117

outside

118  -  202

TMhelix

203  -  225

inside

226  -  229

TMhelix

230  -  252

outside

253  -  278

TMhelix

279  -  301

inside

302  -  312

TMhelix

313  -  335

outside

336  -  354

TMhelix

355  -  377

inside

378  -  411

TMhelix

412  -  434

outside

435  -  443

TMhelix

444  -  466

inside

467  -  486

TMhelix

487  -  506

outside

507  -  520

TMhelix

521  -  543

inside

544  -  619

 

 

Pi

203.655259

Theta

171.773883

Tajima's D

0.897598

CLR

0.350999

CSRT

0.630468476576171

Interpretation

Uncertain