Gene

KWMTBOMO05501

Annotation

serine/threonine_kinase_NLK_[Danaus_plexippus]

Location

Bomo_Chr10(-):3632248-3638346      View in EpiBrowser

Full name

Mitogen-activated protein kinase      

Location in the cell

Extracellular   Reliability : 1.105 Mitochondrial   Reliability : 1.414 Nuclear   Reliability : 1.53

CDS

ATGTTAAGGGCTGTGACGGACCCTCGCGATGGCCGGCGGGTGGCGCTCAAGAAACTGCCGAACGTATTCCAGTCGCTTGTCTCCTCAAAACGTGTCTTCCGCGAGCTCAAGATGCTCTGCTTTTTCAAGCATGAAAATGTACTATCGGCGTTAGACATCCTACAGCCACCTAGCCTCGACTTCTTCCAGGAAATGTCGTACGTGCACGTGTTGTAA

Protein

MLRAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPSLDFFQEMSYVHVL

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mg(2+)

Similarity

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

Feature

chain  Mitogen-activated protein kinase

Uniprot

B4KUQ0   B4N5J3   A0A212F0L8   A0A2A4J508   A0A2H1VWZ9   A0A0N0BCD8   + More
A0A151IPU8   V5GSD5   E2B798   A0A146LMX4   A0A182KPT8   A0A182MIX0   A0A195AVK0   A0A222AJB7   A0A1B6KT99   N6UVZ6   A0A195E8Y6   A0A195FLW0   A0A151XIQ1   A0A084VUL0   A0A026W359   A0A182JED3   A0A158NF03   B4J102   A0A3L8DBW2   W5J4H3   A0A1Q3G0D7   A0A067QPV8   B0WD06   A0A1Y1KQJ1   Q23993   Q7PNN1   A0A182Y2W8   A0A1L8DKB5   Q17BW3   B3NF68   A0A0L0CEF5   B4LHS8   A0A088AVT7   W8AEI4   B3M5P1   Q23994   W8AL57   U5ESA7   A0A182QM77   A0A0R1E1L4   Q8T030   A0A2M4CT02   A0A2M3ZHG0   A0A2M4AIA5   A0A1W4VA92   A0A3B0JY06   B4PCD6   A0A0M4EG94   B4HIY1   B4QKZ5   Q8IQ91   A0A0A9X4S4   A0A0P6ISP4   A0A0K8U4I3   A0A2M4CTC0   A0A0A1WNC6   A0A1B0G6B0   A0A1I8M9M9   A0A0K8T775   A0A0K8T773   A0A0A1WTZ3   A0A034VNH7   A0A1S3D9T1   V5GWA5   A0A1B6JIS3   A0A1J1IJY7   A0A1B6GG47   A0A1J1IIM3   A0A1J1IKK6   A0A0P6IY93   D6WZH1   E0VIW1   A0A023F674   A0A0L7RJJ9   A0A224XDA6   A0A0P5PX17   A0A0P5NWV3   K7IV71   A0A345AH76   A0A0P4W9W6   A0A232FJR6   A0A0P5EW13   A0A2S2QRV9   A0A2S2NNA9   J9JTB4   A0A2H8TH19   A0A154PKQ1   A0A0B4PM25   A0A0S7HZZ2   A0A0P5XJS8   A0A0N8E600   A0A0P5EX51   A0A0P6B4G4   A0A336KM58  

EC Number

2.7.11.24

Pubmed

17994087    22118469    20798317    26823975    20966253    23537049    + More
24438588    24508170    21347285    30249741    20920257    23761445    24845553    28004739    8033204    12364791    14747013    17210077    25244985    17510324    26108605    24495485    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    25401762    25830018    25315136    25348373    26999592    18362917    19820115    20566863    25474469    20075255    28648823   

EMBL

CH933809    EDW18278.2    CH964101    EDW79632.1    AGBW02011059    OWR47295.1    + More
NWSH01002954    PCG67227.1    ODYU01004970    SOQ45377.1    KQ435922    KOX68491.1    KQ976806    KYN08192.1    GALX01003954    JAB64512.1    GL446149    EFN88459.1    GDHC01010094    JAQ08535.1    AXCM01005111    AXCM01005112    KQ976736    KYM76087.1    KY609676    ASO76453.1    GEBQ01025346    JAT14631.1    APGK01007422    APGK01007423    APGK01007426    APGK01007427    KB737275    KB737274    ENN83052.1    ENN83058.1    KQ979479    KYN21292.1    KQ981490    KYN41316.1    KQ982080    KYQ60211.1    ATLV01016935    ATLV01016936    ATLV01016937    ATLV01016938    ATLV01016939    ATLV01016940    ATLV01016941    ATLV01016942    ATLV01016943    ATLV01016944    KE525136    KFB41654.1    KK107455    EZA50507.1    ADTU01013648    ADTU01013649    ADTU01013650    ADTU01013651    ADTU01013652    ADTU01013653    ADTU01013654    ADTU01013655    ADTU01013656    ADTU01013657    CH916366    EDV96857.1    QOIP01000010    RLU17821.1    ADMH02002140    ETN58318.1    GFDL01001776    JAV33269.1    KK853689    KDQ97277.1    DS231892    EDS44081.1    GEZM01081329    JAV61706.1    U12009    AAA21124.1    AAAB01008960    EAA11880.4    GFDF01007176    JAV06908.1    CH477315    EAT43790.1    CH954178    EDV50410.2    JRES01000612    KNC29859.1    CH940647    EDW70653.2    GAMC01019945    JAB86610.1    CH902618    EDV40675.2    U12010    AAA21125.1    GAMC01019943    JAB86612.1    GANO01003330    JAB56541.1    AXCN02000924    CM000159    KRK01418.1    AE014296    AY069602    AAF50497.2    AAL39747.1    GGFL01004275    MBW68453.1    GGFM01007202    MBW27953.1    GGFK01007190    MBW40511.1    OUUW01000012    SPP86945.1    EDW93821.1    CP012525    ALC43402.1    CH480815    EDW40635.1    CM000363    CM002912    EDX09628.1    KMY98258.1    AAN12035.1    GBHO01027877    GDHC01016082    JAG15727.1    JAQ02547.1    GDIQ01002135    JAN92602.1    GDHF01030856    GDHF01015984    JAI21458.1    JAI36330.1    GGFL01004416    MBW68594.1    GBXI01013985    JAD00307.1    CCAG010000597    CCAG010000598    GBRD01004428    JAG61393.1    GBRD01004429    JAG61392.1    GBXI01012419    JAD01873.1    GAKP01015290    JAC43662.1    GALX01003953    JAB64513.1    GECU01025893    GECU01008677    JAS81813.1    JAS99029.1    CVRI01000054    CRL00066.1    GECZ01008389    JAS61380.1    CRL00067.1    CRL00068.1    GDUN01000131    JAN95788.1    KQ971372    EFA10425.2    DS235206    EEB13317.1    GBBI01001995    JAC16717.1    KQ414582    KOC70901.1    GFTR01006001    JAW10425.1    GDIQ01128844    JAL22882.1    GDIQ01146632    JAL05094.1    AAZX01005118    MF175160    AXF35710.1    GDRN01060468    GDRN01060467    JAI65361.1    NNAY01000129    OXU30708.1    GDIQ01267077    JAJ84647.1    GGMS01011057    MBY80260.1    GGMR01005803    MBY18422.1    ABLF02035714    GFXV01001599    MBW13404.1    KQ434936    KZC11878.1    KF828759    AIT40201.1    GBYX01434682    JAO46647.1    GDIP01072500    GDIQ01078497    JAM31215.1    JAN16240.1    GDIP01089514    GDIQ01066061    GDIQ01058468    LRGB01002451    JAM14201.1    JAN36269.1    KZS07628.1    GDIQ01266574    JAJ85150.1    GDIP01033901    JAM69814.1    UFQS01000669    UFQT01000669    SSX05984.1    SSX26341.1   

Proteomes

UP000009192    UP000007798    UP000007151    UP000218220    UP000053105    UP000078542    + More
UP000008237    UP000075882    UP000075883    UP000078540    UP000019118    UP000078492    UP000078541    UP000075809    UP000030765    UP000053097    UP000075880    UP000005205    UP000001070    UP000279307    UP000000673    UP000027135    UP000002320    UP000007062    UP000076408    UP000008820    UP000008711    UP000037069    UP000008792    UP000005203    UP000007801    UP000075886    UP000002282    UP000000803    UP000192221    UP000268350    UP000092553    UP000001292    UP000000304    UP000092444    UP000095301    UP000079169    UP000183832    UP000007266    UP000009046    UP000053825    UP000002358    UP000215335    UP000007819    UP000076502    UP000076858   

PRIDE

Q23993    Q23994    Q8T030    Q8IQ91   

Pfam

PF00069   Pkinase

Interpro

IPR003527   MAP_kinase_CS        + More
IPR000719   Prot_kinase_dom       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR017441   Protein_kinase_ATP_BS       
IPR007110   Ig-like_dom       
IPR013783   Ig-like_fold       

SUPFAM

SSF56112   SSF56112       

Gene 3D

2.60.40.10    

ProteinModelPortal

B4KUQ0   B4N5J3   A0A212F0L8   A0A2A4J508   A0A2H1VWZ9   A0A0N0BCD8   + More
A0A151IPU8   V5GSD5   E2B798   A0A146LMX4   A0A182KPT8   A0A182MIX0   A0A195AVK0   A0A222AJB7   A0A1B6KT99   N6UVZ6   A0A195E8Y6   A0A195FLW0   A0A151XIQ1   A0A084VUL0   A0A026W359   A0A182JED3   A0A158NF03   B4J102   A0A3L8DBW2   W5J4H3   A0A1Q3G0D7   A0A067QPV8   B0WD06   A0A1Y1KQJ1   Q23993   Q7PNN1   A0A182Y2W8   A0A1L8DKB5   Q17BW3   B3NF68   A0A0L0CEF5   B4LHS8   A0A088AVT7   W8AEI4   B3M5P1   Q23994   W8AL57   U5ESA7   A0A182QM77   A0A0R1E1L4   Q8T030   A0A2M4CT02   A0A2M3ZHG0   A0A2M4AIA5   A0A1W4VA92   A0A3B0JY06   B4PCD6   A0A0M4EG94   B4HIY1   B4QKZ5   Q8IQ91   A0A0A9X4S4   A0A0P6ISP4   A0A0K8U4I3   A0A2M4CTC0   A0A0A1WNC6   A0A1B0G6B0   A0A1I8M9M9   A0A0K8T775   A0A0K8T773   A0A0A1WTZ3   A0A034VNH7   A0A1S3D9T1   V5GWA5   A0A1B6JIS3   A0A1J1IJY7   A0A1B6GG47   A0A1J1IIM3   A0A1J1IKK6   A0A0P6IY93   D6WZH1   E0VIW1   A0A023F674   A0A0L7RJJ9   A0A224XDA6   A0A0P5PX17   A0A0P5NWV3   K7IV71   A0A345AH76   A0A0P4W9W6   A0A232FJR6   A0A0P5EW13   A0A2S2QRV9   A0A2S2NNA9   J9JTB4   A0A2H8TH19   A0A154PKQ1   A0A0B4PM25   A0A0S7HZZ2   A0A0P5XJS8   A0A0N8E600   A0A0P5EX51   A0A0P6B4G4   A0A336KM58  

PDB

5UOJ     E-value=2.20498e-09,     Score=142

KEGG

101737550    K04468 nemo like kinase [EC:2.7.11.24] | (RefSeq) serine/threonine-protein kinase NLK

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0004707   GO:0016301   GO:0004672   GO:0046777   GO:0007474   GO:0001736   GO:0016318   GO:0005634   GO:0045887   GO:0048749   GO:0006468   GO:0042332   GO:0004674   GO:0007476   GO:0010468   GO:0035556   GO:0005737   GO:0090090   GO:0048190  

Length:

71

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00576

Exp number, first 60 AAs:

0.00544

Total prob of N-in:

0.42999

outside

1  -  71

 

 

Pi

190.364745

Theta

167.597026

Tajima's D

-0.923757

CLR

0.535836

CSRT

0.153042347882606

Interpretation

Uncertain