Gene

KWMTBOMO05497

Pre Gene Modal

BGIBMGA006717

Annotation

PREDICTED:_integrin_alpha-IIb-like_[Bombyx_mori]

Location

Bomo_Chr10(+):3514587-3547686      View in EpiBrowser

Full name

Integrin alpha-IIb      

Alternative Name

GPalpha IIb
Platelet membrane glycoprotein IIb

Location in the cell

PlasmaMembrane   Reliability : 2.219

CDS

ATGTACGACCACAATTACTGGCTCGGCGCAACTGTGGAGGCTGGACCGACTTTTTTTGTTACTTGCGCTCCACTACTGGTCCACAACATGAGAATAGGCACTGGATCGACCGGAGGATGCTTCATTTCGAAGAACGATTTCTCAATTGAAAAACTTTTTCTAAGAAGGGAGAATTCTCCTATCAGAACATTAAAAGGCCTGATGTCGTCCTACGGTTGGAGTTTAGCGGTTAGTGATAAAAATTCTGTTGTAGTCGGAGGACCTGGCATTTCTAATGGGAAAACTTTACTATACATGACGCCAGAGCCTTCTACTCAACCTGACATCTTGGACGGTATGGATATGAATGTCAATTTCAATTTCGGGTACAGCGTGACGACAGGATACTTTGCAACACCTAAGCTTTTAATGTACGCAGTCAGTAGTACGTACCGCTTAGGGCAGGTTTTATTTTACGGAGAGCAGTGGAGGTTTTTTAAGCAACTTAAGTTCGAACAACCGAAGACGACTGTCGGGGAGATGTTTGGCGCTAGTTTGTGCTCGGCTCGTATCTTCGGCCCACGATCAGACTTGTTAGTCGGAGCTCCGGGACGAGCGAGCGACAAGCAATACAACGTAGGCGCTGTCTACGTATTTGTTGCCGAAAAACCAATGGCTCTAAGTTTCAAAAGGATCATCACTGGCCGAAAGGAAGGCTCGATGTTTGGCAGCGCCATCATCAATATTGGAGACTTGAACGGCGACAGAAAAGACGACATCGCGATAGCGGCGCCATTTGAAAATGACGGTCGAGGGGCAGTGTATCTATATTGCGGCGCTGAAATCCTGGGTAGCAAGGAGAAGAAAAAGCCTTTTAGTTTCTTACAAGTGATCGAATCGGAGGACCATGGATTCGGCCTAGCGCTTAGCGTTTTGAAAGACTACGATCAAAATGGATGTAACGAATTGGCCATTGGTAGTCCATTCAATGACACTGTATACGTTCTACCATGCTTCGCCTACGTCACTGTGCAGTTGTATACTGAATTCCCAGATTTACAGAATCAAGTGATTAAAAACAAAGGTGGAGGTAAAGAGTTCCTTTTCAAGTCTTGCCTGCATGTTACATACCCAAAGAAGCCTGCAAAAGCATATGCCGAAATAGAAGTGCAGGTAGAAATATCAGGCAATACGAACGCATCATTAAGTAACCCGGGTTCCGATGGAAAATACAAAGTGAAAATCGAGAAAACAAATGAACAAACTGAACAGAACCTCTGCAAACAGATCGGTGTCTTTATGCCGAAGGACGGGCAATACGACTCGCCGATAAACGTTAAGATTACTGCGAAACAAATAAATGATCCTCAGCATCAATCGCACTTCGATCCATCCCACGTTCGTATACATGAAAGCAGTCTTTTGACTCTAGGCCACGATGTTTGGGCCGCACAATGCCAAAATAAAATGTCTTGTCTACCTGATATTAGATTGAACATCGTCAATATGTTTCCAGAGCCGTATCTGCTTGGCTCGTCGGAGACGGAGGACATCAAAATGGAGATAAAAAACCACGGCGAGGTGGCTTACAGCGCTTGCCTTAAAGTGGACGTCATCAACGCGGCCATTGTGAGAGCCCCCGCTCTCAGCTGCACTATTAGTCACCACGACTACTCGCTGACATGTATCTCACAGAAACCAATTCATACAAACGACACATGGGACTTAGGTAATATATCACTGAAAATGACACAGGCCACAAATAAAGACGAATTTATAACAATAAGAGTAAAAGTCTTTGGTAACTGCAAGCTTACTCAGAACTTTACGCTGATCGAAAAACAATATAAGCTAACAAGAGATCTTGACGACATAGAAATTATAGGGAGAGCCAGCTTAGGAACTAACATTACATTGACAGCTGAAGAAATTAAACTTGAACAGAAAAACTTGGACCATATTTATACAATAAGGAATAAAGTAGAGAACCCTTGGATTGGAGGTCCAACGCTCCAAATAACTTTTATGAATCTTCAGTACCTGCAATACACGAAAACGCCGATAATTGCCCAAACCGAGACAGGAGTCGAACTAGATTGTGCAATCATAAGTACGGACAGCAAAATAACGACAAATTGCACGGCGGACAAACTGGTGAAAGGCGACCAGATTAATGTGATTATACATATGAATGTCGATCCTTCGAAAATAGATGACGTGATGTCCCTTGAGAATTTAATCGTAGAGTCGAAGATTGAAGTATTCCCAGGCAGTTTATGGAGTGAGCCTTCCTCGAAGACAATTTTATCTCAAAGTGTTGTGACTACTGTTACTATCGAGAAAACGACGGTAGCCCTCTGGATCATAGTTGTGGCATCGCTATTGGGTCTACTGCTTCTCAGCATCATATACTGCATTGTCGTCAAACGAACAAATCTGTTACGTAGGAAGAATAAGGAAAAGACAAAGGTTCTAAGAAAGAGTATTAGAAGGCAAACTATGAGACGTTCGATGATGGCGCAGTCCGCTTATGGAAGACTTCCAGAAGACGAGCCTCGCGCTCTGAGCGTCGTTCAAGAAGATCTCCAGCTGTGCGAAACGCAATCATTTTATCTCTAA

Protein

MYDHNYWLGATVEAGPTFFVTCAPLLVHNMRIGTGSTGGCFISKNDFSIEKLFLRRENSPIRTLKGLMSSYGWSLAVSDKNSVVVGGPGISNGKTLLYMTPEPSTQPDILDGMDMNVNFNFGYSVTTGYFATPKLLMYAVSSTYRLGQVLFYGEQWRFFKQLKFEQPKTTVGEMFGASLCSARIFGPRSDLLVGAPGRASDKQYNVGAVYVFVAEKPMALSFKRIITGRKEGSMFGSAIINIGDLNGDRKDDIAIAAPFENDGRGAVYLYCGAEILGSKEKKKPFSFLQVIESEDHGFGLALSVLKDYDQNGCNELAIGSPFNDTVYVLPCFAYVTVQLYTEFPDLQNQVIKNKGGGKEFLFKSCLHVTYPKKPAKAYAEIEVQVEISGNTNASLSNPGSDGKYKVKIEKTNEQTEQNLCKQIGVFMPKDGQYDSPINVKITAKQINDPQHQSHFDPSHVRIHESSLLTLGHDVWAAQCQNKMSCLPDIRLNIVNMFPEPYLLGSSETEDIKMEIKNHGEVAYSACLKVDVINAAIVRAPALSCTISHHDYSLTCISQKPIHTNDTWDLGNISLKMTQATNKDEFITIRVKVFGNCKLTQNFTLIEKQYKLTRDLDDIEIIGRASLGTNITLTAEEIKLEQKNLDHIYTIRNKVENPWIGGPTLQITFMNLQYLQYTKTPIIAQTETGVELDCAIISTDSKITTNCTADKLVKGDQINVIIHMNVDPSKIDDVMSLENLIVESKIEVFPGSLWSEPSSKTILSQSVVTTVTIEKTTVALWIIVVASLLGLLLLSIIYCIVVKRTNLLRRKNKEKTKVLRKSIRRQTMRRSMMAQSAYGRLPEDEPRALSVVQEDLQLCETQSFYL

Catalytic Activity

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

Subunit

Heterodimer of an alpha and a beta subunit.
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the interactions are stabilized/increased in a calcium and magnesium-dependent manner (By similarity).

Similarity

Belongs to the integrin alpha chain family.
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.

Keywords

Calcium   Cell adhesion   Complete proteome   Disulfide bond   Glycoprotein   Integrin   Membrane   Metal-binding   Receptor   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Integrin alpha-IIb

Uniprot

A0A076JU39   A0A076JP55   H9JB21   Q1G0S7   A0A2A4JEF9   A0A2A4JQ16   + More
A0A2H1VTL5   A0A3S2P8H4   A0A212EXX6   A0A194RNQ6   A0A212FK70   A0A194QJF9   A0A194QPI3   A0A194PIS8   A0A3S2NWJ7   A0A3S2N8M6   A0A076JQH6   A0A2A4JDI8   A0A212F4X5   A0A076JUD8   A0A182PIT2   A0A1J1IUP8   A0A1L8E3W8   A0A182N9J2   A0A084WMT0   A0A182Y859   A0A182RUF9   A0A182MG76   A0A194QI28   A0A1Y1LCJ3   B2RPR7   Q9QUM0   A0A182IK10   B4QGF2   A0A0J9RD24   A0A1I8N608   B4HS20   B4QGF1   A0A0J9RDC1   A0A0J9RD84   A0A182K183   A0A182QXJ7   B3NQF5   A0A2K6GLS0   A0A0C9RL85   A0A1I8NPW8   A0A0N1ITN4   A0A1I8P8N1   A0A1I8P8N4   A0A0R1DQW8  

Pubmed

25064490    19121390    17553801    22118469    26354079    24438588    + More
25244985    28004739    12040188    15489334    10572112    16141072    19468303    1512266    10713093    21183079    17994087    22936249    25315136    17550304   

EMBL

KJ511852    AII79411.1    KJ511851    AII79410.1    BABH01008474    DQ531844    + More
ABF59518.1    NWSH01001781    PCG70156.1    NWSH01000931    PCG73502.1    ODYU01004083    SOQ43584.1    RSAL01000201    RVE44446.1    AGBW02011645    OWR46348.1    KQ459984    KPJ19044.1    AGBW02008132    OWR54131.1    KQ458793    KPJ05055.1    KQ461194    KPJ06885.1    KQ459603    KPI92953.1    RSAL01000043    RVE50694.1    RVE44447.1    KJ511850    AII79409.1    PCG70155.1    AGBW02010302    OWR48769.1    KJ511853    AII79412.1    CVRI01000057    CRL02265.1    GFDF01000775    JAV13309.1    ATLV01024506    KE525352    KFB51524.1    AXCM01009169    KPJ05054.1    GEZM01062083    JAV70050.1    BC137570    CH466558    AAI37571.1    EDL34136.1    AF169829    AF170316    AK142289    AK154619    AL596258    BC120493    S43388    AF045019    AF166384    CM000362    EDX07190.1    CM002911    KMY93933.1    CH480816    EDW47967.1    EDX07189.1    KMY93931.1    KMY93932.1    AXCN02000567    CH954179    EDV55931.1    GBYB01014097    JAG83864.1    KQ435778    KOX74851.1    CM000158    KRJ99639.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000007151    UP000053240    UP000053268    + More
UP000075885    UP000183832    UP000075884    UP000030765    UP000076408    UP000075900    UP000075883    UP000000589    UP000075880    UP000000304    UP000095301    UP000001292    UP000075881    UP000075886    UP000008711    UP000233160    UP000095300    UP000053105    UP000002282   

PRIDE

H9JB21    Q9QUM0   

Pfam

PF01839   FG-GAP        + More
PF08441   Integrin_alpha2
PF00557   Peptidase_M24
PF00246   Peptidase_M14
PF00357   Integrin_alpha

Interpro

IPR000413   Integrin_alpha        + More
IPR013519   Int_alpha_beta-p       
IPR013517   FG-GAP       
IPR028994   Integrin_alpha_N       
IPR013649   Integrin_alpha-2       
IPR032695   Integrin_dom_sf       
IPR018184   Integrin_alpha_C_CS       
IPR002467   Pept_M24A_MAP1       
IPR000994   Pept_M24       
IPR036005   Creatinase/aminopeptidase-like       
IPR017868   Filamin/ABP280_repeat-like       
IPR034223   IGCP-like_CPD       
IPR000834   Peptidase_M14       

SUPFAM

SSF69179   SSF69179        + More
SSF55920   SSF55920       

Gene 3D

2.130.10.130    

CDD

cd01086  MetAP1
cd03860  M14_CP_A-B_like

ProteinModelPortal

A0A076JU39   A0A076JP55   H9JB21   Q1G0S7   A0A2A4JEF9   A0A2A4JQ16   + More
A0A2H1VTL5   A0A3S2P8H4   A0A212EXX6   A0A194RNQ6   A0A212FK70   A0A194QJF9   A0A194QPI3   A0A194PIS8   A0A3S2NWJ7   A0A3S2N8M6   A0A076JQH6   A0A2A4JDI8   A0A212F4X5   A0A076JUD8   A0A182PIT2   A0A1J1IUP8   A0A1L8E3W8   A0A182N9J2   A0A084WMT0   A0A182Y859   A0A182RUF9   A0A182MG76   A0A194QI28   A0A1Y1LCJ3   B2RPR7   Q9QUM0   A0A182IK10   B4QGF2   A0A0J9RD24   A0A1I8N608   B4HS20   B4QGF1   A0A0J9RDC1   A0A0J9RD84   A0A182K183   A0A182QXJ7   B3NQF5   A0A2K6GLS0   A0A0C9RL85   A0A1I8NPW8   A0A0N1ITN4   A0A1I8P8N1   A0A1I8P8N4   A0A0R1DQW8  

PDB

4CAK     E-value=2.95939e-21,     Score=255

KEGG

101737408    no KO assigned | (RefSeq) integrin alpha-IIb-like

GO

GO:0008305   GO:0007229   GO:0007155   GO:0016021   GO:0046872   GO:0070006   GO:0070084   GO:0008270   GO:0004181   GO:0070051   GO:0002687   GO:0005925   GO:0009897   GO:0070527   GO:0050840   GO:0009986   GO:0070062   GO:0042802   GO:0007160   GO:0001555   GO:0005737   GO:0007431   GO:0003344   GO:0045886   GO:0016324   GO:0007508   GO:0048149   GO:0030336   GO:0043277   GO:0042060   GO:0007411   GO:0009925   GO:0007391   GO:0035001   GO:0046982   GO:0007186   GO:0019001   GO:0031683   GO:0001664   GO:0005525   GO:0007264   GO:0003824  

Subcellular location

Membrane  

Length:

865

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

39.5041

Exp number, first 60 AAs:

11.03573

Total prob of N-in:

0.34474

POSSIBLE N-term signal

sequence

outside

1  -  778

TMhelix

779  -  801

inside

802  -  865

 

 

Pi

28.304422

Theta

2.05106

Tajima's D

-1.532757

CLR

208.703613

CSRT

0.0445477726113694

Interpretation

Uncertain