Gene

KWMTBOMO05484

Pre Gene Modal

BGIBMGA006712

Annotation

G_protein_alpha_subunit_[Bombyx_mori]

Location

Bomo_Chr10(+):3113671-3128992      View in EpiBrowser

Full name

Guanine nucleotide-binding protein subunit alpha homolog      

Alternative Name

Protein concertina

Location in the cell

Nuclear   Reliability : 2.979

CDS

ATGGCCAACGATTTGTGGTCATGTACCTGCTGTACAGAGGCTCTGACTTGTTGGCTGCGTCTGAAGCTATCGCCGGAGGAGATAGAGCAACGATATAGGAGTAAAGAGATCGACAGAATACTCGAGAAAGATAAGCAAACTTTGCGGCGGCAGGTGAAGCTGTTGTTACTCGGCGCGGGTGAAAGCGGAAAGTCAACATTCCTCAAACAGATGAGAATCATACACAAAGTGAAATTCGAACCGGAACTCGTGCGGGAGTACCAGCATGTGATATATCAGAACATTGTCAAAGGCATACAGGTGTTAGTGGACGCAAGAGACAAACTCGCGATACCATGGGAGAATCCGCGGAATTTGGATATCGGCCAGCAAGCACTGCACTTCAACAGCACGGCGTCGCTCGACAGCCGACTCTTCATGCACTACGCGCCGCACATACACTCATTGTGGTTAGACAGAGCCATAAAAAGGGCATATGACAGGCGAAGAGAATTTCAATTGAGTGATTCGGTGAGTTACTTCTTCGATGAACTGGAGAGGATCGCTCGGCCGGACTACGTGCCGTCCCACCAGGACATCTTGCACTGTCGGAAGGCAACGAAAGGCATAACGGAGTGCACGATAAACATAAACAACGTTCCTTTCGTGTTCGTCGACGTGGGGGGCCAGCGGACCCAGAGGCAGAAGTGGACTCAGTGCTTCGATTCGGTTACGTCGATACTGTTCCTTGTATCGTCGTCCGAATTCGATCAGGTCTTATCTGAAGACAGGAAAACGAACCGGCTCGAGGAGGCGTTAAACATCTTCGATACGATCGTGAACAACGTCAACTTCAAGGGAATATCGATAATACTTTTCCTGAACAAGTCCGATCTGTTGGCGCGCAAGGTCGCCAGCAAGGAGACCGACATCCGCTGGTACTATCCTCAGTTCGCGGGCGACCCGCACAACCTGCACGACGTCCAAATGTACCTGCTCAACATGTTCGCGAACGTTCGGCGCGAACCGAAAACAACGCTGTACCACCACTTCACGACCGCCATCGACACCCACAACATCGAGGTCGTATTCAATTCTGTCAAAGACACGATCCTAAATCGCAATCTCGAATCTCTGATGTTGCAGTGA

Protein

MANDLWSCTCCTEALTCWLRLKLSPEEIEQRYRSKEIDRILEKDKQTLRRQVKLLLLGAGESGKSTFLKQMRIIHKVKFEPELVREYQHVIYQNIVKGIQVLVDARDKLAIPWENPRNLDIGQQALHFNSTASLDSRLFMHYAPHIHSLWLDRAIKRAYDRRREFQLSDSVSYFFDELERIARPDYVPSHQDILHCRKATKGITECTININNVPFVFVDVGGQRTQRQKWTQCFDSVTSILFLVSSSEFDQVLSEDRKTNRLEEALNIFDTIVNNVNFKGISIILFLNKSDLLARKVASKETDIRWYYPQFAGDPHNLHDVQMYLLNMFANVRREPKTTLYHHFTTAIDTHNIEVVFNSVKDTILNRNLESLMLQ

Description

May play a role in a signal transduction pathway used during gastrulation. Required specifically for the ventral furrow and posterior midgut invaginations, where it is necessary for coordinating cell shape changes.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Subunit

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Similarity

Belongs to the G-alpha family. G(12) subfamily.

Keywords

Complete proteome   Cytoplasm   Developmental protein   Gastrulation   GTP-binding   Magnesium   Metal-binding   Nucleotide-binding   Reference proteome   Transducer  

Feature

chain  Guanine nucleotide-binding protein subunit alpha homolog

Uniprot

F8SXW7   A0A3S2LS69   A0A194RP04   A0A194QJF4   A0A212FEW6   A0A154P8D9   + More
A0A310S7A2   A0A0L7QT98   A0A2A3E838   A0A088A4D7   E2BC73   E2A1K2   K7J9T9   A0A0J7KKE1   A0A195EBW9   F4WNJ1   A0A195B7I5   A0A158NU46   A0A151III5   A0A151WW13   A0A0N0BEE0   A0A026WKZ2   A0A067QX99   A0A2J7QTW6   A0A195FW89   A0A182GYJ2   A0A1Y1N2T4   A0A1Q3EW85   A0A2M4CPS6   A0A2M4AUT5   A0A182F597   B0W256   Q16Y79   Q7QKF7   A0A1B6CQP8   A0A1J1IRB6   A0A146KT85   A0A0C5UTR8   A0A1L8DL08   A0A1W4WF54   W5J919   A0A1B6G5B4   A0A1B6IUL1   A0A2R7WI45   J9K089   B4KI95   A0A0T6B1Z4   A0A1B6MBS2   A0A139WBP6   T1IFR5   A0A2S2PHB3   B4JPE7   A0A023F5N2   B4MUL9   A0A034WT12   A0A2H8THJ9   A0A0K8VZA2   A0A0M4E7X7   A0A0A1XAL5   W8AKL9   N6TVR0   U4UKS9   B4M8Z6   E0VIB0   A0A1B0FEZ4   A0A1A9VIU0   A0A1A9Z412   A0A1B0BJ77   A0A1A9WXG1   A0A0R3P0A7   A0A1I8NFG6   B5DK50   A0A1I8PH88   A0A3B0KP04   A0A2M3ZC35   A0A2M4BS61   A0A084VPR3   A0A1A9XMK3   B3MX12   A0A336LJP3   B4ISM6   M9PDM5   P25157   B3NKF8   B4ILS4   U5ERD0   A0A0J9TTC9   A0A3Q0IP34   A0A0C9R5L6   A0A0R3NVI4   A0A0P4WCB1   V5GCT8   T1JBM3   A0A0N8DNV3   A0A0N8BYF7   A0A2Y9D3F9   A0A182NEK0   E9FRB7   A0A087UM41   B4GXA5  

Pubmed

26354079    22118469    20798317    20075255    21719571    21347285    + More
24508170    30249741    24845553    26483478    28004739    17510324    12364791    14747013    17210077    26823975    20920257    23761445    17994087    18362917    19820115    25474469    25348373    25830018    24495485    23537049    20566863    15632085    25315136    24438588    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    1899050    12537569    10748524    22936249    21292972   

EMBL

HQ699665    AEJ07665.1    RSAL01000267    RVE43243.1    KQ459984    KPJ19050.1    + More
KQ458793    KPJ05050.1    AGBW02008896    OWR52282.1    KQ434842    KZC08111.1    KQ766043    OAD53754.1    KQ414748    KOC61862.1    KZ288344    PBC27674.1    GL447256    EFN86700.1    GL435766    EFN72675.1    AAZX01005588    LBMM01006329    KMQ90689.1    KQ979074    KYN22723.1    GL888237    EGI64184.1    KQ976565    KYM80476.1    ADTU01002835    KQ977477    KYN02462.1    KQ982706    KYQ51865.1    KQ435840    KOX71441.1    KK107167    QOIP01000010    EZA56341.1    RLU18196.1    KK853248    KDR09357.1    NEVH01011193    PNF32014.1    KQ981215    KYN44582.1    JXUM01021185    JXUM01021186    JXUM01021187    JXUM01021188    JXUM01021189    JXUM01021190    JXUM01021191    KQ560593    KXJ81739.1    GEZM01014230    JAV92174.1    GFDL01015475    JAV19570.1    GGFL01003101    MBW67279.1    GGFK01011037    MBW44358.1    DS231825    EDS28184.1    CH477522    EAT39589.1    AAAB01008797    EAA03634.4    GEDC01021584    JAS15714.1    CVRI01000058    CRL02696.1    GDHC01019764    GDHC01014316    JAP98864.1    JAQ04313.1    KM610203    AJQ81034.1    GFDF01007027    JAV07057.1    ADMH02002093    ETN59294.1    GECZ01012152    JAS57617.1    GECU01017082    GECU01002287    JAS90624.1    JAT05420.1    KK854845    PTY19179.1    ABLF02018387    CH933807    EDW12388.1    LJIG01016263    KRT81125.1    GEBQ01010561    GEBQ01006596    JAT29416.1    JAT33381.1    KQ971372    KYB25344.1    ACPB03005594    GGMR01016188    MBY28807.1    CH916372    EDV98777.1    GBBI01002239    JAC16473.1    CH963857    EDW76214.1    GAKP01001633    GAKP01001632    JAC57320.1    GFXV01001706    MBW13511.1    GDHF01008102    GDHF01004953    JAI44212.1    JAI47361.1    CP012523    ALC38014.1    GBXI01006326    JAD07966.1    GAMC01020183    JAB86372.1    APGK01050137    APGK01050138    KB741166    ENN73380.1    KB632257    ERL90776.1    CH940654    EDW57672.1    DS235187    EEB13116.1    CCAG010000397    JXJN01015341    CH379061    KRT04957.1    EDY70676.2    OUUW01000010    SPP85568.1    GGFM01005312    MBW26063.1    GGFJ01006701    MBW55842.1    ATLV01015029    KE524999    KFB39957.1    CH902628    EDV34868.2    UFQS01000017    UFQT01000017    SSW97479.1    SSX17865.1    CH891577    EDW99381.1    AE014134    AGB93231.1    M94285    AY089534    AF211849    CH954179    EDV54262.1    CH480887    EDW55370.1    GANO01003787    JAB56084.1    CM002910    KMY91485.1    GBYB01008077    JAG77844.1    KRT04956.1    GDRN01052831    JAI66242.1    GALX01006622    JAB61844.1    JH432011    GDIP01068308    GDIP01015423    LRGB01002066    JAM88292.1    KZS09442.1    GDIQ01132603    JAL19123.1    GL732523    EFX90227.1    KK120523    KFM78430.1    CH479195    EDW27216.1   

Proteomes

UP000283053    UP000053240    UP000053268    UP000007151    UP000076502    UP000053825    + More
UP000242457    UP000005203    UP000008237    UP000000311    UP000002358    UP000036403    UP000078492    UP000007755    UP000078540    UP000005205    UP000078542    UP000075809    UP000053105    UP000053097    UP000279307    UP000027135    UP000235965    UP000078541    UP000069940    UP000249989    UP000069272    UP000002320    UP000008820    UP000007062    UP000183832    UP000192223    UP000000673    UP000007819    UP000009192    UP000007266    UP000015103    UP000001070    UP000007798    UP000092553    UP000019118    UP000030742    UP000008792    UP000009046    UP000092444    UP000078200    UP000092445    UP000092460    UP000091820    UP000001819    UP000095301    UP000095300    UP000268350    UP000030765    UP000092443    UP000007801    UP000002282    UP000000803    UP000008711    UP000001292    UP000079169    UP000076858    UP000076407    UP000075884    UP000000305    UP000054359    UP000008744   

PRIDE

F8SXW7    M9PDM5    P25157   

Pfam

PF00503   G-alpha

Interpro

IPR001019   Gprotein_alpha_su        + More
IPR027417   P-loop_NTPase       
IPR011025   GproteinA_insert       
IPR000469   Gprotein_alpha_12/13       

SUPFAM

SSF47895   SSF47895        + More
SSF52540   SSF52540       

Gene 3D

1.10.400.10    

CDD

cd00066  G-alpha

ProteinModelPortal

F8SXW7   A0A3S2LS69   A0A194RP04   A0A194QJF4   A0A212FEW6   A0A154P8D9   + More
A0A310S7A2   A0A0L7QT98   A0A2A3E838   A0A088A4D7   E2BC73   E2A1K2   K7J9T9   A0A0J7KKE1   A0A195EBW9   F4WNJ1   A0A195B7I5   A0A158NU46   A0A151III5   A0A151WW13   A0A0N0BEE0   A0A026WKZ2   A0A067QX99   A0A2J7QTW6   A0A195FW89   A0A182GYJ2   A0A1Y1N2T4   A0A1Q3EW85   A0A2M4CPS6   A0A2M4AUT5   A0A182F597   B0W256   Q16Y79   Q7QKF7   A0A1B6CQP8   A0A1J1IRB6   A0A146KT85   A0A0C5UTR8   A0A1L8DL08   A0A1W4WF54   W5J919   A0A1B6G5B4   A0A1B6IUL1   A0A2R7WI45   J9K089   B4KI95   A0A0T6B1Z4   A0A1B6MBS2   A0A139WBP6   T1IFR5   A0A2S2PHB3   B4JPE7   A0A023F5N2   B4MUL9   A0A034WT12   A0A2H8THJ9   A0A0K8VZA2   A0A0M4E7X7   A0A0A1XAL5   W8AKL9   N6TVR0   U4UKS9   B4M8Z6   E0VIB0   A0A1B0FEZ4   A0A1A9VIU0   A0A1A9Z412   A0A1B0BJ77   A0A1A9WXG1   A0A0R3P0A7   A0A1I8NFG6   B5DK50   A0A1I8PH88   A0A3B0KP04   A0A2M3ZC35   A0A2M4BS61   A0A084VPR3   A0A1A9XMK3   B3MX12   A0A336LJP3   B4ISM6   M9PDM5   P25157   B3NKF8   B4ILS4   U5ERD0   A0A0J9TTC9   A0A3Q0IP34   A0A0C9R5L6   A0A0R3NVI4   A0A0P4WCB1   V5GCT8   T1JBM3   A0A0N8DNV3   A0A0N8BYF7   A0A2Y9D3F9   A0A182NEK0   E9FRB7   A0A087UM41   B4GXA5  

PDB

3AB3     E-value=6.80182e-107,     Score=989

KEGG

100862775    K04346 guanine nucleotide-binding protein subunit alpha-12 | (RefSeq) Galpha12; G protein alpha subu

GO

GO:0001664   GO:0005525   GO:0007186   GO:0003924   GO:0031683   GO:0007266   GO:0007165   GO:0005834   GO:0007188   GO:0031526   GO:0031752   GO:0043519   GO:0005737   GO:0046872   GO:0016476   GO:0010470   GO:0010004   GO:0003384   GO:0048383   GO:0005886   GO:0060027   GO:0003380   GO:0070252   GO:0004871   GO:0019001   GO:0007264   GO:0003824  

PANTHER

PTHR10218  

Subcellular location

Cytoplasm  

Length:

375

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.08374

Exp number, first 60 AAs:

0.00205

Total prob of N-in:

0.02289

outside

1  -  375

 

 

Pi

223.816294

Theta

163.665108

Tajima's D

0.95541

CLR

0.515342

CSRT

0.64056797160142

Interpretation

Uncertain