Gene

KWMTBOMO05463

Pre Gene Modal

BGIBMGA006703

Annotation

PREDICTED:_glutamine_synthetase_1?_mitochondrial_[Bombyx_mori]

Location

Bomo_Chr10(+):2838475-2839876      View in EpiBrowser

Full name

Glutamine synthetase       + More
Glutamine synthetase 1, mitochondrial      

Alternative Name

Glutamate--ammonia ligase 1

Location in the cell

Cytoplasmic   Reliability : 2.008 Mitochondrial   Reliability : 1.896

CDS

ATGGAAAATTTACTAAGAAATGTGTTGCTGAGTCGGAAAATAATAACAACAGTAAAAATATGCCGTAGAAATTTACTTAAACATTCTATAAATCATGTTTTAGGAAAAAAGGTATTAGACCGATACATGCGGTTACCTTTACCCTGTAATAAGGTTTTGGCCACATACGTTTGGATTGATGGCTCTGGAATCAACATGCGTTCGAAAGACAGAGTTATGAACTGTGCTCCTTATTCCCCAGAACAGGCTCCCTTATGGACATTTGATGGCAGTTCAACCGGACAAGCTAAGGCGAATAATTCAGACACGACCTTAAAGCCTGTGGCAGTTTACAGAGATCCATTTCGATGCGACCCTCACGTATTGGTGTTATGTGAGGTGTACTATGGCGATGGAACACCAGCTGCGACAAATCATAGAAAATTTTGTAATGATTTGTGTGTTTATCATGCAGCACACGAACCATGGTTCGGCTTAGAACAAGAGTATACTATGCTTGATGTAGACGGGTGGGGTCTGGGTTGGCCTAAGGGGGGCGGTTTCCCTGCTGTAAAATATCAGTATTCATATTGTGGCGTAGGAGCAAAGTACGTTGCGGGAAGAGACATAGTTGAAGCTCACACGAAAGCCTGTTTGTATGCTGGACTAGATTTTGAAGGAACCAATGCAGAAGTTATGTTCGGTTGCTGGGAGTGGCAAATTGGTACTTCAGTAGGTATAAAAGCTCCCGATGATTTGTGGATGTCGCGCTATATCATGGCCAGAGTTGCGGAAGATCACGGTGTTGATATAACATATCATCCTAAGCCTATGGGGCAGTTACATCCTGGCGTTGGTTTGCACCACAATATGAGCACTAAAGGTATGCGTTCTGATGGTGGATTCAAGATTATTGAAGAATCTTTAAAGAAATTGGAGACTAACCATATGAAGCACATCAAACAGTATGGTAACGATGAAGCTACCAACAGACAACGTTTAACAGGTAAATTTGAAACGGCATCGTTCGATAAGTTCTCGTGGGGATTTGCTGACAGAAAAGCATCAATTCGGTTGCAAAGAAATACAAAAGAAAAGGGGAAAGGTTTTATAGAGGATAGAAGGCCTGCTGGTGATTGTGATCCGTATTTGGTTTGTGGGCTACTCCTGGAGACGTGCTTAGGCCCAGCTGGAACGAAAAAGGCAGGAAAACCTGTATGCCCACCAACTAAATAA

Protein

MENLLRNVLLSRKIITTVKICRRNLLKHSINHVLGKKVLDRYMRLPLPCNKVLATYVWIDGSGINMRSKDRVMNCAPYSPEQAPLWTFDGSSTGQAKANNSDTTLKPVAVYRDPFRCDPHVLVLCEVYYGDGTPAATNHRKFCNDLCVYHAAHEPWFGLEQEYTMLDVDGWGLGWPKGGGFPAVKYQYSYCGVGAKYVAGRDIVEAHTKACLYAGLDFEGTNAEVMFGCWEWQIGTSVGIKAPDDLWMSRYIMARVAEDHGVDITYHPKPMGQLHPGVGLHHNMSTKGMRSDGGFKIIEESLKKLETNHMKHIKQYGNDEATNRQRLTGKFETASFDKFSWGFADRKASIRLQRNTKEKGKGFIEDRRPAGDCDPYLVCGLLLETCLGPAGTKKAGKPVCPPTK

Catalytic Activity

ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate

Subunit

Homooctamer.

Similarity

Belongs to the glutamine synthetase family.

Keywords

ATP-binding   Complete proteome   Ligase   Mitochondrion   Nucleotide-binding   Reference proteome   Transit peptide  

Feature

chain  Glutamine synthetase 1, mitochondrial

Uniprot

H9JB08   A0A0G3VJL2   A0A2H1WD59   A0A212FET5   A0A194RSN3   A0A0L7LUZ0   + More
A0A1C9EGF3   A0A194QHK1   A0A2A4IZH7   A0A2A4IZL2   A0A1C9EGE5   A0A220K8L0   A0A0L7LV39   B4MDB7   A0A1A9Z7S4   A0A1B0FIU3   D3TMQ8   A0A1A9UMJ0   A0A1B0B922   A0A1A9XZI6   A0A1A9WZX8   A0A1W4UPW1   B3MLT4   A0A3B0JB12   B4KFN9   A0A0M5IZ31   A0A0R3NRL8   B4GQR9   B4JD48   A0A2L1DH24   A0A0K8WJY5   B4N0M4   A0A034WM87   A0A1I8PPP3   E1JHQ1   P20477   A0A0R3NWU6   A0A0R3NRZ9   A0A194RP39   W8BHI5   B3N774   B4ICS0   B4Q5M3   A0A0A1WJ23   B4P1V4   A0A0L0CBW9   A0A1L8EF02   A0A1L8EFC9   A0A1L8E9I9   T1PFF2   V5SKI8   A0A1I8NGQ5   A0A2M4A9P1   A0A182F2H8   T1E7S5   A0A2M4BQA3   W5J7A8   A0A2M3Z0E5   A0A0K8TNN1   A0A182TK66   A0A182NBK9   A0A182IVS5   C3Z840   A0A182QFU4   A0A1I8PBU0   A0A182V681   A0A1J1HER3   A0A182Y0I6   A0A182WXN5   Q7PWF1   A0A182I7K0   U5EXT8   A0A182WGD3   A0A182SVI5   A0A182M7G3   A0A182RHB9   A0A1L8E240   A0A1L8E2A9   A0A084WC72   B0WWL5   A0A1Q3FHM7   A0A182PNH5   Q17JX2   A0A182HEV7   F4WK81   D6WFH1   A0A182PA28   O96301   A0A182Q4C3   A0A151XJR8   A0A0G3VIA2   A0A1B0D3I2   K1QEH1   A0A182V4E1   F5HK76   A0A182HTB3   T1D449   A0A2W1BMY2   A0A195BGP1   A0A182U6F2  

EC Number

6.3.1.2

Pubmed

19121390    22118469    26354079    26227816    28630352    17994087    + More
20353571    15632085    25348373    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    1969491    12537569    24495485    22936249    25830018    17550304    26108605    25315136    20920257    23761445    26369729    18563158    25244985    12364791    14747013    17210077    24438588    17510324    26483478    21719571    18362917    19820115    9887510    11674996    22992520    24330624    28756777   

EMBL

BABH01008431    KP657637    AKL78862.1    ODYU01007862    SOQ51010.1    AGBW02008896    + More
OWR52259.1    KQ459984    KPJ19076.1    JTDY01000038    KOB79260.1    KX778609    AON96569.1    KQ458793    KPJ05023.1    NWSH01004968    PCG64542.1    PCG64543.1    AON96570.1    MF319714    ASJ26428.1    KOB79259.1    CH940661    EDW71178.1    CCAG010013968    EZ422710    ADD18986.1    JXJN01010188    CH902620    EDV30805.1    OUUW01000004    SPP79195.1    CH933807    EDW11004.1    CP012523    ALC39761.1    CH379059    KRT03707.1    CH479187    EDW39941.1    CH916368    EDW04292.1    KY681698    AVD29896.1    GDHF01001139    JAI51175.1    CH963920    EDW77637.1    GAKP01002286    JAC56666.1    AE014134    ACZ94131.1    X52760    AJ012460    AY058730    KRT03709.1    KRT03708.1    KPJ19075.1    GAMC01008348    JAB98207.1    CH954177    EDV57181.1    CH480829    EDW45346.1    CM000361    CM002910    EDX03173.1    KMY87241.1    GBXI01015621    JAC98670.1    CM000157    EDW87090.1    JRES01000726    KNC28939.1    GFDG01001509    JAV17290.1    GFDG01001510    JAV17289.1    GFDG01003349    JAV15450.1    KA646900    AFP61529.1    KF647646    AHB50508.1    GGFK01004186    MBW37507.1    GAMD01003393    JAA98197.1    GGFJ01006012    MBW55153.1    ADMH02002031    ETN59861.1    GGFM01001246    MBW21997.1    GDAI01001629    JAI15974.1    GG666592    EEN51354.1    AXCN02000676    CVRI01000001    CRK86464.1    AAAB01008984    EAA14864.2    APCN01003411    GANO01000787    JAB59084.1    AXCM01002486    GFDF01001281    JAV12803.1    GFDF01001280    JAV12804.1    ATLV01022579    KE525333    KFB47816.1    DS232149    EDS36107.1    GFDL01008032    JAV27013.1    CH477230    EAT46939.1    JXUM01132749    KQ567886    KXJ69239.1    GL888197    EGI65384.1    KQ971327    EEZ99821.1    AF004351    AF395490    AF395491    AAD01201.1    AAK76447.1    AXCN02000052    KQ982068    KYQ60545.1    KP657638    RSAL01000006    AKL78863.1    RVE54315.1    AJVK01010982    AJVK01010983    JH819086    EKC27195.1    AAAB01008859    EGK96917.1    APCN01000435    GALA01001103    JAA93749.1    KZ150069    PZC74080.1    KQ976491    KYM83318.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000037510    UP000053268    UP000218220    + More
UP000008792    UP000092445    UP000092444    UP000078200    UP000092460    UP000092443    UP000091820    UP000192221    UP000007801    UP000268350    UP000009192    UP000092553    UP000001819    UP000008744    UP000001070    UP000007798    UP000095300    UP000000803    UP000008711    UP000001292    UP000000304    UP000002282    UP000037069    UP000095301    UP000069272    UP000000673    UP000075902    UP000075884    UP000075880    UP000001554    UP000075886    UP000075903    UP000183832    UP000076408    UP000076407    UP000007062    UP000075840    UP000075920    UP000075901    UP000075883    UP000075900    UP000030765    UP000002320    UP000075885    UP000008820    UP000069940    UP000249989    UP000007755    UP000007266    UP000075809    UP000283053    UP000092462    UP000005408    UP000078540   

PRIDE

H9JB08    E1JHQ1    P20477   

Pfam

PF03951   Gln-synt_N        + More
PF00120   Gln-synt_C
PF03874   RNA_pol_Rpb4

Interpro

IPR008147   Gln_synt_b-grasp        + More
IPR027302   Gln_synth_N_conserv_site       
IPR014746   Gln_synth/guanido_kin_cat_dom       
IPR008146   Gln_synth_cat_dom       
IPR036651   Gln_synt_N       
IPR005574   RPB4/RPC9       
IPR010997   HRDC-like_sf       
IPR038324   Rpb4/RPC9_sf       
IPR036282   Glutathione-S-Trfase_C_sf       
IPR006590   RNA_pol_Rpb4/RPC9_core       
IPR027303   Gln_synth_gly_rich_site       

SUPFAM

SSF55931   SSF55931        + More
SSF54368   SSF54368       
SSF47819   SSF47819       
SSF47616   SSF47616       

Gene 3D

3.10.20.70     1.20.1250.40    

ProteinModelPortal

H9JB08   A0A0G3VJL2   A0A2H1WD59   A0A212FET5   A0A194RSN3   A0A0L7LUZ0   + More
A0A1C9EGF3   A0A194QHK1   A0A2A4IZH7   A0A2A4IZL2   A0A1C9EGE5   A0A220K8L0   A0A0L7LV39   B4MDB7   A0A1A9Z7S4   A0A1B0FIU3   D3TMQ8   A0A1A9UMJ0   A0A1B0B922   A0A1A9XZI6   A0A1A9WZX8   A0A1W4UPW1   B3MLT4   A0A3B0JB12   B4KFN9   A0A0M5IZ31   A0A0R3NRL8   B4GQR9   B4JD48   A0A2L1DH24   A0A0K8WJY5   B4N0M4   A0A034WM87   A0A1I8PPP3   E1JHQ1   P20477   A0A0R3NWU6   A0A0R3NRZ9   A0A194RP39   W8BHI5   B3N774   B4ICS0   B4Q5M3   A0A0A1WJ23   B4P1V4   A0A0L0CBW9   A0A1L8EF02   A0A1L8EFC9   A0A1L8E9I9   T1PFF2   V5SKI8   A0A1I8NGQ5   A0A2M4A9P1   A0A182F2H8   T1E7S5   A0A2M4BQA3   W5J7A8   A0A2M3Z0E5   A0A0K8TNN1   A0A182TK66   A0A182NBK9   A0A182IVS5   C3Z840   A0A182QFU4   A0A1I8PBU0   A0A182V681   A0A1J1HER3   A0A182Y0I6   A0A182WXN5   Q7PWF1   A0A182I7K0   U5EXT8   A0A182WGD3   A0A182SVI5   A0A182M7G3   A0A182RHB9   A0A1L8E240   A0A1L8E2A9   A0A084WC72   B0WWL5   A0A1Q3FHM7   A0A182PNH5   Q17JX2   A0A182HEV7   F4WK81   D6WFH1   A0A182PA28   O96301   A0A182Q4C3   A0A151XJR8   A0A0G3VIA2   A0A1B0D3I2   K1QEH1   A0A182V4E1   F5HK76   A0A182HTB3   T1D449   A0A2W1BMY2   A0A195BGP1   A0A182U6F2  

PDB

3FKY     E-value=1.75757e-89,     Score=840

KEGG

101741446    K01915 glutamine synthetase [EC:6.3.1.2] | (RefSeq) glutamine synthetase 1, mitochondrial

PATHWAY

00220    Arginine biosynthesis - Bombyx mori (domestic silkworm)
00250    Alanine, aspartate and glutamate metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
00910    Nitrogen metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0006542   GO:0004356   GO:0000166   GO:0006352   GO:0030880   GO:0005739   GO:0007005   GO:0005524   GO:0006909   GO:0006541   GO:0016021   GO:0006807   GO:0003824   GO:0044237   GO:0016627   GO:0008152   GO:0016491  

Subcellular location

Mitochondrion  

Length:

404

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00777999999999999

Exp number, first 60 AAs:

0.0061

Total prob of N-in:

0.00250

outside

1  -  404

 

 

Pi

272.801933

Theta

189.904463

Tajima's D

1.256248

CLR

0

CSRT

0.731813409329534

Interpretation

Uncertain