Gene

KWMTBOMO05453

Annotation

PREDICTED:_solute_carrier_family_2?_facilitated_glucose_transporter_member_1-like_[Bombyx_mori]

Location

Bomo_Chr10(-):2528024-2557024      View in EpiBrowser

Full name

Solute carrier family 2, facilitated glucose transporter member 4      

Alternative Name

Glucose transporter type 4, insulin-responsive

Location in the cell

PlasmaMembrane   Reliability : 4.946

CDS

ATGGGGGACAGAGCAGCTGGTTCTACCCTGCTTGCCGAAAATCGGCGACGAGAATCTTTTCAATATGTACCACAACCGGTATTCAATGAGAACCAGCATTGGACTAAGACGAACGAGTACACAGCCACCGGGTGGTCGTTTTATTTGATATTGGCCGGAGTCATCACCACCATCGGATCATCCGTCCCTGTAGGATATAATATAGGTGTCGTTAATACACCGGCTGAGGTGATAAAACAATTCTGTAATGAAAGTTTCATCAGCCGTTACGATGTAGTGCTGGACGAGCAATGGATGAATGTTCTTTGGTCTTCGGTGGTGTCTATCTTCATCGTCGGCGGGTGTACCGGCTCTATACTTGGCTCGTACTTAGCTGATAGCCTCGGAAGAAAAATGGCAACGATCGCTACGGGGGCGCTATGGATCGCGGGAGCTTTGCTCTTCTTGCTATGCCGGACGGCTAATTCAGTGGAGATGCTTATAATCGGGAGACTTTTAGTCGGTCTAGCCGGAGGTCTGACTACCAGCATAGTTCCCATGTACCTGACGGAGCTGGCGCCGCCCAGACTAACTGGAGCCATGGGTGTCGCGTGTCCCATGGGGGTCAACGTGGGTGTTCTTGTTGGGCAAGTTATGGGATTGAACTTTTTGTTGGGGGGCCCGGACAACTGGCCGTATCTGCTAGGGGCTTACGCGATTCTAGTCATTGTGTGTTTACCCATACTGTTCATATTGCCGGAGAGCCCGAAGTACTTGTACGTTATGAAACGCGACGAAGGAAAAGCTTTGGAAGAGTTGAGTCGTCTCCGCGGTGTTTCAATGAGCCTGCTGGCGTCAGAGCTGGAGACTCTTCGTGAGGAAGCGGCCACGGCGTCCGTCGTCCAGCGCTACTCGATGCTGCAGGTGGCGCGGGAGCCTGCCCTGCGCCTGCCGCTGCTCCTGGTGGTGGCGCTACAAGCGGGACAGCAGACCAGCGGGATCAACGCGGTGTTCTACTACTCGCAAATGATGTTCGAGCAGGCCGGTCTGACGGCGTACCAGGCTCAGCTGGCGACGATAGCGGCGGGACTCGTGAACGTGTGCACAGCCGCGCTCATGGTGCGCCTCCTGCCGCGCGCCGGCCGCCGCCCCCTCGTGCTGCGCTCCGTGCTCGCCGCCGCCCTCCTCCTGGCCGCCCTGGCCGCCGCCCTTAACTACATGGACGCGGCGCCCTGGATGCCGTACGTGTGCATAGTGGCCGTGTTGTCTTACGTCAACGCGTACGGGTTCGGTCTTGGACCTATAGCGTATTTTATTGCGTCCGAAATGTTCGAGGTGGCGCCGCGCCCCGCCGCCATGGCGTGGGGCTCGTTGGCGAACTGGGGGGGGAACTTTCTCATCGGAATGTCCTTCCAAACGATGCGGGACACCATCGGCGCCTACTCCTTCTTGTTGTTCTCCGCCGTTACCGCAGCCCTGTACGTTTTTATGAGACTGTACTTCCCCGAAACACGAGGAAAGACTCCGGCTCAAGTATCACTCCTATGCAGCCAAGGGTTCCGCTCCAGACCCCTCAGTACATCACAATTGCGTAATGCTGACGTATGA

Protein

MGDRAAGSTLLAENRRRESFQYVPQPVFNENQHWTKTNEYTATGWSFYLILAGVITTIGSSVPVGYNIGVVNTPAEVIKQFCNESFISRYDVVLDEQWMNVLWSSVVSIFIVGGCTGSILGSYLADSLGRKMATIATGALWIAGALLFLLCRTANSVEMLIIGRLLVGLAGGLTTSIVPMYLTELAPPRLTGAMGVACPMGVNVGVLVGQVMGLNFLLGGPDNWPYLLGAYAILVIVCLPILFILPESPKYLYVMKRDEGKALEELSRLRGVSMSLLASELETLREEAATASVVQRYSMLQVAREPALRLPLLLVVALQAGQQTSGINAVFYYSQMMFEQAGLTAYQAQLATIAAGLVNVCTAALMVRLLPRAGRRPLVLRSVLAAALLLAALAAALNYMDAAPWMPYVCIVAVLSYVNAYGFGLGPIAYFIASEMFEVAPRPAAMAWGSLANWGGNFLIGMSFQTMRDTIGAYSFLLFSAVTAALYVFMRLYFPETRGKTPAQVSLLCSQGFRSRPLSTSQLRNADV

Description

Insulin-regulated facilitative glucose transporter.

Subunit

Binds to DAXX. Interacts via its N-terminus with SRFBP1 (By similarity). Interacts with NDUFA9 (By similarity). Interacts with TRARG1; the interaction is required for proper SLC2A4 reacycling after insulin stimulation (By similarity).

Miscellaneous

Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.

Similarity

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
Belongs to the glycosyl hydrolase 18 family.
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Keywords

Cell membrane   Complete proteome   Cytoplasm   Glycoprotein   Membrane   Phosphoprotein   Reference proteome   Sugar transport   Transmembrane   Transmembrane helix   Transport   Ubl conjugation  

Feature

chain  Solute carrier family 2, facilitated glucose transporter member 4

Uniprot

H9JAU7   A0A1C9EGF9   A0A194QHZ3   A0A212FET9   A0A194RP44   A0A0V0GA77   + More
A0A0P4VVV0   A0A0C9QBB7   T1I7R9   A0A0J7KUY3   E9IGW0   E2AX78   A0A2A3EL56   A0A087ZWD5   A0A232FN99   K7ITD7   A0A0N0U4U0   A0A310SWN2   A0A0L7QV88   A0A151HYI0   A0A151IQL3   F4X4W4   A0A3L8DGY7   A0A0A1X8M8   A0A0K8VSD7   A0A0K8US51   A0A1A9WWK3   W8BB30   A0A034WJ29   A0A1Z1XG36   A0A195ETA1   A0A0A9XPY7   A0A026WRM9   A0A0K8SSB0   E2BWS1   A0A151WL51   B3N3H4   B4QCQ0   B4II19   Q0IGX4   B4NYW7   A0A3B0J3B3   A0A1W4VYD3   B4LJL7   Q28YP4   B4H8C8   A0A0R3NP04   B4LNN0   J9K8D7   A0A154PSD6   I3MBY4   I3N8R3   A0A2U3VTD2   A0A0M3QUC7   G3TCE1   A0A3Q7PV76   A0A158NVY7   K7FZI7   I1W0Z5   I1W0Z6   I1W101   M3Z096   S7NG63   G1P2Z3   I1W109   L5M095   I1W103   A0A286XET5   A0A3G1I4G1   I0BWM0   I1W107   A0A0N8BMS5   D7RFB4   Q27994   I1W108   A0A212DAE3   Q6EAS4   L5JWG4   K9IKS0   A0A340X8V1   A0A315VZ20   Q8MJ15   A0A1B1RV26   L9KR18   I1W0Z9   I1W100   Q8WSW5   A0A0N8EAH6   H2NSI2   A0A340XCK2   A0A2K6ENC4   A0A2K6ENB3   A0A2R5L7U2   A0A164SYQ9   I1W104   W5PP99   A0A096P2N6   A0A0P5C448   A0A2K6CH25  

Pubmed

19121390    26354079    22118469    27129103    21282665    20798317    + More
28648823    20075255    21719571    30249741    25830018    24495485    25348373    28588501    25401762    26823975    24508170    17994087    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    15632085    21347285    17381049    22493665    21993624    28440667    24381100    9027564    8925410    15366377    23258410    29703783    19892987    27427908    23385571    20809919   

EMBL

BABH01008412    BABH01008413    BABH01008414    KX778609    AON96566.1    KQ458793    + More
KPJ05014.1    AGBW02008897    OWR52252.1    KQ459984    KPJ19080.1    GECL01001163    JAP04961.1    GDKW01002822    JAI53773.1    GBYB01011380    GBYB01011381    GBYB01011723    JAG81147.1    JAG81148.1    JAG81490.1    ACPB03023874    LBMM01002844    KMQ94292.1    GL763054    EFZ20202.1    GL443520    EFN61961.1    KZ288215    PBC32543.1    NNAY01000006    OXU32115.1    AAZX01003312    KQ435821    KOX72424.1    KQ759851    OAD62556.1    KQ414727    KOC62479.1    KQ976730    KYM76416.1    KQ976772    KYN08452.1    GL888679    EGI58537.1    QOIP01000009    RLU19128.1    GBXI01006820    JAD07472.1    GDHF01010566    JAI41748.1    GDHF01022785    JAI29529.1    GAMC01012347    JAB94208.1    GAKP01004605    JAC54347.1    KY350169    ARX98208.1    KQ981993    KYN31109.1    GBHO01024486    GBHO01024481    GBHO01024476    GBHO01024474    GDHC01005425    GDHC01004839    JAG19118.1    JAG19123.1    JAG19128.1    JAG19130.1    JAQ13204.1    JAQ13790.1    KK107119    EZA58672.1    GBRD01010104    JAG55720.1    GL451188    EFN79785.1    KQ982974    KYQ48584.1    CH954177    EDV59856.2    CM000362    CM002911    EDX05839.1    KMY91668.1    CH480841    EDW49545.1    AE013599    BT028796    AAF57300.2    ABI34177.1    CM000157    EDW89818.2    OUUW01000001    SPP75807.1    CH940648    EDW61585.2    CM000071    EAL25921.2    CH479223    EDW34963.1    KRT02674.1    EDW62210.2    ABLF02041154    KQ435127    KZC14812.1    AGTP01070895    AGTP01107584    CP012524    ALC40433.1    ADTU01027553    ADTU01027554    ADTU01027555    ADTU01027556    AGCU01013080    AGCU01013081    AGCU01013082    JN695651    AFI57553.1    JN695652    AFI57554.1    JN695657    AFI57559.1    AEYP01041520    KE164153    EPQ15455.1    AAPE02052135    AAPE02052136    JN695665    AFI57567.1    KB105946    ELK31781.1    JN695659    AFI57561.1    AAKN02044424    KX168424    ARQ15180.1    JQ343218    AFH66818.1    JN695663    AFI57565.1    GDIQ01162459    JAK89266.1    HM055486    ADI33304.1    D63150    AY458600    BC114082    U18105    JN695664    AFI57566.1    MKHE01000005    OWK15203.1    AY505108    AAS91787.1    KB031076    ELK03794.1    GABZ01005737    JAA47788.1    NHOQ01000739    PWA28910.1    AF531753    AAM95953.2    KT377191    ANU06113.1    KB320771    ELW63617.1    JN695655    AFI57557.1    JN695656    AFI57558.1    AY059413    AAL27090.1    GDIQ01045860    JAN48877.1    ABGA01347993    NDHI03003640    PNJ13036.1    GGLE01001423    MBY05549.1    LRGB01001899    KZS10076.1    JN695660    AFI57562.1    AMGL01018020    AMGL01018021    AHZZ02009643    GDIP01175870    JAJ47532.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000053240    UP000015103    UP000036403    + More
UP000000311    UP000242457    UP000005203    UP000215335    UP000002358    UP000053105    UP000053825    UP000078540    UP000078542    UP000007755    UP000279307    UP000091820    UP000078541    UP000053097    UP000008237    UP000075809    UP000008711    UP000000304    UP000001292    UP000000803    UP000002282    UP000268350    UP000192221    UP000008792    UP000001819    UP000008744    UP000007819    UP000076502    UP000005215    UP000245340    UP000092553    UP000007646    UP000286641    UP000005205    UP000007267    UP000000715    UP000001074    UP000005447    UP000009136    UP000010552    UP000265300    UP000002281    UP000011518    UP000001595    UP000233160    UP000076858    UP000002356    UP000028761    UP000233120   

PRIDE

H9JAU7    Q0IGX4    Q27994   

Pfam

PF00083   Sugar_tr        + More
PF01607   CBM_14
PF00704   Glyco_hydro_18

Interpro

IPR036259   MFS_trans_sf        + More
IPR020846   MFS_dom       
IPR005829   Sugar_transporter_CS       
IPR003663   Sugar/inositol_transpt       
IPR005828   MFS_sugar_transport-like       
IPR011583   Chitinase_II       
IPR036508   Chitin-bd_dom_sf       
IPR017853   Glycoside_hydrolase_SF       
IPR002557   Chitin-bd_dom       
IPR001579   Glyco_hydro_18_chit_AS       
IPR001223   Glyco_hydro18_cat       
IPR029070   Chitinase_insertion_sf       
IPR002441   Glc_transpt_4       
IPR002945   Glc_transpt_3       
IPR002439   Glu_transpt_1       

SUPFAM

SSF103473   SSF103473        + More
SSF54556   SSF54556       
SSF57625   SSF57625       
SSF51445   SSF51445       

Gene 3D

3.10.50.10    

CDD

cd06174  MFS

ProteinModelPortal

H9JAU7   A0A1C9EGF9   A0A194QHZ3   A0A212FET9   A0A194RP44   A0A0V0GA77   + More
A0A0P4VVV0   A0A0C9QBB7   T1I7R9   A0A0J7KUY3   E9IGW0   E2AX78   A0A2A3EL56   A0A087ZWD5   A0A232FN99   K7ITD7   A0A0N0U4U0   A0A310SWN2   A0A0L7QV88   A0A151HYI0   A0A151IQL3   F4X4W4   A0A3L8DGY7   A0A0A1X8M8   A0A0K8VSD7   A0A0K8US51   A0A1A9WWK3   W8BB30   A0A034WJ29   A0A1Z1XG36   A0A195ETA1   A0A0A9XPY7   A0A026WRM9   A0A0K8SSB0   E2BWS1   A0A151WL51   B3N3H4   B4QCQ0   B4II19   Q0IGX4   B4NYW7   A0A3B0J3B3   A0A1W4VYD3   B4LJL7   Q28YP4   B4H8C8   A0A0R3NP04   B4LNN0   J9K8D7   A0A154PSD6   I3MBY4   I3N8R3   A0A2U3VTD2   A0A0M3QUC7   G3TCE1   A0A3Q7PV76   A0A158NVY7   K7FZI7   I1W0Z5   I1W0Z6   I1W101   M3Z096   S7NG63   G1P2Z3   I1W109   L5M095   I1W103   A0A286XET5   A0A3G1I4G1   I0BWM0   I1W107   A0A0N8BMS5   D7RFB4   Q27994   I1W108   A0A212DAE3   Q6EAS4   L5JWG4   K9IKS0   A0A340X8V1   A0A315VZ20   Q8MJ15   A0A1B1RV26   L9KR18   I1W0Z9   I1W100   Q8WSW5   A0A0N8EAH6   H2NSI2   A0A340XCK2   A0A2K6ENC4   A0A2K6ENB3   A0A2R5L7U2   A0A164SYQ9   I1W104   W5PP99   A0A096P2N6   A0A0P5C448   A0A2K6CH25  

PDB

5EQI     E-value=1.06202e-71,     Score=688

KEGG

101736199    no KO assigned | (RefSeq) solute carrier family 2, facilitated glucose transporter member 1-like

GO

GO:0016021   GO:0022857   GO:0008643   GO:0005576   GO:0005975   GO:0008061   GO:0004553   GO:0006030   GO:0071470   GO:0071356   GO:0042383   GO:0042593   GO:0044381   GO:0050873   GO:0005355   GO:0005829   GO:0048471   GO:0030140   GO:0030659   GO:0010021   GO:0070062   GO:0009897   GO:0045121   GO:0005887   GO:0032593   GO:0005768   GO:0032869   GO:0016324   GO:0005737   GO:0033300   GO:0005903   GO:0055056   GO:0005911   GO:0012505   GO:0005886   GO:0002080   GO:0016020   GO:0022891   GO:0005215   GO:0050660   GO:0016627   GO:0008152   GO:0016491   GO:0003824   GO:0055085  

Subcellular location

Cell membrane   Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (By similarity). The dileucine internalization motif is critical for intracellular sequestration (By similarity). Insulin stimulation induces translocation to the cell membrane (By similarity).   With evidence from 2 publications.
Endomembrane system   Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (By similarity). The dileucine internalization motif is critical for intracellular sequestration (By similarity). Insulin stimulation induces translocation to the cell membrane (By similarity).   With evidence from 2 publications.
Cytoplasm   Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (By similarity). The dileucine internalization motif is critical for intracellular sequestration (By similarity). Insulin stimulation induces translocation to the cell membrane (By similarity).   With evidence from 2 publications.
Perinuclear region   Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (By similarity). The dileucine internalization motif is critical for intracellular sequestration (By similarity). Insulin stimulation induces translocation to the cell membrane (By similarity).   With evidence from 2 publications.

Length:

528

Number of predicted TMHs:

11

Exp number of AAs in TMHs:

244.260020000001

Exp number, first 60 AAs:

15.37759

Total prob of N-in:

0.42347

POSSIBLE N-term signal

sequence

outside

1  -  47

TMhelix

48  -  70

inside

71  -  99

TMhelix

100  -  122

outside

123  -  131

TMhelix

132  -  151

inside

152  -  159

TMhelix

160  -  182

outside

183  -  196

TMhelix

197  -  219

inside

220  -  223

TMhelix

224  -  246

outside

247  -  342

TMhelix

343  -  365

inside

366  -  377

TMhelix

378  -  400

outside

401  -  409

TMhelix

410  -  432

inside

433  -  444

TMhelix

445  -  467

outside

468  -  471

TMhelix

472  -  494

inside

495  -  528

 

 

Pi

239.684056

Theta

202.75164

Tajima's D

0.632895

CLR

0.465674

CSRT

0.553972301384931

Interpretation

Uncertain