Gene

KWMTBOMO05392

Pre Gene Modal

BGIBMGA006673

Annotation

PREDICTED:_ubiquitin-conjugating_enzyme_E2_S_[Bombyx_mori]

Location

Bomo_Chr10(+):23566-26004      View in EpiBrowser

Full name

Ubiquitin-conjugating enzyme E2 S      

Alternative Name

E2 ubiquitin-conjugating enzyme S
Ubiquitin carrier protein S
Ubiquitin-protein ligase S

Location in the cell

Nuclear   Reliability : 2.317

CDS

ATGTCGAACGTGGAAAACGTATGTCCTCAAGCGTTGCGTGGCGTGGCACGCGAACTCCGACAGCTGGCGGCTAATCCTCCGCCGGGCATCAAACTGCAGCTGCGAGACGACGACATATCTGACATAGTCGCGCTTATCGATGGTCCCGCGGAGACGCCGTATGAAGGGGGCGTGTTCCGCGTGCGACTCGTGCTCGGACGCGAGTTCCCCGCCAGCGCACCGCGGGCATACTTCGTCACCCGCGTCTTCCACCCCAACGTCGCCGCCGAGACTGGCGAGGTCTGCGTCAACACGCTCGCACGCGACTGGCGCCCCGAGCTCGGGCTCCGGCACGCGCTCCTCGCTCTGCGCTGTCTGCTCATCGCGCCCAACCCTGACTCGGCACTCAACGCGGAGGCCGCCGCCCTACTGCGCGACCGCTACGACGACTACTTCGCGCGCGCCAAGCTGCTCACCGACATCCACGCGACTCGCAGCCGCGCCCCCGCCCCCGCGCCCGCCGCCGCGCCCGCGCACGCGCCCGCCGCCGCGCCCGCGCACGCGCCCGCGCCGCCCGCCAAGCGCCGCCCCGCGCCTCCCCCCCGCGCAGACAAGCGCCGCATCCTGAAGCGGTTATGA

Protein

MSNVENVCPQALRGVARELRQLAANPPPGIKLQLRDDDISDIVALIDGPAETPYEGGVFRVRLVLGREFPASAPRAYFVTRVFHPNVAAETGEVCVNTLARDWRPELGLRHALLALRCLLIAPNPDSALNAEAAALLRDRYDDYFARAKLLTDIHATRSRAPAPAPAAAPAHAPAAAPAHAPAPPAKRRPAPPPRADKRRILKRL

Description

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Catalytic Activity

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Similarity

Belongs to the ubiquitin-conjugating enzyme family.

Keywords

ATP-binding   Cell cycle   Cell division   Complete proteome   Nucleotide-binding   Reference proteome   Transferase   Ubl conjugation pathway  

Feature

chain  Ubiquitin-conjugating enzyme E2 S

Uniprot

A0A212F521   A0A0N0PB60   A0A2W1BC77   A0A194QN79   A0A2H1V9R0   A0A0N1IC68   + More
S4PX77   A0A3M6TAG2   A0A1Y1L1N8   A0A131XVU8   B7QH24   A0A2B4STP0   A0A1I8NR75   A0A1Y1KZ59   W8ASP3   A0A1B6BWX2   J3JXD1   A0A034W7Z2   A0A0A1WHN8   A0A0K8VIC5   T1GXU9   A0A1B6CXU1   A0A1I8MUD6   A0A0T6B2J7   A0A210QCM6   A0A1A9WAP6   A0A1B0FCV6   A0A1A9UE17   A0A1B0BDF0   A0A1A9ZQD6   A0A1A9YJ62   A7SE05   A0A1B6MH50   A0A3S1I0D2   A0A1B0DRE7   A0A131XEL7   A0A161M9L8   A0A0L0BNI5   B4Q2J2   B3NWW9   A0A023FGD8   V4BE59   A0A087UNL6   A0A1B0GJ35   B3MQV3   G3MMN3   A0A1E1WZB9   A0A224ZBA1   A0A131YKD2   A0A224XT97   A0A0V0GBD2   A0A069DPC9   A0A0C9SB77   A0A1E1XUJ9   A0A023F8Y4   L7M4Y2   B4R6G1   B4IF39   A0A0P8XZN5   X2JFX0   Q9VX25   A0A1A9WF61   A0A2R7WWM9   B4N208   A0A2C9K528   A0A2C9K547   A0A1W4V915   A0A1W4X4I7   A0A2P6LA00   C1BRF0   A0A2C9K524   A0A3B0JY61   A0A3B0K3T9   A0A3B0K5G2   K7J8H2   R4FMW4   A0A1W4X4L8   A0A1W4XFA4   A0A0P4WP44   B5DKM4   B4H9W2   A0A0R3P2G4   B4L7V4   D6X2T4   A0A232ELG9   A0A3S4RI68   R4WQD6   A0A1L8DT41   B4JKB7   A0A2T7PYR1   A0A1L8DTA7   A0A2A3ET26   A0A088AGX8   A0A0M4EZ59   A0A067R5L2   A0A0N0U5A1   E2ADL1   A0A0P4VPD9   A0A090X7H8   A0A0L8GCP9  

EC Number

2.3.2.23

Pubmed

22118469    26354079    28756777    23622113    30382153    28004739    + More
24495485    22516182    23537049    25348373    25830018    25315136    28812685    17615350    28049606    26108605    17994087    23254933    22216098    28503490    28797301    26830274    26334808    26131772    29209593    25474469    25576852    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    19822757    15562597    20075255    15632085    18362917    19820115    28648823    23691247    24845553    20798317    27129103    25970599   

EMBL

AGBW02010275    OWR48823.1    KQ461033    KPJ09955.1    KZ150569    PZC70510.1    + More
KQ458793    KPJ04941.1    ODYU01001418    SOQ37575.1    KPJ09954.1    GAIX01005518    JAA87042.1    RCHS01004029    RMX38288.1    GEZM01068947    JAV66698.1    GEFM01005448    JAP70348.1    ABJB010161966    ABJB010601624    DS936107    EEC18146.1    LSMT01000030    PFX31857.1    GEZM01068946    JAV66699.1    GAMC01017363    JAB89192.1    GEDC01031530    GEDC01024758    JAS05768.1    JAS12540.1    APGK01050180    BT127900    KB741167    KB632191    AEE62862.1    ENN73367.1    ERL89823.1    GAKP01008515    JAC50437.1    GBXI01016257    JAC98034.1    GDHF01023574    GDHF01013692    GDHF01005414    JAI28740.1    JAI38622.1    JAI46900.1    CAQQ02148752    CAQQ02148753    GEDC01019087    JAS18211.1    LJIG01016102    KRT81610.1    NEDP02004182    OWF46471.1    CCAG010020088    JXJN01012462    DS469633    GEBQ01020113    GEBQ01004762    JAT19864.1    JAT35215.1    RQTK01000049    RUS89731.1    AJVK01009091    GEFH01004061    JAP64520.1    GEMB01003946    JAR99310.1    JRES01001701    KNC20819.1    CM000162    CH954180    GBBK01003885    JAC20597.1    KB199905    ESP04042.1    KK120751    KFM78955.1    AJWK01019255    CH902622    JO843134    AEO34751.1    GFAC01006856    JAT92332.1    GFPF01013138    MAA24284.1    GEDV01009657    JAP78900.1    GFTR01003378    JAW13048.1    GECL01001421    JAP04703.1    GBGD01002991    JAC85898.1    GBZX01002143    JAG90597.1    GFAA01000477    JAU02958.1    GBBI01000807    JAC17905.1    GACK01006107    JAA58927.1    CM000366    CH480832    KPU74999.1    AE014298    AHN59853.1    AHN59854.1    DQ151896    DQ151897    BT031269    KK855540    PTY23035.1    CH963925    MWRG01000748    PRD35401.1    BT077179    ACO11603.1    OUUW01000003    SPP78699.1    OUUW01000005    SPP80649.1    SPP78698.1    AAZX01000641    AAZX01000642    AAZX01000643    AAZX01004367    AAZX01004650    AAZX01007334    AAZX01009593    AAZX01014562    AAZX01016107    AAZX01017377    ACPB03009184    GAHY01001569    JAA75941.1    GDRN01074708    JAI63190.1    CH379063    CH479232    KRT05935.1    CH933814    KQ971372    EFA09828.2    NNAY01003553    OXU19209.1    NCKU01000219    RWS16505.1    AK417906    BAN21121.1    GFDF01004456    JAV09628.1    CH916370    PZQS01000001    PVD38538.1    GFDF01004457    JAV09627.1    KZ288189    PBC34664.1    CP012528    ALC49392.1    KK852946    KDR13426.1    KQ435794    KOX73852.1    GL438820    EFN68373.1    GDKW01001719    JAI54876.1    GBIH01002698    JAC92012.1    KQ422765    KOF74310.1   

Proteomes

UP000007151    UP000053240    UP000053268    UP000275408    UP000001555    UP000225706    + More
UP000095300    UP000019118    UP000030742    UP000015102    UP000095301    UP000242188    UP000091820    UP000092444    UP000078200    UP000092460    UP000092445    UP000092443    UP000001593    UP000271974    UP000092462    UP000037069    UP000002282    UP000008711    UP000030746    UP000054359    UP000092461    UP000007801    UP000000304    UP000001292    UP000000803    UP000007798    UP000076420    UP000192221    UP000192223    UP000268350    UP000002358    UP000015103    UP000001819    UP000008744    UP000009192    UP000007266    UP000215335    UP000285301    UP000001070    UP000245119    UP000242457    UP000005203    UP000092553    UP000027135    UP000053105    UP000000311    UP000053454   

PRIDE

A7SE05    B4Q2J2    B3NWW9    B3MQV3    B4IF39    Q9VX25    + More
B4H9W2   

Pfam

PF00179   UQ_con        + More
PF10515   APP_amyloid

Interpro

IPR016135   UBQ-conjugating_enzyme/RWD        + More
IPR000608   UBQ-conjugat_E2       
IPR023313   UBQ-conjugating_AS       
IPR019745   Amyloid_glyco_intracell_CS       
IPR019543   APP_amyloid_C       
IPR011993   PH-like_dom_sf       

SUPFAM

SSF54495   SSF54495       

Gene 3D

3.10.110.10     2.30.29.30    

CDD

cd00195  UBCc

ProteinModelPortal

A0A212F521   A0A0N0PB60   A0A2W1BC77   A0A194QN79   A0A2H1V9R0   A0A0N1IC68   + More
S4PX77   A0A3M6TAG2   A0A1Y1L1N8   A0A131XVU8   B7QH24   A0A2B4STP0   A0A1I8NR75   A0A1Y1KZ59   W8ASP3   A0A1B6BWX2   J3JXD1   A0A034W7Z2   A0A0A1WHN8   A0A0K8VIC5   T1GXU9   A0A1B6CXU1   A0A1I8MUD6   A0A0T6B2J7   A0A210QCM6   A0A1A9WAP6   A0A1B0FCV6   A0A1A9UE17   A0A1B0BDF0   A0A1A9ZQD6   A0A1A9YJ62   A7SE05   A0A1B6MH50   A0A3S1I0D2   A0A1B0DRE7   A0A131XEL7   A0A161M9L8   A0A0L0BNI5   B4Q2J2   B3NWW9   A0A023FGD8   V4BE59   A0A087UNL6   A0A1B0GJ35   B3MQV3   G3MMN3   A0A1E1WZB9   A0A224ZBA1   A0A131YKD2   A0A224XT97   A0A0V0GBD2   A0A069DPC9   A0A0C9SB77   A0A1E1XUJ9   A0A023F8Y4   L7M4Y2   B4R6G1   B4IF39   A0A0P8XZN5   X2JFX0   Q9VX25   A0A1A9WF61   A0A2R7WWM9   B4N208   A0A2C9K528   A0A2C9K547   A0A1W4V915   A0A1W4X4I7   A0A2P6LA00   C1BRF0   A0A2C9K524   A0A3B0JY61   A0A3B0K3T9   A0A3B0K5G2   K7J8H2   R4FMW4   A0A1W4X4L8   A0A1W4XFA4   A0A0P4WP44   B5DKM4   B4H9W2   A0A0R3P2G4   B4L7V4   D6X2T4   A0A232ELG9   A0A3S4RI68   R4WQD6   A0A1L8DT41   B4JKB7   A0A2T7PYR1   A0A1L8DTA7   A0A2A3ET26   A0A088AGX8   A0A0M4EZ59   A0A067R5L2   A0A0N0U5A1   E2ADL1   A0A0P4VPD9   A0A090X7H8   A0A0L8GCP9  

PDB

5BNB     E-value=1.27918e-39,     Score=406

KEGG

101745491    K10583 ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23] | (RefSeq) ubiquitin-conjugating enzyme E2 S

PATHWAY

04120    Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)

GO

GO:0016740   GO:0005524   GO:0016874   GO:0006511   GO:0061631   GO:1904668   GO:0031145   GO:0051301   GO:0070979   GO:0005680   GO:0010994   GO:0010458   GO:0016021   GO:0016567   GO:0004842  

Length:

205

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00359

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.21655

outside

1  -  205

 

 

Pi

51.949361

Theta

182.557553

Tajima's D

-0.323482

CLR

159.870966

CSRT

0.286885655717214

Interpretation

Uncertain