Gene

KWMTBOMO05390

Pre Gene Modal

BGIBMGA002556

Annotation

nicotinic_acetylcholine_receptor_subunit_alpha_3_precursor_[Bombyx_mori]

Location

Bomo_Chr9(+):16770404-16782444      View in EpiBrowser

Full name

Acetylcholine receptor subunit alpha-like      

Alternative Name

MARA1

Location in the cell

PlasmaMembrane   Reliability : 4.178

CDS

ATGTGCGGTACAACCGTGCACGGGTGCGCCGGCAACCCGGACGCCAAGCGGCTCTACGACGACCTGCTTAGCAACTACAACAAGCTGGTGCGACCCGTGCTCAACGTCAGCGACGCGCTCACCGTGCGTATCAAGCTCAAGCTCAGTCAGCTCATCGACGTGAACCTCAAGAATCAAATTATGACAACGAATTTATGGGTGGAACAGACTTGGTATGACTACAAGCTGTCGTGGGAGCCGCGCGAGTACGGCGGCGTCGAGATGCTGCATGTGCCCTCGGACCACATCTGGAGGCCGGACATCGTGCTCTACAACAACGCGGACGGGAACTTCGAGGTGACGCTGGCGACGAAGGCGACGCTCAACTACACGGGGCGCGTGGAGTGGCGCCCGCCCGCCATCTACAAGTCCTCCTGCGAGATCGACGTCGAGTACTTCCCCTTCGATCAGCAGACGTGCGTCATGAAGTTTGGTTCATGGACCTATGACGGATTCCAGGTGGACCTCCGTCACATAGACGAGGTGCGCGGCACCAACGTGGTGGAGCTCGGGGTGGACCTCTCCGAGTTCTATACGTCTGTTGAGTGGGACATACTCGAGGTTCCTGCCGTCCGAAATGAAAAGTTCTACACGTGCTGCGACGAGCCCTACCTGGATATAACGTTCAATATCACGATGCGGCGAAAGACCCTGTTCTATACCGTCAACCTGATTATCCCGTGCATGGGCATCTCATTTCTGACGGTGCTGGTGTTCTATCTGCCTTCCGACAGCGGCGAGAAAGTGTCGCTCTCAATCTCCATCCTCCTCTCCTTGACTGTGTTCTTCCTGCTGCTCGCGGAGATCATCCCGCCGACGTCCCTGGTGGTGCCTCTGCTGGGCAAGTTCGTCCTCTTCACCATGATACTCGACACGTTCAGTATATGCGTGACGGTGGTAGTGCTGAACGTGCACTTCCGGTCCCCGCAGACGCACACGATGTCCCCGTGGGTGCGGCGCGTCTTCATTCACGTGTTGCCGCGACTGCTCGTCATGCGCCGACCACATTACCGCCTCGACCCCCACCGCAGTCGCTTCGCGGGTCTTGTATCGGGCGTGGAGGCGCCGTGGGAGGAAGTGCCGCACGCGGAAGTGCCTGCCCCCCCGCGGCCCCCCCGCACCCCGGCGCCCACCTGCGCCGTCTGCGCGCCAGAGGAGGCACCCGTCCTGTGCGACACGCTGCGGCGCTGGCACCGCTGTCCCGAGCTCCACAAGGCAATCGACGGCATCAACTACATCGCGGAACAGACACGCAAGGAGGAGGAGTCCACTAGGGTGAAGGAGGACTGGAAGTACGTGGCGATGGTGCTGGACCGACTGTTCCTGTGGATCTTCACGCTGGCGGTGGTGGTGGGGTCGGCGGGGATCATCTTGCAGGCGCCCACGCTGTACGATGAGCGCGCGCCGATCGACGTGCGGCTCTCGGAGATCGCGTACGCCACCGCCAAGCCGCGCCCCCCTCCGCCCCGCTGA

Protein

MCGTTVHGCAGNPDAKRLYDDLLSNYNKLVRPVLNVSDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQTWYDYKLSWEPREYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDQQTCVMKFGSWTYDGFQVDLRHIDEVRGTNVVELGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTVLVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVVVLNVHFRSPQTHTMSPWVRRVFIHVLPRLLVMRRPHYRLDPHRSRFAGLVSGVEAPWEEVPHAEVPAPPRPPRTPAPTCAVCAPEEAPVLCDTLRRWHRCPELHKAIDGINYIAEQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTLAVVVGSAGIILQAPTLYDERAPIDVRLSEIAYATAKPRPPPPR

Description

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.

Keywords

Cell junction   Cell membrane   Disulfide bond   Glycoprotein   Ion channel   Ion transport   Ligand-gated ion channel   Membrane   Postsynaptic cell membrane   Receptor   Signal   Synapse   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Acetylcholine receptor subunit alpha-like

Uniprot

A8HTB4   A8CGK3   A0A2W1BD31   A0A2H1WD61   O46128   A0A212ENH2   + More
P91766   A0A0H4TME3   A0A0N0PDZ6   A0A2A4J2A0   A0A182QH70   E9H6S6   A0A0J9URY4   M9PDC9   A0A1B0FI68   A0A0Q5UKR8   A0A0K8UN00   G9F9Q2   A0A0A1WQH3   W8BPC7   A0A1J1HPX3   A0A182YR92   E0WN34   E2C7L3   A0A1D8GS56   A0A0K0QSP6   H9NAE9   W6E959   A0A348BSV3   A0A154PLB9   A0A0G3VKJ9   A0A1W4WUV6   A0A1J1HTA2   A0A0N0U3K0   R4JK58   A0A1L4BJY3   E0VB18   A0A1L4BJY5   A0A348BSV4   A0A1B6CSI7  

Pubmed

17868469    28756777    22118469    9753155    26354079    21292972    + More
22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17994087    25830018    24495485    25244985    20798317    25701599    20566863   

EMBL

EU143794    ABV72685.1    EU082076    ABV45513.1    KZ150352    PZC71247.1    + More
ODYU01007550    SOQ50414.1    AJ000399    CAA04056.1    AGBW02013653    OWR43038.1    Y09795    KP711045    AKQ12741.1    KQ460036    KPJ18445.1    NWSH01003444    PCG66287.1    AXCN02002021    AXCN02002022    GL732598    EFX72561.1    CM002912    KMZ01301.1    AE014296    AGB94927.1    CCAG010001331    CH954178    KQS44458.1    GDHF01025676    GDHF01024353    JAI26638.1    JAI27961.1    JN052924    AEM05861.1    GBXI01013609    JAD00683.1    GAMC01003560    GAMC01003559    JAC02996.1    CVRI01000012    CRK89444.1    FR689749    CBX19385.1    GL453383    EFN76089.1    KU557777    AOT81839.1    KR021292    AKR16132.1    JQ609337    AFF19540.1    KF873581    AHJ11210.1    LC389177    BBE49556.1    KQ434943    KZC12264.1    KP339869    AKL79439.2    CVRI01000020    CRK91227.1    KQ435878    KOX70082.1    KC153234    AGK89908.1    KX021829    API81619.1    DS235021    EEB10574.1    KX021831    API81621.1    LC389178    BBE49557.1    GEDC01020789    JAS16509.1   

Proteomes

UP000007151    UP000053240    UP000218220    UP000075886    UP000000305    UP000000803    + More
UP000092444    UP000008711    UP000183832    UP000076408    UP000008237    UP000076502    UP000192223    UP000053105    UP000009046   

PRIDE

A8HTB4    A8CGK3    M9PDC9   

Pfam

PF02931   Neur_chan_LBD        + More
PF02932   Neur_chan_memb

Interpro

IPR036734   Neur_chan_lig-bd_sf        + More
IPR006029   Neurotrans-gated_channel_TM       
IPR006202   Neur_chan_lig-bd       
IPR036719   Neuro-gated_channel_TM_sf       
IPR002394   Nicotinic_acetylcholine_rcpt       
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR006201   Neur_channel       

SUPFAM

SSF90112   SSF90112        + More
SSF63712   SSF63712       

Gene 3D

2.70.170.10    

ProteinModelPortal

A8HTB4   A8CGK3   A0A2W1BD31   A0A2H1WD61   O46128   A0A212ENH2   + More
P91766   A0A0H4TME3   A0A0N0PDZ6   A0A2A4J2A0   A0A182QH70   E9H6S6   A0A0J9URY4   M9PDC9   A0A1B0FI68   A0A0Q5UKR8   A0A0K8UN00   G9F9Q2   A0A0A1WQH3   W8BPC7   A0A1J1HPX3   A0A182YR92   E0WN34   E2C7L3   A0A1D8GS56   A0A0K0QSP6   H9NAE9   W6E959   A0A348BSV3   A0A154PLB9   A0A0G3VKJ9   A0A1W4WUV6   A0A1J1HTA2   A0A0N0U3K0   R4JK58   A0A1L4BJY3   E0VB18   A0A1L4BJY5   A0A348BSV4   A0A1B6CSI7  

PDB

6CNK     E-value=6.63635e-103,     Score=956

KEGG

100126152    K05312 nicotinic acetylcholine receptor, invertebrate | (RefSeq) nAChRa3, Achra3; nicotinic acetylch

GO

GO:0022848   GO:0016021   GO:0004888   GO:0045211   GO:0030054   GO:0043005   GO:0045202   GO:0005887   GO:0050877   GO:0007268   GO:0034220   GO:0042391   GO:0007165   GO:0030431   GO:0005892   GO:0006811   GO:0016020   GO:0005230   GO:0006810   GO:0004889   GO:0005216   GO:0016491   GO:0003824  

PANTHER

PTHR18945  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

Length:

503

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

88.8639399999999

Exp number, first 60 AAs:

0.00021

Total prob of N-in:

0.06399

outside

1  -  231

TMhelix

232  -  254

inside

255  -  260

TMhelix

261  -  283

outside

284  -  295

TMhelix

296  -  318

inside

319  -  452

TMhelix

453  -  475

outside

476  -  503

 

 

Pi

223.920998

Theta

171.604786

Tajima's D

0.872087

CLR

0.055635

CSRT

0.626618669066547

Interpretation

Uncertain