Gene

KWMTBOMO05385

Annotation

hypothetical_protein_KGM_01125_[Danaus_plexippus]

Location

Bomo_Chr9(-):16572713-16577773      View in EpiBrowser

Full name

Transmembrane protein 138      

Location in the cell

PlasmaMembrane   Reliability : 4.827

CDS

ATGAAGCTTTCTACGCCAAAATACACGATATGTATAATTATTCAGTTTATTTTCATGTTTTGCGACTTAATATTTAATTGTGTGAGTTTATTTCCGAGAACTAAGGATGCACTTCTTGTATTATTCATATTTCAGGACCTGTTCTTGGTCCTATCTATAACAGCGATGCTGATGACGTTCTTCTCCACCTATCTATTTCAAGCTGGTCTGGTAGAGGTGCTGGTGCGCAAGTTCCGCGCGGCGGGCGCGGTGTGCGCGGCGTACGCGGCGGCCAGCGTGCTGCTGCATGCGGTGTGGCTGCAGCAGCAGTGGCACGAGCCGGGCTCGGCGTCGAGACCAGCGGTCATATTCCTGTTCTTGGTCCAGAGATGCTTGTCCCCCTGGTACTACTTCTTCTACAAACGAGCAGCTCTGCGCGTTAGTGATCCTCGCTTCTATGAAGACATAGAATGGATAAGTCATCAGTTACAGCAACATTGA

Protein

MKLSTPKYTICIIIQFIFMFCDLIFNCVSLFPRTKDALLVLFIFQDLFLVLSITAMLMTFFSTYLFQAGLVEVLVRKFRAAGAVCAAYAAASVLLHAVWLQQQWHEPGSASRPAVIFLFLVQRCLSPWYYFFYKRAALRVSDPRFYEDIEWISHQLQQH

Description

Required for ciliogenesis.

Miscellaneous

TMEM138 and TMEM216 genes are adjacent and are aligned in a head-to-tail configuration. They share some cis regulatory region and display coordinated expression. Genes were joined by chromosomal rearrangement at the amphiboan to reptile evolutionary transition around 340 million years ago (PubMed:22282472).

Similarity

Belongs to the TMEM138 family.

Keywords

Alternative splicing   Cell projection   Ciliopathy   Cilium   Complete proteome   Disease mutation   Glycoprotein   Joubert syndrome   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Vacuole  

Feature

chain  Transmembrane protein 138
splice variant  In isoform 2.
sequence variant  In JBTS16; dbSNP:rs387907132.

Uniprot

A0A2H1WCN1   A0A212EWD6   A0A2W1BHV5   A0A3S2PDB8   A0A0L7LQ38   A0A194QIS6   + More
A0A0N1I9X7   I4DN49   A0A2A4K8I9   E0VIA7   A0A0T6AWT8   A0A067QR57   A0A084WD31   A7T130   A0A182XB63   A0A182IY92   A0A182VSY7   A0A182R6V6   A0A182K0A6   A0A3M6UNE5   A0A182N8Q3   A0A182P8C8   A0A182R0V3   A0NG40   A0A182I0Q7   A0A2B4S3Z4   A0A1I7SWF8   A0A2M4C270   A0A2M4C1P2   A0A1W4X1S6   A0A2M4CJ02   Q16Z35   A0A023EHC6   A0A1S3JN00   A0A182H3Z8   A0A0K2UPC7   A0A182FMU7   A0A2M4AYE6   T1EB80   A0A2M4AYF8   V3ZVN2   R7VJC8   A0A026WMF2   A0A2P8Y7A3   U4UN81   A0A1Q3FI50   B0XJ62   A0A210PZW4   E2AKA4   B3SC41   F4WLS7   A0A151I3Z3   A0A158NXS8   A0A232EQN6   C3XQZ3   A0A0L7RH53   A0A2G8JFW3   A0A0B2VN96   A0A0M8ZRK5   A0A224XMZ5   T1G6Z5   A0A1U7RYB7   R4FKZ8   A0A1U7SL42   H2ND83   A0A0B1T1Z0   A0A182SKX4   A0A151NXQ0   G5AYG3   A0A1S3G6W0   S4RZE2   A0A3Q0DFM5   A0A3Q2DCL1   G3QN90   A0A3S1BDN2   A0A2R8Z879   H2Q3U1   A0A1B6JFJ2   H0XEQ1   A0A091DGN5   A0A3Q2Q120   T2M540   A0A0L8HUC5   F7HCV4   A0A3Q4HPM5   A0A195FXD2   A0A3Q2PYT9   H9Z9V8   A0A1S3G786   Q9NPI0   A0A3Q2ZKF4   A0A1I8G130   A0A1A6FXW2   A0A2K5HMV8   A0A267DTB1   A0A1A8R4X4   A0A1A8MRQ7   A0A1A8A9S9   A0A1A8BSI4  

Pubmed

22118469    28756777    26227816    26354079    22651552    20566863    + More
24845553    24438588    17615350    30382153    12364791    14747013    17210077    21909270    17510324    24945155    26383154    26483478    23254933    24508170    30249741    29403074    23537049    28812685    20798317    18719581    21719571    21347285    28648823    18563158    29023486    22293439    21993625    22398555    22722832    16136131    24065732    25243066    25186727    25319552    14702039    11042152    17974005    16554811    15489334    22282472    26392545   

EMBL

ODYU01007770    SOQ50823.1    AGBW02012018    OWR45793.1    KZ150352    PZC71253.1    + More
RSAL01000089    RVE48121.1    JTDY01000359    KOB77552.1    KQ458714    KPJ05417.1    KQ460036    KPJ18443.1    AK402717    BAM19339.1    NWSH01000037    PCG80389.1    DS235184    EEB13113.1    LJIG01022681    KRT79278.1    KK853056    KDR11936.1    ATLV01022925    KE525338    KFB48125.1    DS470072    EDO30334.1    RCHS01001119    RMX55141.1    AXCN02001858    AAAB01008980    EAU76134.1    APCN01005234    LSMT01000171    PFX24621.1    GGFJ01010110    MBW59251.1    GGFJ01010074    MBW59215.1    GGFL01001148    MBW65326.1    CH477499    EAT39915.1    GAPW01005312    JAC08286.1    JXUM01025946    KQ560739    KXJ81063.1    HACA01022549    CDW39910.1    GGFK01012479    MBW45800.1    GAMD01000163    JAB01428.1    GGFK01012506    MBW45827.1    KB203357    ESO84991.1    AMQN01000514    KB291799    ELU18754.1    KK107151    QOIP01000003    EZA57247.1    RLU24393.1    PYGN01000839    PSN40138.1    KB632375    ERL93918.1    GFDL01007836    JAV27209.1    DS233443    EDS30025.1    NEDP02005322    OWF42043.1    GL440210    EFN66129.1    DS985267    EDV19737.1    GL888216    EGI64809.1    KQ976462    KYM84658.1    ADTU01003493    NNAY01002746    OXU20637.1    GG666456    EEN69588.1    KQ414596    KOC70036.1    MRZV01002115    PIK34641.1    JPKZ01001280    KHN82912.1    KQ435944    KOX68203.1    GFTR01002559    JAW13867.1    AMQM01007296    KB097594    ESN93779.1    ACPB03012702    GAHY01002299    JAA75211.1    ABGA01076010    ABGA01076011    NDHI03003558    PNJ22107.1    KN553739    KHJ89812.1    AKHW03001628    KYO41662.1    JH167515    EHB02074.1    CABD030079455    CABD030079456    CABD030079457    RQTK01000155    RUS85944.1    AJFE02100930    AJFE02100931    AACZ04057297    GABD01008324    NBAG03000297    JAA24776.1    PNI45198.1    GECU01009615    JAS98091.1    AAQR03147862    KN122588    KFO29455.1    HAAD01000934    CDG67166.1    KQ417345    KOF92395.1    GAMT01005361    GAMS01008901    GAMR01002042    GAMQ01001457    GAMP01010703    JAB06500.1    JAB14235.1    JAB31890.1    JAB40394.1    JAB42052.1    KQ981204    KYN44972.1    JU475920    AFH32724.1    AK303219    AF151030    AF151032    AL832879    AP003108    BC005201    LZPO01110809    OBS58761.1    NIVC01003245    NIVC01002277    PAA52416.1    PAA59321.1    HAEH01014696    HAEI01016650    SBS00772.1    HAEF01017995    HAEG01004623    SBR59154.1    HADY01012953    HAEJ01017475    SBP51438.1    HADZ01006218    HAEA01013723    SBP70159.1   

Proteomes

UP000007151    UP000283053    UP000037510    UP000053268    UP000053240    UP000218220    + More
UP000009046    UP000027135    UP000030765    UP000001593    UP000076407    UP000075880    UP000075920    UP000075900    UP000075881    UP000275408    UP000075884    UP000075885    UP000075886    UP000007062    UP000075840    UP000225706    UP000095284    UP000192223    UP000008820    UP000085678    UP000069940    UP000249989    UP000069272    UP000030746    UP000014760    UP000053097    UP000279307    UP000245037    UP000030742    UP000002320    UP000242188    UP000000311    UP000009022    UP000007755    UP000078540    UP000005205    UP000215335    UP000001554    UP000053825    UP000230750    UP000031036    UP000053105    UP000015101    UP000189705    UP000015103    UP000189704    UP000001595    UP000075901    UP000050525    UP000006813    UP000081671    UP000245300    UP000265020    UP000001519    UP000271974    UP000240080    UP000002277    UP000005225    UP000028990    UP000265000    UP000053454    UP000008225    UP000261580    UP000078541    UP000005640    UP000264800    UP000095280    UP000092124    UP000233080    UP000215902   

PRIDE

Q9NPI0   

Pfam

PF14935   TMEM138

Interpro

IPR024133   TM_138        + More
IPR000731   SSD       

ProteinModelPortal

A0A2H1WCN1   A0A212EWD6   A0A2W1BHV5   A0A3S2PDB8   A0A0L7LQ38   A0A194QIS6   + More
A0A0N1I9X7   I4DN49   A0A2A4K8I9   E0VIA7   A0A0T6AWT8   A0A067QR57   A0A084WD31   A7T130   A0A182XB63   A0A182IY92   A0A182VSY7   A0A182R6V6   A0A182K0A6   A0A3M6UNE5   A0A182N8Q3   A0A182P8C8   A0A182R0V3   A0NG40   A0A182I0Q7   A0A2B4S3Z4   A0A1I7SWF8   A0A2M4C270   A0A2M4C1P2   A0A1W4X1S6   A0A2M4CJ02   Q16Z35   A0A023EHC6   A0A1S3JN00   A0A182H3Z8   A0A0K2UPC7   A0A182FMU7   A0A2M4AYE6   T1EB80   A0A2M4AYF8   V3ZVN2   R7VJC8   A0A026WMF2   A0A2P8Y7A3   U4UN81   A0A1Q3FI50   B0XJ62   A0A210PZW4   E2AKA4   B3SC41   F4WLS7   A0A151I3Z3   A0A158NXS8   A0A232EQN6   C3XQZ3   A0A0L7RH53   A0A2G8JFW3   A0A0B2VN96   A0A0M8ZRK5   A0A224XMZ5   T1G6Z5   A0A1U7RYB7   R4FKZ8   A0A1U7SL42   H2ND83   A0A0B1T1Z0   A0A182SKX4   A0A151NXQ0   G5AYG3   A0A1S3G6W0   S4RZE2   A0A3Q0DFM5   A0A3Q2DCL1   G3QN90   A0A3S1BDN2   A0A2R8Z879   H2Q3U1   A0A1B6JFJ2   H0XEQ1   A0A091DGN5   A0A3Q2Q120   T2M540   A0A0L8HUC5   F7HCV4   A0A3Q4HPM5   A0A195FXD2   A0A3Q2PYT9   H9Z9V8   A0A1S3G786   Q9NPI0   A0A3Q2ZKF4   A0A1I8G130   A0A1A6FXW2   A0A2K5HMV8   A0A267DTB1   A0A1A8R4X4   A0A1A8MRQ7   A0A1A8A9S9   A0A1A8BSI4  

KEGG

101743135    K22867 transmembrane protein 138 | (RefSeq) transmembrane protein 138-like

GO

GO:0016021   GO:0005929   GO:0060271   GO:0005774  

PANTHER

PTHR13306  

Subcellular location

Vacuole membrane  
Cell projection  
Cilium  

Length:

159

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

87.03763

Exp number, first 60 AAs:

36.80432

Total prob of N-in:

0.95492

POSSIBLE N-term signal

sequence

inside

1  -  11

TMhelix

12  -  34

outside

35  -  48

TMhelix

49  -  71

inside

72  -  77

TMhelix

78  -  100

outside

101  -  109

TMhelix

110  -  132

inside

133  -  159

 

 

Pi

164.541968

Theta

153.067167

Tajima's D

0.316887

CLR

0.026576

CSRT

0.462876856157192

Interpretation

Uncertain