Gene

KWMTBOMO05370  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002376

Annotation

PREDICTED:_3-hydroxyisobutyryl-CoA_hydrolase?_mitochondrial_[Papilio_xuthus]

Location

Bomo_Chr9(-):15702304-15705644      View in EpiBrowser

Full name

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial      

Alternative Name

3-hydroxyisobutyryl-coenzyme A hydrolase

Location in the cell

Mitochondrial   Reliability : 2.332

CDS

ATGTATAGTTTAATAAAACTTAAACAAGCAACATTGCCTTTGTTAAGAAGGACAATGTCTTCCCAAGAACCTGATGTTTTATTTGAAGCATTAAACAATGCTGGCATAGTAACCCTCAATCGACCCAAAGCATTAAATTCCCTCAACACATCTATGGTGTCAAAATTATTACCACAACTTCAAGAATGGGAGAAATCAAAGTCTCTGGTTATAATTAAGGGTGCTGGAGAGAAAGCTTTCTGTGCTGGTGGTGATGTGAAAGCTGCCATAGACAAAATGGAAGGGCCTAGGTTCTTCCATACGGAATACAATGTTAATTACTTGATTGGAAACTATAAAATCCCATATATTGCATTTATAAATGGAATCACAATGGGAGGAGGTCTTGGACTCTCAGTCCATGGCAGATACAGAGTAGCAACAGAGAAGACATTAATAGCCATGCCAGAGACTAAGATAGGACTATTCCCAGATGTTGGTGGATCATTCTTTTTACCTCGTTTACAAGTTAATTTGGGATTGTACTTAGGGTTGACCGGTGACAGATTGAAAGGTAAAGACGTTGTGAAAGCTGGAATAGCTACACACTTTGTACCAAGCAAACGTCTGTATGAACTCGAAATGCTCCTTTCTCGGTGCGCTAATGATATAGAAGTTAATTCACTACTCAATAAATTCCACGAACCCTCGGAGGACTTCTCACTTGCATCAAATATCAAGCATATAAACTACTGTTTTGCGGCTTCGACTGTTGAAGAGATCATTGAGCGACTGGAGAAAGTTCAAAATGAATGGTCCGTTAAGACTTTAGAGACTCTTCATCAAATGTGTCCTGGCTCTCTCAAGATTACACTGCGAGCCCTCCAACGAGGCGCTCAGCTGGACCTGGGCCAGTGTCTACAGATGGAGTACAGACTGGCCTGCCGAGCCACTGAGAACCATGATTTCCCTGAAGGTGTGAGAGCTCTGCTCATCGACAAGGACAACAAGCCCCAGTGGAACCCCAAGTCTCTGGCCGAAGCTGATGATGAATATGTCGAGAGTTATTTCAAGAGGCTGCCCGAAGACAAAGAACTCAAATTCTTCGACTCCAAACTCTAA

Protein

MYSLIKLKQATLPLLRRTMSSQEPDVLFEALNNAGIVTLNRPKALNSLNTSMVSKLLPQLQEWEKSKSLVIIKGAGEKAFCAGGDVKAAIDKMEGPRFFHTEYNVNYLIGNYKIPYIAFINGITMGGGLGLSVHGRYRVATEKTLIAMPETKIGLFPDVGGSFFLPRLQVNLGLYLGLTGDRLKGKDVVKAGIATHFVPSKRLYELEMLLSRCANDIEVNSLLNKFHEPSEDFSLASNIKHINYCFAASTVEEIIERLEKVQNEWSVKTLETLHQMCPGSLKITLRALQRGAQLDLGQCLQMEYRLACRATENHDFPEGVRALLIDKDNKPQWNPKSLAEADDEYVESYFKRLPEDKELKFFDSKL

Description

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite.

Catalytic Activity

3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)

Similarity

Belongs to the enoyl-CoA hydratase/isomerase family.

Uniprot

H9IYP2   A0A2H1V310   A0A3S2NCD3   A0A2A4J756   A0A0N1ID25   A0A194QIQ0   + More
A0A068FL83   A0A0L7KSG9   A0A0L7K3Z7   V5I815   A0A1I8PG25   A0A1I8PGA5   A0A1I8PG41   A0A1A9VLV9   A0A1I8MUP3   A0A1I8MUP0   A0A0L0BZ30   A0A0L7R4N1   T1PCM3   T1PC23   D3TLD0   D6X3R7   A0A1A9W2U7   Q960K8   Q86BP1   A0A0R1E9B9   B4PS39   A0A1Y1KBE0   B3MSU0   A0A0P8XE63   B3P0V9   A0A195CSV4   A0A1W4VF24   A0A1W4VS18   B4HM22   E2A6R8   A0A2M3Z9X9   A0A2P8YBE1   B4QYI3   A0A2M3ZAC7   A0A158NIN6   A0A2M3Z9W8   A0A154P6H7   U4U241   A0A2M4AKP7   A0A151JQI3   A0A0Q9X4J3   B4KAQ0   B4NAU1   W5JCR8   A0A2M4BRS1   B4M5Z4   A0A0M4EGI5   Q7PH36   E9IZM3   A0A1I8JW73   A0A1A9YFT1   A0A182JSH7   A0A0Q9WBF2   A0A3L8DI43   W8BDX4   A0A182L7K7   A0A182V5D2   A0A026WMN3   A0A336LWI3   U5EWB6   A0A3B0JJ12   E2BCN8   A0A0K8V6Q1   Q29BE1   B4GNT9   A0A0R3NKE4   A0A0K8UEN6   F4WDJ8   A0A0K8VM74   A0A182F774   A0A023EQY7   A0A182PNM7   A0A1S4FP05   Q16U65   A0A182Y753   A0A151WG81   A0A1Y9HAB9   A0A0P4WCR1   A0A182RID0   B4JU41   A0A182T1N3   A0A034VRP5   A0A034VQY3   A0A182HCD9   A0A084VCI1   A0A088AET4   A0A3R7QX48   A0A0T6B2K3   A0A182TUV5   K7IWX1   A0A182N5K7   A0A182I7Z8   A0A1B6CRN6  

EC Number

3.1.2.4

Pubmed

19121390    26354079    26385554    26227816    25315136    26108605    + More
20353571    18362917    19820115    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17994087    17550304    28004739    20798317    29403074    21347285    23537049    20920257    23761445    12364791    14747013    17210077    21282665    30249741    24495485    20966253    24508170    15632085    21719571    24945155    17510324    25244985    25348373    26483478    24438588    20075255   

EMBL

BABH01011177    ODYU01000446    SOQ35230.1    RSAL01000103    RVE47419.1    NWSH01002810    + More
PCG67498.1    KQ460864    KPJ11808.1    KQ458714    KPJ05433.1    KJ622098    AID66688.1    JTDY01006213    KOB66192.1    JTDY01011199    KOB57386.1    GALX01005475    JAB62991.1    JRES01001133    KNC25261.1    KQ414657    KOC65721.1    KA646486    AFP61115.1    KA646239    AFP60868.1    CCAG010005443    CCAG010005444    EZ422232    ADD18508.1    KQ971377    EEZ97382.1    AE014297    AY052009    AAF55181.2    AAK93433.1    BT126275    AAN13658.2    AEB39636.1    CM000160    KRK03767.1    EDW97459.2    GEZM01087220    JAV58832.1    CH902623    EDV30330.2    KPU72800.1    CH954181    EDV49007.1    KQ977306    KYN03607.1    CH480815    EDW42059.1    GL437197    EFN70862.1    GGFM01004596    MBW25347.1    PYGN01000732    PSN41571.1    CM000364    EDX12828.1    GGFM01004647    MBW25398.1    ADTU01017028    GGFM01004572    MBW25323.1    KQ434810    KZC06740.1    KB631615    ERL84686.1    GGFK01008044    MBW41365.1    KQ978673    KYN29336.1    CH933806    KRG02297.1    EDW16787.2    CH964232    EDW80905.2    ADMH02001534    ETN62147.1    GGFJ01006618    MBW55759.1    CH940652    EDW59070.2    CP012526    ALC47491.1    AAAB01008880    EAA44701.5    GL767232    EFZ13911.1    KRF78660.1    QOIP01000007    RLU20110.1    GAMC01018586    JAB87969.1    KK107152    EZA57173.1    UFQS01000235    UFQT01000235    SSX01793.1    SSX22170.1    GANO01003023    JAB56848.1    OUUW01000005    SPP80743.1    GL447336    EFN86548.1    GDHF01028827    GDHF01017702    JAI23487.1    JAI34612.1    CM000070    EAL27057.1    CH479186    EDW38822.1    KRS99748.1    GDHF01027554    GDHF01027239    JAI24760.1    JAI25075.1    GL888087    EGI67778.1    GDHF01012327    JAI39987.1    GAPW01002060    JAC11538.1    CH477631    EAT38068.1    KQ983189    KYQ46817.1    AXCN02001161    GDRN01080807    JAI62131.1    CH916374    EDV91011.1    GAKP01014766    GAKP01014764    JAC44188.1    GAKP01014762    JAC44190.1    JXUM01127484    KQ567197    KXJ69562.1    ATLV01010759    KE524612    KFB35675.1    QCYY01000974    ROT81432.1    LJIG01016113    KRT81576.1    AAZX01008308    APCN01002591    GEDC01021237    JAS16061.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053240    UP000053268    UP000037510    + More
UP000095300    UP000078200    UP000095301    UP000037069    UP000053825    UP000092444    UP000007266    UP000091820    UP000000803    UP000002282    UP000007801    UP000008711    UP000078542    UP000192221    UP000001292    UP000000311    UP000245037    UP000000304    UP000005205    UP000076502    UP000030742    UP000078492    UP000009192    UP000007798    UP000000673    UP000008792    UP000092553    UP000007062    UP000076407    UP000092443    UP000075881    UP000279307    UP000075882    UP000075903    UP000053097    UP000268350    UP000008237    UP000001819    UP000008744    UP000007755    UP000069272    UP000075885    UP000008820    UP000076408    UP000075809    UP000075886    UP000075900    UP000001070    UP000075901    UP000069940    UP000249989    UP000030765    UP000005203    UP000283509    UP000075902    UP000002358    UP000075884    UP000075840   

PRIDE

H9IYP2    Q960K8    Q86BP1   

Pfam

PF16113   ECH_2        + More
PF13639   zf-RING_2
PF11712   Vma12

Interpro

IPR029045   ClpP/crotonase-like_dom_sf        + More
IPR032259   HIBYL-CoA-H       
IPR001841   Znf_RING       
IPR013083   Znf_RING/FYVE/PHD       
IPR021013   ATPase_Vma12       

SUPFAM

SSF52096   SSF52096       

Gene 3D

3.30.40.10    

ProteinModelPortal

H9IYP2   A0A2H1V310   A0A3S2NCD3   A0A2A4J756   A0A0N1ID25   A0A194QIQ0   + More
A0A068FL83   A0A0L7KSG9   A0A0L7K3Z7   V5I815   A0A1I8PG25   A0A1I8PGA5   A0A1I8PG41   A0A1A9VLV9   A0A1I8MUP3   A0A1I8MUP0   A0A0L0BZ30   A0A0L7R4N1   T1PCM3   T1PC23   D3TLD0   D6X3R7   A0A1A9W2U7   Q960K8   Q86BP1   A0A0R1E9B9   B4PS39   A0A1Y1KBE0   B3MSU0   A0A0P8XE63   B3P0V9   A0A195CSV4   A0A1W4VF24   A0A1W4VS18   B4HM22   E2A6R8   A0A2M3Z9X9   A0A2P8YBE1   B4QYI3   A0A2M3ZAC7   A0A158NIN6   A0A2M3Z9W8   A0A154P6H7   U4U241   A0A2M4AKP7   A0A151JQI3   A0A0Q9X4J3   B4KAQ0   B4NAU1   W5JCR8   A0A2M4BRS1   B4M5Z4   A0A0M4EGI5   Q7PH36   E9IZM3   A0A1I8JW73   A0A1A9YFT1   A0A182JSH7   A0A0Q9WBF2   A0A3L8DI43   W8BDX4   A0A182L7K7   A0A182V5D2   A0A026WMN3   A0A336LWI3   U5EWB6   A0A3B0JJ12   E2BCN8   A0A0K8V6Q1   Q29BE1   B4GNT9   A0A0R3NKE4   A0A0K8UEN6   F4WDJ8   A0A0K8VM74   A0A182F774   A0A023EQY7   A0A182PNM7   A0A1S4FP05   Q16U65   A0A182Y753   A0A151WG81   A0A1Y9HAB9   A0A0P4WCR1   A0A182RID0   B4JU41   A0A182T1N3   A0A034VRP5   A0A034VQY3   A0A182HCD9   A0A084VCI1   A0A088AET4   A0A3R7QX48   A0A0T6B2K3   A0A182TUV5   K7IWX1   A0A182N5K7   A0A182I7Z8   A0A1B6CRN6  

PDB

3BPT     E-value=7.67335e-90,     Score=842

KEGG

101741452    K05605 3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4] | (RefSeq) 3-hydroxyisobutyryl-CoA hydrolase,

PATHWAY

00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
00410    beta-Alanine metabolism - Bombyx mori (domestic silkworm)
00640    Propanoate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0006574   GO:0003860   GO:0005739   GO:0006635   GO:1903035   GO:0016021   GO:0070072   GO:0005549   GO:0007608   GO:0016020   GO:0003779   GO:0008270   GO:0006511   GO:0005525   GO:0016491   GO:0003824  

Subcellular location

Mitochondrion  

Length:

366

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

8.33759

Exp number, first 60 AAs:

0.0013

Total prob of N-in:

0.29458

outside

1  -  366

 

 

Pi

216.257796

Theta

178.029309

Tajima's D

0.537284

CLR

0.527515

CSRT

0.536173191340433

Interpretation

Uncertain