Gene

KWMTBOMO05364  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002544

Annotation

PREDICTED:_moesin/ezrin/radixin_homolog_1_isoform_X2_[Amyelois_transitella]

Location

Bomo_Chr9(+):15588575-15656897      View in EpiBrowser

Full name

Moesin/ezrin/radixin homolog 1      

Alternative Name

Moesin
Protein D17

Location in the cell

Cytoplasmic   Reliability : 3.374

CDS

ATGAACGTCCGCGTGACGACGATGGACGCGGAACTCGAGTTCGCGATCCAGCAGACGACCACCGGGAAGCAACTCTTCGATCAAGTTGTGAAGACGATCGGCCTCCGCGAGGTGTGGTTCTTCGGTCTTCAGTACACCGACTCCAAGGGCGACCTCACTTGGATCAAGTTGTATAAGAAGGTGATGCAACAAGACGTCAAGAAAGAGAATCCACTGCAGTTCAAATTCCGAGCCAAATTCTATCCTGAGGATGTCGCCGATGAGCTCATACAGGAGATCACATTGAAACTCTTCTATCTACAGGTGAAAAACGCGATTTTATCCGATGAAATATACTGCCCTCCGGAGACCTCGGTGTTGTTGGCTTCGTACGCGGTCCAAGCCAGACACGGAGAACACAATCCCGCTCTGCACGGGCCGGGATTCCTGGCCAATGACCGTTTACTTCCTCAAAGAGTGACCGACCAACACAAGATGTCCCGCGAGGAATGGGAGCAGAGCATCACTAACTGGTGGCAGGAACACCGCGAGATGCTCCGCGAAGACGCCATGATGGAGTACCTGAAGATTGCTCAGGACCTGGAGATGTACGGCGTCAACTACTTCGAGATCCGCAACAAGAAAAATACAGAGCTATGGCTCGGTGTTGATGCCCTCGGGCTCAATATCTATGAGAAGGATGACAAATTGACCCCGAAAATCGGGTTCCCCTGGTCTGAAATCCGGAACATCTCGTTCAACGACCGCAAGTTCATCATCAAGCCGATCGACAAGAAGGCGCCCGACTTCGTGTTCTTCGCGCCGCGCGTCCGCGTCAACAAGCGCATCCTCGCGCTGTGCATGGGCAACCACGAGCTGTACATGCGCCGCCGCAAGCCCGACACCATCGACGTGCAGCAGATGAAGGCGCAGGCGCGAGAGGAGAAGCTCGCCAAGCAGGCGCAGAGAAAGAAGCTCCAGTTGGAGATAGCCGCGCGTGAGCGTGCCGAGAAGAAGCAACAGGAGTACGAAGACCGGCTGCGGCAGATGCAGGAAGAGATGGAGCGGTCACAGGCCAACTTGCTCGAGGCCCAGGACATGATCCGGCGCTTGGAGGAACAGCTCAAGCAGTTGCAGGCCGCCAAGGAGGAGCTGGAGCGGAGACAGGGAGAGCTGCACGACATGATGCAGAGACTCGAGGAGACCAAGAATATGGAAGCAGCAGAACGTGCCAAGTTAGAAGAGGAAATCCGCACTAAACAAGAGGAAGTACAACGCATTCAAACCGAAGTCGAGCTCAAGGACTCGGAGACGCGGCGCCTGCAGGACGAGGTGGAGGAGGCCCGGCGCAAGCAGGACGAGGCCGCGGCGCTCCTGGCGGCCGCCACCACCCCGCAGCACCACCACGTGGCTGAGGACGGCGGGGTGGACGACGGCTCCGACCACGGCGAGGAGTCCGGCGGCGGAGACCTGCACCAGGCGCCCGACGACCTCGTCGACCCGGTCGAGGCCAGGACCACCTTGGCCGAGAAGAACGAGCGGCTACACAACCAGCTCAAGGCGCTGAAACAAGACCTCGCGCAGTCCCGCGACGAAACTAAAGAGACGGCCATGGACAAGATCCACCGCGAGAACGTCCGCCAGGGACGAGACAAGTACAAGACGCTCCGCGAGATCCGCAAGGGCAACACCAAACGTCGCGTCGACCAGTTCGAGAACATGTAA

Protein

MNVRVTTMDAELEFAIQQTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDLTWIKLYKKVMQQDVKKENPLQFKFRAKFYPEDVADELIQEITLKLFYLQVKNAILSDEIYCPPETSVLLASYAVQARHGEHNPALHGPGFLANDRLLPQRVTDQHKMSREEWEQSITNWWQEHREMLREDAMMEYLKIAQDLEMYGVNYFEIRNKKNTELWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDRKFIIKPIDKKAPDFVFFAPRVRVNKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKLAKQAQRKKLQLEIAARERAEKKQQEYEDRLRQMQEEMERSQANLLEAQDMIRRLEEQLKQLQAAKEELERRQGELHDMMQRLEETKNMEAAERAKLEEEIRTKQEEVQRIQTEVELKDSETRRLQDEVEEARRKQDEAAALLAAATTPQHHHVAEDGGVDDGSDHGEESGGGDLHQAPDDLVDPVEARTTLAEKNERLHNQLKALKQDLAQSRDETKETAMDKIHRENVRQGRDKYKTLREIRKGNTKRRVDQFENM

Description

Involved in connections of major cytoskeletal structures to the plasma membrane.
Involved in connections of major cytoskeletal structures to the plasma membrane (PubMed:8666669). Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr (PubMed:23544124). In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles (PubMed:28554770).

Subunit

Interacts with cytoskeletal actin.
Interacts with Mer and arm at the adherens junction. Interacts with cytoskeletal actin at apical buds of microvilli in the precellularised embryo (By similarity).
Interacts with wgn (PubMed:23544124). Interacts with Mer and arm at the adherens junction (PubMed:8666669). Interacts with cytoskeletal actin at apical buds of microvilli in the precellularised embryo (PubMed:8666669). Interacts with PCID2 (possibly via FERM domain) (PubMed:28554770).

Keywords

Actin-binding   Cell junction   Cell membrane   Complete proteome   Cytoplasm   Cytoskeleton   Membrane   Reference proteome   Alternative splicing   Chromosome   Neurogenesis   Nucleus  

Feature

chain  Moesin/ezrin/radixin homolog 1
splice variant  In isoform C.

Uniprot

A0T1L9   A0A2A4JBH2   A0A2A4J9L4   A0A212EUR9   H9IZ59   A0A1B6LV26   + More
A0A0U3SXA5   A0A1B6KCV7   A0A2R7WVJ9   A0A1B6EHS6   A0A0K8TP34   U5EXP4   A0A1B6FI87   A0A1L8E5J0   A0A1L8E585   R4WQU4   A0A1Q3FAR0   A0A1Q3FAX5   A0A0Q9WBJ3   A0A0A1XHC0   A0A034W4W5   A0A0Q9VZ78   A0A0Q9WW85   A0A1I8P563   B0WYY2   A0A0P8XIU1   A0A0P9A8S6   A0A0P8ZJ02   A0A0P9BSU9   A0A336MNW7   V5GHY0   D3TNC2   A0A1W4XME9   A0A0R3P0Q3   Q29GR8   A0A1J1HR81   A0A1W4XNA5   A0A0R3P0N6   D6W9I6   A0A1W4USB8   A0A1W4UDV2   A0A0R1EB68   A0A0Q5TI71   T1PDC0   A0A1W4UDD1   A0A3B0KRU1   A0A1L8EH18   P46150-2   A0A1W4UDC8   A0A0Q5TJ22   A0A0R1EAZ2   A0A224X9W6   A0A0R1EBB2   A0A0Q5T3G5   A0A0P4VUQ0   A0A069DVT0   R4G483   Q170J7   A0A023EU26   M9NG50   A0A0R1EHU0   A0A0Q9WX60   A0A0Q9WWA5   A0A0Q5T6B7   P46150   A0A0Q9WXI9   W8B8R5   A0A1I8P529   A0A0R3P5Z3   A0A0R3P0L2   A0A336L331   A0A023F9S7   A0A2H8TZ55   M9PHG2   A0A1B6EGR6   J9KAN2   A0A1B6EAS9   A0A1B0FIT7   A0A0P6JNU5   A0A1S4FI28   A0A182VK54   A0A0L0BYZ6   A0A2M4CI86   A0A2S2PBY0   A0A182JFQ2   A0A2M4CT69   A0A2M4CTL4   A0A2M3ZZR6   A0A1Y1M9R2   A0A182QVE3   T1DG51   A0A2M3YY44   A0A2M4A005   B4JKC9   Q7PS12-3   A0A1Y1MA66   A0A182M0J9   B4MD92   A0A0P8Y6B6   B3MZH6  

Pubmed

17134719    22118469    19121390    26694822    26369729    23691247    + More
17994087    25830018    25348373    20353571    15632085    18362917    19820115    17550304    25315136    8666669    10731132    12537572    12537569    8183953    23544124    28554770    18057021    27129103    26334808    17510324    24945155    12537568    12537573    12537574    16110336    17569856    17569867    24495485    25474469    26108605    28004739    12364791   

EMBL

EF071985    ABK60307.1    NWSH01002259    PCG68772.1    PCG68775.1    AGBW02012297    + More
OWR45250.1    BABH01011173    GEBQ01012487    JAT27490.1    KU218696    ALX00076.1    GEBQ01030694    JAT09283.1    KK855698    PTY23584.1    GECZ01032282    JAS37487.1    GDAI01001466    JAI16137.1    GANO01000850    JAB59021.1    GECZ01019851    JAS49918.1    GFDF01000279    JAV13805.1    GFDF01000280    JAV13804.1    AK418046    BAN21261.1    GFDL01010436    JAV24609.1    GFDL01010324    JAV24721.1    CH940660    KRF78158.1    GBXI01003945    GBXI01002074    JAD10347.1    JAD12218.1    GAKP01009606    GAKP01009605    JAC49347.1    KRF78156.1    CH933810    KRF93942.1    DS232201    EDS37245.1    CH902635    KPU74747.1    KPU74745.1    KPU74751.1    KPU74750.1    UFQS01001779    UFQT01001779    SSX12319.1    SSX31770.1    GALX01004817    JAB63649.1    EZ422924    ADD19200.1    CH379064    KRT06804.1    CVRI01000020    CRK90584.1    KRT06801.1    KQ971312    EEZ98498.2    CM000162    KRK06635.1    CH954180    KQS29924.1    KA645928    AFP60557.1    OUUW01000015    SPP88616.1    GFDG01000831    JAV17968.1    L38909    AE014298    AY069855    U23798    U08218    KQS29925.1    KQS29926.1    KQS29931.1    KRK06632.1    KRK06636.1    KRK06640.1    GFTR01007290    JAW09136.1    KRK06637.1    KQS29929.1    GDKW01000312    JAI56283.1    GBGD01000968    JAC87921.1    ACPB03021236    ACPB03021237    ACPB03021238    ACPB03021239    GAHY01001001    JAA76509.1    CH477473    EAT40344.1    GAPW01000703    JAC12895.1    AFH07298.1    KRK06634.1    CH964291    KRG00357.1    KRG00358.1    KQS29928.1    KRF93940.1    GAMC01016991    GAMC01016989    JAB89566.1    KRT06800.1    KRT06798.1    SSX12318.1    SSX31769.1    GBBI01000567    JAC18145.1    GFXV01007788    MBW19593.1    AGB95204.1    GEDC01000218    JAS37080.1    ABLF02016878    GEDC01002314    JAS34984.1    CCAG010016654    GDIQ01002129    JAN92608.1    JRES01001135    KNC25240.1    GGFL01000884    MBW65062.1    GGMR01014331    MBY26950.1    GGFL01004366    MBW68544.1    GGFL01004427    MBW68605.1    GGFK01000722    MBW34043.1    GEZM01036631    JAV82552.1    AXCN02002225    GAMD01002896    JAA98694.1    GGFM01000442    MBW21193.1    GGFK01000719    MBW34040.1    CH916370    EDW00032.1    AAAB01008846    GEZM01036630    JAV82553.1    AXCM01000578    EDW58164.1    KPU74749.1    EDV33777.1   

Proteomes

UP000218220    UP000007151    UP000005204    UP000008792    UP000009192    UP000095300    + More
UP000002320    UP000007801    UP000192223    UP000001819    UP000183832    UP000007266    UP000192221    UP000002282    UP000008711    UP000095301    UP000268350    UP000000803    UP000015103    UP000008820    UP000007798    UP000007819    UP000092444    UP000075903    UP000037069    UP000075880    UP000075886    UP000001070    UP000007062    UP000075883   

PRIDE

H9IZ59    B0WYY2    Q29GR8    P46150    Q170J7    M9NG50    + More
Q7PS12   

Pfam

PF09379   FERM_N        + More
PF09380   FERM_C
PF00373   FERM_M
PF00769   ERM

Interpro

IPR018980   FERM_PH-like_C        + More
IPR000299   FERM_domain       
IPR011174   ERM       
IPR029071   Ubiquitin-like_domsf       
IPR018979   FERM_N       
IPR041789   ERM_FERM_C       
IPR019747   FERM_CS       
IPR019748   FERM_central       
IPR000798   Ez/rad/moesin-like       
IPR011993   PH-like_dom_sf       
IPR011259   ERM_C_dom       
IPR035963   FERM_2       
IPR008954   Moesin_tail_sf       
IPR014352   FERM/acyl-CoA-bd_prot_sf       
IPR019749   Band_41_domain       

SUPFAM

SSF47031   SSF47031        + More
SSF48678   SSF48678       
SSF54236   SSF54236       

Gene 3D

1.20.80.10     1.25.40.1020     2.30.29.30    

CDD

cd14473  FERM_B-lobe
cd13194  FERM_C_ERM

ProteinModelPortal

A0T1L9   A0A2A4JBH2   A0A2A4J9L4   A0A212EUR9   H9IZ59   A0A1B6LV26   + More
A0A0U3SXA5   A0A1B6KCV7   A0A2R7WVJ9   A0A1B6EHS6   A0A0K8TP34   U5EXP4   A0A1B6FI87   A0A1L8E5J0   A0A1L8E585   R4WQU4   A0A1Q3FAR0   A0A1Q3FAX5   A0A0Q9WBJ3   A0A0A1XHC0   A0A034W4W5   A0A0Q9VZ78   A0A0Q9WW85   A0A1I8P563   B0WYY2   A0A0P8XIU1   A0A0P9A8S6   A0A0P8ZJ02   A0A0P9BSU9   A0A336MNW7   V5GHY0   D3TNC2   A0A1W4XME9   A0A0R3P0Q3   Q29GR8   A0A1J1HR81   A0A1W4XNA5   A0A0R3P0N6   D6W9I6   A0A1W4USB8   A0A1W4UDV2   A0A0R1EB68   A0A0Q5TI71   T1PDC0   A0A1W4UDD1   A0A3B0KRU1   A0A1L8EH18   P46150-2   A0A1W4UDC8   A0A0Q5TJ22   A0A0R1EAZ2   A0A224X9W6   A0A0R1EBB2   A0A0Q5T3G5   A0A0P4VUQ0   A0A069DVT0   R4G483   Q170J7   A0A023EU26   M9NG50   A0A0R1EHU0   A0A0Q9WX60   A0A0Q9WWA5   A0A0Q5T6B7   P46150   A0A0Q9WXI9   W8B8R5   A0A1I8P529   A0A0R3P5Z3   A0A0R3P0L2   A0A336L331   A0A023F9S7   A0A2H8TZ55   M9PHG2   A0A1B6EGR6   J9KAN2   A0A1B6EAS9   A0A1B0FIT7   A0A0P6JNU5   A0A1S4FI28   A0A182VK54   A0A0L0BYZ6   A0A2M4CI86   A0A2S2PBY0   A0A182JFQ2   A0A2M4CT69   A0A2M4CTL4   A0A2M3ZZR6   A0A1Y1M9R2   A0A182QVE3   T1DG51   A0A2M3YY44   A0A2M4A005   B4JKC9   Q7PS12-3   A0A1Y1MA66   A0A182M0J9   B4MD92   A0A0P8Y6B6   B3MZH6  

PDB

2I1K     E-value=0,     Score=2135

KEGG

101741026    no KO assigned | (RefSeq) moesin/ezrin/radixin homolog 1

GO

GO:0003779   GO:0005856   GO:0005912   GO:0045197   GO:0005886   GO:0005737   GO:0030866   GO:0008104   GO:0005938   GO:0009952   GO:0016057   GO:0043622   GO:0045807   GO:0016324   GO:0035003   GO:0005829   GO:0072499   GO:0032956   GO:0008284   GO:0005654   GO:0032154   GO:0030036   GO:0006405   GO:0045313   GO:0005546   GO:0035149   GO:0060446   GO:0007314   GO:0005634   GO:0007315   GO:1902846   GO:0007318   GO:0002009   GO:0030029   GO:0035327   GO:0042462   GO:0008092   GO:1990023   GO:0008360   GO:0005703   GO:0007010   GO:0034453   GO:0035088   GO:0008017   GO:0042052   GO:0016336   GO:0007368   GO:0019898   GO:0008270   GO:0006511   GO:0005525   GO:0016491   GO:0003824  

Subcellular location

Cell junction  
Adherens junction  
Cell membrane  
Cytoplasm  
Cytoskeleton  
Nucleus   Nuclear localization is dependent on Nup98 and Rae1. Associated with the active ecdysone-regulated loci on polytene chromosomes and heat shock-induced puffs. Colocalizes with messenger ribonucleoprotein (mRNP) particles probably through interaction with the mRNA export factor PCID2.   With evidence from 4 publications.
Nucleoplasm   Nuclear localization is dependent on Nup98 and Rae1. Associated with the active ecdysone-regulated loci on polytene chromosomes and heat shock-induced puffs. Colocalizes with messenger ribonucleoprotein (mRNP) particles probably through interaction with the mRNA export factor PCID2.   With evidence from 4 publications.
Chromosome   Nuclear localization is dependent on Nup98 and Rae1. Associated with the active ecdysone-regulated loci on polytene chromosomes and heat shock-induced puffs. Colocalizes with messenger ribonucleoprotein (mRNP) particles probably through interaction with the mRNA export factor PCID2.   With evidence from 4 publications.

Length:

567

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00203

Exp number, first 60 AAs:

0.00163

Total prob of N-in:

0.00575

outside

1  -  567

 

 

Pi

237.118077

Theta

176.549835

Tajima's D

0.921063

CLR

0.535082

CSRT

0.632268386580671

Interpretation

Uncertain