SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO05362  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA002542
Annotation
alpha-tubulin_[Bombyx_mori]
Full name
Tubulin alpha chain      
Location in the cell
Cytoplasmic   Reliability : 3.574
 

Sequence

CDS
ATGCTTTTATTAACGAGGGAATGCATCTCCGTTCACATCGGTCAAGCCGGCGTACAGATTGGCAACGCCTGCTGGGAGCTGTACTGCCTCGAGCATGGAATCCAGCCTGATGGTCAGATGCCGTCAGATAAGACCCTCGGCGGTGGAGACGACTCCTTTAACACGTTCTTCAGCGAGACCGGCGCGGGAAAGCACGTGCCACGAGCTGTCTTTGTTGATTTGGAACCAACTGTAGTCGACGAGGTTCGTACCGGCACTTACCGTCAACTGTTCCACCCCGAGCAGCTCATCACTGGCAAAGAGGATGCTGCCAATAACTATGCCCGAGGACATTATACCATTGGCAAGGAGATCGTAGACGTAGTTTTGGACAGGATCAGGAAGCTGGCTGACCAATGCACAGGGCTTCAGGGTTTCCTCGTGTTTCACTCGTTCGGAGGTGGAACCGGCTCCGGATTCACATCACTTCTGATGGAGCGTCTCTCCGTTGACTACGGAAAGAAGTCCAAGCTTGAGTTTTCCATCTATCCTGCTCCACAGGTGTCCACAGCGGTGGTGGAACCTTACAACTCGATCCTGACCACCCACACCACCCTCGAGCACTCGGACTGCGCGTTCATGGTGGACAATGAAGCCATCTACGACATCTGTAGACGCAACTTGGACATCGAAAGGCCTACGTACACTAACCTGAATAGACTTATTGGACAGATCGTGTCGTCAATAACCGCTTCGCTTCGCTTCGACGGCGCGCTGAACGTGGACCTGACGGAGTTCCAGACGAACCTGGTGCCGTACCCGCGCATCCACTTCCCGCTCGCCACGTACGCGCCCGTCATCTCCGCGGAGAAGGCCTACCACGAGCAGCTCACGGTCGCCGAGATCACCAACGCGTGCTTCGAGCCCGCCAACCAGATGGTGAAATGTGACCCGCGTCATGGAAAATACATGGCTTGTTGCATGCTGTACAGAGGAGACGTTGTGCCGAAGGACGTGAATGCGGCCATCGCAACCATCAAAACAAAGAGAACCATCCAGTTCGTGGACTGGTGCCCAACTGGTTTCAAGGTGGGCATCAATTACCAGCCCCCGACTGTGGTGCCGGGCGGAGACCTCGCCAAGGTGCAGCGCGCCGTGTGCATGTTGTCCAACACAACCGCCATCGCCGAGGCGTGGGCCAGATTGGACCACAAGTTCGACTTGATGTACGCTAAGCGCGCATTCGTGCACTGGTACGTGGGTGAGGGTATGGAGGAGGGGGAGTTCTCCGAAGCCCGCGAGGACTTGGCAGCTCTAGAGAAGGACTACGAGGAAGTAGGCGTGGACTCCACTGAAGGGGAGTTGGACGAAGAAAATGAATATTAA
Protein
MLLLTRECISVHIGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTLGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSTEGELDEENEY

Summary

Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Subunit
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Similarity
Belongs to the tubulin family.
Feature
chain  Tubulin alpha chain
EMBL
NWSH01002259    PCG68769.1    ODYU01000898    SOQ36349.1    AB072305    BAB86850.1    + More
BABH01011160    KQ460864    KPJ11804.1    KB111160    ELK26268.1    KQ971311    EEZ99331.1    GECU01019952    GECU01019424    JAS87754.1    JAS88282.1    GECU01019068    GECU01016338    JAS88638.1    JAS91368.1    JRES01000426    KNC31385.1    CCAG010023980    CCAG010023981    GFTR01006330    JAW10096.1    GDKW01000590    JAI56005.1    GAHY01000452    JAA77058.1    GEZM01036488    GEZM01036487    JAV82650.1    UFQS01000650    UFQT01000650    SSX05753.1    SSX26112.1    JXJN01024715    JXJN01024716    ACPB03013303    DS235297    EEB14490.1    GBGD01001440    JAC87449.1    JH431936    JXUM01049614    JXUM01049615    JXUM01049616    KQ561613    KXJ78003.1    AJVK01010926    GDAI01001462    JAI16141.1    AF465692    FN653015    FN654394    AAP80594.1    CBY20619.1    CBY43752.1    AXCP01008126    ADMH02001274    ETN63259.1    ABLF02019437    CM001285    EHH65655.1    GL192766    EFB29355.1    ACTA01026147    AAEX03014886    CM001265    EHH22506.1    AAPE02038830    AAPE02038831    RAZU01000269    RLQ61503.1    AAKN02007347    AAKN02007348    KU871110    APD32952.1    BC089547    AK132775    CH466523    CH466572    AAH89547.1    BAE21352.1    EDK99823.1    EDL10693.1    ADFV01132330    AEMK02000096    DQIR01230412    HDB85889.1    DQIR01110232    DQIR01160642    HDA65708.1    AQIB01162844    AJFE02118783    AJFE02118784    AHZZ02003436    AEYP01011249    AEYP01011250    KB016594    EPY86664.1    ABGA01362868    ABGA01362869    NDHI03003868    NDHI03003739    NDHI03003328    PNJ02092.1    PNJ04512.1    PNJ85051.1    AQIA01007889    AQIA01007890    AQIA01013713    CABD030087857    CABD030087858    CABD030087859    AACZ04002701    AC182490    AK305564    NBAG03000606    NBAG03000041    BAK62558.1    PNI13405.1    PNI94670.1    JSUE03008336    JSUE03017710    JV046100    JV046101    JV635935    AFI36171.1    AFJ71275.1    RAZU01000250    RLQ62278.1    KE163720    EPQ13504.1    KU728808    AOR07105.1    CAAE01014729    CAG03831.1    NEDP02002403    OWF51016.1    RQTK01001116    RUS72082.1   
Pfam
PF03953   Tubulin_C        + More
PF00091   Tubulin
PF13516   LRR_6
PF00916   Sulfate_transp
Interpro
IPR002452   Alpha_tubulin        + More
IPR017975   Tubulin_CS       
IPR037103   Tubulin/FtsZ_C_sf       
IPR023123   Tubulin_C       
IPR036525   Tubulin/FtsZ_GTPase_sf       
IPR008280   Tub_FtsZ_C       
IPR003008   Tubulin_FtsZ_GTPase       
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR000217   Tubulin       
IPR001611   Leu-rich_rpt       
IPR032675   LRR_dom_sf       
IPR011547   SLC26A/SulP_dom       
IPR027309   P2X_extracellular_dom_sf       
IPR001429   P2X_purnocptor       
SUPFAM
SSF55307   SSF55307        + More
SSF52490   SSF52490       
PDB
5KX5     E-value=0,     Score=2317

Ontologies

Topology

Subcellular location
  
Length:
454
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.49477
Exp number, first 60 AAs:
0.00082
Total prob of N-in:
0.02221
outside
1  -  454
 
 

Population Genetic Test Statistics

Pi
385.998742
Theta
201.586579
Tajima's D
2.394949
CLR
0.099285
CSRT
0.936703164841758
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Peptides ×
Source Sequence Identity Evalue
28556443 LADQCTGLQGFLIFH 96.15 5e-11
28556443 LADQCTGLQGFLIFHSF 96.15 5e-11
28556443 LIGQIVSSITA 95.45 2e-10
25044914 AYHEGMSVSEITAEIFEPQNQMVK 95.83 3e-10
28467696 AYHEQISVAEITNACFEPANQMVK 95.83 3e-10
28556443 AYHEQLSVAEITNACFEPANQMVK 95.83 3e-10
28556443 AYHEQLSVAEITNACFEPANQMVK 95.83 3e-10
28556443 AYHEQLSVAEITNACFEPANQMVK 95.83 3e-10
28556443 AYHEQLSVAEITNACFEPANQMVK 95.83 3e-10
28556443 AVFVDLEPTVVDEVR 95.83 3e-10
28556443 AVFVDLEPTVVDEVR 95.83 3e-10
28467696 RAEVNTFNATNR 100.00 9e-10
28556443 VGINYQPPTVVPGGDLAK 100.00 4e-09
28556443 VGINYQPPTVVPGGDLAK 100.00 4e-09
26280517 AFSGYIGEDK 100.00 7e-09
28467696 AFVDEIVPVPVPQKR 100.00 7e-09
28556443 AFVHWYVGEGMEEGEFSEAR 100.00 7e-09
28556443 AFVHWYVGEGMEEGEFSEAR 100.00 7e-09
28556443 AFVHWYVGEGMEEGEFSEAR 100.00 7e-09
28556443 DVNAAIATIKTK 100.00 7e-09
28556443 WLDSNQLADKEEYEHK 100.00 7e-09
26280517 VGFIIPVEGTTDQFVVGVER 95.24 8e-09
28556443 AIYPAPQVSTAVVEPYNSILTTH 95.65 1e-08
28556443 AFVHWYVGEGMEEGEFSEAR 95.65 1e-08
28556443 AFVHWYVGEGMEEGEFSEAR 95.65 1e-08
28556443 EIVDLVLDR 100.00 1e-08
28556443 EIVDLVLDR 100.00 1e-08
21761556 TIGGGDDSFNTFFSETGAGK 100.00 5e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 5e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 5e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 5e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 5e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 5e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 5e-07
28556443 TTAIAEAWAR 100.00 5e-07
28556443 TTAIAEAWAR 100.00 5e-07
28556443 GDVVPKDVNAAIATIK 100.00 1e-06
28556443 AVCMLSNTTAIAEAWAR 100.00 6e-06
28556443 AVCMLSNTTAIAEAWAR 100.00 6e-06
28556443 AIYPAPQVSTAVVEPYNSILTTH 100.00 6e-06
28556443 AIYPAPQVSTAVVEPYNSILTTH 100.00 6e-06
28556443 VGINYQPPTVVPGGDLAKVQR 100.00 9e-06
28556443 VGINYQPPTVVPGGDLAKVQR 100.00 9e-06
26822097 ISVDYGK 100.00 2e-05
26280517 RANNTEYGIASGVFTR 100.00 2e-05
25044914 RTIDIIAAK 100.00 2e-05
28467696 RTIFGEKDEIVAEK 100.00 2e-05
26822097 VGINYQPPTVVPGGDIAK 100.00 1e-04
26280517 QFDHDAFIGEDQAK 100.00 1e-04
25044914 TIQAIEADFNVR 100.00 1e-04
24093152 TIPYWNNVIVPQIK 100.00 1e-04
28467696 TIQFEPSTTVYDACR 100.00 1e-04
28556443 TIQFVDWCPTGFK 100.00 1e-04
28556443 TIQFVDWCPTGFK 100.00 1e-04
28556443 TIGGGDDSFNTFFSETGAGK 100.00 1e-04
28556443 TIGGGDDSFNTFFSETGAGK 100.00 1e-04
28556443 LSVDYGK 100.00 3e-04
28556443 NLDIERPTYTNLNR 100.00 6e-04
28556443 MLSNTTAIAEAWAR 100.00 6e-04
28556443 MLSNTTAIAEAWAR 100.00 6e-04
28556443 LSVDYGK 100.00 0.002
28556443 LIGQIVSSITASLR 100.00 0.002
28556443 EDLAALEK 100.00 0.004
28556443 AVFVDLEPTVVDEVR 100.00 0.006
28556443 AVFVDLEPTVVDEVR 100.00 0.006
28556443 AVFVDLEPTVVDEVR 100.00 0.006
28556443 AVFVDLEPTVVDEVR 100.00 0.006
28556443 AVFVDLEPTVVDEVR 100.00 0.006
28556443 AVFVDLEPTVVDEVR 100.00 0.006
28556443 AVFVDLEPTVVDEVR 100.00 0.006
28556443 AVFVDLEPTVVDEVR 100.00 0.006
28556443 AVFVDLEPTVVDEVR 100.00 0.006
28556443 AVCMLSNTTAIAEAWAR 100.00 0.006
28556443 AVCMLSNTTAIAEAWAR 100.00 0.006
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