Gene

KWMTBOMO05362  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002542

Annotation

alpha-tubulin_[Bombyx_mori]

Location

Bomo_Chr9(+):15564845-15576243      View in EpiBrowser

Full name

Tubulin alpha chain      

Location in the cell

Cytoplasmic   Reliability : 3.574

CDS

ATGCTTTTATTAACGAGGGAATGCATCTCCGTTCACATCGGTCAAGCCGGCGTACAGATTGGCAACGCCTGCTGGGAGCTGTACTGCCTCGAGCATGGAATCCAGCCTGATGGTCAGATGCCGTCAGATAAGACCCTCGGCGGTGGAGACGACTCCTTTAACACGTTCTTCAGCGAGACCGGCGCGGGAAAGCACGTGCCACGAGCTGTCTTTGTTGATTTGGAACCAACTGTAGTCGACGAGGTTCGTACCGGCACTTACCGTCAACTGTTCCACCCCGAGCAGCTCATCACTGGCAAAGAGGATGCTGCCAATAACTATGCCCGAGGACATTATACCATTGGCAAGGAGATCGTAGACGTAGTTTTGGACAGGATCAGGAAGCTGGCTGACCAATGCACAGGGCTTCAGGGTTTCCTCGTGTTTCACTCGTTCGGAGGTGGAACCGGCTCCGGATTCACATCACTTCTGATGGAGCGTCTCTCCGTTGACTACGGAAAGAAGTCCAAGCTTGAGTTTTCCATCTATCCTGCTCCACAGGTGTCCACAGCGGTGGTGGAACCTTACAACTCGATCCTGACCACCCACACCACCCTCGAGCACTCGGACTGCGCGTTCATGGTGGACAATGAAGCCATCTACGACATCTGTAGACGCAACTTGGACATCGAAAGGCCTACGTACACTAACCTGAATAGACTTATTGGACAGATCGTGTCGTCAATAACCGCTTCGCTTCGCTTCGACGGCGCGCTGAACGTGGACCTGACGGAGTTCCAGACGAACCTGGTGCCGTACCCGCGCATCCACTTCCCGCTCGCCACGTACGCGCCCGTCATCTCCGCGGAGAAGGCCTACCACGAGCAGCTCACGGTCGCCGAGATCACCAACGCGTGCTTCGAGCCCGCCAACCAGATGGTGAAATGTGACCCGCGTCATGGAAAATACATGGCTTGTTGCATGCTGTACAGAGGAGACGTTGTGCCGAAGGACGTGAATGCGGCCATCGCAACCATCAAAACAAAGAGAACCATCCAGTTCGTGGACTGGTGCCCAACTGGTTTCAAGGTGGGCATCAATTACCAGCCCCCGACTGTGGTGCCGGGCGGAGACCTCGCCAAGGTGCAGCGCGCCGTGTGCATGTTGTCCAACACAACCGCCATCGCCGAGGCGTGGGCCAGATTGGACCACAAGTTCGACTTGATGTACGCTAAGCGCGCATTCGTGCACTGGTACGTGGGTGAGGGTATGGAGGAGGGGGAGTTCTCCGAAGCCCGCGAGGACTTGGCAGCTCTAGAGAAGGACTACGAGGAAGTAGGCGTGGACTCCACTGAAGGGGAGTTGGACGAAGAAAATGAATATTAA

Protein

MLLLTRECISVHIGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTLGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSTEGELDEENEY

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Similarity

Belongs to the tubulin family.

Feature

chain  Tubulin alpha chain

Uniprot

A0A2A4JAA1   A0A2H1V6C6   Q8T8B5   H9IZ57   A0A0N0PBQ1   A0A1A9UJX4   + More
L5LLI6   D6WBL0   A0A1B6IMY7   A0A1B6INX8   A0A0L0CGN0   A0A1A9YUF9   A0A1A9XMZ8   A0A1B0A8T1   A0A224XCE3   A0A0P4VZJ1   R4G8S7   A0A1Y1MDH6   A0A336KRR7   A0A1B0C2X1   T1HWF2   A0A1A9W6N7   E0VM84   A0A069DZ13   T1J7L5   G1U031   A0A182G9P4   A0A1B0D3C0   A0A0K8TPT9   Q7YZZ5   F6RP72   A0A182IM33   H2ZGV6   A0A1S3IWS5   F7B0Q2   W5JKF4   G1RHD8   F6YDT3   A0A3Q2I621   J9JYZ7   G7PH99   D2HEW5   G1LX08   F1PE21   G3T189   A0A3Q2H5A5   A0A3Q2HH45   F7CD56   A0A2K6PI36   A0A2I3RDC8   G7NB59   G1PRA0   G1KAW4   A0A3L7H6L4   H0VZ17   A0A286XMV9   A0A1J0N2A2   Q5FW91   A0A2K6D2H7   A0A384CMW3   J9NXT1   M3ZBN8   I3LDR2   F1RK98   A0A2K5Z4G6   A0A288CFV7   A0A0D9RWH9   A0A3Q7MXL5   A0A2R9A341   A0A2I3MCC7   F6V4Z9   A0A2K5KPS1   A0A2Y9LNY1   F2Z4K0   A0A2U3VYD5   M3XX31   S9XG46   A0A3Q7U1L3   A0A2J8R7L3   A0A2U3YLF9   A0A2K5U687   A0A2Y9IQW7   A0A2K5PG68   F6R810   G3RBT2   G2HFQ0   F7H3X6   A0A3Q2LQ20   A0A096NXX2   A0A3Q7UPQ8   A0A384CLU5   A0A3Q2HXF8   A0A3L7H8J8   A0A2R2MK77   S7N8D7   A0A286Q4X6   Q4S6A1   A0A3B4A8C8   A0A210QQK1   A0A3S1B0R6  

Pubmed

12459208    19121390    26354079    18362917    19820115    26108605    + More
27129103    28004739    20566863    26334808    21993624    26483478    26369729    21097902    19393038    12481130    15114417    20920257    23761445    19892987    22002653    20010809    16341006    25362486    29704459    10349636    11042159    11076861    11217851    12466851    12040188    15489334    16141073    21183079    30723633    22722832    17495919    23149746    21270892    22398555    16136131    21484476    17431167    25319552    29021169    15496914    25463417    28812685   

EMBL

NWSH01002259    PCG68769.1    ODYU01000898    SOQ36349.1    AB072305    BAB86850.1    + More
BABH01011160    KQ460864    KPJ11804.1    KB111160    ELK26268.1    KQ971311    EEZ99331.1    GECU01019952    GECU01019424    JAS87754.1    JAS88282.1    GECU01019068    GECU01016338    JAS88638.1    JAS91368.1    JRES01000426    KNC31385.1    CCAG010023980    CCAG010023981    GFTR01006330    JAW10096.1    GDKW01000590    JAI56005.1    GAHY01000452    JAA77058.1    GEZM01036488    GEZM01036487    JAV82650.1    UFQS01000650    UFQT01000650    SSX05753.1    SSX26112.1    JXJN01024715    JXJN01024716    ACPB03013303    DS235297    EEB14490.1    GBGD01001440    JAC87449.1    JH431936    JXUM01049614    JXUM01049615    JXUM01049616    KQ561613    KXJ78003.1    AJVK01010926    GDAI01001462    JAI16141.1    AF465692    FN653015    FN654394    AAP80594.1    CBY20619.1    CBY43752.1    AXCP01008126    ADMH02001274    ETN63259.1    ABLF02019437    CM001285    EHH65655.1    GL192766    EFB29355.1    ACTA01026147    AAEX03014886    CM001265    EHH22506.1    AAPE02038830    AAPE02038831    RAZU01000269    RLQ61503.1    AAKN02007347    AAKN02007348    KU871110    APD32952.1    BC089547    AK132775    CH466523    CH466572    AAH89547.1    BAE21352.1    EDK99823.1    EDL10693.1    ADFV01132330    AEMK02000096    DQIR01230412    HDB85889.1    DQIR01110232    DQIR01160642    HDA65708.1    AQIB01162844    AJFE02118783    AJFE02118784    AHZZ02003436    AEYP01011249    AEYP01011250    KB016594    EPY86664.1    ABGA01362868    ABGA01362869    NDHI03003868    NDHI03003739    NDHI03003328    PNJ02092.1    PNJ04512.1    PNJ85051.1    AQIA01007889    AQIA01007890    AQIA01013713    CABD030087857    CABD030087858    CABD030087859    AACZ04002701    AC182490    AK305564    NBAG03000606    NBAG03000041    BAK62558.1    PNI13405.1    PNI94670.1    JSUE03008336    JSUE03017710    JV046100    JV046101    JV635935    AFI36171.1    AFJ71275.1    RAZU01000250    RLQ62278.1    KE163720    EPQ13504.1    KU728808    AOR07105.1    CAAE01014729    CAG03831.1    NEDP02002403    OWF51016.1    RQTK01001116    RUS72082.1   

Proteomes

UP000218220    UP000005204    UP000053240    UP000078200    UP000007266    UP000037069    + More
UP000092444    UP000092443    UP000092445    UP000092460    UP000015103    UP000091820    UP000009046    UP000001811    UP000069940    UP000249989    UP000092462    UP000009136    UP000075880    UP000007875    UP000085678    UP000008144    UP000000673    UP000001073    UP000002281    UP000007819    UP000009130    UP000008912    UP000002254    UP000007646    UP000233200    UP000002277    UP000001074    UP000001646    UP000273346    UP000005447    UP000233120    UP000261680    UP000008227    UP000233140    UP000029965    UP000286641    UP000240080    UP000028761    UP000002280    UP000233060    UP000248483    UP000245340    UP000000715    UP000286642    UP000001595    UP000245341    UP000233100    UP000248482    UP000233040    UP000001519    UP000006718    UP000261520    UP000242188    UP000271974   

PRIDE

Q8T8B5    H9IZ57    Q7YZZ5    F7B0Q2    F1PE21    J9NXT1    + More
I3LDR2    F1RK98    A0A288CFV7    F2Z4K0   

Pfam

PF03953   Tubulin_C        + More
PF00091   Tubulin
PF13516   LRR_6
PF00916   Sulfate_transp

Interpro

IPR002452   Alpha_tubulin        + More
IPR017975   Tubulin_CS       
IPR037103   Tubulin/FtsZ_C_sf       
IPR023123   Tubulin_C       
IPR036525   Tubulin/FtsZ_GTPase_sf       
IPR008280   Tub_FtsZ_C       
IPR003008   Tubulin_FtsZ_GTPase       
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR000217   Tubulin       
IPR001611   Leu-rich_rpt       
IPR032675   LRR_dom_sf       
IPR011547   SLC26A/SulP_dom       
IPR027309   P2X_extracellular_dom_sf       
IPR001429   P2X_purnocptor       

SUPFAM

SSF55307   SSF55307        + More
SSF52490   SSF52490       

Gene 3D

1.10.287.600     3.30.1330.20     3.40.50.1440     3.80.10.10     2.60.490.10    

ProteinModelPortal

A0A2A4JAA1   A0A2H1V6C6   Q8T8B5   H9IZ57   A0A0N0PBQ1   A0A1A9UJX4   + More
L5LLI6   D6WBL0   A0A1B6IMY7   A0A1B6INX8   A0A0L0CGN0   A0A1A9YUF9   A0A1A9XMZ8   A0A1B0A8T1   A0A224XCE3   A0A0P4VZJ1   R4G8S7   A0A1Y1MDH6   A0A336KRR7   A0A1B0C2X1   T1HWF2   A0A1A9W6N7   E0VM84   A0A069DZ13   T1J7L5   G1U031   A0A182G9P4   A0A1B0D3C0   A0A0K8TPT9   Q7YZZ5   F6RP72   A0A182IM33   H2ZGV6   A0A1S3IWS5   F7B0Q2   W5JKF4   G1RHD8   F6YDT3   A0A3Q2I621   J9JYZ7   G7PH99   D2HEW5   G1LX08   F1PE21   G3T189   A0A3Q2H5A5   A0A3Q2HH45   F7CD56   A0A2K6PI36   A0A2I3RDC8   G7NB59   G1PRA0   G1KAW4   A0A3L7H6L4   H0VZ17   A0A286XMV9   A0A1J0N2A2   Q5FW91   A0A2K6D2H7   A0A384CMW3   J9NXT1   M3ZBN8   I3LDR2   F1RK98   A0A2K5Z4G6   A0A288CFV7   A0A0D9RWH9   A0A3Q7MXL5   A0A2R9A341   A0A2I3MCC7   F6V4Z9   A0A2K5KPS1   A0A2Y9LNY1   F2Z4K0   A0A2U3VYD5   M3XX31   S9XG46   A0A3Q7U1L3   A0A2J8R7L3   A0A2U3YLF9   A0A2K5U687   A0A2Y9IQW7   A0A2K5PG68   F6R810   G3RBT2   G2HFQ0   F7H3X6   A0A3Q2LQ20   A0A096NXX2   A0A3Q7UPQ8   A0A384CLU5   A0A3Q2HXF8   A0A3L7H8J8   A0A2R2MK77   S7N8D7   A0A286Q4X6   Q4S6A1   A0A3B4A8C8   A0A210QQK1   A0A3S1B0R6  

PDB

5KX5     E-value=0,     Score=2317

KEGG

692429    K07374 tubulin alpha | (RefSeq) Tua2, bmtua2; alpha-tubulin

PATHWAY

04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0007017   GO:0005737   GO:0003924   GO:0005200   GO:0005874   GO:0005525   GO:0000226   GO:0000278   GO:0016021   GO:0005887   GO:0098794   GO:0033198   GO:0004931   GO:0001614   GO:0008270   GO:0006511   GO:0016491   GO:0003824  

PANTHER

PTHR11588  

Subcellular location

  

Length:

454

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.49477

Exp number, first 60 AAs:

0.00082

Total prob of N-in:

0.02221

outside

1  -  454

 

 

Pi

385.998742

Theta

201.586579

Tajima's D

2.394949

CLR

0.099285

CSRT

0.936703164841758

Interpretation

Uncertain