Gene

KWMTBOMO05357  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002539

Annotation

PREDICTED:_V-type_proton_ATPase_116_kDa_subunit_a_isoform_1_[Bombyx_mori]

Location

Bomo_Chr9(+):15432626-15469099      View in EpiBrowser

Full name

V-type proton ATPase subunit a      

Location in the cell

PlasmaMembrane   Reliability : 4.661

CDS

ATGGGGTCTTTGTTTCGGAGTGAGGAGATGACACTATGTCAGCTTTTCCTGCAAAGTGAAGCTGCTTATGCCTGCGTGTCCGAGCTCGGGGAGTTGGGGCTAGTTCAGTTCCGAGATTTGAATCCTGACGTAAATGCCTTCCAACGTAAGTTCGTCAATGAAGTACGTCGCTGCGATGAGATGGAACGTAAGCTCCGCTACCTGGAGAAGGAGATCAGACGTGACGGCATCCCCATGCTGGAGATCCCCGGAGAGTGTCCCGAAGCGCCTCAACCCAGGGAGATGATCGATCTTGAAGCGACCTTCGAAAAGCTTGAGAATGAGCTGCGAGAGGTTAACCAGAACGCTGAGGCTCTTAAGAGGAACTACCTCGAGTTAACAGAATTAAAACACATTTTGAGGAAGACTCAAGTGTTCTTCGATGAGATGGCGGATCCGTCGAGGGAGGAGGAACAAGTCACCCTACTGGGGGAGGAGGGCCTCATGGCGGGAGGGCAAGCGCTCAAGCTGGGTTTCGTCGCGGGCGTGATTCTGAGGGAGAGAATACCGGCGTTCGAGCGCATGTTGTGGCGGGCCTGCAGGGGAAACGTGTTCCTGAGGCAGGCTGAGATCGACACGCCCCTGGAAGATCCATCATCATCGGATCAGGTTTACAAATCGGTGTTCATCATATTCTTCCAAGGCGACCAGCTGAAGACGCGCGTCAAGAAAATATGCGAAGGTTTCAGGGCGACGCTGTATCCGTGCCCGGAGTCGCCGGCCGACCGCCGGGAGATGGCCATGGGCGTCATGACCAGGATCGAGGATCTGAACACCGTCTTAGGTCAGACCCAGGACCATCGTCACCGCGTGCTGGTCGCCGCCGCCAAGAACATTAAGAACTGGTTCGTGAAAGTGCGCAAGATCAAGGCCATCTACCACACGTTGAATCTGTTCAATCTGGACGTGACCCAGAAGTGCCTCATCGCCGAGTGCTGGGTGCCCGCGCTCGACATGGAGACTATCCAACTGGCTCTGAGGAGAGGAACGGAACGCAGTGGCAGCTCGGTTCCCCCGATCCTCAACCGGATGGAGACTATAGAAGACCCGCCGACGTATAACAGGACCAATAAGTTCACTTCGGCCTTCCAGCACCTCATCTACGCGTACGGCGTGGCCACGTACCGCGAGGTCAACCCGGCACCCTACACGGTCATAACGTTCCCGTTCTTGTTCGCGGTGATGTTCGGCGACCTCGGCCACGGCGCCATCATGGCCGCCTTCGGGTTCTGGATGTGCTACAAGGAGAAGCCGCTGCAGGCCAAGAAAATCGACAGCGAGATCTGGAATATATTCTTCGGCGGTCGCTACATCATCCTGCTCATGGGCCTGTTCTCGATGTACACGGGCCTCATATACAACGACATATTCTCGAAGAGCTTGAACATATTCGGCTCGTCGTGGAGGAACAACTACGACGGCTCCACGCTGCAGAGCAACCAGCTGCTGCAGCTGAACCCCGACTCCAAAGACTACCTGCAGTACCCTTACCCGTTCGGCATCGACCCGGTCTGGCAGCTCGCAGAAGCCAACAAGATTATCTTCATGAACGGTTACAAGATGAAGATTTCTATCATAATAGGTGTCTTCCACATGTTGTTCGGTGTCTGTCTCTCGCTTTGGAATCATTTGTACTTCAAGCGTCGCATCAGCATCTACGTGGAGTTCATCCCCCAGATACTGTTCCTGAGCCTGCTGTTCTTCTACATGGTGCTGCTCATGTTCATCAAGTGGACCACGTACGGCGCCACGCCCGGACACTTCGGCAGCCAGGACCCCGAGATAGTGAAGACGAGCGCGTTCTGCGCCCCGTCCATCCTCATCACGTTCATCAACATGATGCTGTTCAAGCACGACAAGAACACGCGGCCGCAGTGCGACGACTTCATGTTCTCCGGACAGATGTTCATACAGAAGCTGTTCGTGATCGTGGCTCTGCTGTGCGTGCCCATCATGCTGTTCGGGAAGCCGTACTTCATCATGCGCGAGCAGAAGCAGCGCGCCAGACAAGGTCACCAGCCGGTAGAAGGTAACGCCGAGAACGGCACGGCGGGCGGCGCTCCCGTCCCGGCCTCGGGACATCACGACGAAGAGATCACCGAGGTCTTCATTCACCAGGCCATCCACACCATAGAGTTCGTGTTGGGCAGCGTGTCGCACACGGCGTCGTACCTGCGGCTGTGGGCGCTCTCCCTCGCGCACGCGCAGCTCGCTGAGGTCGCCTGGAACATGCTGCTCAGGAAGGGTCTGATGTCCAACGACTACCAGGGCGGGATCTTCCTGTACGTGGTGTTCGCGGGCTGGGCGGCCATCTCCGTCTCCATCCTCGTGCTCATGGAGGGGCTCTCGGCCTTCCTGCACACGCTGCGTCTGCACTGGGTCGAGTTCCAGAGCAAGTTCTACGGAGGAGAAGGCTACCTCTTCCAGCCCTTCTCGTTCGAGATCATTCTAGACTCGGCGGGTCAGGCAGAAGAATAA

Protein

MGSLFRSEEMTLCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKLRYLEKEIRRDGIPMLEIPGECPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNYLELTELKHILRKTQVFFDEMADPSREEEQVTLLGEEGLMAGGQALKLGFVAGVILRERIPAFERMLWRACRGNVFLRQAEIDTPLEDPSSSDQVYKSVFIIFFQGDQLKTRVKKICEGFRATLYPCPESPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNIKNWFVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPALDMETIQLALRRGTERSGSSVPPILNRMETIEDPPTYNRTNKFTSAFQHLIYAYGVATYREVNPAPYTVITFPFLFAVMFGDLGHGAIMAAFGFWMCYKEKPLQAKKIDSEIWNIFFGGRYIILLMGLFSMYTGLIYNDIFSKSLNIFGSSWRNNYDGSTLQSNQLLQLNPDSKDYLQYPYPFGIDPVWQLAEANKIIFMNGYKMKISIIIGVFHMLFGVCLSLWNHLYFKRRISIYVEFIPQILFLSLLFFYMVLLMFIKWTTYGATPGHFGSQDPEIVKTSAFCAPSILITFINMMLFKHDKNTRPQCDDFMFSGQMFIQKLFVIVALLCVPIMLFGKPYFIMREQKQRARQGHQPVEGNAENGTAGGAPVPASGHHDEEITEVFIHQAIHTIEFVLGSVSHTASYLRLWALSLAHAQLAEVAWNMLLRKGLMSNDYQGGIFLYVVFAGWAAISVSILVLMEGLSAFLHTLRLHWVEFQSKFYGGEGYLFQPFSFEIILDSAGQAEE

Description

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.

Similarity

Belongs to the V-ATPase 116 kDa subunit family.

Uniprot

Q9U5M9   A0A2R8G1V7   A0A3S2L4Y8   A0A2H1WF76   A0A1E1WNG2   A0A2J7QFQ9   + More
A0A2J7QFR4   E0V9Q8   A0A158NXX8   A0A151IVV4   A0A3L8DJ15   V9I760   A0A1E1WEP8   A0A084WR28   K7IYB2   A0A1Y1MAK7   A0A139WN05   K7IYB1   A0A2M4CS16   A0A1Y1MG49   K7IYB3   A0A2M3YZG4   A0A2M4BDD5   A0A182GWD2   A0A1Y0AWQ7   A0A182W305   F5HLG5   K7IYB0   A0A2J7QFT0   V5GRH0   A0A0A9ZE97   J9K3R8   A0A0C9S0C2   B0WEX4   A0A0K8T8E8   F5HLG3   A0A0A9ZEA0   A0A0C9S300   K7IYB4   A0A0K8T8E6   A0A0Q9X0Y9   A0A0Q9XCS9   A0A182F8F2   U4UFR4   A0A026X2Y9   A0A1I8N3G3   A0A1I8N3G6   A0A2M4A3S2   A0A1L8DF17   A0A2M3YZI3   A0A2M4BDR5   A0A182WVE5   A0A0M9A440   A0A182I925   A0A182V339   A0A0Q9X8P4   A0A0Q9X9R1   A0A1A9UQ47   A0A1I8NPJ1   A0A1I8NPJ9   A0A182MQW0   A0A182Q8Y9   W5JHE2   Q0IFY3   U5EY30   A0A182TZM2   W8AJG4   A0A1I8N3I1   A0A1I8N3G5   A0A182PQQ1   Q5TT36   A0A0A9Z8V9   A0A034VNS1   V9I8F4   A0A2A3E040   A0A0Q9X1I2   A0A1I8NPI7   A0A1Q3FFS3   A0A182KXZ5   A0A0A9Z8W6   A0A1I8NPJ3   A0A0Q9X2Q6   A0A1B6E585   A0A0A7DW87   A0A069DZK7   K7IYB5   A0A0K8T8T5   A0A0A1XBK4   A0A182R8D8   A0A1B6KBS1   A0A224X765   W8B5T4   A0A0P4VSP4   A0A1Y1MAZ1   A0A0Q9X0A0   A0A1B6H9J3   A0A0Q9X256   A0A0T6BAC8   A0A1B6FBA4   A0A2H8TQP4  

Pubmed

11030595    20566863    21347285    30249741    24438588    20075255    + More
28004739    18362917    19820115    26483478    28341416    12364791    14747013    17210077    25401762    26823975    17994087    23537049    24508170    25315136    18057021    20920257    23761445    17510324    24495485    25348373    20966253    26334808    25830018    27129103   

EMBL

AJ249390    CAB55500.1    KY921845    AVP73917.1    RSAL01000148    RVE45836.1    + More
ODYU01008280    SOQ51729.1    GDQN01002673    JAT88381.1    NEVH01014852    PNF27426.1    PNF27427.1    DS234995    EEB10093.1    ADTU01003697    ADTU01003698    ADTU01003699    ADTU01003700    KQ980882    KYN11932.1    QOIP01000007    RLU20143.1    JR036121    AEY56933.1    GDQN01005584    JAT85470.1    ATLV01025906    ATLV01025907    KE525402    KFB52672.1    GEZM01036239    JAV82869.1    KQ971311    KYB29409.1    GGFL01003956    MBW68134.1    GEZM01036241    JAV82866.1    GGFM01000911    MBW21662.1    GGFJ01001919    MBW51060.1    JXUM01092931    JXUM01092932    JXUM01092933    JXUM01092934    KQ564021    KXJ72912.1    KY921838    ART29427.1    AAAB01008888    EGK97125.1    PNF27428.1    GALX01004254    JAB64212.1    GBHO01001936    GDHC01018959    JAG41668.1    JAP99669.1    ABLF02026125    GBYB01015260    JAG85027.1    DS231912    EDS25832.1    GBRD01003998    JAG61823.1    EGK97126.1    GBHO01001931    JAG41673.1    GBYB01015261    JAG85028.1    GBRD01003999    JAG61822.1    CH933806    KRG01557.1    KRG01555.1    KB632277    ERL91208.1    KK107019    EZA62635.1    GGFK01002088    MBW35409.1    GFDF01009160    JAV04924.1    GGFM01000938    MBW21689.1    GGFJ01002002    MBW51143.1    KQ435762    KOX75459.1    APCN01003164    KRG01556.1    KRG01554.1    AXCM01000016    AXCN02001184    ADMH02001252    ETN63486.1    CH477281    EAT44941.1    GANO01000629    JAB59242.1    GAMC01017875    GAMC01017871    JAB88680.1    EAL40624.3    GBHO01001932    GDHC01015774    JAG41672.1    JAQ02855.1    GAKP01013981    GAKP01013980    JAC44971.1    JR036120    AEY56932.1    KZ288510    PBC25118.1    CH964232    KRF99395.1    GFDL01008651    JAV26394.1    GBHO01001922    GDHC01012224    JAG41682.1    JAQ06405.1    KRF99393.1    GEDC01004206    JAS33092.1    KF986377    AIY24627.1    GBGD01000470    JAC88419.1    GBRD01004000    JAG61821.1    GBXI01005967    JAD08325.1    GEBQ01031086    JAT08891.1    GFTR01008131    JAW08295.1    GAMC01017874    JAB88681.1    GDKW01001098    JAI55497.1    GEZM01036243    JAV82864.1    KRG01558.1    GECU01036404    JAS71302.1    KRG01561.1    LJIG01002646    KRT84294.1    GECZ01022307    GECZ01013541    JAS47462.1    JAS56228.1    GFXV01004708    MBW16513.1   

Proteomes

UP000283053    UP000235965    UP000009046    UP000005205    UP000078492    UP000279307    + More
UP000030765    UP000002358    UP000007266    UP000069940    UP000249989    UP000075920    UP000007062    UP000007819    UP000002320    UP000009192    UP000069272    UP000030742    UP000053097    UP000095301    UP000053105    UP000075840    UP000075903    UP000078200    UP000095300    UP000075883    UP000075886    UP000000673    UP000008820    UP000075902    UP000075885    UP000242457    UP000007798    UP000075882    UP000075900   

Pfam

PF01496   V_ATPase_I

Interpro

IPR026028   V-type_ATPase_116kDa_su_euka        + More
IPR002490   V-ATPase_116kDa_su       

ProteinModelPortal

Q9U5M9   A0A2R8G1V7   A0A3S2L4Y8   A0A2H1WF76   A0A1E1WNG2   A0A2J7QFQ9   + More
A0A2J7QFR4   E0V9Q8   A0A158NXX8   A0A151IVV4   A0A3L8DJ15   V9I760   A0A1E1WEP8   A0A084WR28   K7IYB2   A0A1Y1MAK7   A0A139WN05   K7IYB1   A0A2M4CS16   A0A1Y1MG49   K7IYB3   A0A2M3YZG4   A0A2M4BDD5   A0A182GWD2   A0A1Y0AWQ7   A0A182W305   F5HLG5   K7IYB0   A0A2J7QFT0   V5GRH0   A0A0A9ZE97   J9K3R8   A0A0C9S0C2   B0WEX4   A0A0K8T8E8   F5HLG3   A0A0A9ZEA0   A0A0C9S300   K7IYB4   A0A0K8T8E6   A0A0Q9X0Y9   A0A0Q9XCS9   A0A182F8F2   U4UFR4   A0A026X2Y9   A0A1I8N3G3   A0A1I8N3G6   A0A2M4A3S2   A0A1L8DF17   A0A2M3YZI3   A0A2M4BDR5   A0A182WVE5   A0A0M9A440   A0A182I925   A0A182V339   A0A0Q9X8P4   A0A0Q9X9R1   A0A1A9UQ47   A0A1I8NPJ1   A0A1I8NPJ9   A0A182MQW0   A0A182Q8Y9   W5JHE2   Q0IFY3   U5EY30   A0A182TZM2   W8AJG4   A0A1I8N3I1   A0A1I8N3G5   A0A182PQQ1   Q5TT36   A0A0A9Z8V9   A0A034VNS1   V9I8F4   A0A2A3E040   A0A0Q9X1I2   A0A1I8NPI7   A0A1Q3FFS3   A0A182KXZ5   A0A0A9Z8W6   A0A1I8NPJ3   A0A0Q9X2Q6   A0A1B6E585   A0A0A7DW87   A0A069DZK7   K7IYB5   A0A0K8T8T5   A0A0A1XBK4   A0A182R8D8   A0A1B6KBS1   A0A224X765   W8B5T4   A0A0P4VSP4   A0A1Y1MAZ1   A0A0Q9X0A0   A0A1B6H9J3   A0A0Q9X256   A0A0T6BAC8   A0A1B6FBA4   A0A2H8TQP4  

PDB

6O7T     E-value=1.24199e-155,     Score=1413

KEGG

101738141    K02154 V-type H+-transporting ATPase subunit a | (RefSeq) V-type proton ATPase 116 kDa subunit a iso

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)
04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0000220   GO:0016021   GO:0015078   GO:0016787   GO:0015991   GO:0006811   GO:0051117   GO:0016471   GO:0046961   GO:0007035   GO:0005886   GO:0033179   GO:0051452   GO:0097352   GO:0005516   GO:0005769   GO:0009416   GO:0048749   GO:0009881   GO:0008021   GO:0007430   GO:0016020   GO:0008270   GO:0006511   GO:0005525   GO:0016491   GO:0003824  

PANTHER

PTHR11629  

Length:

838

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

156.16653

Exp number, first 60 AAs:

0.00088

Total prob of N-in:

0.00353

outside

1  -  401

TMhelix

402  -  424

inside

425  -  444

TMhelix

445  -  467

outside

468  -  535

TMhelix

536  -  558

inside

559  -  564

TMhelix

565  -  587

outside

588  -  649

TMhelix

650  -  672

inside

673  -  769

TMhelix

770  -  792

outside

793  -  838

 

 

Pi

199.094363

Theta

159.245694

Tajima's D

0.75394

CLR

0.561409

CSRT

0.587770611469427

Interpretation

Uncertain