Gene

KWMTBOMO05338  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002526

Annotation

PREDICTED:_ecdysteroid-inducible_angiotensin-converting_enzyme-related_gene_product_isoform_X4_[Bombyx_mori]

Location

Bomo_Chr9(+):14967266-14997935      View in EpiBrowser

Full name

Angiotensin-converting enzyme      

Location in the cell

Cytoplasmic   Reliability : 2.886

CDS

ATGCTGAAAGTGGGGGGCGGTGCGGTATTGATCGCGGCGATCGTTGCCGTGTTCATCGTGGCCACTCAGGGACGGGACCCGGACCTCGAGGCGCGGGAGCACGAGGCGCGGGAGTACATGCTGCATCTGGATAAAGCGACCGGCCTGAGGAAGAACAGGGCCAGCTTAGCCGAATGGGAGTACACCTCGAATATCACGAAGGAGAACGAAGAGAAATCGATACAAACTCACCTGGAGCTCTCGCGTCAAGAGAAAGCAGCCTGGGAGGAGACCAAGATGTACGGGTGGCAGGACTTCCAGGATTTCACGTTGCGTAGAATGTTCAAGAAATACAGTCAGCTGGGCGTTGCGGCTCTGCCTGACGACAAATTCCAAGCTTTGATGAGAACTGTGTCTGGAATGGAATCGAACTATGCCACTGCGAAGATCTGCTCGTACAAGAATGAAAGTAAATGCGATCTATCTTTGGAGCCTGAGATAACTGAAATATTCTCCACGAGCCAAGACCCTGAGGAGTTGAAGCATGCCTGGGTGGAGTGGCACAACGCGGCCGGCGCGACAGCGAAGAAGAACTTCACCGACTACGTGAACCTTTACAACGAGGCCGCCAAGCTTAATGGTTTCGATAACGTAGCCGAATGGTGGCAATCAGAATACGAGGTACCGGACTTCGAGGAGCAGCTGGCGAAGCTGTGGGAGGACGTGAAGCCTCTGTACCAGCAGCTGCACGCCTACGTCAGGAAGAGGCTGCGGGACAAGTACGGAGACAAGGTCGTGTCCGCCAGAGGACCGATACCGGCGCATTTACTGGGCAACATGTGGGCCCAGACGTGGAACAACATCGAATCCTTCACTCGTCCTTATCCGGACAAGAAGGAGATCGACGTCACACAAGCGATGAGAGACCAGAACTACACTCCGATGAAGATGTTTCAAATGTCAGACGAATTCTTTAGGTCGTTGAACTTGACCGCTATGCCCGAGAAGTTCTGGAAGAACTCTATAATAGAGAAGCCGACGGATAGAGAAATCGTTTGTCACGCCTCCGCCTGGGACTTCTTTGATGGTGAAGATTTTAGGATCAAAATGTGCACGACGGTGAACGTGGAACACCTGAGGACGGTGCACCACGAGATGGGACACATTCAGTATTTCTTGCAGTACAGACATCAGCCTTCGGTCTTCCGCGAGGGAGCGAATTCAGGTTTCCACGAAGCGGTCGGGGACACGATAGCTCTCTCGGTGTCGTCACCGAAACATCTGCGTCGGGTCGGTCTGGCCACGGGCGATGCCGAGGACGAACAGACAGAGATCAATCAGCTTTATAAGATGGGAATAGACAAGATCGCATTCCTACCGTTCGCATACACCCTGGACCTGTTCCGATACGGTGTGTTCAGAAGGAAGACGCTGCCGGAAGACTACAACTGCCACTACTGGAAGCTAAGGGAGCAGCTACAAGGCGTGGAGCCGCCCGTCAATAGAACTGAGGACGACTTCGACGCCGCAGCCAAGTACCATGTGTCTGCCAACGTCGAATACGCCAGATATTACGTGTCGTTCATAATCCAGTTCCAGTTCCACCGTGCGCTGTGCCAGCTGGCGGGCGAGCACGCGGCCGGGGACCCCAACAAGAAGCTGGTCGACTGCGACATCTACCAGAGCGTCGCCGCCGGGAACGCGCTCGCAAACATGCTGAAGATGGGTTCGTCTAAGCCCTGGCCGGACGCGATGGAGGCGCTGACCGGACAGCGGGAGATGAAGGCAGACGGCCTCCTGGAGTACTTCCGGCCGCTCCACGACTGGCTGCGGGCGGAGAACCAGCGGACCGGCGAGCACATCGGCTGGGAACCGACCAACATGGAGTACTGCACGCCGAGCCAATTGTCGGAGCTAAACGTGAAGGAGCCGGCGTCGAGTCCAGCGACGCAACAATCTGACTCTTGA

Protein

MLKVGGGAVLIAAIVAVFIVATQGRDPDLEAREHEAREYMLHLDKATGLRKNRASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYSQLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEELKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFEEQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIESFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTDREIVCHASAWDFFDGEDFRIKMCTTVNVEHLRTVHHEMGHIQYFLQYRHQPSVFREGANSGFHEAVGDTIALSVSSPKHLRRVGLATGDAEDEQTEINQLYKMGIDKIAFLPFAYTLDLFRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVSFIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEALTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTNMEYCTPSQLSELNVKEPASSPATQQSDS

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M2 family.

Feature

chain  Angiotensin-converting enzyme

Uniprot

H9IZ41   Q9NDS8   A0A194QIX2   A0A0N1ICA6   A0A2H1V7I0   A0A212F3I4   + More
A0A3S2LLM4   A0A0L7LS53   I4DJQ5   A0A212F3H8   A0A2H1VQG9   B0LJE2   H9IZ42   A0A1E1W694   A0A3S2M2A7   B9X255   A0A0N0PEJ7   A0A2A4IWT8   A0A0U3KDL0   A0A2J7QUF6   A0A2J7QUE9   Q6RX62   A0A1I9WL53   A0A1S6J0Y7   A0A1S4G6D0   M9PM20   J9E9A1   A0A023EVK4   A0A023EXC8   A0A2J7QUG0   A0A023EVB9   A0A023EUI3   W5JI94   A0A1Q3FRW0   A0A1Q3FRM3   A0A2M4DP36   A0A1Y1NHL6   A0A182JL55   A0A182GI44   A0A182XN90   J9HF68   A0A182KU25   A0A0N0BEI9   A0A2C9GR23   A0A1Y9G9N3   A0A084VR61   B0WR90   A0A182PQ22   A0A310SP14   U4UDS6   A0A2M4AJS0   A0A2M4BH75   A0A2M4AK82   A0A2M4BH14   A0A182GQM8   A0A2M4BH35   A0A1Q3FFN8   A0A182JYE2   A0A2M4AK25   A0A2M4AJQ6   A0A1Q3FFN2   A0A2M4BGX1   A0A182UC23   A0A2C9GR16   A0A2M4BHR7   A0A1Q3FG20   A0A1Q3FG39   A0A182Y0N8   B0WR89   A0NFU8   A0A182US62   T1DLB0   A0A182WGJ2   A0A2C9GR18   A0A182MAY2   A0A1S4HDX3   A0A224XGM1   A0A1B6EFN8   E0VYZ8   A0A182LUT3   A0A182J606   A0A1Y9G8B0   W5JG17   A0A1I8JUD4   A0A182KG45   A0A1B6C745   A0A1B6DC58   D6X4L0   A0A154PK20   A0A182NBR7   A0A182TYM7   A0A087ZRC1   A0A2K8JLZ7   A0A1Y9G9F7   T1I107   A0A1I8JUB2   A0A0L7QKN3   A0A2C9GR30   A0NFV1   A0A182QUK4  

EC Number

3.4.-.-

Pubmed

19121390    11102839    26354079    22118469    26227816    22651552    + More
26694822    27538518    27414796    25581109    17510324    24945155    20920257    23761445    28004739    26483478    20966253    24438588    23537049    25244985    12364791    20566863    18362917    19820115    14747013    17210077   

EMBL

BABH01011115    AB026110    AB485780    BAA97657.1    BAH23568.1    KQ458714    + More
KPJ05462.1    KQ461002    KPJ10041.1    ODYU01000895    SOQ36342.1    AGBW02010565    OWR48273.1    RSAL01000066    RVE49366.1    JTDY01000210    KOB78277.1    AK401523    BAM18145.1    OWR48272.1    ODYU01003823    SOQ43060.1    EU170161    ABW34729.1    BABH01011116    GDQN01008554    JAT82500.1    RVE49365.1    AB485781    BAH23569.1    KQ459934    KPJ19243.1    NWSH01006011    PCG63754.1    KU218691    ALX00071.1    NEVH01011186    PNF32210.1    PNF32208.1    AY487174    AAR85358.1    KU932237    APA33873.1    KU764440    AQS60686.1    KC437298    AGC79111.1    CH477248    EJY57431.1    GAPW01000531    JAC13067.1    GAPW01000529    JAC13069.1    PNF32211.1    GAPW01000530    JAC13068.1    GAPW01000528    JAC13070.1    ADMH02001324    ETN63008.1    GFDL01004760    JAV30285.1    GFDL01004795    JAV30250.1    GGFL01015113    MBW79291.1    GEZM01002421    JAV97269.1    JXUM01065208    JXUM01065209    KQ562335    KXJ76120.1    EJY57432.1    KQ435827    KOX71968.1    APCN01001774    ATLV01015459    KE525014    KFB40455.1    DS232053    EDS33274.1    KQ762196    OAD56126.1    KB632277    ERL91207.1    GGFK01007715    MBW41036.1    GGFJ01003160    MBW52301.1    GGFK01007707    MBW41028.1    GGFJ01003208    MBW52349.1    JXUM01016020    JXUM01016021    KQ560447    KXJ82379.1    GGFJ01003206    MBW52347.1    GFDL01008681    JAV26364.1    GGFK01007818    MBW41139.1    GGFK01007699    MBW41020.1    GFDL01008678    JAV26367.1    GGFJ01003159    MBW52300.1    GGFJ01003207    MBW52348.1    GFDL01008546    JAV26499.1    GFDL01008526    JAV26519.1    EDS33273.1    AAAB01008980    EAU76037.2    GAMD01000546    JAB01045.1    AXCM01007217    GFTR01007468    JAW08958.1    GEDC01000545    JAS36753.1    DS235848    EEB18604.1    ETN63011.1    GEDC01028238    JAS09060.1    GEDC01024908    GEDC01014015    JAS12390.1    JAS23283.1    KQ971380    EEZ97252.2    KQ434943    KZC12209.1    KY031095    ATU82846.1    ACPB03016228    KQ414954    KOC59071.1    EAU76040.2    AXCN02000684   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000283053    UP000037510    + More
UP000218220    UP000235965    UP000008820    UP000000673    UP000075880    UP000069940    UP000249989    UP000076407    UP000075882    UP000053105    UP000075840    UP000069272    UP000030765    UP000002320    UP000075885    UP000030742    UP000075881    UP000075902    UP000076408    UP000007062    UP000075903    UP000075920    UP000075883    UP000009046    UP000075900    UP000007266    UP000076502    UP000075884    UP000005203    UP000015103    UP000053825    UP000075886   

PRIDE

H9IZ41    Q9NDS8    H9IZ42    B9X255   

Pfam

PF01401   Peptidase_M2        + More
PF05160   DSS1_SEM1

Interpro

IPR001548   Peptidase_M2        + More
IPR011989   ARM-like       
IPR007834   DSS1_SEM1       

Gene 3D

1.25.10.10    

CDD

cd06461  M2_ACE

ProteinModelPortal

H9IZ41   Q9NDS8   A0A194QIX2   A0A0N1ICA6   A0A2H1V7I0   A0A212F3I4   + More
A0A3S2LLM4   A0A0L7LS53   I4DJQ5   A0A212F3H8   A0A2H1VQG9   B0LJE2   H9IZ42   A0A1E1W694   A0A3S2M2A7   B9X255   A0A0N0PEJ7   A0A2A4IWT8   A0A0U3KDL0   A0A2J7QUF6   A0A2J7QUE9   Q6RX62   A0A1I9WL53   A0A1S6J0Y7   A0A1S4G6D0   M9PM20   J9E9A1   A0A023EVK4   A0A023EXC8   A0A2J7QUG0   A0A023EVB9   A0A023EUI3   W5JI94   A0A1Q3FRW0   A0A1Q3FRM3   A0A2M4DP36   A0A1Y1NHL6   A0A182JL55   A0A182GI44   A0A182XN90   J9HF68   A0A182KU25   A0A0N0BEI9   A0A2C9GR23   A0A1Y9G9N3   A0A084VR61   B0WR90   A0A182PQ22   A0A310SP14   U4UDS6   A0A2M4AJS0   A0A2M4BH75   A0A2M4AK82   A0A2M4BH14   A0A182GQM8   A0A2M4BH35   A0A1Q3FFN8   A0A182JYE2   A0A2M4AK25   A0A2M4AJQ6   A0A1Q3FFN2   A0A2M4BGX1   A0A182UC23   A0A2C9GR16   A0A2M4BHR7   A0A1Q3FG20   A0A1Q3FG39   A0A182Y0N8   B0WR89   A0NFU8   A0A182US62   T1DLB0   A0A182WGJ2   A0A2C9GR18   A0A182MAY2   A0A1S4HDX3   A0A224XGM1   A0A1B6EFN8   E0VYZ8   A0A182LUT3   A0A182J606   A0A1Y9G8B0   W5JG17   A0A1I8JUD4   A0A182KG45   A0A1B6C745   A0A1B6DC58   D6X4L0   A0A154PK20   A0A182NBR7   A0A182TYM7   A0A087ZRC1   A0A2K8JLZ7   A0A1Y9G9F7   T1I107   A0A1I8JUB2   A0A0L7QKN3   A0A2C9GR30   A0NFV1   A0A182QUK4  

PDB

5A2R     E-value=0,     Score=1675

KEGG

692400    K01283 peptidyl-dipeptidase A [EC:3.4.15.1] | (RefSeq) ecdysteroid-inducible angiotensin-converting

GO

GO:0016020   GO:0008241   GO:0046872   GO:0004180   GO:0008237   GO:0016021   GO:0005886   GO:0008239   GO:0008238   GO:0005615   GO:0006406   GO:0043248   GO:0008541   GO:0006508   GO:0008270   GO:0006511   GO:0005525   GO:0016491   GO:0003824  

PANTHER

PTHR10514  

SignalP

Position:   1 - 24,         Likelihood:  0.796706

 

 

Length:

648

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

17.7533099999999

Exp number, first 60 AAs:

17.56389

Total prob of N-in:

0.91066

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  22

outside

23  -  648

 

 

Pi

229.072229

Theta

161.621061

Tajima's D

2.316762

CLR

0.369099

CSRT

0.926253687315634

Interpretation

Uncertain