Gene

KWMTBOMO05321  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002393

Annotation

PREDICTED:_calcium-binding_mitochondrial_carrier_protein_Aralar1_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr9(-):13834582-13862577      View in EpiBrowser

Full name

Calcium-binding mitochondrial carrier protein Aralar1      

Location in the cell

Cytoplasmic   Reliability : 1.425 Mitochondrial   Reliability : 1.339

CDS

ATGTTTAAATCTTTGTTCGGCTCCTTGTTAACTCAAGCCAGCTGTCAAGAGGGGGCTGGTTATTTGAAACGGGCTGATTCAGAGAAGCTACATGAGATCTTCTTGAAGTACGCCACCGTTGAGAAGAACGGTGAGAAGCATATCACAAGCGAAGATTTTGTAAGAAAATATCTAGGATTATTCTCCGAAGATGATTTCAACAAAGAATCGGTCCAGCTCATCGCTGGAATCGTCGACATGGACAAGGACGGTTACATATCGTTCTCCGAGTTCCAGGCGTTTGAAGGTCTGCTGTGCGTGCCGGACGCTCTGTACAAAACCGCCTTTCAACTATTCGATACGAATGGGAATGGACTTGTTGCTTTTGACGAATTCGCCGAGGTTATGCGAAAAACGGCCCTCCACAAGAAGCTGCCCTTCAACATGGAGAGCACGTTCGTTCGCCTGTACTTCGGCAAGGATAAGAAGCGGCTCGTAACCTACCCTGAGTTCAGTCAGTTCTTGCACGACTTCCACGAAGAATACGGAGTCGAAGCGTTCAAGAAATGCGACAAGGAAGGCACCGGATTCATCACAGCCGGCGACTTCAGAAATATCATGATGTCGGTGAAGAGCCATCTTCTCACAAAGGATTTGAAAAGTAAAGTCATCACTGCCTCTGGTTTTCCGCAAGGCGAGCGAAAGATCAGTTTCCCTTACTATATGGCCTTCAATTCATTATTAAACAACATGGAGCTAATCAAGAGGGTGTACCTAAACGCCACGAACGGCCATCGCACGCAAGAGGTCACCAAAGAGGAGTTTCTGCACTCTGCCCAGATGATGAGTCAAATCACGCCCCTAGAAGTGGACATATTGTTCAACTTGTGCGACATTCTGCACCATACAAATGGTCGCATTGTGTACAACGATTTGAACTCCATAACGCCAGAGCAATACTTCAAGCAGGTTACACGAAGAGTAGCAGAAATTAAAGCTGTTTCCAGCCCGGAGGAGAGAGGTGTGCTAATACAAATCCTAGAGAGCACGTACAGATTCACGCTAGGTTCCGTAGCCGGGGCCGTGGGAGCCTCGGCGGTGTACCCGATAGATCTAGTCAAGACCCGGATGCAGAACCAGCGCACCGGCTCGTTCATCGGCGAAGTGGCGTACCGGAACTCGTGGGACTGCTTCAAGAAGGTGATCCGGCACGAGGGCGTGTTCGGCCTGTACCGGGGCCTCGTGCCGCAGCTCATCGGCGTCGCCCCGGAGAAAGCCATCAAGCTAACGGTCAACGATTTAGTTCGCGATAAATTCATGGACAAAAAAGGAAACATATCATTGTACGCTGAGATCATCGCCGGCGCATGTGCGGGCGGTTCTCAAGTGGTGTTCACGAATCCCCTGGAAATTGTCAAAATTCGTCTTCAAGTCGCCGGCGAGATAGCCGGGGGGACCAAAGTGAAGGCCTGGTCCGTCGTCAAGGACCTCGGGCTCTTCGGACTGTACAAGGGGGCGAAGGCCTGCCTCCTCCGCGACGTGCCCTTCAGCGCCATATACTTCCCGGCCTATGCTCATGTTAAGGCTAAGTTCGCGGATGAGAACGGCTACAACCATCCCCTGACGCTGCTGGCGGCGGGCGCCATCGCGGGCATCCCCGCCGCGTCGCTCGTCACCCCCGCTGACGTCATCAAAACCAGATTACAGGTGGTGGCGCGGTCCGGACAAACAACTTACAACGGAGTTATAGACGCGACCAGGAAGATATACGCAGAGGAAGGCGCCAGAGCTTTCTGGAAGGGCGCTATCGCTCGCGTGTTCCGCTCGTCGCCGCAGTTCGGCGTCACGCTGGTCACCTACGAAATATTACAGCGACTCTTCTACGTCGACTTCGGAGGGTCTCGTCCAACGGGCTCGGAGCTCCACGTGGCGACCCCCATCGAGGAATCGATAAAGAAGCCGCACCACATCGGCGGCTACCAAGTGGCCCTACCGGTACTGACAGGACTCGAAACCAAATTCGGAATCTCCCTGCCGAGGTTCTCGTATCCGAAACCAGCGCAGCAATGA

Protein

MFKSLFGSLLTQASCQEGAGYLKRADSEKLHEIFLKYATVEKNGEKHITSEDFVRKYLGLFSEDDFNKESVQLIAGIVDMDKDGYISFSEFQAFEGLLCVPDALYKTAFQLFDTNGNGLVAFDEFAEVMRKTALHKKLPFNMESTFVRLYFGKDKKRLVTYPEFSQFLHDFHEEYGVEAFKKCDKEGTGFITAGDFRNIMMSVKSHLLTKDLKSKVITASGFPQGERKISFPYYMAFNSLLNNMELIKRVYLNATNGHRTQEVTKEEFLHSAQMMSQITPLEVDILFNLCDILHHTNGRIVYNDLNSITPEQYFKQVTRRVAEIKAVSSPEERGVLIQILESTYRFTLGSVAGAVGASAVYPIDLVKTRMQNQRTGSFIGEVAYRNSWDCFKKVIRHEGVFGLYRGLVPQLIGVAPEKAIKLTVNDLVRDKFMDKKGNISLYAEIIAGACAGGSQVVFTNPLEIVKIRLQVAGEIAGGTKVKAWSVVKDLGLFGLYKGAKACLLRDVPFSAIYFPAYAHVKAKFADENGYNHPLTLLAAGAIAGIPAASLVTPADVIKTRLQVVARSGQTTYNGVIDATRKIYAEEGARAFWKGAIARVFRSSPQFGVTLVTYEILQRLFYVDFGGSRPTGSELHVATPIEESIKKPHHIGGYQVALPVLTGLETKFGISLPRFSYPKPAQQ

Description

Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane.

Subunit

Homodimer (via N-terminus).

Miscellaneous

Binds to one calcium ion with high affinity.

Similarity

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Keywords

Alternative splicing   Calcium   Complete proteome   Membrane   Metal-binding   Mitochondrion   Mitochondrion inner membrane   Reference proteome   Repeat   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Calcium-binding mitochondrial carrier protein Aralar1
splice variant  In isoform 2.

Uniprot

H9IYQ9   A0A1B4ZD97   A0A2H1VRP5   A0A212EJY7   A0A3S2NCE3   V9I7V9   + More
A0A151XFX4   A0A2A3EEL7   A0A3L8DC71   K7ITU3   A0A232F7R5   A0A158NIU7   A0A087ZSN2   A0A067QIM5   A0A310SGZ1   A0A0C9Q9J2   A0A2J7QIT8   A0A0L7QT27   D6W9D8   F4WHU3   U4UPY1   A0A1W4WCU3   E2C9H0   N6TSH9   A0A1Y1MLH6   A0A195BDX4   A0A1W4WMV5   A0A0M9A7S9   A0A1Y1MLH8   A0A026WKA1   E9IFM1   A0A154PRQ4   A0A0C9QM70   A0A1B6DSW7   A0A1B6EFM0   A0A1B6HDJ3   A0A146LJF4   A0A1B6IG65   A0A1B6GVS6   E0VR32   A0A1D2MAS7   A0A0K8TMB1   B0W7H6   U5ESC9   T1PBJ9   A0A1Q3FF55   A0A1I8N2P2   A0A023EVK9   A0A1Q3FF15   Q176G2   A0A1Q3FF57   A0A0P4W6V6   A0A1I8N2P4   A0A0L0BLG1   A0A3R7NK42   A0A1I8N2N7   D3TP39   W8BND3   A0A1I8NTP5   A0A182FMC0   A0A2M4BGE2   A0A1Y9J165   A0A182GBZ6   A0A2M4CI16   A0A2M3Z1X4   A0A340TBB3   A0A340TBG4   A0A2M4A4Z4   W5JI23   A0A1Y9J169   A0A182MN31   Q7QI16   A0A034VDS4   A0A240PLZ6   A0A182IJC8   A0A0K8WLZ4   A0A182Q3N9   W8B8A9   A0A182Y552   A0A1I8NTM9   W8B1B6   A0A182R9G5   A0A034VG37   A0A0A1WYR7   A0A034VH80   A0A2Y9D1M1   A0A1L8E1C1   A0A1I8NTN6   A0A1I8NTP2   A0A1L8E0V6   A0A0A1XLN7   A0A1J1HRB7   A0A0A1XD50   A0A1J1HSJ6   A0A0C9RD22   Q9VA73   A0A3B0JIF9   Q29C41   B4GNM3   B4PLW7  

Pubmed

19121390    22118469    30249741    20075255    28648823    21347285    + More
24845553    18362917    19820115    21719571    23537049    20798317    28004739    24508170    21282665    26823975    20566863    27289101    26369729    25315136    24945155    17510324    26108605    20353571    24495485    26483478    20920257    23761445    12364791    14747013    17210077    25348373    25244985    25830018    10642534    10731132    12537572    12537569    15632085    17994087    17550304   

EMBL

BABH01011012    BABH01011013    BABH01011014    LC179624    BAV57413.1    ODYU01004044    + More
SOQ43523.1    AGBW02014362    OWR41791.1    RSAL01000103    RVE47433.1    JR036441    AEY57150.1    KQ982179    KYQ59289.1    KZ288266    PBC30177.1    QOIP01000010    RLU17906.1    NNAY01000705    OXU26881.1    ADTU01016820    ADTU01016821    ADTU01016822    ADTU01016823    ADTU01016824    ADTU01016825    KK853323    KDR08517.1    KQ761389    OAD57680.1    GBYB01011043    JAG80810.1    NEVH01013579    PNF28492.1    KQ414756    KOC61626.1    KQ971312    EEZ99446.2    GL888168    EGI66230.1    KB632314    ERL92201.1    GL453862    EFN75400.1    APGK01053787    APGK01053788    APGK01053789    KB741235    ENN72210.1    GEZM01027992    JAV86532.1    KQ976513    KYM82414.1    KQ435718    KOX78990.1    GEZM01027993    JAV86531.1    KK107167    EZA56455.1    GL762878    EFZ20626.1    KQ435090    KZC14553.1    GBYB01004624    JAG74391.1    GEDC01008526    JAS28772.1    GEDC01000566    JAS36732.1    GECU01034948    GECU01026567    JAS72758.1    JAS81139.1    GDHC01017833    GDHC01011194    JAQ00796.1    JAQ07435.1    GECU01027492    GECU01021800    JAS80214.1    JAS85906.1    GECZ01003336    JAS66433.1    DS235442    EEB15838.1    LJIJ01002237    ODM90012.1    GDAI01002538    JAI15065.1    DS231854    EDS38011.1    GANO01002413    JAB57458.1    KA646137    AFP60766.1    GFDL01008867    JAV26178.1    GAPW01000405    JAC13193.1    GFDL01008897    JAV26148.1    CH477387    EAT42054.1    GFDL01008862    JAV26183.1    GDRN01085641    GDRN01085640    JAI61321.1    JRES01001702    KNC20798.1    QCYY01004662    ROT60649.1    EZ423191    ADD19467.1    GAMC01011669    JAB94886.1    GGFJ01002902    MBW52043.1    JXUM01053667    JXUM01053668    JXUM01053669    JXUM01053670    KQ561786    KXJ77545.1    GGFL01000799    MBW64977.1    GGFM01001750    MBW22501.1    GGFK01002471    MBW35792.1    ADMH02001125    ETN64037.1    AXCM01006947    AAAB01008811    EAA04934.5    GAKP01017482    GAKP01017481    GAKP01017480    GAKP01017476    JAC41471.1    GDHF01016372    GDHF01000429    JAI35942.1    JAI51885.1    AXCN02001284    GAMC01011668    JAB94887.1    GAMC01011670    JAB94885.1    GAKP01017479    GAKP01017478    JAC41474.1    GBXI01010083    JAD04209.1    GAKP01017475    GAKP01017474    JAC41477.1    GFDF01001789    JAV12295.1    GFDF01001790    JAV12294.1    GBXI01010697    GBXI01004913    GBXI01002794    JAD03595.1    JAD09379.1    JAD11498.1    CVRI01000019    CRK90515.1    GBXI01005407    JAD08885.1    CRK90514.1    GBYB01011042    JAG80809.1    Y18197    AE014297    AY058654    OUUW01000005    SPP80092.1    CM000070    EAL26805.1    CH479186    EDW39349.1    CM000160    EDW99104.2   

Proteomes

UP000005204    UP000007151    UP000283053    UP000075809    UP000242457    UP000279307    + More
UP000002358    UP000215335    UP000005205    UP000005203    UP000027135    UP000235965    UP000053825    UP000007266    UP000007755    UP000030742    UP000192223    UP000008237    UP000019118    UP000078540    UP000053105    UP000053097    UP000076502    UP000009046    UP000094527    UP000002320    UP000095301    UP000008820    UP000037069    UP000283509    UP000095300    UP000069272    UP000076407    UP000069940    UP000249989    UP000075920    UP000000673    UP000075883    UP000007062    UP000075885    UP000075880    UP000075886    UP000076408    UP000075900    UP000075884    UP000183832    UP000000803    UP000268350    UP000001819    UP000008744    UP000002282   

PRIDE

H9IYQ9    Q9VA73   

Pfam

PF13833   EF-hand_8        + More
PF00153   Mito_carr
PF00036   EF-hand_1
PF13202   EF-hand_5
PF13405   EF-hand_6
PF18701   DUF5641
PF00059   Lectin_C
PF08969   USP8_dimer
PF01398   JAB

Interpro

IPR018108   Mitochondrial_sb/sol_carrier        + More
IPR023395   Mt_carrier_dom_sf       
IPR002067   Mit_carrier       
IPR011992   EF-hand-dom_pair       
IPR002048   EF_hand_dom       
IPR018247   EF_Hand_1_Ca_BS       
IPR040676   DUF5641       
IPR018378   C-type_lectin_CS       
IPR016187   CTDL_fold       
IPR016186   C-type_lectin-like/link_sf       
IPR001304   C-type_lectin-like       
IPR037518   MPN       
IPR015063   USP8_dimer       
IPR000555   JAMM/MPN+_dom       

SUPFAM

SSF47473   SSF47473        + More
SSF103506   SSF103506       
SSF56436   SSF56436       

Gene 3D

1.50.40.10     3.10.100.10    

CDD

cd00051  EFh

ProteinModelPortal

H9IYQ9   A0A1B4ZD97   A0A2H1VRP5   A0A212EJY7   A0A3S2NCE3   V9I7V9   + More
A0A151XFX4   A0A2A3EEL7   A0A3L8DC71   K7ITU3   A0A232F7R5   A0A158NIU7   A0A087ZSN2   A0A067QIM5   A0A310SGZ1   A0A0C9Q9J2   A0A2J7QIT8   A0A0L7QT27   D6W9D8   F4WHU3   U4UPY1   A0A1W4WCU3   E2C9H0   N6TSH9   A0A1Y1MLH6   A0A195BDX4   A0A1W4WMV5   A0A0M9A7S9   A0A1Y1MLH8   A0A026WKA1   E9IFM1   A0A154PRQ4   A0A0C9QM70   A0A1B6DSW7   A0A1B6EFM0   A0A1B6HDJ3   A0A146LJF4   A0A1B6IG65   A0A1B6GVS6   E0VR32   A0A1D2MAS7   A0A0K8TMB1   B0W7H6   U5ESC9   T1PBJ9   A0A1Q3FF55   A0A1I8N2P2   A0A023EVK9   A0A1Q3FF15   Q176G2   A0A1Q3FF57   A0A0P4W6V6   A0A1I8N2P4   A0A0L0BLG1   A0A3R7NK42   A0A1I8N2N7   D3TP39   W8BND3   A0A1I8NTP5   A0A182FMC0   A0A2M4BGE2   A0A1Y9J165   A0A182GBZ6   A0A2M4CI16   A0A2M3Z1X4   A0A340TBB3   A0A340TBG4   A0A2M4A4Z4   W5JI23   A0A1Y9J169   A0A182MN31   Q7QI16   A0A034VDS4   A0A240PLZ6   A0A182IJC8   A0A0K8WLZ4   A0A182Q3N9   W8B8A9   A0A182Y552   A0A1I8NTM9   W8B1B6   A0A182R9G5   A0A034VG37   A0A0A1WYR7   A0A034VH80   A0A2Y9D1M1   A0A1L8E1C1   A0A1I8NTN6   A0A1I8NTP2   A0A1L8E0V6   A0A0A1XLN7   A0A1J1HRB7   A0A0A1XD50   A0A1J1HSJ6   A0A0C9RD22   Q9VA73   A0A3B0JIF9   Q29C41   B4GNM3   B4PLW7  

PDB

4P5W     E-value=4.99465e-74,     Score=709

KEGG

101739472    K15105 solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 | (Ref

GO

GO:0022857   GO:0016021   GO:0005509   GO:0015810   GO:0015183   GO:0015813   GO:0043490   GO:0005313   GO:0030246   GO:0042802   GO:0042060   GO:0005743   GO:0005739   GO:0006839   GO:0005515   GO:0006508   GO:0008237   GO:0008270   GO:0006511   GO:0005525   GO:0016491   GO:0003824   GO:0055085  

Subcellular location

Mitochondrion inner membrane  

Length:

682

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

7.86101

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00044

outside

1  -  682

 

 

Pi

205.446026

Theta

155.618831

Tajima's D

0.781635

CLR

0.42829

CSRT

0.596670166491675

Interpretation

Uncertain