Gene

KWMTBOMO05320  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002520

Annotation

PREDICTED:_cysteine-type_peptidase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr9(+):13821688-13826699      View in EpiBrowser

Full name

Ubiquitin thioesterase OTU1      

Location in the cell

Cytoplasmic   Reliability : 2.12

CDS

ATGTCTGCATTAGTATTCAAAATTAAAAGTAAAAACGGACAGCAAGTTTTGAAAGATTTGACCTCAGAAAGTACTGTGGGCGAATTGAAGATGTTTTTGTCCAGCATATCCGATATTAGCATTGAAAGAGTTAATATATTATGCGGGTACCCTCCTAAGGCATTAGACACGAGTGATAATAGTAAAACATTGAGTGAATTAGGACTAAAAACTGGTGAAACTTTGATTGTGGAAGAAAAAGCTGTGACCAAGATTAATGCGACGCAAACCGAGACACGACCTTCCCAGAACGGAGTAGAGTCTCATGAAACAATAGAATCATGTCGACCTGGTATATTAATGAAAAAAGTAGTTCCTTCTGATAATTCATGCCTTTTCACTAGCATAGGTTTTGTTTTAAATGGTAGCATAGACACATCAGTACATACATTAATGAGGCAAATAATAGCTATGGAGGTGGCCAGTGACCGCGACACATACAATGAAGCAATGCTTGGCAAACCAAACGCTGAATATTGCGATTGGATACAGCAGCCCAGCTCTTGGGGAGGAGCGATTGAGGTAGCCATTTTATCTCGATTTTACGGTTTAGAAATGGCGGTGGTCGACACTCTAAATGCGATCATCAACAGATTCGGCGAAGATAAGAATTATGGGCAGCGCGTCTTTCTGCTATTTGATGGAGTTCATTACGATCCACTATATTTAGAACAATCCGACGGCGGACTTCAAACGATATTCCCGGCCGAGGATATGGAGGTTTACCGGGAGGCGGAGCAGCTAGCTCACGAAGCGAAATCGTCGAGACAGTTCACTGACCTTAACAAGTTCACGCTGAAATGTATGATCTGTGACAAGTTCCTGACCGGGCAGGCGGAGGCGCAGAAACACGCTAAAGAGACAATGCACACTAACTTCGGGGAGGTCTAG

Protein

MSALVFKIKSKNGQQVLKDLTSESTVGELKMFLSSISDISIERVNILCGYPPKALDTSDNSKTLSELGLKTGETLIVEEKAVTKINATQTETRPSQNGVESHETIESCRPGILMKKVVPSDNSCLFTSIGFVLNGSIDTSVHTLMRQIIAMEVASDRDTYNEAMLGKPNAEYCDWIQQPSSWGGAIEVAILSRFYGLEMAVVDTLNAIINRFGEDKNYGQRVFLLFDGVHYDPLYLEQSDGGLQTIFPAEDMEVYREAEQLAHEAKSSRQFTDLNKFTLKCMICDKFLTGQAEAQKHAKETMHTNFGEV

Description

Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Keywords

Complete proteome   Hydrolase   Metal-binding   Protease   Reference proteome   Thiol protease   Ubl conjugation pathway   Zinc   Zinc-finger  

Feature

chain  Ubiquitin thioesterase OTU1

Uniprot

H9IZ35   A0A2A4K2J1   A0A3S2PCF9   A0A212EJZ1   A0A194QPR7   A0A194QTQ2   + More
A0A1E1W4K5   Q1HPI2   A0A1B6GCP4   A0A1B6JSC0   A0A1Y1N977   A0A067QKW3   D6X4C4   A0A0K8TSL9   A0A1B6CSE9   A0A0J7K2W8   A0A0V0GB56   A0A034WF95   W8C9W7   A0A0A1X606   E9IEG1   A0A154PLE2   A0A0L7RC56   K7IY26   A0A2J7PPB0   A0A232FCZ1   A0A0K8W5F2   A0A1B6MJL6   A0A158NME8   A0A2M4BUT1   E2A3U4   A0A0L0BN06   A0A224XU86   U5EMM2   A0A2M4AY30   A0A182FCJ8   A0A151WPH1   A0A0T6AYU5   A0A195CCK3   F4X5V1   W5JRX7   A0A026WF92   A0A151JVU8   A0A151JLN4   A0A1A9ZMI6   A0A2P8Y408   A0A182R9V3   E2BJM1   A0A182K3I5   A0A1A9VN19   A0A146LL47   A0A182WHY2   A0A310S946   E0V9N4   A0A182P138   A0A069DRP5   A0A182MDR7   A0A084WRQ7   A0A087ZQT1   A0A1B0GH65   D3TNN5   A0A0P4VSJ3   A0A1I8PX27   A0A1A9XIL8   A0A1B0AQD2   A0A182QJR1   Q16HK6   A0A182ULA0   Q7QIP8   A0A182V045   A0A182Y311   A0A182TC00   A0A023ENA4   A0A3B0KFN6   A0A182I6W3   T1PDY1   A0A182IUK4   B6IDQ5   Q9VRJ9   A0A182WWM7   M9PED6   B4KWZ1   A0A1W4WR28   B4QRI0   A0A1A9X0H8   B4HUD3   Q29FC9   B4H1I1   A0A182N831   B3NG90   A0A1W4UTL7   A0A1Q3FD26   A0A1B0DGQ7   B4IWZ7   B4PID9   B3M408   T1DID0   B0XED2   A0A1L8DLZ3  

EC Number

3.4.19.12

Pubmed

19121390    22118469    26354079    28004739    24845553    18362917    + More
19820115    26369729    25348373    24495485    25830018    21282665    20075255    28648823    21347285    20798317    26108605    21719571    20920257    23761445    24508170    30249741    29403074    26823975    20566863    26334808    24438588    20353571    27129103    17510324    12364791    14747013    17210077    25244985    24945155    26483478    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17994087    15632085    17550304   

EMBL

BABH01011011    BABH01011012    NWSH01000234    PCG78148.1    RSAL01000103    RVE47432.1    + More
AGBW02014362    OWR41790.1    KQ458714    KPJ05476.1    KQ461154    KPJ08380.1    GDQN01009185    JAT81869.1    DQ443420    ABF51509.1    GECZ01009574    JAS60195.1    GECU01015525    GECU01005630    JAS92181.1    JAT02077.1    GEZM01011806    GEZM01011805    JAV93430.1    KK853234    KDR09586.1    KQ971410    EEZ97288.1    GDAI01000490    JAI17113.1    GEDC01020842    JAS16456.1    LBMM01015797    KMQ84662.1    GECL01000888    JAP05236.1    GAKP01004751    JAC54201.1    GAMC01001794    JAC04762.1    GBXI01008117    JAD06175.1    GL762591    EFZ21030.1    KQ434960    KZC12676.1    KQ414616    KOC68424.1    NEVH01023278    PNF18182.1    NNAY01000442    OXU28353.1    GDHF01006037    JAI46277.1    GEBQ01003820    JAT36157.1    ADTU01020420    GGFJ01007560    MBW56701.1    GL436500    EFN71888.1    JRES01001708    KNC20664.1    GFTR01004897    JAW11529.1    GANO01000964    JAB58907.1    GGFK01012334    MBW45655.1    KQ982865    KYQ49766.1    LJIG01022586    KRT79783.1    KQ977957    KYM98445.1    GL888742    EGI58191.1    ADMH02000350    ETN66871.1    KK107238    QOIP01000007    EZA54790.1    RLU20071.1    KQ981706    KYN37421.1    KQ979011    KYN26638.1    PYGN01000952    PSN38997.1    GL448604    EFN84079.1    GDHC01011162    JAQ07467.1    KQ769179    OAD52951.1    DS234995    EEB10103.1    GBGD01002284    JAC86605.1    AXCM01010914    ATLV01026176    KE525407    KFB52901.1    AJWK01003997    CCAG010020395    EZ423037    ADD19313.1    GDKW01000485    JAI56110.1    JXJN01001810    AXCN02000914    CH478161    EAT33728.1    AAAB01008807    EAA04284.2    JXUM01115661    GAPW01002721    KQ565904    JAC10877.1    KXJ70549.1    OUUW01000012    SPP87170.1    APCN01003703    KA646148    AFP60777.1    BT050495    AE014296    ACJ13202.1    AGB94131.1    AY069295    AGB94130.1    CH933809    EDW18612.2    CM000363    EDX09291.1    CH480817    EDW50554.1    CH379067    CH479202    EDW30158.1    CH954178    EDV50991.2    GFDL01009653    JAV25392.1    AJVK01060219    CH916366    EDV96303.1    CM000159    EDW93481.2    CH902618    EDV40370.2    GAMD01001946    JAA99644.1    DS232821    EDS25906.1    GFDF01006591    JAV07493.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000007151    UP000053268    UP000053240    + More
UP000027135    UP000007266    UP000036403    UP000076502    UP000053825    UP000002358    UP000235965    UP000215335    UP000005205    UP000000311    UP000037069    UP000069272    UP000075809    UP000078542    UP000007755    UP000000673    UP000053097    UP000279307    UP000078541    UP000078492    UP000092445    UP000245037    UP000075900    UP000008237    UP000075881    UP000078200    UP000075920    UP000009046    UP000075885    UP000075883    UP000030765    UP000005203    UP000092461    UP000092444    UP000095300    UP000092443    UP000092460    UP000075886    UP000008820    UP000075902    UP000007062    UP000075903    UP000076408    UP000075901    UP000069940    UP000249989    UP000268350    UP000075840    UP000095301    UP000075880    UP000000803    UP000076407    UP000009192    UP000192223    UP000000304    UP000091820    UP000001292    UP000001819    UP000008744    UP000075884    UP000008711    UP000192221    UP000092462    UP000001070    UP000002282    UP000007801    UP000002320   

PRIDE

H9IZ35    Q1HPI2    B6IDQ5    Q9VRJ9   

Pfam

PF00789   UBX        + More
PF02338   OTU

Interpro

IPR038765   Papain-like_cys_pep_sf        + More
IPR039138   OTU1       
IPR013087   Znf_C2H2_type       
IPR029071   Ubiquitin-like_domsf       
IPR003323   OTU_dom       
IPR001012   UBX_dom       
IPR000626   Ubiquitin_dom       

SUPFAM

SSF54001   SSF54001        + More
SSF54236   SSF54236       

ProteinModelPortal

H9IZ35   A0A2A4K2J1   A0A3S2PCF9   A0A212EJZ1   A0A194QPR7   A0A194QTQ2   + More
A0A1E1W4K5   Q1HPI2   A0A1B6GCP4   A0A1B6JSC0   A0A1Y1N977   A0A067QKW3   D6X4C4   A0A0K8TSL9   A0A1B6CSE9   A0A0J7K2W8   A0A0V0GB56   A0A034WF95   W8C9W7   A0A0A1X606   E9IEG1   A0A154PLE2   A0A0L7RC56   K7IY26   A0A2J7PPB0   A0A232FCZ1   A0A0K8W5F2   A0A1B6MJL6   A0A158NME8   A0A2M4BUT1   E2A3U4   A0A0L0BN06   A0A224XU86   U5EMM2   A0A2M4AY30   A0A182FCJ8   A0A151WPH1   A0A0T6AYU5   A0A195CCK3   F4X5V1   W5JRX7   A0A026WF92   A0A151JVU8   A0A151JLN4   A0A1A9ZMI6   A0A2P8Y408   A0A182R9V3   E2BJM1   A0A182K3I5   A0A1A9VN19   A0A146LL47   A0A182WHY2   A0A310S946   E0V9N4   A0A182P138   A0A069DRP5   A0A182MDR7   A0A084WRQ7   A0A087ZQT1   A0A1B0GH65   D3TNN5   A0A0P4VSJ3   A0A1I8PX27   A0A1A9XIL8   A0A1B0AQD2   A0A182QJR1   Q16HK6   A0A182ULA0   Q7QIP8   A0A182V045   A0A182Y311   A0A182TC00   A0A023ENA4   A0A3B0KFN6   A0A182I6W3   T1PDY1   A0A182IUK4   B6IDQ5   Q9VRJ9   A0A182WWM7   M9PED6   B4KWZ1   A0A1W4WR28   B4QRI0   A0A1A9X0H8   B4HUD3   Q29FC9   B4H1I1   A0A182N831   B3NG90   A0A1W4UTL7   A0A1Q3FD26   A0A1B0DGQ7   B4IWZ7   B4PID9   B3M408   T1DID0   B0XED2   A0A1L8DLZ3  

PDB

4BOQ     E-value=6.67504e-44,     Score=445

KEGG

733039    K13719 ubiquitin thioesterase OTU1 [EC:3.1.2.-] | (RefSeq) cysteine-type peptidase

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0016579   GO:0004843   GO:1904265   GO:0003676   GO:0030433   GO:0030968   GO:0005829   GO:0046872   GO:0016021   GO:0005515   GO:0006508   GO:0008237   GO:0008270   GO:0006511   GO:0005525   GO:0016491   GO:0003824  

PANTHER

PTHR13312  

Length:

309

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.07075

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01849

outside

1  -  309

 

 

Pi

212.413655

Theta

184.69731

Tajima's D

0.497778

CLR

0.35619

CSRT

0.517174141292935

Interpretation

Uncertain