Silkworm Genome Informatics Database

Gene

KWMTBOMO05319 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002519

Annotation

PREDICTED:_tolloid-like_protein_1_[Bombyx_mori]

Location

Bomo_Chr9(+):13776208-13816410 View in EpiBrowser

Full name

Metalloendopeptidase

Location in the cell

Nuclear Reliability : 3.41

CDS

ATGAATATTCATAGCGCACCTATCGTAAACCGCCATGTCCAATACCGGCTGTGAAACTTCCAAGGTGACATTGCGATCCCGGATTCAGATCTTTATAAAACGGCGACTAGCCCTCCGGTCAAGATCGACAAGTCCTTCCAAGAAGAAGTTGAACGACTGAAGAAGGAGGTTCTGCTCGAAGGTCTACAGGTCGAGGAGGAAGGTCTTCCGGATATATTAAGGAAAAGGACAAAACAGCCCGTCCAACTATCTCAAGACAAGAAGGGTTACAATGACGCGGCACTTATGAGTGAGTCACTACCAGAAGGAGTAGACAAGTCGCTTGTGCTCAAAAACGGCAAGCTACTTCCAGAAGAAATCCTAGATAACAGTACAGAATTTAACGAAACCAAATCCGATGTGCACATTGCAAACAGGTCCAGCGTAGAGAACATTTCCGAATCTGAGAGCCTAGAGCAAGACGGCGTACTGGTTGTAAACATATCTACTGACAACATCCTCAATTTGGACGAACTGTATCCTTTTATTCAAATATCAAATGCCTCAAGGAAACAGGACGAAAAGACAAATAAAATCCAGAGCAACAGCCGAGAAATAACAGGAGATTCAAACAATATACAGTTCAAAGACATACCAGAGAACGTGACGATGGCTCCTGCTCCCACAAATGGTTTTTTATCGAACAGCGACCAAGACGACGAAAAGGAAATCAATAAAACTGAACGGGAATTAAAAGTTAAGAATATTGATTTATTGAAACCCACAGAAAGCTTGCAAAATTTGACTCTCGAGAATCCAGGAAGAAGGAATCGAAGAAGACGCAGACACGGCAATCGAAGAAGACTAAGAAACATAAGTTCGGGCGAAAGGATTTCACCGAATTCACTAAGCGAAGGACGCTCCTTAGACGACCATTTCGCGAGAAAGAAGTTTTTTCGTCACCACAAGAGGCACAGCGGCAGCAAAGAGTACAGGAGCTCGGAAAGGAAACTCGAAGTACCGGAACACGAATTTGAAGATAAGTTCGAAGTGAAACCGCCGCCGAAAAATCTAACGGAATTCGATCCGTTTAAAGACATGGTCTTTCGGGACACCGAAGAAGATTTAATGATGGCCGAAAGTAACCAGTACAATTCCACCGGGCCTAAAAAGCGACACCGCACGATCCGGGCCGCCACAAACCGTAAGGAACGTATCTGGGACAACGGTGTCATTCCTTACGAGATAGATGGAAACTTCAGTGGCGCCCACAAGTCATTATTCAAGCAAGCTATGAGGCATTGGGAGAATTTTACTTGCGTCAAATTTGTCGAAAGGGATCCAGAAGTGCATAAGGATTACATTGTGTTCACGGAACGGCCTTGTGGCTGCTGCTCATTCGTCGGCAAAAGGGGCGCAGGCGCCCAGGCTATATCAATTGGGAAGAACTGCGACAAATTCGGCATCGTGGTTCACGAGCTGGGCCACGTTGTCGGCTTCTGGCACGAGCATACGAGGCCCGACAGGGATAACCACGTGCAGATCATACGGGACAACATCATGCTCGGCCAAGAATACAATTTCAACAAGCTAACAGTTGAAGAAGTAAATTCACTAGGACAAACGTACGATTATGATTCAATAATGCATTACGCACGAAACACGTTCAGTAAAGGATCATTTTTGGACACTATCTTGCCGTTGGAGGTGCACGGAAAGAAACGACCAGAGATCGGGCAGAGAATCAAACTTAGCGCCAGTGACATAGCGCAGACTAATCTATTATATAAATGTGCCAAATGCGGCAGGACATTATTGGGCAACTCTGGGTGGTTCAACTCGCCTGGCTGGGGAACCGAGCCAGCGCCCACAACACCAGAACGTTGCGAGTGGAGGATCGTGGCTACTCACGGAGAAAGGGTCGTGCTCAATATCACTGAAATTGACATTCACAAGTCTGAAGACTGCCGTTCGGAGTGGGTTGAAATACGAGACGGCTATATGCCCGACGCTCCAGTTTTGGGCAGGTTGTGCGGGTCCGGAAAGGGTCCTATGATGAGGTCTACTGGATCAAGACTCACTGTGGTCTATCAACCGGGCTTGAGGCTTAAGCCGCATAGAGGATTCCGAGCATTCTACGAAGCCGTTTGCGGAGGTGATATAGAAGTGGATTCGAATGGACACCTCGAATCGCCGAACTATCCTGACGATTACCAGCCTAACAAACTATGTATCTGGAAACTATCAGTACCACAGGACTACCAAGTTGCTTTGAGGTTCCATTCGTTCGAAGTGGAAAACCACGATACATGCTCCTACGACAAAGTCAAGGTCAGAGACGGCGATTCAATGGACAGTCCACTTATCGGCATGTTCTGTGGACATAAGATACCTCCCGATATAAGGTCCACATCGAACAAGCTTCTGGTGATTTTCGAGTCGGACAGCACAGTCCAGAAAGCTGGTTTTTCAGCCACGTTCATGAAGGAATTCGACGAATGCGCTTCCATCGATCACGGCTGCAGCCACTCCTGCGTGAACACCCTCGGTGGATACGAGTGCGCGTGCGACATCGGATATGAACTCCATTCGGACGGAAAGAAATGTGAAAACGCATGCGGAGGAGCACTCTACGGCCCCAACGGTACGATCACATCACCTTCCTTCCCCGAACTGTATCCTCCGTTGAAGAACTGCCTCTGGGAGATCGTGGCGCCGCCCCAGCATCGCATTACGCTGAACTTCACACATTTCGACTTAGAAGGGAACCATATGTATCAACAGGAATGTGAATATGATAGTGTAACAGTACATTCGAAGCTAGGAGCTGATGTGCTCAGGAGGCACGGAGCGTTTTGTGGGACCGCCTTACCACCACCGGTCACTTCGGATGGATCGGTTTTGAGAGTTCAGTTCACATCAGACGGCTCGGTCCACCGGTCCGGTTTCGCGGCAGTGTACTACATAGACGTGGACGAATGCGCCGAGAACAACGGGGGATGTCAGCACGAGTGCCACAACACGCTGGGAGGATACGAGTGCGCCTGTCACAGCGGCTTCACTTTACATCCGAACAAGCACGACTGCAAGGAAGGCGGATGCAAGCATGACGTTACATTACCCCACGGAACTATTTTCAGTCCGAATTATCCGGCCGCGTACCCAGCAAGGAAAGATTGCGTTTGGCAATTCTCTACGACACCCGGTCATCGAATTAAACTGATCTTCAACGTCTTCGAATTAGAGCCTCACCAAGAATGCGCTTACGACCACGTCACGATCTACGACGGAGCTTCGGCCGACGTAAAAACGCTCGGCATATTCTGCGGCAGTAAGCTCCCGCATCTGGTCATGGCATCTCAGAACCAGATGTACATGGTATTCAAGAGTGACGGCTCTGTGCAGAGAAAGGGATTCTTGGCTACGCATTCTACTGCATGTGGAGGGTATCTCTCTGCGACGGAAGAGGTGAAGCATCTCTATTCTCACGCGCGCTACGGAGACAACGCCTACGAGTCCCGGGCTGATTGCGATTGGAACATCGAAGCTCCACGCAATCACTTCGTTAAGCTCACCTTCCTGACCTTTGAGCTGGAGAGGGAAGCGAACTGCAGATACGACTACGTCCAAGTGTTTGGTGGTTTGGGAGGAAGCGGCGGGAACTATGGAACGTTCTGTGGTATTAAGATGCCACCTGAAATCGTATCAACCTCAGAGGCCTTACTAGTCAGATTCCGTACCGACGATTCCTTGGTCTTCAAAGGCTTTTCGGCATCGTATCAGATGGTAAAACCGACTTGGAGCGACGAAGACAGCTTGGAAGGCGGAGAATATGAGGCTGAGGAGGAGGACGAGCGCATGCCTCCCCTGGTGCTCAAGACTTGA

Protein

MNIHSAPIVNRHVQYRLXNFQGDIAIPDSDLYKTATSPPVKIDKSFQEEVERLKKEVLLEGLQVEEEGLPDILRKRTKQPVQLSQDKKGYNDAALMSESLPEGVDKSLVLKNGKLLPEEILDNSTEFNETKSDVHIANRSSVENISESESLEQDGVLVVNISTDNILNLDELYPFIQISNASRKQDEKTNKIQSNSREITGDSNNIQFKDIPENVTMAPAPTNGFLSNSDQDDEKEINKTERELKVKNIDLLKPTESLQNLTLENPGRRNRRRRRHGNRRRLRNISSGERISPNSLSEGRSLDDHFARKKFFRHHKRHSGSKEYRSSERKLEVPEHEFEDKFEVKPPPKNLTEFDPFKDMVFRDTEEDLMMAESNQYNSTGPKKRHRTIRAATNRKERIWDNGVIPYEIDGNFSGAHKSLFKQAMRHWENFTCVKFVERDPEVHKDYIVFTERPCGCCSFVGKRGAGAQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDNHVQIIRDNIMLGQEYNFNKLTVEEVNSLGQTYDYDSIMHYARNTFSKGSFLDTILPLEVHGKKRPEIGQRIKLSASDIAQTNLLYKCAKCGRTLLGNSGWFNSPGWGTEPAPTTPERCEWRIVATHGERVVLNITEIDIHKSEDCRSEWVEIRDGYMPDAPVLGRLCGSGKGPMMRSTGSRLTVVYQPGLRLKPHRGFRAFYEAVCGGDIEVDSNGHLESPNYPDDYQPNKLCIWKLSVPQDYQVALRFHSFEVENHDTCSYDKVKVRDGDSMDSPLIGMFCGHKIPPDIRSTSNKLLVIFESDSTVQKAGFSATFMKEFDECASIDHGCSHSCVNTLGGYECACDIGYELHSDGKKCENACGGALYGPNGTITSPSFPELYPPLKNCLWEIVAPPQHRITLNFTHFDLEGNHMYQQECEYDSVTVHSKLGADVLRRHGAFCGTALPPPVTSDGSVLRVQFTSDGSVHRSGFAAVYYIDVDECAENNGGCQHECHNTLGGYECACHSGFTLHPNKHDCKEGGCKHDVTLPHGTIFSPNYPAAYPARKDCVWQFSTTPGHRIKLIFNVFELEPHQECAYDHVTIYDGASADVKTLGIFCGSKLPHLVMASQNQMYMVFKSDGSVQRKGFLATHSTACGGYLSATEEVKHLYSHARYGDNAYESRADCDWNIEAPRNHFVKLTFLTFELEREANCRYDYVQVFGGLGGSGGNYGTFCGIKMPPEIVSTSEALLVRFRTDDSLVFKGFSASYQMVKPTWSDEDSLEGGEYEAEEEDERMPPLVLKT

Cofactor

Zn(2+)

Feature

chain Metalloendopeptidase

Uniprot

A0A2A4K265 W5VNE1 A0A3S2LIK7 A0A194QDA0 A0A212EJW7 A0A1Y1L8M6 + More
A0A1W4WLM8 A0A139WL18 U4ULT5 N6T3K5 B4LW38

EC Number

3.4.24.-

Pubmed

26354079 22118469 28004739 18362917 19820115 23537049 + More
17994087

EMBL

NWSH01000234 PCG78149.1 KF670144 AHH80651.1 RSAL01000103 RVE47431.1 + More
KQ459220 KPJ02950.1 AGBW02014362 OWR41789.1 GEZM01062075 JAV70059.1 KQ971326 KYB28517.1 KB632275 ERL91141.1 APGK01053961 KB741239 ENN72173.1 CH940650 EDW66543.1

Proteomes

UP000218220 UP000283053 UP000053268 UP000007151 UP000192223 UP000007266 + More
UP000030742 UP000019118 UP000008792

Pfam

PF07645   EGF_CA        + More
PF00431   CUB
PF01400   Astacin

Interpro

IPR001881   EGF-like_Ca-bd_dom        + More
IPR024079   MetalloPept_cat_dom_sf
IPR000859   CUB_dom
IPR035914   Sperma_CUB_dom_sf
IPR034036   ZnMP_TLD/BMP1
IPR000152   EGF-type_Asp/Asn_hydroxyl_site
IPR015446   BMP_1/tolloid-like
IPR018097   EGF_Ca-bd_CS
IPR001506   Peptidase_M12A
IPR013032   EGF-like_CS
IPR006026   Peptidase_Metallo
IPR000742   EGF-like_dom
IPR009030   Growth_fac_rcpt_cys_sf
IPR013087   Znf_C2H2_type

SUPFAM

SSF49854 SSF49854 + More
SSF57184 SSF57184

Gene 3D

2.60.120.290 3.40.390.10

CDD

cd04281 ZnMc_BMP1_TLD
cd00041 CUB

ProteinModelPortal

A0A2A4K265 W5VNE1 A0A3S2LIK7 A0A194QDA0 A0A212EJW7 A0A1Y1L8M6 + More
A0A1W4WLM8 A0A139WL18 U4ULT5 N6T3K5 B4LW38

PDB

3EDI E-value=1.00401e-83, Score=795

KEGG

101736902 K13046 tolkin [EC:3.4.24.-] | (RefSeq) tolloid-like protein 1

GO

GO:0004222 GO:0008270 GO:0005509 GO:0046872 GO:0003676 GO:0006508 GO:0005515 GO:0008237 GO:0006511 GO:0005525 GO:0016491 GO:0003824

Length:

1287

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00780999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00000

outside

1 - 1287

Pi

255.18082

Theta

162.262867

Tajima's D

1.589796

CLR

0.501889

CSRT

0.806359682015899

Interpretation

Uncertain

Source	Sequence	Identity	Evalue
26280517	HAIPAGFVIK	95.45	2e-09
24402669	HDVKPTIKPASK	95.45	2e-09
24402669	KDAHITIEMANK	100.00	5e-04
26280517	DCTCYNDGQIVKPGGVTESGCIK	100.00	0.002

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics