Gene

KWMTBOMO05318  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002394

Annotation

PREDICTED:_methionine_aminopeptidase_1_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr9(-):13662037-13666827      View in EpiBrowser

Full name

Methionine aminopeptidase      

Location in the cell

Cytoplasmic   Reliability : 2.032

CDS

ATGGCGACGCTTGGAATGTGCGAAACTCCCGGGTGCAAATCAATCGCACAATTACAATGCCCTACTTGTATCAAACTCGGGATTAAAGGCTCGTTCTTTTGTAACCAAGACTGTTTCAAAAAATCGTGGAAGACTCATAAAATAATTCATTCATTAGCGAAAGGTGACAATACCGATGCTGCAAACGTGGAATATAACCCATGGCCGTCGTATACCTTTACGGGAAAGCTGAGACCGTTCCCGGCAGGGCCAAAACGCACTGTGCCGCCTCATATAGGTCGTCCGGATTACGCTGATCATCCGACCGGGTTCCCGGCTTCAGAGTATGCTGCTAAAGGTTCAGCTCAAATCAAGATCCTTGACGATGAAGAGATTGAGGGCATGCGTGTTGCTTGCCGCCTCGGCAGAGAAGTTCTGGATGAAGCAGCTAGAGTGTGTGATGTAGGAGTTAGCACAGATGAGATTGACCGTGTAGTCCACGAGGCTTGCATTGAACGGGAATGTTACCCAAGTCCCCTGAATTATTATAATTTCCCCAACAGTTGTTGTACTTCAATTAATGAGGTTATATGTCATGGAATACCAGATTTACGTCCATTACAGGATGGGGACATATGCAATGTTGATGTAACAGTTTACCATAGAGGTTTCCATGGTGATCTAAATGAAACCTTTTTTGTTGGGAATGTACCAGAGACTACTCGTAAATTAGTTCAGGTCACCCATGAATGCTTACAGAAAGCCATAGATATAGTCCGTCCTGGTGAAAAGTACAGGGAGATTGGCAATGTAATACAGAAACATGCTCAAGCAAATGGATATAGTGTAGTAAGATCTTATTGTGGTCATGGCATACATAGATTGTTTCATACAGCTCCAAATGTACCACATTATGCTAAAAACAAAGCTATTGGTATTATGAAAGTAGGACATTGTTTCACAATAGAACCAATGATCAATGAAGGAGGCTGGCGGGACGAGCAGTGGCCCGATCACTGGACAGCCGTTACCGCTGATGGATCAAGATCTGCACAGTTTGAACAAACCCTTCTAGTAACAGAATCGGGCTGTGACATTTTAACCAAACGTAACACGGGAAGACCCTGGTTCCTTGATCAACTCGAGAAAATTGAAGCGAAGGATAAGTCTTAG

Protein

MATLGMCETPGCKSIAQLQCPTCIKLGIKGSFFCNQDCFKKSWKTHKIIHSLAKGDNTDAANVEYNPWPSYTFTGKLRPFPAGPKRTVPPHIGRPDYADHPTGFPASEYAAKGSAQIKILDDEEIEGMRVACRLGREVLDEAARVCDVGVSTDEIDRVVHEACIERECYPSPLNYYNFPNSCCTSINEVICHGIPDLRPLQDGDICNVDVTVYHRGFHGDLNETFFVGNVPETTRKLVQVTHECLQKAIDIVRPGEKYREIGNVIQKHAQANGYSVVRSYCGHGIHRLFHTAPNVPHYAKNKAIGIMKVGHCFTIEPMINEGGWRDEQWPDHWTAVTADGSRSAQFEQTLLVTESGCDILTKRNTGRPWFLDQLEKIEAKDKS

Description

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

Catalytic Activity

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

Similarity

Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Belongs to the peptidase M24A family.

Uniprot

H9IYR0   A0A2A4K1K6   S4P7N6   A0A2H1VWB4   A0A194QBM5   A0A212EJW8   + More
A0A088AK91   D6X4P7   A0A0L7QQE3   A0A0M8ZVR5   A0A2A3ECH8   A0A1Y1NMM5   A0A0C9RES9   A0A026W4M4   A0A0T6B8S3   F4WU86   A0A158NTW4   A0A195C854   A0A232F417   A0A151JQQ9   K7IR17   E9IH60   E2BLG2   A0A182PTT1   A0A182W2Z1   A0A310SLT2   A0A182JYB7   A0A182WVF8   A0A182R8C9   A0A182I937   A0A182M4K1   R4WK40   A0A182YEU7   A0A182QXY3   A0A154PEU5   A0A182NCK4   A0A2J7RI72   A0A182KXY0   Q7QAH2   A0A182GP12   A0A182VLA5   Q0IFY6   A0A084WR40   E0VK43   A0A182JMZ4   A0A182SEW5   A0A1B6GC21   A0A1B6HYE0   B0WEW3   A0A182TJU8   A0A069DTH1   A0A182F8E1   A0A0A9Y188   A0A0P4VR59   A0A2M4BRK8   R4G8A5   W5JJK1   A0A1Q3FE60   A0A1B6LG69   A0A1B6CLC8   A0A2M4AQQ9   A0A0K8SLU0   A0A224YNV7   A0A131YSJ1   A0A194QSB9   A0A131X9M3   A0A023GJG4   G3MNE0   A0A023FKV8   A0A1B0C8Y0   U4USJ6   A0A1L8E2P3   L7M8Z5   A0A0P5K4P4   A0A1Z5L5F0   A0A0P6ASA1   A0A2R5LM79   A0A0P5G1E8   A0A0P5T2W0   A0A1S3D0B2   A0A336L8V3   A0A1E1X561   A0A0K8RD90   A0A293MTK8   U5EZB0   A0A0C9SCA6   A0A1W4W2P6   E2AWT8   E9GAH7   A0A1A9WC32   B4PV57   A0A067QZU9   B4HH59   T1G1H4   Q9VC48   A0A210R4V1   B3M040   A0A1B0A8U0   T1IS65   A0A034WMP3  

EC Number

3.4.11.18

Pubmed

19121390    23622113    26354079    22118469    18362917    19820115    + More
28004739    24508170    30249741    21719571    21347285    28648823    20075255    21282665    20798317    23691247    25244985    20966253    12364791    14747013    17210077    26483478    17510324    24438588    20566863    26334808    25401762    26823975    27129103    20920257    23761445    28797301    26830274    28049606    22216098    23537049    25576852    28528879    28503490    26131772    21292972    17994087    17550304    24845553    23254933    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28812685    25348373   

EMBL

BABH01010999    NWSH01000234    PCG78151.1    GAIX01004509    JAA88051.1    ODYU01004846    + More
SOQ45141.1    KQ459220    KPJ02948.1    AGBW02014362    OWR41787.1    KQ971380    EEZ97675.1    KQ414792    KOC60741.1    KQ435827    KOX71937.1    KZ288285    PBC29445.1    GEZM01002596    JAV97197.1    GBYB01015104    JAG84871.1    KK107423    QOIP01000009    EZA51002.1    RLU18315.1    LJIG01009113    KRT83730.1    GL888355    EGI62194.1    ADTU01026172    KQ978143    KYM96830.1    NNAY01001082    OXU25210.1    KQ978646    KYN29450.1    GL763174    EFZ20105.1    GL449017    EFN83514.1    KQ761453    OAD57539.1    AXCM01000016    AK417975    BAN21190.1    AXCN02001184    KQ434889    KZC10361.1    NEVH01003505    PNF40531.1    AAAB01008888    EAA08766.5    JXUM01077428    KQ563008    KXJ74647.1    CH477281    EAT44938.1    ATLV01025918    KE525402    KFB52684.1    DS235239    EEB13749.1    GECZ01009782    JAS59987.1    GECU01028022    JAS79684.1    DS231912    EDS25821.1    GBGD01001828    JAC87061.1    GBHO01020334    GDHC01017032    JAG23270.1    JAQ01597.1    GDKW01001567    JAI55028.1    GGFJ01006472    MBW55613.1    ACPB03018778    GAHY01001312    JAA76198.1    ADMH02001252    ETN63473.1    GFDL01009200    JAV25845.1    GEBQ01017413    JAT22564.1    GEDC01023110    JAS14188.1    GGFK01009806    MBW43127.1    GBRD01011512    JAG54312.1    GFPF01004396    MAA15542.1    GEDV01006333    JAP82224.1    KQ461154    KPJ08382.1    GEFH01004287    JAP64294.1    GBBM01001359    JAC34059.1    JO843391    AEO35008.1    GBBK01002688    JAC21794.1    AJWK01001597    KB632345    ERL93075.1    GFDF01001097    JAV12987.1    GACK01004687    JAA60347.1    GDIQ01190970    LRGB01002019    JAK60755.1    KZS09631.1    GFJQ02004470    JAW02500.1    GDIP01025116    JAM78599.1    GGLE01006488    MBY10614.1    GDIQ01250912    JAK00813.1    GDIP01131800    JAL71914.1    UFQS01002356    UFQT01002356    SSX13859.1    SSX33279.1    GFAC01004786    JAT94402.1    GADI01004701    JAA69107.1    GFWV01018711    MAA43439.1    GANO01001119    JAB58752.1    GBZX01001433    JAG91307.1    GL443425    EFN62058.1    GL732537    EFX83524.1    CM000160    EDW98906.1    KK852809    KDR15975.1    CH480815    EDW43535.1    AMQM01002988    KB095959    ESO09558.1    AE014297    AY058368    AAF56327.1    AAL13597.1    NEDP02000449    OWF55934.1    CH902617    EDV41997.2    JH431424    GAKP01002136    GAKP01002135    JAC56816.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000005203    UP000007266    + More
UP000053825    UP000053105    UP000242457    UP000053097    UP000279307    UP000007755    UP000005205    UP000078542    UP000215335    UP000078492    UP000002358    UP000008237    UP000075885    UP000075920    UP000075881    UP000075900    UP000075883    UP000076408    UP000075886    UP000076502    UP000075884    UP000235965    UP000075882    UP000007062    UP000069940    UP000249989    UP000075903    UP000008820    UP000030765    UP000009046    UP000075880    UP000075901    UP000002320    UP000075902    UP000069272    UP000015103    UP000000673    UP000053240    UP000092461    UP000030742    UP000076858    UP000079169    UP000192221    UP000000311    UP000000305    UP000091820    UP000002282    UP000027135    UP000001292    UP000015101    UP000000803    UP000242188    UP000007801    UP000092445   

PRIDE

H9IYR0    Q9VC48   

Pfam

PF00557   Peptidase_M24        + More
PF15801   zf-C6H2
PF04101   Glyco_tran_28_C
PF15745   AP1AR
PF04950   RIBIOP_C
PF08142   AARP2CN

Interpro

IPR031615   Zfn-C6H2        + More
IPR001714   Pept_M24_MAP       
IPR002467   Pept_M24A_MAP1       
IPR000994   Pept_M24       
IPR036005   Creatinase/aminopeptidase-like       
IPR007235   Glyco_trans_28_C       
IPR007034   BMS1_TSR1_C       
IPR037875   Bms1_N       
IPR030387   G_Bms1/Tsr1_dom       
IPR031483   AP1AR       
IPR039761   Bms1/Tsr1       
IPR027417   P-loop_NTPase       
IPR012948   AARP2CN       

SUPFAM

SSF55920   SSF55920        + More
SSF52540   SSF52540       

CDD

cd01086  MetAP1
cd01882  BMS1

ProteinModelPortal

H9IYR0   A0A2A4K1K6   S4P7N6   A0A2H1VWB4   A0A194QBM5   A0A212EJW8   + More
A0A088AK91   D6X4P7   A0A0L7QQE3   A0A0M8ZVR5   A0A2A3ECH8   A0A1Y1NMM5   A0A0C9RES9   A0A026W4M4   A0A0T6B8S3   F4WU86   A0A158NTW4   A0A195C854   A0A232F417   A0A151JQQ9   K7IR17   E9IH60   E2BLG2   A0A182PTT1   A0A182W2Z1   A0A310SLT2   A0A182JYB7   A0A182WVF8   A0A182R8C9   A0A182I937   A0A182M4K1   R4WK40   A0A182YEU7   A0A182QXY3   A0A154PEU5   A0A182NCK4   A0A2J7RI72   A0A182KXY0   Q7QAH2   A0A182GP12   A0A182VLA5   Q0IFY6   A0A084WR40   E0VK43   A0A182JMZ4   A0A182SEW5   A0A1B6GC21   A0A1B6HYE0   B0WEW3   A0A182TJU8   A0A069DTH1   A0A182F8E1   A0A0A9Y188   A0A0P4VR59   A0A2M4BRK8   R4G8A5   W5JJK1   A0A1Q3FE60   A0A1B6LG69   A0A1B6CLC8   A0A2M4AQQ9   A0A0K8SLU0   A0A224YNV7   A0A131YSJ1   A0A194QSB9   A0A131X9M3   A0A023GJG4   G3MNE0   A0A023FKV8   A0A1B0C8Y0   U4USJ6   A0A1L8E2P3   L7M8Z5   A0A0P5K4P4   A0A1Z5L5F0   A0A0P6ASA1   A0A2R5LM79   A0A0P5G1E8   A0A0P5T2W0   A0A1S3D0B2   A0A336L8V3   A0A1E1X561   A0A0K8RD90   A0A293MTK8   U5EZB0   A0A0C9SCA6   A0A1W4W2P6   E2AWT8   E9GAH7   A0A1A9WC32   B4PV57   A0A067QZU9   B4HH59   T1G1H4   Q9VC48   A0A210R4V1   B3M040   A0A1B0A8U0   T1IS65   A0A034WMP3  

PDB

4IU6     E-value=5.42359e-156,     Score=1413

KEGG

101739230    K01265 methionyl aminopeptidase [EC:3.4.11.18] | (RefSeq) methionine aminopeptidase 1

GO

GO:0070084   GO:0046872   GO:0070006   GO:0004177   GO:0008235   GO:0016758   GO:0048203   GO:2000146   GO:0005525   GO:1900025   GO:0034315   GO:0035650   GO:0005829   GO:0005634   GO:0042254   GO:0006508   GO:0000287   GO:0030955   GO:0016579   GO:0006511   GO:0016491   GO:0003824  

PANTHER

PTHR12858  

Length:

383

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00217

Exp number, first 60 AAs:

0.00217

Total prob of N-in:

0.00612

outside

1  -  383

 

 

Pi

304.407119

Theta

216.675805

Tajima's D

1.274865

CLR

0

CSRT

0.733863306834658

Interpretation

Uncertain