Gene

KWMTBOMO05317

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_uncharacterized_protein_LOC100878911_[Megachile_rotundata]

Location

Bomo_Chr9(+):13650358-13651672      View in EpiBrowser

Full name

Fatty acyl-CoA reductase       + More
NAD-dependent protein deacylase      

Alternative Name

Regulatory protein SIR2 homolog

Location in the cell

Mitochondrial   Reliability : 2.17

CDS

ATGACAGGATTCAGGAAGAGGAATCCTGAAATATCTGTTCGCATGTTCCAAAACCTTACTAGATCAAGAGCTGTAATATCCAAGGAGCATTTTAAAGAGGTACAGAGATTCTTGGATCAGACTCAACAAAAATACATCTTACAAGATCTTAGAAGGATCTTTAATACAGATGAAACTGCTTTTATTCTAAATCCGAAGGGTGGTAAGGTTTTAGCAAAAAAGGGGAACGAGAAAGTATATCAGCAAGTCAATCCGGATGAGAAAGAATGCCTATCAGTTCTTGTGACGGGTAGCGCATCTGGTGACCTCCTCCAACAGTTTTGTTTAAGTATAAAATAA

Protein

MTGFRKRNPEISVRMFQNLTRSRAVISKEHFKEVQRFLDQTQQKYILQDLRRIFNTDETAFILNPKGGKVLAKKGNEKVYQQVNPDEKECLSVLVTGSASGDLLQQFCLSIK

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide

Cofactor

Zn(2+)

Similarity

Belongs to the fatty acyl-CoA reductase family.
Belongs to the sirtuin family. Class II subfamily.

Uniprot

A0A224XMA5   A0A1Y1MDI2   H9JJ11   A0A0A9X621   A0A0A9X0L6   A0A0J7KF01   + More
A0A1Y1KC33   A0A336KT24   A0A336L8I1   E9J8S3   A0A3L8E170   A0A1S4EH29   A0A3L8DK92   H9JW02   A0A0J7N979   A0A0A9W8Z7   J9K4C6   J9KY69   A0A0L7K2A4   A0A1B6G7C3   A0A3Q0JHK5   A0A151I654   A0A0L7K8J9   J9JM91   J9M4D1   A0A151J810   J9L8K0   H9JU07   J9KMK9   A0A2G8JN90   K7JEB0   X1X0E1   J9LC60   A0A0J7MZB4   A8E0Z6   J9K1I8   A0A1E1WTE0   A0A1B6MFI3   A0A2S2NKL5   A0A0J7K1X7   A0A182XPH4   X1XJF5   A0A2S2NUN9   J9L927   A0A2S2NH94   K7JEG9   W4YGX8   A0A2H1V3I1   A0A1S4EWX1   A0A0J7K2Z5   J9K668   A0A1Y1LYQ2   A0A1Y1LYU9   A0A1W7R625   A0A0P6IZY2   A0A2H1WY43   X1X791   X1WKJ5   A0A0L7L4B7   A0A182RZX0   X1WWX4   K7JP93   W4XWS8   A0A2S2NI89   A0A146NU82   A0A0N0PCP7   A0A2G8L1I0   A0A232EES1   X1XIJ7   A0A182PX43   A0A1B0DJ12   X1X3T4   K7JYS7   A0A2G8KHW0   A0A2C9KVQ1   A0A1X7SJH2   A0A2C9LKU7   K7JIQ4   J9JNH9   K7JHX5   J9LHM9   A0A1J1IVU2   A0A151J1R0   A0A2C9LK08   J9L1T1   A0A0C9Q4V7   A0A336MFM0   K7JGS0   A0A2C9KFK5   A0A2C9LW81   A0A1Y1K439   A0A2S2R564   A0A182I8H3  

EC Number

1.2.1.84
3.5.1.-

Pubmed

28004739    19121390    25401762    21282665    30249741    26227816    + More
29023486    20075255    17510324    26999592    26354079    28648823    15562597   

EMBL

GFTR01007287    JAW09139.1    GEZM01036846    JAV82375.1    BABH01023137    GBHO01029341    + More
JAG14263.1    GBHO01029337    JAG14267.1    LBMM01008491    KMQ88832.1    GEZM01087011    JAV58914.1    UFQS01000884    UFQT01000884    SSX07497.1    SSX27837.1    UFQS01002482    UFQT01002482    SSX14138.1    SSX33554.1    GL769049    EFZ10780.1    QOIP01000001    RLU26272.1    QOIP01000007    RLU20864.1    BABH01036510    LBMM01008012    KMQ89220.1    GBHO01039345    JAG04259.1    ABLF02013955    ABLF02007555    JTDY01015613    KOB51941.1    GECZ01011460    JAS58309.1    KQ978511    KYM93390.1    JTDY01010230    KOB59708.1    ABLF02017693    ABLF02017444    KQ979615    KYN20115.1    ABLF02006580    BABH01003862    ABLF02007625    ABLF02020143    MRZV01001531    PIK37236.1    AAZX01000647    AAZX01004403    AAZX01010750    AAZX01017323    ABLF02061385    ABLF02023847    LBMM01013145    KMQ85800.1    AM850132    CAO98966.1    ABLF02038792    GDQN01000745    JAT90309.1    GEBQ01005260    JAT34717.1    GGMR01005058    MBY17677.1    LBMM01016829    KMQ84299.1    ABLF02038785    GGMR01008133    MBY20752.1    ABLF02039566    GGMR01003952    MBY16571.1    AAZX01007240    AAZX01008809    AAZX01008867    AAZX01017227    AAZX01018662    AAZX01023390    AAZX01023918    AAZX01026511    AAGJ04065074    AAGJ04065075    ODYU01000509    SOQ35403.1    LBMM01015444    KMQ84803.1    ABLF02017438    ABLF02017439    GEZM01043830    JAV78744.1    GEZM01043833    JAV78742.1    GEHC01001021    JAV46624.1    GDUN01000556    JAN95363.1    ODYU01011524    SOQ57304.1    ABLF02064650    ABLF02025656    ABLF02025658    JTDY01003103    KOB70151.1    ABLF02017764    AAZX01014012    AAGJ04120197    GGMR01004250    MBY16869.1    GCES01151013    JAQ35309.1    KQ460474    KPJ14372.1    MRZV01000262    PIK54124.1    NNAY01005248    OXU16828.1    ABLF02016564    AJVK01063592    ABLF02004347    AAZX01009120    MRZV01000572    PIK47582.1    AAZX01014011    ABLF02024890    AAZX01012377    ABLF02010575    CVRI01000058    CRL02657.1    KQ980507    KYN15781.1    ABLF02017442    ABLF02017446    GBYB01009113    JAG78880.1    UFQS01000961    UFQS01001389    UFQT01000961    UFQT01001389    SSX07977.1    SSX10646.1    SSX28211.1    GEZM01095923    GEZM01095922    JAV55258.1    GGMS01015966    MBY85169.1    APCN01007703   

Proteomes

UP000005204    UP000036403    UP000279307    UP000079169    UP000007819    UP000037510    + More
UP000078542    UP000078492    UP000230750    UP000002358    UP000076407    UP000007110    UP000075900    UP000053240    UP000215335    UP000075885    UP000092462    UP000076420    UP000007879    UP000183832    UP000075840   

PRIDE

H9JJ11    H9JW02    H9JU07   

Pfam

PF03184   DDE_1        + More
PF03221   HTH_Tnp_Tc5
PF05225   HTH_psq
PF03564   DUF1759
PF15251   DUF4588
PF17921   Integrase_H2C2
PF18701   DUF5641
PF00665   rve
PF16012   DUF4780
PF03015   Sterile
PF07993   NAD_binding_4
PF02146   SIR2
PF00628   PHD

Interpro

IPR009057   Homeobox-like_sf        + More
IPR007889   HTH_Psq       
IPR006600   HTH_CenpB_DNA-bd_dom       
IPR004875   DDE_SF_endonuclease_dom       
IPR005312   DUF1759       
IPR013083   Znf_RING/FYVE/PHD       
IPR001965   Znf_PHD       
IPR011011   Znf_FYVE_PHD       
IPR019786   Zinc_finger_PHD-type_CS       
IPR019787   Znf_PHD-finger       
IPR029196   DUF4588       
IPR036397   RNaseH_sf       
IPR041588   Integrase_H2C2       
IPR040676   DUF5641       
IPR012337   RNaseH-like_sf       
IPR001584   Integrase_cat-core       
IPR031961   DUF4780       
IPR026055   FAR       
IPR033640   FAR_C       
IPR013120   Male_sterile_NAD-bd       
IPR036291   NAD(P)-bd_dom_sf       
IPR002219   PE/DAG-bd       
IPR029035   DHS-like_NAD/FAD-binding_dom       
IPR026590   Ssirtuin_cat_dom       
IPR026587   Sirtuin_class_II       
IPR026591   Sirtuin_cat_small_dom_sf       
IPR003000   Sirtuin       

SUPFAM

SSF46689   SSF46689        + More
SSF57903   SSF57903       
SSF53098   SSF53098       
SSF51735   SSF51735       
SSF52467   SSF52467       

Gene 3D

3.30.40.10     3.30.420.10     3.30.1600.10    

CDD

cd09071  FAR_C

ProteinModelPortal

A0A224XMA5   A0A1Y1MDI2   H9JJ11   A0A0A9X621   A0A0A9X0L6   A0A0J7KF01   + More
A0A1Y1KC33   A0A336KT24   A0A336L8I1   E9J8S3   A0A3L8E170   A0A1S4EH29   A0A3L8DK92   H9JW02   A0A0J7N979   A0A0A9W8Z7   J9K4C6   J9KY69   A0A0L7K2A4   A0A1B6G7C3   A0A3Q0JHK5   A0A151I654   A0A0L7K8J9   J9JM91   J9M4D1   A0A151J810   J9L8K0   H9JU07   J9KMK9   A0A2G8JN90   K7JEB0   X1X0E1   J9LC60   A0A0J7MZB4   A8E0Z6   J9K1I8   A0A1E1WTE0   A0A1B6MFI3   A0A2S2NKL5   A0A0J7K1X7   A0A182XPH4   X1XJF5   A0A2S2NUN9   J9L927   A0A2S2NH94   K7JEG9   W4YGX8   A0A2H1V3I1   A0A1S4EWX1   A0A0J7K2Z5   J9K668   A0A1Y1LYQ2   A0A1Y1LYU9   A0A1W7R625   A0A0P6IZY2   A0A2H1WY43   X1X791   X1WKJ5   A0A0L7L4B7   A0A182RZX0   X1WWX4   K7JP93   W4XWS8   A0A2S2NI89   A0A146NU82   A0A0N0PCP7   A0A2G8L1I0   A0A232EES1   X1XIJ7   A0A182PX43   A0A1B0DJ12   X1X3T4   K7JYS7   A0A2G8KHW0   A0A2C9KVQ1   A0A1X7SJH2   A0A2C9LKU7   K7JIQ4   J9JNH9   K7JHX5   J9LHM9   A0A1J1IVU2   A0A151J1R0   A0A2C9LK08   J9L1T1   A0A0C9Q4V7   A0A336MFM0   K7JGS0   A0A2C9KFK5   A0A2C9LW81   A0A1Y1K439   A0A2S2R564   A0A182I8H3  

KEGG

NA   

GO

GO:0003677   GO:0003676   GO:0005634   GO:0016021   GO:0046872   GO:0015074   GO:0102965   GO:0080019   GO:0006629   GO:0035556   GO:0070403   GO:0008270   GO:0006471   GO:0034979   GO:0005759  

PANTHER

PTHR11011  

Subcellular location

Nucleus  
Mitochondrion matrix  

Length:

112

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00365

Exp number, first 60 AAs:

0

Total prob of N-in:

0.38267

outside

1  -  112

 

 

Pi

330.496342

Theta

214.040512

Tajima's D

1.762546

CLR

0.336573

CSRT

0.844207789610519

Interpretation

Uncertain