Silkworm Genome Informatics Database

Gene

KWMTBOMO05301

Pre Gene Modal

BGIBMGA002400

Annotation

PREDICTED:_calcium-activated_potassium_channel_slowpoke_[Bombyx_mori]

Location

Bomo_Chr9(-):13337439-13412887 View in EpiBrowser

Full name

Calcium-activated potassium channel slowpoke

Alternative Name

BK channel
Maxi K channel

Location in the cell

PlasmaMembrane Reliability : 3.358

CDS

ATGGTCTACTTTTTTATACGATTTATAGCGGCTAGTGACAAACTATGGTTCATGCTCGAGATGTATTCGTTTGTAGATTATTTCACGATACCCCCATCATTTGTATCGATATACTTGGACAGAACGTGGATAGGTCTGAGATTTCTCAGGGCTCTGCGTTTAATGACCGTGCCTGATATTTTGCAATACCTCAATATATTAAAAACGTCAAGCTCAATCCGCTTAGCGCAATTAGTTTCTATATTTATATCAGTGTGGTTAACAGCCGCCGGTATTATTCATTTGCTGGAAAACTCAGGGGATCCGTTGGAATTCGCTAACTCACAGAAGCTCTCATACTGGACATGCGTGTATTTCCTTATAGTGACGATGTCCACAGTAGGTTACGGTGATGTGTTCTGTCACACTGTACTAGGCAGAACCTTTTTGGTATTTTTTCTCCTCGTTGGTTTGGCGATATTTGCCAGTTGTATCCCAGAGATAATTGACTTAATCGGCACTAGACCCAAGTACGGCGGCACCCTCAAGAATGAGCGGGGACGCAGGCACATTGTTGTATGTGGCCATATAACATACGAATCAGTGAGTCATTTTTTAAAAGACTTCCTACACGAAGATCGAGAGGATGTGGATGTTGAGGTGGTTTTTTTACACAGGAAACCGCCCGACCTGGAGCTCGAAGGCCTGTTCAAGAGACACTTTACCACTGTGGAATTCTTTCAAGGCACCATTATGAATCCAATCGACCTGCAAAGGGTAAAAGTCCATGAAGCAGATGCTTGTCTGGTGCTAGCCAACAAATACTGCCAGGATCCGGACGCTGAGGACGCAGCCAATATCATGAGGGTCATCTCTATCAAGAACTACTCCGACGATATCAGGGTCATCATACAGCTCATGCAGTACCATAATAAGGCCTATCTGTTAAACATTCCATCATGGGATTGGAAGCAAGGAGACGACGTGATTTGCTTGGCGGAACTTAAACTCGGCTTCATCGCCCAGAGCTGCCTTGCGCCTGGCTTCTCGACCATGATGGCTAACCTCTTCGCCATGCGGAGCTTCAAGACGTCCCAAGACATGGCTATATGGACTAATGACTACATGCGAGGTACCGGGATGGAGATGTACACAGAGACCCTTAGTCCTACGTTTATCGGGATGCCTTTCATTGAAGCAGCCGAGTTATGCTTTACGAAACTCAAGCTTCTTCTATTAGCAATAGAGATCAAGGGAGAAGAGGGAGCCGATAGCAAAATATCGATAAACCCTCGCAACGCGAAAATCCATGCCAATACCCAAGGGTTCTTCATAGCACAGTCGGCTGATGAAGTCAAAAGAGCGTGGTTTTATTGTAAGGCCTGCCACGAGGACATCAAAGACGAAACACTCATCAAGAAGTGCAAATGCAAAAACTATGTCGGAATGATGATGATGCAGACTGGGATGGTGAAACAAAGTCTTAATACGTACCGTGCTCTCGATGATGATCACCATCCTCCCCCCACCTTCACGCCGCCAGAGTTGCCCAAGAAGGTCCATGTTCGAGGCGAAATCGCCCGCGAAAGGGGGGAAGATACAAACTTAATAAATCGCAACCATCGGAACGCGCCGACGGCGATGCTGTCTCCAATGGCGAACCAGCTGGTGAACACGACGACGACTCGGCAAGTCAACAAAGTAAAGCCGAACGTCAATCGAGTACCGCCCGATACGAATCCTCAAGATCAAGACACGAATTACCAGGCCTATCACCTTGCCTACGAAGTGAAAAAGCTCATGCCTACTAGCAGAAGCAGTGGGGGTAATCAGAACAGCAATGGAGTTAGTCTGCCTGCTGGATTGGCAGACGACCAGTCGAAAGACTTCGACTTTGAAAAGACTGAAATGAAATACGACTCAACAGGCATGTTCCATTGGAGCCCTGCCAGGAATCTTGAAGATTGTATATTAGACAGAAACCAAGCGGCTATGACGGTTCTAAATGGTCACGTTGTCGTGTGTCTATTCGCGGATCCAGACTCGCCACTGATCGGCTTGAGGAATCTCGTGATGCCGCTAAGAGCCTCCAATTTCCACTACCACGAGTTGAAACACGTGGTTATCGTAGGAAGCGTCGACTACATACGAAGAGAATGGAAAATGTTGCAGAATCTTCCGAAGATATCTGTATTGAATGGTTCACCGCTAAGCCGGGCCGACTTGCGTGCAGTAAACGTGAACCTATGCGACATGTGCTGTATCCTGTCAGCGAAGGTGCCATCGAACGATGACCCTACACTGGCGGACAAGGAAGCTATCTTGGCTTCGTTGAACATCAAGGCGATGACGTTCGACGACACGATAGGAGTGCTCAGCGCCGGCGCGGGGGCCAACGGCAGCAACGCGCAGCCGCTGCCGGGCCAGCCCCCCGCGCCCGTGCTGCTACAGAGGAGGGGATCCGTATACGGTGCTAATGTACCTATGATTACAGAGCTGGTGAACGATAGCAACGTGCAGTTCTTAGACCAGGACGACGACGACGACCCCGACACGGAGCTGTACTTGACGCAACCGTTTGCCTGCGGCACTGCGTTTGCCGTCAGCGTACTCGACTCTCTCATGTCCACTACGTACTTCAACCAAAACGCGTTGACACTGATCCGTTCGCTGATAACGGGCGGCGCGACCCCCGAGCTGGAGCTGATCCTCGCCGAAGGTGCCGGGCTCCGCGGCGGGTACTCCACGCCCGAGAGTCTGGCCAACAGGTCTCCGCACTACTCACTAAACAAATACCAAACTCGATGA

Protein

MVYFFIRFIAASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGLRFLRALRLMTVPDILQYLNILKTSSSIRLAQLVSIFISVWLTAAGIIHLLENSGDPLEFANSQKLSYWTCVYFLIVTMSTVGYGDVFCHTVLGRTFLVFFLLVGLAIFASCIPEIIDLIGTRPKYGGTLKNERGRRHIVVCGHITYESVSHFLKDFLHEDREDVDVEVVFLHRKPPDLELEGLFKRHFTTVEFFQGTIMNPIDLQRVKVHEADACLVLANKYCQDPDAEDAANIMRVISIKNYSDDIRVIIQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSQDMAIWTNDYMRGTGMEMYTETLSPTFIGMPFIEAAELCFTKLKLLLLAIEIKGEEGADSKISINPRNAKIHANTQGFFIAQSADEVKRAWFYCKACHEDIKDETLIKKCKCKNYVGMMMMQTGMVKQSLNTYRALDDDHHPPPTFTPPELPKKVHVRGEIARERGEDTNLINRNHRNAPTAMLSPMANQLVNTTTTRQVNKVKPNVNRVPPDTNPQDQDTNYQAYHLAYEVKKLMPTSRSSGGNQNSNGVSLPAGLADDQSKDFDFEKTEMKYDSTGMFHWSPARNLEDCILDRNQAAMTVLNGHVVVCLFADPDSPLIGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNGSPLSRADLRAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASLNIKAMTFDDTIGVLSAGAGANGSNAQPLPGQPPAPVLLQRRGSVYGANVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTPESLANRSPHYSLNKYQTR

Description

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Kinetics are determined by alternative splicing, phosphorylation status and its combination interaction with Slob and 14-3-3-zeta. While the interaction with Slob1 alone increases its activity, its interaction with both Slob1 and 14-3-3-zeta decreases its activity.

Subunit

Homotetramer; which constitutes the calcium-activated potassium channel (By similarity). Interacts with Slip1. Interacts with Slob, and, indirectly with 14-3-3-zeta via its interaction with Slob. Interacts with Pka-C1 and Src kinases, which can bind simultaneously to it.

Similarity

Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.

Keywords

Alternative splicing Calcium Complete proteome Ion channel Ion transport Membrane Phosphoprotein Potassium Potassium channel Potassium transport Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel

Feature

chain Calcium-activated potassium channel slowpoke
splice variant In isoform 6, isoform B and isoform C.

Uniprot

A0A3S2L4Y1 A0A2A4J791 A0A1I8NVX3 Q4VS08 A0A1I8NVV0 A0A1I8NVY2 + More
A0A1I8NVW4 A0A0R3NEJ5 A0A1W4VQ27 A0A0Q9X5Q4 A0A1W4W270 A0A0K8V1I6 A0A1W4W2R8 A0A2J7Q2E0 A0A0Q9X757 A0A146M5Z5 A0A1W4VPS9 A0A1I8NVW5 A0A1I8NVY4 A0A1I8NVX6 A0A1I8NVX4 A0A1W4VQ34 A0A034VBF9 A0A0Q9WZL0 A0A151WZ87 B4JEJ3 A0A1I8NVV9 A0A1L8DEY2 A0A0R3NEL9 A0A034VC34 A0A1B6JC67 A0A1I8NCH7 A0A1B6J7W9 A0A0R1E5N0 A0A1Q3EUQ3 A0A0Q9WXN9 A0A1W4W250 Q03720-2 A0A1W4W1B4 A0A1I8NVU4 A0A1W4W2S7 A0A0R3NK01 A0A0R1E5Q1 B3M043 Q03720-3 I5AMY0 D6X3R4 A0A1W4W2T4 A0A0Q9WZM6 A0A1I8NVW2 A0A1I8NVV6 A0A1W4VQ22 B4K514 A0A1W4W1B9 A0A0Q9WXN5 A0A0R1EAG5 A0A0R3NKF6 A0A195F4I3 A0A1I8NVW6 A0A1W4W274 A0A0Q9WPI2 A0A1I8NVW0 A0A1W4VPT4 A0A0Q9WYF8 A0A0Q9WXS2 A0A0R3NF49 Q03720-4 A0A1I8NVX8 A0A1I8NCH2 A0A1I8NVU8 B4LW34 A0A1I8NCG3 A0A1W4VQ40 A0A1I8NCG2 A0A0R3NK40 A0A0P5ESN0 A0A0Q9X9R3 A0A1I8NVY5 A0A1J1HU24 A0A0N8P1C0 A0A0P8YDD8 A0A0R3NIX5 Q03720-16 A0A1W4W2U8 A0A0R1EB14 A0A0P8XXN1 A0A1I8NCH0 A0A0P8XXU9 A0A0Q9WTD6 A0A1W4VPS4 A0A0R3NK22 A0A0Q9X1Q9 A0A0Q9WXL9 B4PVR0 A0A1W4VQ48 A0A0B4KHT2 A0A0R1E5P6 A0A3B0JLT8 A0A0R1E5R2 A0A0Q9WDW2

Pubmed

16244175 15632085 17994087 26823975 25348373 25315136 + More
17550304 1857984 1497890 10731132 12537572 12537569 8774450 7666207 9502797 9539129 10234050 10230800 11274367 12019304 18362917 19820115 12537568 12537573 12537574 16110336 17569856 17569867

EMBL

RSAL01000148 RVE45825.1 NWSH01002925 PCG67283.1 AY644784 AAT44358.1 + More
CM000070 KRS99607.1 CH933806 KRG00756.1 GDHF01019849 JAI32465.1 NEVH01019371 PNF22750.1 KRG00770.1 GDHC01004432 JAQ14197.1 GAKP01019842 JAC39110.1 KRG00761.1 KQ982649 KYQ53198.1 CH916369 EDV93124.1 GFDF01009086 JAV04998.1 KRS99617.1 GAKP01019839 JAC39113.1 GECU01011143 JAS96563.1 GECU01012448 JAS95258.1 CM000160 KRK04534.1 GFDL01016010 JAV19035.1 KRG00784.1 M69053 M96840 AE014297 BT004876 U40315 KRS99604.1 KRK04520.1 CH902617 EDV42000.2 EIM52315.2 KQ971377 EEZ97457.2 KRG00777.1 EDW13985.2 KRG00774.1 KRK04545.1 KRS99618.1 KQ981805 KYN35490.1 CH940650 KRF82788.1 KRG00757.1 KRG00779.1 KRS99625.1 EDW66539.2 KRS99628.1 GDIQ01265070 JAJ86654.1 KRG00776.1 CVRI01000021 CRK91501.1 KPU79500.1 KPU79497.1 KRS99614.1 KRK04522.1 KPU79493.1 KPU79482.1 CH964232 KRF99477.1 KRS99620.1 KRF99475.1 KRG00783.1 EDW98909.2 AGB96304.1 KRK04528.1 OUUW01000005 SPP81292.1 KRK04540.1 KRF82793.1

Proteomes

UP000283053 UP000218220 UP000095300 UP000001819 UP000192221 UP000009192 + More
UP000235965 UP000075809 UP000001070 UP000095301 UP000002282 UP000000803 UP000007801 UP000007266 UP000078541 UP000008792 UP000183832 UP000007798 UP000268350

PRIDE

Q03720

Pfam

PF00520   Ion_trans        + More
PF03493   BK_channel_a
PF07885   Ion_trans_2

Interpro

IPR036291   NAD(P)-bd_dom_sf        + More
IPR027359   Volt_channel_dom_sf
IPR003929   K_chnl_BK_asu
IPR005821   Ion_trans_dom
IPR024939   Ca-act_K_channel_Slo-1
IPR013099   K_chnl_dom

SUPFAM

SSF51735 SSF51735

Gene 3D

1.20.120.350

ProteinModelPortal

A0A3S2L4Y1 A0A2A4J791 A0A1I8NVX3 Q4VS08 A0A1I8NVV0 A0A1I8NVY2 + More
A0A1I8NVW4 A0A0R3NEJ5 A0A1W4VQ27 A0A0Q9X5Q4 A0A1W4W270 A0A0K8V1I6 A0A1W4W2R8 A0A2J7Q2E0 A0A0Q9X757 A0A146M5Z5 A0A1W4VPS9 A0A1I8NVW5 A0A1I8NVY4 A0A1I8NVX6 A0A1I8NVX4 A0A1W4VQ34 A0A034VBF9 A0A0Q9WZL0 A0A151WZ87 B4JEJ3 A0A1I8NVV9 A0A1L8DEY2 A0A0R3NEL9 A0A034VC34 A0A1B6JC67 A0A1I8NCH7 A0A1B6J7W9 A0A0R1E5N0 A0A1Q3EUQ3 A0A0Q9WXN9 A0A1W4W250 Q03720-2 A0A1W4W1B4 A0A1I8NVU4 A0A1W4W2S7 A0A0R3NK01 A0A0R1E5Q1 B3M043 Q03720-3 I5AMY0 D6X3R4 A0A1W4W2T4 A0A0Q9WZM6 A0A1I8NVW2 A0A1I8NVV6 A0A1W4VQ22 B4K514 A0A1W4W1B9 A0A0Q9WXN5 A0A0R1EAG5 A0A0R3NKF6 A0A195F4I3 A0A1I8NVW6 A0A1W4W274 A0A0Q9WPI2 A0A1I8NVW0 A0A1W4VPT4 A0A0Q9WYF8 A0A0Q9WXS2 A0A0R3NF49 Q03720-4 A0A1I8NVX8 A0A1I8NCH2 A0A1I8NVU8 B4LW34 A0A1I8NCG3 A0A1W4VQ40 A0A1I8NCG2 A0A0R3NK40 A0A0P5ESN0 A0A0Q9X9R3 A0A1I8NVY5 A0A1J1HU24 A0A0N8P1C0 A0A0P8YDD8 A0A0R3NIX5 Q03720-16 A0A1W4W2U8 A0A0R1EB14 A0A0P8XXN1 A0A1I8NCH0 A0A0P8XXU9 A0A0Q9WTD6 A0A1W4VPS4 A0A0R3NK22 A0A0Q9X1Q9 A0A0Q9WXL9 B4PVR0 A0A1W4VQ48 A0A0B4KHT2 A0A0R1E5P6 A0A3B0JLT8 A0A0R1E5R2 A0A0Q9WDW2

PDB

5TJI E-value=0, Score=1762

KEGG

101738409 K04936 potassium large conductance calcium-activated channel subfamily M alpha member 1 | (RefSeq) c

GO

GO:0016021 GO:0005249 GO:0060072 GO:0008076 GO:0045433 GO:0043005 GO:0015269 GO:0005886 GO:0006813 GO:0043025 GO:0042493 GO:0016020 GO:0008582 GO:1900074 GO:0048512 GO:0007623 GO:0034765 GO:0000287 GO:0030955 GO:0016579 GO:0006511 GO:0005525 GO:0016491 GO:0003824

PANTHER

PTHR10027:SF28

Subcellular location

Membrane

Length:

928

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

83.6358200000003

Exp number, first 60 AAs:

19.05992

Total prob of N-in:

0.16687

POSSIBLE N-term signal

sequence

outside

1 - 14

TMhelix

15 - 37

inside

38 - 77

TMhelix

78 - 96

outside

97 - 110

TMhelix

111 - 133

inside

134 - 139

TMhelix

140 - 162

outside

163 - 928

Pi

265.52197

Theta

187.839653

Tajima's D

1.209871

CLR

0.404745

CSRT

0.72046397680116

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics