Gene

KWMTBOMO05283

Pre Gene Modal

BGIBMGA002404

Annotation

PREDICTED:_cytosolic_carboxypeptidase-like_protein_5_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr9(-):12679629-12684643      View in EpiBrowser

Full name

Cytosolic carboxypeptidase-like protein 5      

Alternative Name

ATP/GTP-binding protein-like 5

Location in the cell

Cytoplasmic   Reliability : 1.011 Nuclear   Reliability : 1.212

CDS

ATGGATCAAAATAACATTATAGAATGTGGAGGATTTTATTTTATACATAATTTTGATTCTGGGAATCTGGGACATGTCGAAAGAGTACCGACAGAGCTTATAGCTCCTGGCATAAATCATAAAACAAATGCACCTGAAACACCAGACTATGAATTTAATATATGGACGCGTCCAGATTGTGCTGGTACCGAATTTGAGAATGGAAACCGAACCTGGTTCTACTTTGGTGTTCAAGCAACAGAGCAAAATGTTCTCGTGCGGTTAAACTTGGTAAACTTAAACAAACAAGGAAAGATGTACAATCAAGGTATGGCTCCAGTTACCAGAACCCTACCAGGCAAACCACAGTGGGAGAGGATCAGAGATAGACCCGTGCATTCGACCGACGACAACACATTCATGTTAAGTTTCAAATACAGAACGGCAGATAATTTGAAAGCAACGACATTCTTTGCCTTCACATATCCGTTCTCTTTTGCCGAACTACAGATAGCTTTGAACTCGATCGACCTAAAAATGCTACCTCTACCGCCCCCTCAGTCACCAGACGACATATACTACTATAGAGAATGTCTCATACATTCACTAGAAGGTAGGCGGGTGGATCTGCTAACTGTATCATCATACCACGGTATATCAACTGACAGGGAAGAAAAACTAACGAACCTCTTTCCGGAAAACCAAGAGAGGCCATTCAAGTTTCCTAATAAAAAGGTAGTGTTCATATCGGCGCGGGTACATCCAGGCGAGACGCCGTCCAGCTTCGTGTTCAATGGGTTTTTGAACCTACTCCTCACGAGGAACGATCCGGTCGCGATACAGTTGCGGAAACTATACGTCTTCAAGATGATACCGTTTCTGAATCCTGACGGAGTCGCCCGGGGCCACTACAGGACCGACACGAGGGGCGTTAATCTCAACAGAGTTTATTTAAATCCATCTCTGAGTTACCATCCAACGGTCTACGCTTCGAGGGCCTTGATAAGATATTATCACTTTGGTTGTGAAAAAGAAGACAGTTTCGAGGAGGGAAATCTATCCATGCGCAGCATCCAGAATGTCAACGAGACAAGCGAGACTTAG

Protein

MDQNNIIECGGFYFIHNFDSGNLGHVERVPTELIAPGINHKTNAPETPDYEFNIWTRPDCAGTEFENGNRTWFYFGVQATEQNVLVRLNLVNLNKQGKMYNQGMAPVTRTLPGKPQWERIRDRPVHSTDDNTFMLSFKYRTADNLKATTFFAFTYPFSFAELQIALNSIDLKMLPLPPPQSPDDIYYYRECLIHSLEGRRVDLLTVSSYHGISTDREEKLTNLFPENQERPFKFPNKKVVFISARVHPGETPSSFVFNGFLNLLLTRNDPVAIQLRKLYVFKMIPFLNPDGVARGHYRTDTRGVNLNRVYLNPSLSYHPTVYASRALIRYYHFGCEKEDSFEEGNLSMRSIQNVNETSET

Description

Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M14 family.

Keywords

Alternative splicing   Carboxypeptidase   Complete proteome   Cytoplasm   Cytoskeleton   Disease mutation   Hydrolase   Metal-binding   Metalloprotease   Nucleus   Phosphoprotein   Polymorphism   Protease   Reference proteome   Retinitis pigmentosa   Zinc  

Feature

chain  Cytosolic carboxypeptidase-like protein 5
splice variant  In isoform 3.
sequence variant  In RP75; unknown pathological significance.

Uniprot

H9IYS0   A0A2H1WAK5   A0A212F1E3   A0A194QD67   A0A1E1W5B5   A0A0N1PJ56   + More
D7EIR9   A0A0T6BCC1   A0A1Y1L9Z6   A0A1Y1L9X3   A0A2P8Z4J6   A0A1Y1L9V7   A0A1Y1LEP4   A0A1Y1LHF1   A0A1Y1L9X4   A0A1B6G9L3   A0A1B6IIP5   A0A1B6I206   A0A1B6KY10   A0A1B6M3L8   A0A2J7Q029   A0A2J7Q025   A0A348G602   A0A0L7RGR2   A0A088ADR5   A0A2A3EPE4   A0A1W4X7M2   A0A154PAK8   E1ZVU4   A0A0N0BBY4   F4WLT0   E0VU60   N6TUW6   A0A195FWC3   A0A151ITI0   A0A1B6E047   A0A1B6BZZ5   A0A151I4H5   A0A3Q0JHZ1   A0A232FA33   E2BW14   K7IZZ1   A0A026W388   A0A3L8DRZ6   M1ECV1   A0A3Q0IUK8   A0A067RR11   G1NVE8   A0A2F0BIA9   U6DM03   L5LLP7   S7N9X2   A0A2Y9ETM7   A0A0P6J6P0   A0A2G9RSI1   Q8NDL9-3   A0A384AVD9   U3DA09   A0A2J8VMS1   Q58CX9-2   H9EQT8   A0A2R9AVJ3   K7DJ08   G2HFJ2   A0A2Y9DN96   L8YBE8   M3YDF6   A0A2K6KUA3   F7BT54   A0A384AVE0   A0A3Q2I3I3   A0A384AVF0   A0A287ASG5   Q8NDL9-2   A0A2Y9NAI8   A0A341CZP9   A0A2J8VMS0   I3LU97   A0A2Y9N6P3   A0A286XJK3   H0WV03   A0A2I2YHG4   A0A3Q2LCQ5   A0A2K5QXN4   G3GXS1   A0A3Q1MYW4   G5BYZ0   L5KRI5   A0A0S7IFG7   A0A2Y9N5G1   A0A2Y9EUB7   A0A091CUV5   A0A2Y9ET83   A0A2J8NKZ2   G3TDG9   A0A2Y9EUY3   A0A212CY99   A0A3Q3EMS7   A0A2Y9NKX1   A0A2U4BZJ2  

EC Number

3.4.17.-

Pubmed

19121390    22118469    26354079    18362917    19820115    28004739    + More
29403074    20798317    21719571    20566863    23537049    28648823    20075255    24508170    30249741    23236062    24845553    21993624    17974005    14702039    15815621    15489334    23085998    26720455    26355662    27842159    27764769    25243066    16305752    19390049    25319552    22722832    16136131    21484476    23385571    19892987    30723633    22398555    21804562    19393038    21993625    23258410   

EMBL

BABH01010910    BABH01010911    BABH01010912    ODYU01007394    SOQ50111.1    AGBW02010898    + More
OWR47541.1    KQ459220    KPJ02920.1    GDQN01008900    JAT82154.1    KQ459927    KPJ19309.1    DS497685    EFA12270.1    LJIG01002097    KRT84843.1    GEZM01061471    GEZM01061469    GEZM01061468    JAV70454.1    GEZM01061467    GEZM01061463    GEZM01061459    JAV70459.1    PYGN01000199    PSN51416.1    GEZM01061480    GEZM01061474    GEZM01061472    GEZM01061460    JAV70442.1    GEZM01061482    GEZM01061477    GEZM01061461    GEZM01061458    GEZM01061456    JAV70445.1    GEZM01061479    GEZM01061478    GEZM01061475    GEZM01061466    GEZM01061465    GEZM01061462    JAV70457.1    GEZM01061481    GEZM01061476    GEZM01061473    GEZM01061470    GEZM01061464    GEZM01061457    JAV70452.1    GECZ01010649    JAS59120.1    GECU01034832    GECU01020914    JAS72874.1    JAS86792.1    GECU01026750    JAS80956.1    GEBQ01023639    JAT16338.1    GEBQ01009489    GEBQ01004605    JAT30488.1    JAT35372.1    NEVH01020327    PNF21934.1    PNF21933.1    FX985541    BBF97875.1    KQ414596    KOC70019.1    KZ288206    PBC33076.1    KQ434864    KZC08976.1    GL434640    EFN74695.1    KQ435944    KOX68218.1    GL888216    EGI64812.1    DS235780    EEB16916.1    APGK01017572    APGK01017573    KB740042    ENN81868.1    KQ981204    KYN44965.1    KQ981015    KYN10277.1    GEDC01006000    JAS31298.1    GEDC01030461    JAS06837.1    KQ976462    KYM84654.1    NNAY01000597    OXU27482.1    GL451091    EFN80046.1    KK107510    EZA49504.1    QOIP01000004    RLU23205.1    JP005284    AER93881.1    KK852517    KDR22169.1    AAPE02039345    NTJE010217487    MBW02730.1    HAAF01011318    CCP83142.1    KB110330    ELK27389.1    KE163671    EPQ13100.1    GEBF01003736    JAN99896.1    KV931187    PIO30852.1    AL833844    AK302091    AC013403    AC013472    CH471053    BC007415    BC018584    BC131498    AK023398    AK025492    GAMT01005296    GAMS01006235    GAMR01008472    GAMQ01007201    GAMP01007223    JAB06565.1    JAB16901.1    JAB25460.1    JAB34650.1    JAB45532.1    NDHI03003415    PNJ58825.1    PNJ58826.1    PNJ58830.1    PNJ58832.1    BT021818    AAFC03088657    BC126504    JU320991    AFE64747.1    AJFE02095132    AJFE02095133    AJFE02095134    AACZ04002055    AACZ04002056    AACZ04002057    GABC01006352    GABF01009296    GABD01001683    GABE01002850    NBAG03000227    JAA04986.1    JAA12849.1    JAA31417.1    JAA41889.1    PNI72444.1    AK305506    BAK62500.1    KB360584    ELV13748.1    AEYP01063333    AEYP01063334    AEMK02000021    DQIR01065488    DQIR01068879    DQIR01071098    DQIR01085500    DQIR01098474    DQIR01098476    DQIR01161607    DQIR01167229    HDA20964.1    HDA53950.1    PNJ58828.1    DQIR01204849    HDB60326.1    AAKN02023455    AAQR03049341    AAQR03049342    CABD030013741    CABD030013742    CABD030013743    JH000061    EGV95860.1    JH172504    EHB14501.1    KB030580    ELK14054.1    GBYX01429443    JAO51848.1    KN123775    KFO23354.1    PNI72439.1    PNI72440.1    PNI72441.1    MKHE01000011    OWK10834.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000007266    UP000245037    + More
UP000235965    UP000053825    UP000005203    UP000242457    UP000192223    UP000076502    UP000000311    UP000053105    UP000007755    UP000009046    UP000019118    UP000078541    UP000078492    UP000078540    UP000079169    UP000215335    UP000008237    UP000002358    UP000053097    UP000279307    UP000027135    UP000001074    UP000248484    UP000005640    UP000261681    UP000009136    UP000240080    UP000002277    UP000248480    UP000011518    UP000000715    UP000233180    UP000002281    UP000008227    UP000248483    UP000252040    UP000005447    UP000005225    UP000001519    UP000233040    UP000001075    UP000006813    UP000010552    UP000028990    UP000007646    UP000261660    UP000245320   

PRIDE

H9IYS0    Q8NDL9    Q58CX9    I3LU97    G3GXS1   

Pfam

PF00246   Peptidase_M14        + More
PF18027   Pepdidase_M14_N

Interpro

IPR040626   Pepdidase_M14_N        + More
IPR000834   Peptidase_M14       
IPR034286   M14_AGBL5-like       

CDD

cd06236  M14_AGBL5_like

ProteinModelPortal

H9IYS0   A0A2H1WAK5   A0A212F1E3   A0A194QD67   A0A1E1W5B5   A0A0N1PJ56   + More
D7EIR9   A0A0T6BCC1   A0A1Y1L9Z6   A0A1Y1L9X3   A0A2P8Z4J6   A0A1Y1L9V7   A0A1Y1LEP4   A0A1Y1LHF1   A0A1Y1L9X4   A0A1B6G9L3   A0A1B6IIP5   A0A1B6I206   A0A1B6KY10   A0A1B6M3L8   A0A2J7Q029   A0A2J7Q025   A0A348G602   A0A0L7RGR2   A0A088ADR5   A0A2A3EPE4   A0A1W4X7M2   A0A154PAK8   E1ZVU4   A0A0N0BBY4   F4WLT0   E0VU60   N6TUW6   A0A195FWC3   A0A151ITI0   A0A1B6E047   A0A1B6BZZ5   A0A151I4H5   A0A3Q0JHZ1   A0A232FA33   E2BW14   K7IZZ1   A0A026W388   A0A3L8DRZ6   M1ECV1   A0A3Q0IUK8   A0A067RR11   G1NVE8   A0A2F0BIA9   U6DM03   L5LLP7   S7N9X2   A0A2Y9ETM7   A0A0P6J6P0   A0A2G9RSI1   Q8NDL9-3   A0A384AVD9   U3DA09   A0A2J8VMS1   Q58CX9-2   H9EQT8   A0A2R9AVJ3   K7DJ08   G2HFJ2   A0A2Y9DN96   L8YBE8   M3YDF6   A0A2K6KUA3   F7BT54   A0A384AVE0   A0A3Q2I3I3   A0A384AVF0   A0A287ASG5   Q8NDL9-2   A0A2Y9NAI8   A0A341CZP9   A0A2J8VMS0   I3LU97   A0A2Y9N6P3   A0A286XJK3   H0WV03   A0A2I2YHG4   A0A3Q2LCQ5   A0A2K5QXN4   G3GXS1   A0A3Q1MYW4   G5BYZ0   L5KRI5   A0A0S7IFG7   A0A2Y9N5G1   A0A2Y9EUB7   A0A091CUV5   A0A2Y9ET83   A0A2J8NKZ2   G3TDG9   A0A2Y9EUY3   A0A212CY99   A0A3Q3EMS7   A0A2Y9NKX1   A0A2U4BZJ2  

PDB

3L2N     E-value=7.67674e-16,     Score=204

KEGG

101736372    K23438 cytosolic carboxypeptidase-like protein 5 [EC:3.4.17.-] | (RefSeq) cytosolic carboxypeptidase

GO

GO:0016021   GO:0008270   GO:0004181   GO:0004180   GO:0035608   GO:0051607   GO:0035611   GO:0072686   GO:0005634   GO:0030496   GO:0005829   GO:0045171   GO:0015631   GO:0015630   GO:0005737   GO:0006508   GO:0051920   GO:0003887   GO:0005524   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

Subcellular location

Cytoplasm   Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.   With evidence from 2 publications.
Cytosol   Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.   With evidence from 2 publications.
Nucleus   Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.   With evidence from 2 publications.
Cytoskeleton   Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.   With evidence from 2 publications.
Spindle   Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.   With evidence from 2 publications.
Midbody   Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.   With evidence from 2 publications.

Length:

360

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.67093

Exp number, first 60 AAs:

0.00182

Total prob of N-in:

0.09898

outside

1  -  360

 

 

Pi

26.900749

Theta

23.898301

Tajima's D

0.3789

CLR

0.018253

CSRT

0.484475776211189

Interpretation

Uncertain