Gene

KWMTBOMO05278  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002502

Annotation

PREDICTED:_histone-lysine_N-methyltransferase_2D-like?_partial_[Bombyx_mori]

Location

Bomo_Chr9(+):12609454-12618218      View in EpiBrowser

Full name

Histone-lysine N-methyltransferase      

Location in the cell

Nuclear   Reliability : 4.142

CDS

ATGCTGCTGCTGCTGTGCGACGACTGCGACACCACGTGGCACACGTACTGCGCGCGCCCGCCGCTGGCCGACGTGCCGCGCGGCGCCTGGCGCTGCGAGCGCTGTCGCCGCTGTCTCACGTGCGGCACGCGCGACGCGCTCTCCTGGTGCACCGACAACTACACGGAATGTGCACCGTGCGCTTCCTTAGTGATGTGCTGTGTGTGTTCCGAACCTTATTCAGATGGAGAACTAATCATTCAGTGCGAAGCTTGTACTCGGTGGCTTCATGCATCCTGTGATTCAATTCGCAGTGAAAATGATGCCGAAATATGCTGTCGAGCTGGGTACAAGTGCGTGGGATGCCGCGGCGCGGAGACGGCGCCGCCGCACGTGGCGCGCGTGGCGTGCGTGCCCAGCGCCGCCCGCAGCGCGCCGCGCCCCACGCCGCAGTCGCTGGGCTTGGCGGGCGAGTACTACGTGGACGACGTGTGTCTGTCGCAGCGCGGCGCGCACCACATGAAGCAGCTGGAGGCCGACCTCGGCATCACGCATACCAGACGAAAGAGGCGTTTCAAAAATGAGAACCCCGACAAAGATGCCGTGGTTCAGAACGCTGACGTCGAGATGGCCGACGACTCCAAGCCTGACAGCACAGCCGAAGTCAAAGATGAACCAGGTCTTCCTCCTAACGCAAACTTTAAAGAAGGAACTCTGTGGAACATTTTAACCGACGGTCCCCCTCCTGAGGGGTTCACTGTATATACAACAGATTCAGGACTGACCGTACTCCGAAGGAAACGACAAAGAAACCTCAATAAATTAGGTATTGGAGGTTTCGTGGTTAGACAAAGACAGACTACAATCAAAGCTCAGGCAGATGAAGACAAAGATGGTGACGGCACACAGGCTTCTGGAGAATCCCCAAGCAACAAGCGCAAACCTCGTAGAAAGCCACGGTCAAAACTGATGGAACAATTTCCACCTTACATGCAAGAAGCTTTTTTTGGAAAGGAACTCCTCGATCCCCAAGTCAAATCTGCTGTTAGTTCCACTGGTAACCCTTCAGAGAGTCCAGCTGGTACTCTGAGACCAAATACCCCAGAAGGATACCGTGAACTGCGAGACTTTAAATTTGACTTTGAGAATTCTGACAGTGAAGGCGAAGATGTCCTGGCTGCTTTGACTTCTTTCAATGATCATGACAACACTGTTATCATCACCCTTAATAACGAAGAACTAGAGTTAATGCAATCACTAAAACCGAAACAAGAAAAAGAAGATCCATCCAACACTAATTCTGACGGTGTGAAAATAAAGACAGAGTCAGATGATGGTCAAGTGAAACAAACTGAGGATTCTACTGCCCTCAAGAATGCCTTGTTGGGCCCCCAGACCAACGAAGGAGAATCGACAGTGGGTGCGGCTGAAAGCGGATCCGCCACCCATAGCACGAAAACTGAGAACCTTAGCAGCGAGACAACATCATCTCAAGCGTCGACAATATCTCCGAAAGATGACCTGTCGCTGCTGGGCGTGAACTTGGACGCCATGGTGCGCGACACGCTTCCCGACATGGACAGCAACGATGTCGACGAGATATTCAAGGGCGTCCTTACTGATGACTCTCAGGAATCACAGGAATCATCAGTATCCTATGTGAATGCAATGACTCCATACTCTCAGAGACAGCAGCTGCAGAGTCCCATGGAGTACTCGTCACCCTACCATTCGGAGTTTGGGAACAGCAGTGGGGGCGCGCTGAGTCCGCTGGTGAGCGAGTCCACGTGGAGCGAGTCCGCGCCCGCCCCCGCGCCCTCCTACAACCAGCGCAGCGCCGACAAGATGCGCGCCGACGAGAGCTTAGGTTCTGCGGCTACGATATCCGCCGTGCTGTACGCGAACACAAACCACCCCGAATGGAAAACCGAGTTTCCCAACTGGGTCGATCGGTGCAAGCAGATCCTGAAGAAGTGGCGCGCCTTGCCCTCGGAGCACAAGGCGCCCTACTTGCAAAGGGCTAGGGACAACCGGAGCGCCATTCGCATGAAGAAAGCCCAGCAGGAACAGGAACGGGCTTGTGGACAGCAGCGTAGTGCTCGAGAGGCCGAGCAGGAGAGGGCGTGGAAGAACTTGCAGCAACAACGCCAGCAGCAGACCCAGCAGCAACAACAGATCATACACGATCAACGGATGCAAGGTACAGACTTGGCGACACTGCCTAAGGGATTTTGA

Protein

MLLLLCDDCDTTWHTYCARPPLADVPRGAWRCERCRRCLTCGTRDALSWCTDNYTECAPCASLVMCCVCSEPYSDGELIIQCEACTRWLHASCDSIRSENDAEICCRAGYKCVGCRGAETAPPHVARVACVPSAARSAPRPTPQSLGLAGEYYVDDVCLSQRGAHHMKQLEADLGITHTRRKRRFKNENPDKDAVVQNADVEMADDSKPDSTAEVKDEPGLPPNANFKEGTLWNILTDGPPPEGFTVYTTDSGLTVLRRKRQRNLNKLGIGGFVVRQRQTTIKAQADEDKDGDGTQASGESPSNKRKPRRKPRSKLMEQFPPYMQEAFFGKELLDPQVKSAVSSTGNPSESPAGTLRPNTPEGYRELRDFKFDFENSDSEGEDVLAALTSFNDHDNTVIITLNNEELELMQSLKPKQEKEDPSNTNSDGVKIKTESDDGQVKQTEDSTALKNALLGPQTNEGESTVGAAESGSATHSTKTENLSSETTSSQASTISPKDDLSLLGVNLDAMVRDTLPDMDSNDVDEIFKGVLTDDSQESQESSVSYVNAMTPYSQRQQLQSPMEYSSPYHSEFGNSSGGALSPLVSESTWSESAPAPAPSYNQRSADKMRADESLGSAATISAVLYANTNHPEWKTEFPNWVDRCKQILKKWRALPSEHKAPYLQRARDNRSAIRMKKAQQEQERACGQQRSAREAEQERAWKNLQQQRQQQTQQQQQIIHDQRMQGTDLATLPKGF

Catalytic Activity

L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine

Uniprot

H9IZ17   A0A3S2NCM7   A0A194QBS6   A0A2A4IVZ3   A0A0N0PAW7   A0A212F1E6   + More
A0A158NUC5   A0A1B6D156   F4WR72   A0A1Y1L2Y7   A0A1Y1L3C7   A0A1B6GJ31   A0A023F0J6   A0A1B6F6S2   D6W9D4   A0A139WMS0   A0A195BAP5   A0A151IQH0   A0A0C9R071   A0A151JCE8   A0A2S2QNC8   A0A1Y1L6R4   A0A1Y1L8Z9   A0A2S2Q7Q2   J9JLG9   A0A195FJK3   A0A146LFJ3   A0A2H8TLB4   U4UBC4   A0A146M7P4   N6TZM2   A0A034WMJ1   A0A0K8V2M0   A0A0K8V3I4   W8C427   A0A3L8DEF9   A0A1A9Y6I4   T1IZ38   A0A1B0FJW5   Q17A65   A0A182GXI3   B0WUW9   A0A1S4FAE3   A0A336ML50   A0A336MJT3   A0A336MIG1   A0A336MH66   A0A1V9XSL7   A0A336MLN0   A0A026WTW3   A0A1B0CJ96   A0A182MGK2   A0A3Q0DU86   K7J2B3   A0A1B0DCK0   A0A3P8WR26   A0A3P8WR02   A0A1D2N616  

EC Number

2.1.1.43

Pubmed

19121390    26354079    22118469    21347285    21719571    28004739    + More
25474469    18362917    19820115    26823975    23537049    25348373    24495485    30249741    17510324    26483478    28327890    24508170    20075255    24487278    27289101   

EMBL

BABH01010903    BABH01010904    BABH01010905    BABH01010906    BABH01010907    BABH01010908    + More
RSAL01000222    RVE44033.1    KQ459220    KPJ02917.1    NWSH01005542    PCG64137.1    KQ461135    KPJ08858.1    AGBW02010898    OWR47544.1    ADTU01026316    ADTU01026317    ADTU01026318    ADTU01026319    ADTU01026320    ADTU01026321    GEDC01017945    JAS19353.1    GL888284    EGI63299.1    GEZM01066211    GEZM01066209    GEZM01066202    GEZM01066200    GEZM01066199    GEZM01066198    GEZM01066193    JAV68063.1    GEZM01066212    GEZM01066197    GEZM01066195    GEZM01066192    GEZM01066191    JAV68084.1    GECZ01007317    JAS62452.1    GBBI01004228    JAC14484.1    GECZ01024206    JAS45563.1    KQ971312    EEZ98177.2    KYB29184.1    KQ976532    KYM81621.1    KQ976780    KYN08397.1    GBYB01009504    JAG79271.1    KQ979048    KYN23222.1    GGMS01010062    MBY79265.1    GEZM01066213    GEZM01066205    GEZM01066204    GEZM01066203    GEZM01066196    JAV68070.1    GEZM01066214    GEZM01066210    GEZM01066208    GEZM01066207    GEZM01066206    GEZM01066201    GEZM01066194    JAV68056.1    GGMS01004541    MBY73744.1    ABLF02022838    ABLF02022842    ABLF02022849    KQ981512    KYN40840.1    GDHC01012872    JAQ05757.1    GFXV01003024    MBW14829.1    KB632184    ERL89633.1    GDHC01002846    JAQ15783.1    APGK01048496    APGK01048497    KB741112    ENN73816.1    GAKP01002201    JAC56751.1    GDHF01019142    JAI33172.1    GDHF01018827    JAI33487.1    GAMC01002517    JAC04039.1    QOIP01000009    RLU18533.1    AFFK01020382    CCAG010018850    CH477339    EAT43161.1    JXUM01095568    KQ564203    KXJ72592.1    DS232111    EDS35112.1    UFQT01001259    SSX29729.1    SSX29731.1    SSX29730.1    SSX29732.1    MNPL01004750    OQR76504.1    SSX29733.1    KK107119    EZA58544.1    AJWK01014351    AJWK01014352    AXCM01003735    AAZX01001561    AJVK01005146    AJVK01005147    AJVK01005148    AJVK01005149    LJIJ01000202    ODN00515.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000218220    UP000053240    UP000007151    + More
UP000005205    UP000007755    UP000007266    UP000078540    UP000078542    UP000078492    UP000007819    UP000078541    UP000030742    UP000019118    UP000279307    UP000092443    UP000092444    UP000008820    UP000069940    UP000249989    UP000002320    UP000192247    UP000053097    UP000092461    UP000075883    UP000189704    UP000002358    UP000092462    UP000265120    UP000094527   

PRIDE

H9IZ17   

Pfam

PF00628   PHD        + More
PF05964   FYRN
PF05965   FYRC
PF00856   SET
PF00096   zf-C2H2
PF09011   HMG_box_2
PF06090   Ins_P5_2-kin

Interpro

IPR003888   FYrich_N        + More
IPR034732   EPHD       
IPR036910   HMG_box_dom_sf       
IPR001841   Znf_RING       
IPR011011   Znf_FYVE_PHD       
IPR019787   Znf_PHD-finger       
IPR001965   Znf_PHD       
IPR013083   Znf_RING/FYVE/PHD       
IPR001214   SET_dom       
IPR009071   HMG_box_dom       
IPR003889   FYrich_C       
IPR003616   Post-SET_dom       
IPR019786   Zinc_finger_PHD-type_CS       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       
IPR000637   HMGI/Y_DNA-bd_CS       
IPR000679   Znf_GATA       
IPR037877   KMT2C       
IPR009286   Ins_P5_2-kin       

SUPFAM

SSF57903   SSF57903        + More
SSF47095   SSF47095       
SSF57667   SSF57667       

Gene 3D

1.10.30.10     3.30.40.10    

ProteinModelPortal

H9IZ17   A0A3S2NCM7   A0A194QBS6   A0A2A4IVZ3   A0A0N0PAW7   A0A212F1E6   + More
A0A158NUC5   A0A1B6D156   F4WR72   A0A1Y1L2Y7   A0A1Y1L3C7   A0A1B6GJ31   A0A023F0J6   A0A1B6F6S2   D6W9D4   A0A139WMS0   A0A195BAP5   A0A151IQH0   A0A0C9R071   A0A151JCE8   A0A2S2QNC8   A0A1Y1L6R4   A0A1Y1L8Z9   A0A2S2Q7Q2   J9JLG9   A0A195FJK3   A0A146LFJ3   A0A2H8TLB4   U4UBC4   A0A146M7P4   N6TZM2   A0A034WMJ1   A0A0K8V2M0   A0A0K8V3I4   W8C427   A0A3L8DEF9   A0A1A9Y6I4   T1IZ38   A0A1B0FJW5   Q17A65   A0A182GXI3   B0WUW9   A0A1S4FAE3   A0A336ML50   A0A336MJT3   A0A336MIG1   A0A336MH66   A0A1V9XSL7   A0A336MLN0   A0A026WTW3   A0A1B0CJ96   A0A182MGK2   A0A3Q0DU86   K7J2B3   A0A1B0DCK0   A0A3P8WR26   A0A3P8WR02   A0A1D2N616  

PDB

2YUK     E-value=1.77541e-16,     Score=213

KEGG

101736107    K09188 histone-lysine N-methyltransferase MLL3 [EC:2.1.1.43] | (RefSeq) histone-lysine N-methyltrans

GO

GO:0042800   GO:0046872   GO:0035097   GO:0018024   GO:0005634   GO:0044666   GO:0003677   GO:0003713   GO:0045944   GO:0042393   GO:0016021   GO:0003676   GO:0006355   GO:0043565   GO:0008270   GO:0005524   GO:0035299   GO:0008168   GO:0005515   GO:0045454   GO:0051920   GO:0003887   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

PANTHER

PTHR45888:SF1  

Subcellular location

Nucleus  

Length:

737

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00018

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00003

outside

1  -  737

 

 

Pi

235.577466

Theta

195.242579

Tajima's D

0.378678

CLR

0.353943

CSRT

0.47747612619369

Interpretation

Uncertain