Gene

KWMTBOMO05277  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002502

Annotation

PREDICTED:_histone-lysine_N-methyltransferase_2D-like?_partial_[Bombyx_mori]

Location

Bomo_Chr9(+):12601024-12608534      View in EpiBrowser

Full name

Histone-lysine N-methyltransferase      

Location in the cell

Nuclear   Reliability : 3.288

CDS

ATGGAAGTACCGGACGAAAATGTTCTAGAGGTAGATTTGTTAGCTGATGATGGATCAGAAGATGAAGGCGAAGCCCCGCCGTCTTCAGAATTTTACACCGGACCTGGGTCGACACCAACATCATGTGCGTCATCTCCTCGAGGTGAAGAACCAGCATCTCCCCATGCAGGTCTCACACAACCATCCTTCTTCCATCATCAAGGTTACACTCGCCCGTTTTTTACCTCGGCCAGGCGAGGTCCGGGTAGACCACGGAAAGAAGGACCCAAGTTAGCTCGTGAAGGCAAGATTGTTAGAAGATACAGAGGAAATCCAGGATCTTTAAGAGGGGCAAAAAGACATCGTGGTAGTAGGGATGATGCATCTGAAGACATGATGGACGAAGATGATTTTACAATACCACCTGTCCCCGAGGAACCTCCCTATATGCCCGAAAAATGGCCTGGTAAAGTTTGCTCACTTTGTAACTTGGGTGAACGCAGTCAACTAGGCCAGGGTGAAATGAGACAAATTCATTGCAATATTGGTGAAGCAGAGGGTAGTACGACACCTTTAGTTACCAATTCAGGAGGAGCCACACCAACAAGCATTGCTACTCCTACTAGTACTCCAACGACACCTGTCACACCAGGCTTAGTTTCTCCTCCACCAGAGCTAGTAGATCCCAACCAACATCCTCTTGGGCTACCGCTCAGCAGGCGCCAGAAATCTTTCAACAAGTGCAAAACACCACTCTACAATATGGAACACACAGATGAATTATCAATTATCGGTCACAATGACTCTCTAGAAATACAAGCAGTAGTGTCTTCTGGAGCATTGTACATTCACCGTTGTTGCCTTGAGTTCAGTCCACCATTCCAAGCAACATCATCTGAGGAAGACCTTGAGCAAGCAGAGGAGACGAGAATCAGAGGAATAGTCACTTCTGCTCTTACAAGAAAATGTGCCTTTTGTACTAGACATGGTGCAAGTATTCCTTGTAAGATGAGCTGTAACAAATACTACCATCTACCATGTCTTCTAGCATCAGGTGGTTTTATGGATTTTCAAAGCAAGGGCTCATTTTGTAAAGATCATTTATATCAAGTTCCCCTTGTCTGTACATCAGAAATCGACTGCAGGACTTGTAGGACTATCGGCGATATTGCGAATCTGATGACTTGCGTGGTTTGTGGAGCGCATTATCATGGAACTTGTGTCGGTCTTGCTCAGCTACCAGGCGTCCGGTCGGGCTGGGCGTGCCGCGGGTGCCGCGTGTGCCAGGTGTGCCGCGAGCCGGCGCCGGGCGAGGCGCGCGCCGTGTGCTGCGACCACTGCGACAAGCTCTACCACGCCGCCTGTCTACGACCTCTCATGGCCACCGTGCCCAAGTACGGCTGGAAGTGCAAGTGTTGCCGGGTGTGCTCCGACTGCGGGTCGCGGTCGCCGGGCGCCGGGCCGTCGTCCCGCTGGCACGCGCACTACACGGTGTGCGACTCGTGCTACCAGCAGCGCAACAAGGGCTCGTGCTGTCCGCTGTGTCGCCGAGCTTACCGCGCCGCCGCCTACCGCGACATGATACGGTGCACGCTCTGCAAGAGATACGTCCATGGCACCTGTGATCCAGATGCGGAGCCTCAACAGTATAGGAAAAACAAAGATCAGAATCCATCTTATGAATACAGCTGTCCTATATGCAAGAGTCAACTTGCACTGACCGGATCTAAACCTGGGTCTTTTGAAGAAGATAGCACTGCTTCAGTGTCTCAAGATTCTTCATATGGAGATGACAACTCTAATTTACAAGATCAGGACCCACTTGCGATTGAAACAAAGCCTGATGTTGGTCTTGGAAAAGGAAAACCTTTCTCAGTATCTTCAAAGGTAGCCAAAAAAAAAATTGGAGGCTACAAACTGAAAGGTGGATTCCCTGCGGGTGGCAAGTTGGGCTTCCAGAAACGCCAACGTTCTCTGTTGGACTTCGGTCGGAAAAGGGCATCTAAACCTAAAATGCGAGGAGTTTTTGGAGTACCAGGATTGGGGCTACAGAGACCCCAAGCTCCTGACAGTAAAAGCTCTGAGGATGATCCAGGAATGGAGAATAAACTAGTGCTGTGTTCAAGCAAAGACAAGTTTGTGCTCACACAAGATTTGTGCGTTATGTGTGGTGCTGTCGGTACGGACTCTGAGGGATGCCTTATTGCTTGTGCCCAGTGTGGACAGACTTATCATCCGTACTGCGTAAACATAAAGGTGATACAAAATTAA

Protein

MEVPDENVLEVDLLADDGSEDEGEAPPSSEFYTGPGSTPTSCASSPRGEEPASPHAGLTQPSFFHHQGYTRPFFTSARRGPGRPRKEGPKLAREGKIVRRYRGNPGSLRGAKRHRGSRDDASEDMMDEDDFTIPPVPEEPPYMPEKWPGKVCSLCNLGERSQLGQGEMRQIHCNIGEAEGSTTPLVTNSGGATPTSIATPTSTPTTPVTPGLVSPPPELVDPNQHPLGLPLSRRQKSFNKCKTPLYNMEHTDELSIIGHNDSLEIQAVVSSGALYIHRCCLEFSPPFQATSSEEDLEQAEETRIRGIVTSALTRKCAFCTRHGASIPCKMSCNKYYHLPCLLASGGFMDFQSKGSFCKDHLYQVPLVCTSEIDCRTCRTIGDIANLMTCVVCGAHYHGTCVGLAQLPGVRSGWACRGCRVCQVCREPAPGEARAVCCDHCDKLYHAACLRPLMATVPKYGWKCKCCRVCSDCGSRSPGAGPSSRWHAHYTVCDSCYQQRNKGSCCPLCRRAYRAAAYRDMIRCTLCKRYVHGTCDPDAEPQQYRKNKDQNPSYEYSCPICKSQLALTGSKPGSFEEDSTASVSQDSSYGDDNSNLQDQDPLAIETKPDVGLGKGKPFSVSSKVAKKKIGGYKLKGGFPAGGKLGFQKRQRSLLDFGRKRASKPKMRGVFGVPGLGLQRPQAPDSKSSEDDPGMENKLVLCSSKDKFVLTQDLCVMCGAVGTDSEGCLIACAQCGQTYHPYCVNIKVIQN

Catalytic Activity

L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine

Uniprot

H9IZ17   A0A3S2NCM7   A0A212F1E6   A0A194QBS6   A0A2H1W9I8   A0A2A4IVZ3   + More
A0A1B0CJ96   A0A182GXI3   A0A1B0DCK0   Q17A65   A0A182TGZ4   A0A1S4FAE3   A0A182ILT4   A0A182HFW5   A0A182JNE9   A0A084WCC3   A0A182NZI8   A0A182VKR8   A0A182X5J0   A0A182YEC8   B0WUW9   A0A1J1I3M1   A0A182QZL4   A0A336MLN0   A0A336MJT3   A0A336ML50   A0A336MIG1   A0A336MH66   A0A2A3E2H1   A0A1Y1L2Y7   A0A1Y1L3C7   A0A1Y1L8Z9   A0A1Y1L6R4   A0A087ZQZ5   A0A2M4A4V8   A0A2M4A549   A0A026WTW3   A0A139WMS0   D6W9D4   A0A182MGK2   A0A182FVU2   K7J2B3   A0A182WDF0   A0A0C9R071   A0A182RTG3   A0A182MXJ6   E0VS51   U4UBC4   A0A151IQH0   A0A195FJK3   F4WR72   A0A195BAP5   A0A1B6F6S2   A0A1B6GJ31   A0A1B6D156   N6TZM2   A0A1B6K3T0   A0A182LHR2   A0A2H8TLB4   J9JLG9   A0A2S2Q7Q2   A0A2S2QNC8   A0A023F0J6   E9IRP1   A0A0L0C8T6   A0A1I8MA62   A0A1I8MA66   A0A1B0A978   A0A1A9WP71   A0A1A9UJ12   A0A1B0FJW5   A0A151JCE8   A0A1I8NS86   T1GGQ9   B4KMC6   A0A0A1WV58   B4J645   A0A0K8UTG6   A0A0M4EBI1   W8C427   A0A0K8UPC3   A0A0K8V2M0   A0A0K8V3I4   B4LNY9   B3MCM2   T1IZ38  

EC Number

2.1.1.43

Pubmed

19121390    22118469    26354079    26483478    17510324    24438588    + More
25244985    28004739    24508170    18362917    19820115    20075255    20566863    23537049    21719571    20966253    25474469    21282665    26108605    25315136    17994087    25830018    24495485   

EMBL

BABH01010903    BABH01010904    BABH01010905    BABH01010906    BABH01010907    BABH01010908    + More
RSAL01000222    RVE44033.1    AGBW02010898    OWR47544.1    KQ459220    KPJ02917.1    ODYU01007184    SOQ49738.1    NWSH01005542    PCG64137.1    AJWK01014351    AJWK01014352    JXUM01095568    KQ564203    KXJ72592.1    AJVK01005146    AJVK01005147    AJVK01005148    AJVK01005149    CH477339    EAT43161.1    AXCP01008506    APCN01005430    ATLV01022651    KE525335    KFB47867.1    DS232111    EDS35112.1    CVRI01000040    CRK94795.1    AXCN02001722    UFQT01001259    SSX29733.1    SSX29731.1    SSX29729.1    SSX29730.1    SSX29732.1    KZ288474    PBC25301.1    GEZM01066211    GEZM01066209    GEZM01066202    GEZM01066200    GEZM01066199    GEZM01066198    GEZM01066193    JAV68063.1    GEZM01066212    GEZM01066197    GEZM01066195    GEZM01066192    GEZM01066191    JAV68084.1    GEZM01066214    GEZM01066210    GEZM01066208    GEZM01066207    GEZM01066206    GEZM01066201    GEZM01066194    JAV68056.1    GEZM01066213    GEZM01066205    GEZM01066204    GEZM01066203    GEZM01066196    JAV68070.1    GGFK01002516    MBW35837.1    GGFK01002521    MBW35842.1    KK107119    EZA58544.1    KQ971312    KYB29184.1    EEZ98177.2    AXCM01003735    AAZX01001561    GBYB01009504    JAG79271.1    DS235745    EEB16207.1    KB632184    ERL89633.1    KQ976780    KYN08397.1    KQ981512    KYN40840.1    GL888284    EGI63299.1    KQ976532    KYM81621.1    GECZ01024206    JAS45563.1    GECZ01007317    JAS62452.1    GEDC01017945    JAS19353.1    APGK01048496    APGK01048497    KB741112    ENN73816.1    GECU01001608    JAT06099.1    GFXV01003024    MBW14829.1    ABLF02022838    ABLF02022842    ABLF02022849    GGMS01004541    MBY73744.1    GGMS01010062    MBY79265.1    GBBI01004228    JAC14484.1    GL765280    EFZ16759.1    JRES01000737    KNC28853.1    CCAG010018850    KQ979048    KYN23222.1    CAQQ02111077    CAQQ02111078    CAQQ02111079    CH933808    EDW09814.2    GBXI01011892    JAD02400.1    CH916367    EDW01903.1    GDHF01022320    JAI29994.1    CP012524    ALC42621.1    GAMC01002517    JAC04039.1    GDHF01023765    JAI28549.1    GDHF01019142    JAI33172.1    GDHF01018827    JAI33487.1    CH940648    EDW61158.1    CH902619    EDV36256.1    AFFK01020382   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053268    UP000218220    UP000092461    + More
UP000069940    UP000249989    UP000092462    UP000008820    UP000075902    UP000075880    UP000075840    UP000075881    UP000030765    UP000075885    UP000075903    UP000076407    UP000076408    UP000002320    UP000183832    UP000075886    UP000242457    UP000005203    UP000053097    UP000007266    UP000075883    UP000069272    UP000002358    UP000075920    UP000075900    UP000075884    UP000009046    UP000030742    UP000078542    UP000078541    UP000007755    UP000078540    UP000019118    UP000075882    UP000007819    UP000037069    UP000095301    UP000092445    UP000091820    UP000078200    UP000092444    UP000078492    UP000095300    UP000015102    UP000009192    UP000001070    UP000092553    UP000008792    UP000007801   

PRIDE

H9IZ17   

Pfam

PF00628   PHD        + More
PF05964   FYRN
PF05965   FYRC
PF00856   SET
PF09011   HMG_box_2
PF00096   zf-C2H2
PF06090   Ins_P5_2-kin

Interpro

IPR003888   FYrich_N        + More
IPR034732   EPHD       
IPR036910   HMG_box_dom_sf       
IPR001841   Znf_RING       
IPR011011   Znf_FYVE_PHD       
IPR019787   Znf_PHD-finger       
IPR001965   Znf_PHD       
IPR013083   Znf_RING/FYVE/PHD       
IPR001214   SET_dom       
IPR009071   HMG_box_dom       
IPR003889   FYrich_C       
IPR003616   Post-SET_dom       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       
IPR000637   HMGI/Y_DNA-bd_CS       
IPR019786   Zinc_finger_PHD-type_CS       
IPR000679   Znf_GATA       
IPR037877   KMT2C       
IPR009286   Ins_P5_2-kin       

SUPFAM

SSF57903   SSF57903        + More
SSF47095   SSF47095       
SSF57667   SSF57667       

Gene 3D

1.10.30.10     3.30.40.10    

ProteinModelPortal

H9IZ17   A0A3S2NCM7   A0A212F1E6   A0A194QBS6   A0A2H1W9I8   A0A2A4IVZ3   + More
A0A1B0CJ96   A0A182GXI3   A0A1B0DCK0   Q17A65   A0A182TGZ4   A0A1S4FAE3   A0A182ILT4   A0A182HFW5   A0A182JNE9   A0A084WCC3   A0A182NZI8   A0A182VKR8   A0A182X5J0   A0A182YEC8   B0WUW9   A0A1J1I3M1   A0A182QZL4   A0A336MLN0   A0A336MJT3   A0A336ML50   A0A336MIG1   A0A336MH66   A0A2A3E2H1   A0A1Y1L2Y7   A0A1Y1L3C7   A0A1Y1L8Z9   A0A1Y1L6R4   A0A087ZQZ5   A0A2M4A4V8   A0A2M4A549   A0A026WTW3   A0A139WMS0   D6W9D4   A0A182MGK2   A0A182FVU2   K7J2B3   A0A182WDF0   A0A0C9R071   A0A182RTG3   A0A182MXJ6   E0VS51   U4UBC4   A0A151IQH0   A0A195FJK3   F4WR72   A0A195BAP5   A0A1B6F6S2   A0A1B6GJ31   A0A1B6D156   N6TZM2   A0A1B6K3T0   A0A182LHR2   A0A2H8TLB4   J9JLG9   A0A2S2Q7Q2   A0A2S2QNC8   A0A023F0J6   E9IRP1   A0A0L0C8T6   A0A1I8MA62   A0A1I8MA66   A0A1B0A978   A0A1A9WP71   A0A1A9UJ12   A0A1B0FJW5   A0A151JCE8   A0A1I8NS86   T1GGQ9   B4KMC6   A0A0A1WV58   B4J645   A0A0K8UTG6   A0A0M4EBI1   W8C427   A0A0K8UPC3   A0A0K8V2M0   A0A0K8V3I4   B4LNY9   B3MCM2   T1IZ38  

PDB

2YSM     E-value=2.13652e-19,     Score=238

KEGG

101736107    K09188 histone-lysine N-methyltransferase MLL3 [EC:2.1.1.43] | (RefSeq) histone-lysine N-methyltrans

GO

GO:0042800   GO:0046872   GO:0035097   GO:0018024   GO:0005634   GO:0044666   GO:0003677   GO:0003713   GO:0045944   GO:0042393   GO:0003676   GO:0006355   GO:0016021   GO:0003682   GO:0035076   GO:0005700   GO:0018990   GO:1900114   GO:0030374   GO:0008230   GO:0007474   GO:0000790   GO:0008586   GO:0043565   GO:0008270   GO:0005524   GO:0035299   GO:0005515   GO:0045454   GO:0051920   GO:0003887   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

PANTHER

PTHR45888:SF1  

Subcellular location

Nucleus  

Length:

749

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00238

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00008

outside

1  -  749

 

 

Pi

163.509393

Theta

158.905019

Tajima's D

-0.806418

CLR

159.611833

CSRT

0.176441177941103

Interpretation

Uncertain