Gene

KWMTBOMO05248  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002424

Annotation

PREDICTED:_STAM-binding_protein-like_A_[Amyelois_transitella]

Location

Bomo_Chr9(-):12010513-12019934      View in EpiBrowser

Full name

STAM-binding protein-like A      

Location in the cell

Nuclear   Reliability : 2.727

CDS

ATGCAGTTGGAAGAAAAACGCCCCAAACATGTTGATCTAGCTTCAATGGAACCTTCAGCAAGAGTTAAGCAGCTCGCAAACTACGGGACGATGGTTGACGTCGATCCTAATGTTCCACCTAGAAGGTACTATAGATCTGGTCTTGAGATGGTAAGAATGGCTAATGTGTATCTAGCAGAAGGGAGCTTGGAGAATGCATATATTCTATATATGAAGTTCATGACACTATTCCTGGAAAAGATACGGAAACATCCAGAATACAGTAGTGTGCCTGCACAAGTGAAATCTGTCAATCAGGGTAAACTCAAAGAGGTGATGCCTAAAGCTGAGAAACTGAAACAAAAGCTCTTGGATCAGTATGCTAAAGAACATGCCCAGTATAAAGAGAATGAGGAAAAGCGACAGATTGCCGAAGCACAAAAGAAGAAACAAGAGCAGGCCGATGCGAAACTCGCTGAAAGATTACAAGCAGATGAAAATAAGAGAGATGGAAACTCAACAATCCCTCACTTATTGAATAATGAACAATGGGTAGTTTCACCGTCTGCACCAGCTGTTGATAGGGTCTTGTATCCTGATGACTTTGCAGCAGAACCTCCGCAAGCACCTCCCCATCACTACCAACCTGTGCCACCTCTTATACCACCTTCAAGGCCACATAATGACAGCAGTCTTGGGGGTGCGTTGTACGGTTCTCACCGACTCCGCACCGTGGTTGTGCCCGCGGCGTTACTCGGACGATTCTTGCGTCTCGCTGCCGATAATACCACACGAAATATAGAGACCTGTGGTATACTTGCGGGGATACTGGAGCGGAACCAGTTGAAGATCACACACGTTATAGTCCCAAAGCAGTCCGGTACCCCGGACTCATGCAGCACCAACAACGAAGAGGAGATATTTCACTACCAGGACCAACATAACCTCATCACACTAGGATGGATACATACGCATCCGACGCAGACCGCGTTCCTGTCGTCGGTGGATCTGCACACGCAGTGCTCGTACCAGCTGATGATGGCCGAAGCGATCGCGATCGTTTGCGCGCCCAAATACAACGAAACTGGCTACTTCGCCTTAACACCGGACTACGGTATGCAGTTCATAGCGAACTGTAGACAGAGCGGCTTCCACCCGCACCCCAATGACCCGCCTCTGTTTCACAATGTATCACATATAAACGTAGACGACGCAGCTCCTATAGAAATGGTCGATCTCAGGAGATGA

Protein

MQLEEKRPKHVDLASMEPSARVKQLANYGTMVDVDPNVPPRRYYRSGLEMVRMANVYLAEGSLENAYILYMKFMTLFLEKIRKHPEYSSVPAQVKSVNQGKLKEVMPKAEKLKQKLLDQYAKEHAQYKENEEKRQIAEAQKKKQEQADAKLAERLQADENKRDGNSTIPHLLNNEQWVVSPSAPAVDRVLYPDDFAAEPPQAPPHHYQPVPPLIPPSRPHNDSSLGGALYGSHRLRTVVVPAALLGRFLRLAADNTTRNIETCGILAGILERNQLKITHVIVPKQSGTPDSCSTNNEEEIFHYQDQHNLITLGWIHTHPTQTAFLSSVDLHTQCSYQLMMAEAIAIVCAPKYNETGYFALTPDYGMQFIANCRQSGFHPHPNDPPLFHNVSHINVDDAAPIEMVDLRR

Description

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes (By similarity).

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M67C family.

Keywords

Complete proteome   Hydrolase   Metal-binding   Metalloprotease   Protease   Reference proteome   Ubl conjugation pathway   Zinc  

Feature

chain  STAM-binding protein-like A

Uniprot

H9IYT9   A0A2A4JEZ5   A0A194QBG4   A0A212EHR8   A0A2H1WJZ4   A0A2A4IT09   + More
A0A336MJ09   A0A336L450   A0A067RMR1   A0A1L8DME8   A0A0K8TKB2   D6X4C6   A0A1Y1JXA6   B0W7H5   A0A1Q3F798   N6UE47   B4JVA3   U4U056   A0A1I8PTP5   W8BLD5   A0A154PU72   B4LYM2   A0A034VZX0   A0A0A9XYL0   A0A0K8UQY4   A0A0A1X9R0   Q9VA71   B4R1M5   Q8T8R5   B4PLW8   A0A3L8DD54   B3P585   B4HZR2   B4NGW0   A0A0L0BLE6   A0A1A9XTD2   B4K8R5   E0VIA9   A0A1B0BUR2   Q176G0   A0A1I8MC82   A0A3B0K3A1   A0A1W4W458   Q29C42   A0A1A9ZZK4   A0A0M3QYH5   A0A151IQG2   A0A158NU93   A0A1B0FR88   B3MTC0   A0A0P5ECE0   F4WR70   A0A151JCT4   A0A1A9WN38   A0A1B6DP92   A0A195BBN9   A0A0N0BF55   A0A0P4WA17   A0A232FC62   K7J2B7   E9H3M7   R7UEM3   A0A0P5YAE6   A0A1B6G315   C3XZW8   A0A0P6IFD4   A0A3B3YK73   A0A1Z5L619   A0A1B6HV73   A0A293LZQ2   A0A3B3QTS4   A0A2B4RMA9   A0A3B4EER2   E2BU25   Q6TH47   A0A2D0QZI6   F1QBG8   A0A2R5LNF0   A0A3B3X5Z8   U3ID15   A0A3M6V5R6   A0A087XLE7   A0A1A9VVI2   A0A1S3PKR0   R0L8X6   K7FH03   A0A3B3UUW0   A0A0L8GQP8   A0A3N0Z715   A0A0L8GRS4   M4AM50   F7EMR4   W5KDA0   A0A3P8Y729   K7FH21   A0A1A7X4E7   A0A1U7RXZ4   V9KWF6   R7VTM2   A0A093J235  

EC Number

3.4.19.-

Pubmed

19121390    26354079    22118469    24845553    26369729    18362917    + More
19820115    28004739    23537049    17994087    24495485    25348373    25401762    26823975    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    30249741    26108605    20566863    17510324    25315136    15632085    21347285    21719571    28648823    20075255    21292972    23254933    18563158    28528879    29240929    20798317    15520368    23594743    23749191    30382153    17381049    23542700    20431018    25329095    25069045    24402279    23371554   

EMBL

BABH01010846    NWSH01001719    PCG70346.1    KQ459220    KPJ02883.1    AGBW02014807    + More
OWR41029.1    ODYU01009163    SOQ53403.1    NWSH01007570    PCG62905.1    UFQT01001304    SSX29920.1    UFQS01001467    UFQT01001467    SSX11127.1    SSX30698.1    KK852417    KDR24328.1    GFDF01006462    JAV07622.1    GDAI01002919    JAI14684.1    KQ971410    EEZ97535.1    GEZM01098748    JAV53773.1    DS231854    EDS38010.1    GFDL01011604    JAV23441.1    APGK01026102    KB740615    ENN79985.1    CH916374    EDV91423.1    KB631815    ERL86452.1    GAMC01006948    JAB99607.1    KQ435180    KZC14994.1    CH940650    EDW68042.1    GAKP01010106    JAC48846.1    GBHO01018610    GDHC01009153    JAG24994.1    JAQ09476.1    GDHF01023318    JAI28996.1    GBXI01006253    GBXI01000039    JAD08039.1    JAD14253.1    AE014297    BT133327    AAF57051.1    AFE85380.1    CM000364    EDX15013.1    AY075309    AAL68176.1    CM000160    EDW99105.1    QOIP01000009    RLU18261.1    CH954182    EDV53068.1    CH480819    EDW53519.1    CH964272    EDW84457.1    JRES01001702    KNC20778.1    CH933806    EDW15484.1    DS235184    EEB13115.1    JXJN01020881    JXJN01020882    CH477387    EAT42056.1    OUUW01000005    SPP80096.1    CM000070    EAL26804.1    CP012526    ALC47629.1    KQ976780    KYN08391.1    ADTU01026313    CCAG010022123    CH902623    EDV30510.1    GDIP01143999    GDIQ01081659    LRGB01000568    JAJ79403.1    JAN13078.1    KZS17970.1    GL888284    EGI63297.1    KQ979048    KYN23227.1    GEDC01009800    JAS27498.1    KQ976532    KYM81625.1    KQ435812    KOX72861.1    GDRN01087612    JAI61015.1    NNAY01000456    OXU28265.1    AAZX01001561    GL732589    EFX73539.1    AMQN01001639    KB304239    ELU02238.1    GDIP01062053    JAM41662.1    GECZ01012933    JAS56836.1    GG666477    EEN66334.1    GDIQ01005345    JAN89392.1    GFJQ02004114    JAW02856.1    GECU01029166    JAS78540.1    GFWV01008807    MAA33536.1    LSMT01000470    PFX17477.1    GL450575    EFN80799.1    AY398309    BC055512    BC171484    BX005309    CR925773    GGLE01006822    MBY10948.1    ADON01064568    RCHS01000065    RMX61231.1    AYCK01002589    AYCK01002590    KB742995    EOB02104.1    AGCU01127871    AGCU01127872    KQ420799    KOF79313.1    RJVU01007007    ROL54121.1    KOF79310.1    AAMC01014187    HADW01011284    HADW01014888    HADX01012714    SBP12684.1    JW870395    AFP02913.1    KB375463    AKCR02000216    EMC87227.1    PKK18274.1    KK604060    KFW07973.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000027135    UP000007266    + More
UP000002320    UP000019118    UP000001070    UP000030742    UP000095300    UP000076502    UP000008792    UP000000803    UP000000304    UP000002282    UP000279307    UP000008711    UP000001292    UP000007798    UP000037069    UP000092443    UP000009192    UP000009046    UP000092460    UP000008820    UP000095301    UP000268350    UP000192221    UP000001819    UP000092445    UP000092553    UP000078542    UP000005205    UP000092444    UP000007801    UP000076858    UP000007755    UP000078492    UP000091820    UP000078540    UP000053105    UP000215335    UP000002358    UP000000305    UP000014760    UP000001554    UP000261480    UP000261540    UP000225706    UP000261440    UP000008237    UP000000437    UP000221080    UP000016666    UP000275408    UP000028760    UP000078200    UP000087266    UP000007267    UP000261500    UP000053454    UP000002852    UP000008143    UP000018467    UP000265140    UP000189705    UP000053872   

PRIDE

H9IYT9    Q9VA71    Q8T8R5    Q6TH47   

Pfam

PF08969   USP8_dimer        + More
PF01398   JAB

Interpro

IPR015063   USP8_dimer        + More
IPR000555   JAMM/MPN+_dom       
IPR037518   MPN       

ProteinModelPortal

H9IYT9   A0A2A4JEZ5   A0A194QBG4   A0A212EHR8   A0A2H1WJZ4   A0A2A4IT09   + More
A0A336MJ09   A0A336L450   A0A067RMR1   A0A1L8DME8   A0A0K8TKB2   D6X4C6   A0A1Y1JXA6   B0W7H5   A0A1Q3F798   N6UE47   B4JVA3   U4U056   A0A1I8PTP5   W8BLD5   A0A154PU72   B4LYM2   A0A034VZX0   A0A0A9XYL0   A0A0K8UQY4   A0A0A1X9R0   Q9VA71   B4R1M5   Q8T8R5   B4PLW8   A0A3L8DD54   B3P585   B4HZR2   B4NGW0   A0A0L0BLE6   A0A1A9XTD2   B4K8R5   E0VIA9   A0A1B0BUR2   Q176G0   A0A1I8MC82   A0A3B0K3A1   A0A1W4W458   Q29C42   A0A1A9ZZK4   A0A0M3QYH5   A0A151IQG2   A0A158NU93   A0A1B0FR88   B3MTC0   A0A0P5ECE0   F4WR70   A0A151JCT4   A0A1A9WN38   A0A1B6DP92   A0A195BBN9   A0A0N0BF55   A0A0P4WA17   A0A232FC62   K7J2B7   E9H3M7   R7UEM3   A0A0P5YAE6   A0A1B6G315   C3XZW8   A0A0P6IFD4   A0A3B3YK73   A0A1Z5L619   A0A1B6HV73   A0A293LZQ2   A0A3B3QTS4   A0A2B4RMA9   A0A3B4EER2   E2BU25   Q6TH47   A0A2D0QZI6   F1QBG8   A0A2R5LNF0   A0A3B3X5Z8   U3ID15   A0A3M6V5R6   A0A087XLE7   A0A1A9VVI2   A0A1S3PKR0   R0L8X6   K7FH03   A0A3B3UUW0   A0A0L8GQP8   A0A3N0Z715   A0A0L8GRS4   M4AM50   F7EMR4   W5KDA0   A0A3P8Y729   K7FH21   A0A1A7X4E7   A0A1U7RXZ4   V9KWF6   R7VTM2   A0A093J235  

PDB

3RZU     E-value=1.71086e-56,     Score=555

KEGG

101744622    K11866 STAM-binding protein [EC:3.4.19.12] | (RefSeq) STAM-binding protein-like A

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0016020   GO:0070536   GO:0005768   GO:0061578   GO:0004843   GO:0016579   GO:0008233   GO:0016021   GO:0046872   GO:0032154   GO:0008237   GO:0019904   GO:0005654   GO:0005829   GO:0043524   GO:0014067   GO:0046580   GO:0000281   GO:0005515   GO:0005509   GO:0006281   GO:0006772   GO:0003677   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

Length:

408

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.00728

Exp number, first 60 AAs:

0.38842

Total prob of N-in:

0.06374

outside

1  -  408

 

 

Pi

298.247527

Theta

182.384592

Tajima's D

1.667095

CLR

0.006465

CSRT

0.822958852057397

Interpretation

Uncertain