Gene

KWMTBOMO05243  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002426

Annotation

PREDICTED:_mannosyl-oligosaccharide_alpha-1?2-mannosidase_isoform_A_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr9(-):11932949-11948394      View in EpiBrowser

Full name

alpha-1,2-Mannosidase       + More
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA      

Alternative Name

Man(9)-alpha-mannosidase
Mannosidase-1

Location in the cell

Cytoplasmic   Reliability : 0.984

CDS

ATGCGTGCTTATCCCCGTTTGATTTTGACCGCGGTCACTGTTATGATCTGTATGAGCTTGCCTGTCCAAACATTCAACGCGGGACAGGGAACATCGGTGCATCCAGCTAGTCGCCTGGCCCGCGAGGCCCGATCACTTCAATCTAACCAAATCGAAGCTGGTAACAGCAGCAGCTACAGCGGAGCGTTAGATTCCCAGTCATCAGTCGAAAAACAGCGGCACATTATCGAGATGATGCGACACGCTTGGAACAATTACAAACTGTACGCTTGGGGTAAAAATGAACTGAACCCGATATCTAAACGCGCACATTTGTCGAGCGTGTTTGGCTCCGGGGAGATGGGAGCCACCATTGTTGACGGCCTGGACACCTTGTACGTGATGGGCCTGACCGACGAGTTCCGTGAGGGACGTGACTGGATCGCGGAACATTTCAACATCAACGAAATCGATTCCGAACTATCAGTGTTCGAAACGACGATACGTTTTTTGGGAGGTCTGCTGTCTTGCTACGCTCTGACCGGTGACACCATCTTCAGAGACAAAGCCGCCGAGGTCGCCGACGCCCTGCTGCCTGCCTTCGAAACTCCCACTGGACTTCCATACGCTTTAATCAATCCATCCACTAATGCCAGCCGCCAGTATCACTGGGCAGACTCGAACAGTATTCTCTCTGAATTGGGTACATTACACCTCGAGTTCTCATACCTGAGTGACGTCACAGGACGTGAAGTCTACAAGAACAAAGTGGATAAAATACGTGAAGTACTCTACACCATTGAGAAGCCCGGTGATCTTTATCCGAACTACATCAATCCTCGAACCGGACAGTGGGGACAAAGACACATATCCCTGGGAGCTCTGGGTGACTCGTTCTACGAGTACCTGCTGAAGGCCTGGCTCGCGTCGAACCGCGGCGACGAGCAGGCGCGCACCATGTTCGACACGGCGATGCAGGCCGCGCTCGACAAGATGCTGCGCGTGTCGCCCTCCGGCCTCGCCTACCTCGCCGAACTCAAGTACGGCTGGGTCATCGAAGAGAAGATGGAACACTTGTCTTGCTTCGCTGGTGGCATGTTCGCATTAGCCGCTACGACATTGGAGAATTCGTTTTCTGAACGGTACATGGACGTCGCAAGGAAACTGACCCACACCTGCCACGAGTCCTACTTCAGATCCGAAACTAAACTGGGACCAGAGGCATTCAGATTTTCGAACGCAGTCGAAGCCCGAGCTCAGAAGAGCGACGAGAAAGTTTACTTGCTGAGGCCGGAGACGTTTGAGAGCTACTTCATCATGTGGCGACTCACCAAGGAGCAGAAGTACCGCGACTGGGGCTGGGAGGCGGTTCAAGCGCTAGAGAAGCATTGTCGCGTCGAAGGCGGCTACACCGGACTCACGAACGTCTACCACCAGAACCCTCAGGGCGACGACGTGCAGCAGAGCTACTTCCTCGCTGAAACACTTAAGTACCTCTACCTTCTGTTCTCGGACGACTCTCTCCTTTCGCTCGACGAGTGGGTGTTCAACACTGAAGCTCATCCGCTTCCAATTAAAGGCAAGAATCCCCTGTACCGCATGGCGAGCACGCCCGTGCCAATAGAAGACAACCGAGTCTAA

Protein

MRAYPRLILTAVTVMICMSLPVQTFNAGQGTSVHPASRLAREARSLQSNQIEAGNSSSYSGALDSQSSVEKQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFLGGLLSCYALTGDTIFRDKAAEVADALLPAFETPTGLPYALINPSTNASRQYHWADSNSILSELGTLHLEFSYLSDVTGREVYKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAETLKYLYLLFSDDSLLSLDEWVFNTEAHPLPIKGKNPLYRMASTPVPIEDNRV

Description

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).

Catalytic Activity

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).

Similarity

Belongs to the glycosyl hydrolase 47 family.

Keywords

Alternative promoter usage   Calcium   Complete proteome   Disulfide bond   Glycoprotein   Glycosidase   Golgi apparatus   Hydrolase   Membrane   Metal-binding   Reference proteome   Signal-anchor   Transmembrane   Transmembrane helix  

Feature

chain  alpha-1,2-Mannosidase
splice variant  In isoform K.

Uniprot

H9IYU1   H9IZ01   A0A194QD26   A0A2H1WJZ7   A0A194RNB4   A0A212EHT2   + More
O18498   B4JXQ3   P53624   A0A139WAB1   A0A139WAC4   A0A0Q5TDT9   P53624-2   Q8IRL4   A0A1Y1KXM7   B4IDP0   A0A0Q5THZ9   B3NW46   A0A0R1EBX4   A0A1I8MGL1   A0A0Q9WMV7   B4PXH4   A0A1Y1KZY0   A0A0R1ECD8   A0A0Q9WPD3   A0A0Q9WM44   T1P828   B4L336   A0A1W4VUH6   A0A1W4VTQ6   A0A1W4VG52   A0A2J7QK67   A0A1I8PYM2   A0A1B0C9F4   B3MW69   V5H014   A0A1I8PYK5   U4UXU6   A0A3B0JZ12   B4M3C5   A0A0L0C1T1   A0A1J1HHC9   B4NDR0   A0A0M4EUG7   A0A084VDD7   A0A1J1HHC8   A0A1I8MQ91   A0A182IR84   A0A1L8DR25   Q29CI1   E0VI77   A0A0K8UXX6   A0A067R784   A0A0K8UCW3   U5EW55   A0A336LLS7   A0A0A1WR15   A0A1B0FJA7   B4H0T3   A0A0V0G9J1   A0A1W4WPU2   A0A1Q3G2C4   A0A1Q3FXU1   A0A1Q3G2D8   A0A1Q3FXV6   A0A182FK62   A0A069DWB1   A0A0T6B9R8   A0A1A9XXP1   A0A1A9VY99   A0A1B0APE7   A0A1B0ADR1   A0A0P6J5H2   A0A2M4AMB6   A0A224XK05   A0A2M4A8U7   A0A2M4BFT9   A0A0P4W0H0   A0A146M1M6   A0A2M4CS39   A0A2M4CS71   A0A2M4ACR5   A0A2M4BIY6   A0A2M4CSW7   A0A2M3Z0S8   A0A2M4A6G7   A0A1A9W8L9   A0A2M3YYF6   A0A2M4A6C9   A0A2M4A694   A0A0A9X5C5   A0A1S4G324   A0A182GD08   A0A182N1H4   E9FX86   Q16FK8   B0WSW5   Q16IH0   A7USG7   A0A1Y1L4V4  

EC Number

3.2.1.-
3.2.1.113

Pubmed

19121390    26354079    22118469    9147053    17994087    7729592    + More
10731132    12537572    18362917    19820115    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28004739    17550304    25315136    18057021    23537049    26108605    24438588    15632085    20566863    24845553    25830018    26334808    26999592    27129103    26823975    25401762    17510324    26483478    21292972    12364791    14747013    17210077   

EMBL

BABH01010836    BABH01010837    BABH01010832    KQ459220    KPJ02880.1    ODYU01009163    + More
SOQ53401.1    KQ459984    KPJ19002.1    AGBW02014807    OWR41031.1    AF005035    AAB62720.1    CH916376    EDV95152.1    X82640    X82641    AE014298    BT011036    KQ971410    KYB24855.1    KYB24856.1    CH954180    KQS29861.1    BT024451    AAN09256.2    ABC86513.1    GEZM01071031    JAV66112.1    CH480830    EDW45698.1    KQS29860.1    EDV46179.1    CM000162    KRK07020.1    CH933810    KRF93895.1    EDX02925.1    GEZM01071035    JAV66108.1    KRK07021.1    CH940651    KRF82176.1    KRF82175.1    KA644704    AFP59333.1    EDW06964.1    NEVH01013277    PNF28973.1    AJWK01002278    CH902625    EDV35214.1    GALX01002318    JAB66148.1    KB632410    ERL95186.1    OUUW01000011    SPP86313.1    EDW65300.1    KRF82174.1    JRES01000996    KNC26313.1    CVRI01000004    CRK87431.1    CH964239    EDW81879.1    CP012528    ALC49401.1    ATLV01011268    ATLV01011269    KE524660    KFB35981.1    CRK87432.1    GFDF01005260    JAV08824.1    CH475471    EAL29254.3    DS235184    EEB13083.1    GDHF01020931    JAI31383.1    KK852898    KDR14159.1    GDHF01028114    GDHF01008468    JAI24200.1    JAI43846.1    GANO01001574    JAB58297.1    UFQT01000005    SSX17317.1    GBXI01013332    JAD00960.1    CCAG010011096    CCAG010011097    CH479201    EDW29998.1    GECL01001616    JAP04508.1    GFDL01001067    JAV33978.1    GFDL01002648    JAV32397.1    GFDL01001060    JAV33985.1    GFDL01002638    JAV32407.1    GBGD01000758    JAC88131.1    LJIG01002912    KRT84028.1    JXJN01001384    GDUN01000555    JAN95364.1    GGFK01008551    MBW41872.1    GFTR01007494    JAW08932.1    GGFK01003829    MBW37150.1    GGFJ01002779    MBW51920.1    GDKW01000233    JAI56362.1    GDHC01005952    JAQ12677.1    GGFL01003988    MBW68166.1    GGFL01003989    MBW68167.1    GGFK01005250    MBW38571.1    GGFJ01003637    MBW52778.1    GGFL01003750    MBW67928.1    GGFM01001386    MBW22137.1    GGFK01003024    MBW36345.1    GGFM01000534    MBW21285.1    GGFK01002990    MBW36311.1    GGFK01003003    MBW36324.1    GBHO01031304    GBHO01012830    GBRD01008954    GDHC01013097    JAG12300.1    JAG30774.1    JAG56867.1    JAQ05532.1    JXUM01055002    JXUM01055003    KQ561847    KXJ77349.1    GL732526    EFX88311.1    CH478417    EAT33026.1    DS232077    EDS34093.1    CH478078    EAT34060.1    AAAB01008846    EDO64315.2    GEZM01071036    JAV66107.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000001070    UP000000803    + More
UP000007266    UP000008711    UP000001292    UP000002282    UP000095301    UP000009192    UP000008792    UP000192221    UP000235965    UP000095300    UP000092461    UP000007801    UP000030742    UP000268350    UP000037069    UP000183832    UP000007798    UP000092553    UP000030765    UP000075880    UP000001819    UP000009046    UP000027135    UP000092444    UP000008744    UP000192223    UP000069272    UP000092443    UP000078200    UP000092460    UP000092445    UP000091820    UP000069940    UP000249989    UP000075884    UP000000305    UP000008820    UP000002320    UP000007062   

PRIDE

H9IYU1    H9IZ01    P53624    Q8IRL4   

Pfam

PF01532   Glyco_hydro_47

Interpro

IPR001382   Glyco_hydro_47        + More
IPR012341   6hp_glycosidase-like_sf       
IPR036026   Seven-hairpin_glycosidases       

SUPFAM

SSF48225   SSF48225       

Gene 3D

1.50.10.10    

ProteinModelPortal

H9IYU1   H9IZ01   A0A194QD26   A0A2H1WJZ7   A0A194RNB4   A0A212EHT2   + More
O18498   B4JXQ3   P53624   A0A139WAB1   A0A139WAC4   A0A0Q5TDT9   P53624-2   Q8IRL4   A0A1Y1KXM7   B4IDP0   A0A0Q5THZ9   B3NW46   A0A0R1EBX4   A0A1I8MGL1   A0A0Q9WMV7   B4PXH4   A0A1Y1KZY0   A0A0R1ECD8   A0A0Q9WPD3   A0A0Q9WM44   T1P828   B4L336   A0A1W4VUH6   A0A1W4VTQ6   A0A1W4VG52   A0A2J7QK67   A0A1I8PYM2   A0A1B0C9F4   B3MW69   V5H014   A0A1I8PYK5   U4UXU6   A0A3B0JZ12   B4M3C5   A0A0L0C1T1   A0A1J1HHC9   B4NDR0   A0A0M4EUG7   A0A084VDD7   A0A1J1HHC8   A0A1I8MQ91   A0A182IR84   A0A1L8DR25   Q29CI1   E0VI77   A0A0K8UXX6   A0A067R784   A0A0K8UCW3   U5EW55   A0A336LLS7   A0A0A1WR15   A0A1B0FJA7   B4H0T3   A0A0V0G9J1   A0A1W4WPU2   A0A1Q3G2C4   A0A1Q3FXU1   A0A1Q3G2D8   A0A1Q3FXV6   A0A182FK62   A0A069DWB1   A0A0T6B9R8   A0A1A9XXP1   A0A1A9VY99   A0A1B0APE7   A0A1B0ADR1   A0A0P6J5H2   A0A2M4AMB6   A0A224XK05   A0A2M4A8U7   A0A2M4BFT9   A0A0P4W0H0   A0A146M1M6   A0A2M4CS39   A0A2M4CS71   A0A2M4ACR5   A0A2M4BIY6   A0A2M4CSW7   A0A2M3Z0S8   A0A2M4A6G7   A0A1A9W8L9   A0A2M3YYF6   A0A2M4A6C9   A0A2M4A694   A0A0A9X5C5   A0A1S4G324   A0A182GD08   A0A182N1H4   E9FX86   Q16FK8   B0WSW5   Q16IH0   A7USG7   A0A1Y1L4V4  

PDB

5KKB     E-value=2.83478e-142,     Score=1296

KEGG

101744477    K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113] | (RefSeq) mannosyl-oligosaccha

PATHWAY

00510    N-Glycan biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0016020   GO:0008152   GO:0005509   GO:0004571   GO:0016021   GO:0000139   GO:0006486   GO:0008340   GO:0012505   GO:0072347   GO:0035010   GO:0005783   GO:0006491   GO:0006281   GO:0006772   GO:0003677   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

Subcellular location

Golgi apparatus membrane  

SignalP

Position:   1 - 24,         Likelihood:  0.958902

 

 

Length:

539

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

10.58299

Exp number, first 60 AAs:

10.52847

Total prob of N-in:

0.51653

POSSIBLE N-term signal

sequence

outside

1  -  539

 

 

Pi

144.455212

Theta

142.297566

Tajima's D

0.181859

CLR

121.495375

CSRT

0.422428878556072

Interpretation

Uncertain