SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO05242  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA002486
Annotation
PREDICTED:_mannosyl-oligosaccharide_alpha-1?2-mannosidase_isoform_A_isoform_X2_[Bombyx_mori]
Full name
alpha-1,2-Mannosidase       + More
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA      
Alternative Name
Man(9)-alpha-mannosidase
Mannosidase-1
Location in the cell
Cytoplasmic   Reliability : 1.095 Mitochondrial   Reliability : 1.058
 

Sequence

CDS
ATGCGTGCTTATCCCCGTTTGATTTTGACCGCGGTCACTGCTATTATCTGTATGAGTTTGCTTGTCCAAACATTCAACGCGGGACAGGGAACATCGGTGCATCCAGCTAGTCACCTGGCCCGCGAGGCCCGATCACTTCAATCTAACCAAATCGAAGCTGGTAACAGCAGCAGCTACAGCGGAGCGTTAGATTCCCAGTCATCAGTCGAAAAACAGCGGTACATTATCGAGATGATGCGACACGCTTGGAACAATTACAAACTGTACGCTTGGGGTAAAAATGAACTGAAACCGATATCTAAACGCGCACATTTGTCGAGCGTGTTTGGCTCCGGGGAGATGGGAGCCACCATTGTTGACGGCCTGGACACCTTGTACGTGATGGGCCTGACCGACGAGTTCCGTGAGGGACGTGACTGGATCGCGGAACATTTCAACATCAACGAAATCGATTCCGAACTATCAGTATTCGAAACGACGATACGTTTTGTGGGAGGTCTGCTGTCTTGCTACGCTCTGACCGGTGACACCATCTTCAGAGACAAAGCCGCCGAGGTCGCCGACGCCCTGCTGCCTGCCTTCGAAACTCCCACTGGACTCCCATACGCTTTAATCAATCCATCCACTAAGGCCAGCCGCCAGTATCACTGGGCAGGCCCGAACAGTATCCTCTCTGAATTGGGTACATTGCACCTCGAGTTCTCATACCTGAGTGACGTCACAGGACGTGAAGTCTACAGGAACAAAGTGGATAAAATACGTGAAGTTCTCTACAACATTGAGAAGCCCGGTGATCTTTATCCGAACTTCATCAATCCTCGAACCGGACAGTGGGGACAAAGACACATATCCCTGGGAGCTCTGGGCGACTCGTTCTACGAGTACCTGCTGAAGGCCTGGCTCGCGTCGAACCGCGGCGACGAGCAGGCGCGCACCATGTTCGACACGGCGATGCAGGCCGCGCTCGACAAGATGCTGCGCGTGTCGCCCTCCGGCCTCGCCTACCTCGCCGAACTCAAGTACGGCAGGGTCATCGAAGAGAAGATGGATCACTTGTCTTGCTTCGCTGGTGGCATGTTCGCTTTGGCCGCTACGACATTGGAGAATTCGTTGTCTGAACGGTACATGGACGTCGCAAGGAAACTGACCCACACCTGCCACGAGTCCTACTTCAGATCCGAAACTAAACTGGGACCAGAGGCATTCAGATTTTCGAACGCAGTCGAAGCCCGAGCTCAGAAGAGCAACGAGAAAGTTTACATACTGAGGCCGGAGACGTTCGAGAGCTACTTCATCATGTGGCGACTCACCAAGGAGCAGAAGTACCGCGACTGGGGCTGGGAGGCGGTTCAGGCGCTAGAGAAGCATTGTCGCGTCGAAGGCGGCTACACCGGACTCACGAACGTCTACCACCAGAACCCTCAGGGCGACGACGTGCAACAGAGCTACTTCCTCGCTGAAACACTTAAGTACCTCTACCTTCTGTTCTCGGACGACTCTCTCCTTTCGCTCGACGAGTGGGTGTTCAACACTGAAGCTCATCCGCTTCCAATTAAAGGCAAGAATCCCCTGTACCGCATGGCGAGCACGCCCGTGCCAATAGAAGACAACCGAGTCTAA
Protein
MRAYPRLILTAVTAIICMSLLVQTFNAGQGTSVHPASHLAREARSLQSNQIEAGNSSSYSGALDSQSSVEKQRYIIEMMRHAWNNYKLYAWGKNELKPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADALLPAFETPTGLPYALINPSTKASRQYHWAGPNSILSELGTLHLEFSYLSDVTGREVYRNKVDKIREVLYNIEKPGDLYPNFINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGRVIEEKMDHLSCFAGGMFALAATTLENSLSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSNEKVYILRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAETLKYLYLLFSDDSLLSLDEWVFNTEAHPLPIKGKNPLYRMASTPVPIEDNRV

Summary

Description
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Catalytic Activity
Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).
Similarity
Belongs to the glycosyl hydrolase 47 family.
Keywords
Alternative promoter usage   Calcium   Complete proteome   Disulfide bond   Glycoprotein   Glycosidase   Golgi apparatus   Hydrolase   Membrane   Metal-binding   Reference proteome   Signal-anchor   Transmembrane   Transmembrane helix  
Feature
chain  alpha-1,2-Mannosidase
splice variant  In isoform K.
EC Number
3.2.1.-
3.2.1.113
EMBL
BABH01010832    BABH01010836    BABH01010837    ODYU01009163    SOQ53401.1    KQ459220    + More
KPJ02880.1    KQ459984    KPJ19002.1    AF005035    AAB62720.1    AGBW02014807    OWR41031.1    CH916376    EDV95152.1    X82640    X82641    AE014298    BT011036    KQ971410    KYB24856.1    KYB24855.1    GEZM01071031    JAV66112.1    CH480830    EDW45698.1    CH954180    KQS29861.1    EDV46179.1    BT024451    AAN09256.2    ABC86513.1    CH933810    KRF93895.1    CM000162    EDX02925.1    KQS29860.1    KRK07021.1    GEZM01071035    JAV66108.1    KRK07020.1    KA644704    AFP59333.1    EDW06964.1    CH940651    KRF82176.1    KRF82175.1    NEVH01013277    PNF28973.1    CH902625    EDV35214.1    GALX01002318    JAB66148.1    AJWK01002278    OUUW01000011    SPP86313.1    CH964239    EDW81879.1    EDW65300.1    KRF82174.1    CP012528    ALC49401.1    ATLV01011268    ATLV01011269    KE524660    KFB35981.1    JRES01000996    KNC26313.1    KB632410    ERL95186.1    CH475471    EAL29254.3    CVRI01000004    CRK87431.1    CRK87432.1    GFDF01005260    JAV08824.1    DS235184    EEB13083.1    KK852898    KDR14159.1    GANO01001574    JAB58297.1    CCAG010011096    CCAG010011097    GECL01001616    JAP04508.1    GDHF01020931    JAI31383.1    CH479201    EDW29998.1    GDHF01028114    GDHF01008468    JAI24200.1    JAI43846.1    UFQT01000005    SSX17317.1    GBXI01013332    JAD00960.1    GBGD01000758    JAC88131.1    GFTR01007494    JAW08932.1    GDKW01000233    JAI56362.1    JXJN01001384    GFDL01002638    JAV32407.1    GFDL01002648    JAV32397.1    LJIG01002912    KRT84028.1    GFDL01001067    JAV33978.1    GFDL01001060    JAV33985.1    GDHC01005952    JAQ12677.1    GBHO01031304    GBHO01012830    GBRD01008954    GDHC01013097    JAG12300.1    JAG30774.1    JAG56867.1    JAQ05532.1    GDUN01000555    JAN95364.1    GGFJ01003637    MBW52778.1    GGFJ01002779    MBW51920.1    GGFL01003750    MBW67928.1    GGFM01000534    MBW21285.1    GGFK01008551    MBW41872.1    GGFK01003829    MBW37150.1    GGFM01001386    MBW22137.1    GGFK01002990    MBW36311.1    GGFK01005250    MBW38571.1    GGFK01003003    MBW36324.1    GGFK01003024    MBW36345.1    DS232077    EDS34093.1    GGFL01003989    MBW68167.1    GGFL01003988    MBW68166.1    CH478417    EAT33026.1    GL732526    EFX88311.1    JXUM01055002    JXUM01055003    KQ561847    KXJ77349.1    GEZM01071036    JAV66107.1    CH478078    EAT34060.1   
Pfam
PF01532   Glyco_hydro_47
Interpro
IPR012341   6hp_glycosidase-like_sf        + More
IPR036026   Seven-hairpin_glycosidases       
IPR001382   Glyco_hydro_47       
SUPFAM
SSF48225   SSF48225       
Gene 3D
PDB
5KKB     E-value=2.02919e-144,     Score=1315

Ontologies

Topology

Subcellular location
Golgi apparatus membrane  
SignalP
Position:   1 - 24,         Likelihood:  0.840795
 
 
Length:
539
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
17.8818799999999
Exp number, first 60 AAs:
17.82193
Total prob of N-in:
0.86994
POSSIBLE N-term signal
sequence
inside
1  -  6
TMhelix
7  -  29
outside
30  -  539
 
 

Population Genetic Test Statistics

Pi
222.152756
Theta
179.338326
Tajima's D
0.996069
CLR
0.002785
CSRT
0.658767061646918
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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