Gene

KWMTBOMO05231  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002428

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_membrane-associated_protein_Hem_[Bombyx_mori]

Location

Bomo_Chr9(-):11643322-11646990      View in EpiBrowser

Full name

Membrane-associated protein Hem      

Alternative Name

dHem-2

Location in the cell

Cytoplasmic   Reliability : 1.037 Nuclear   Reliability : 1.55 PlasmaMembrane   Reliability : 1.307

CDS

ATGTCCACATTATCAAGATCCCTGAATATTAGTCAGCAAAAATTAGCTGAGAAGCTAATTATACTGAATGACAGAGGTATTGGTATTTTAACAAGAGTTTACAACATTAAGAAAGCCTGTGGAGATGCCAAATCGAAACCAGCATTTCTATCTGATAAAGCATTGGAGTCATCAATTAAGCACATAGTTAGGAGATTTCCCAACATTGACGTTAAAGGACTCCAAGCAATTACACCAATACGGAATGAAGTAATCAAATCATTGTCGCTATACTATTACACATTTGTAGATTTGTTAGATTTTAAAGACAATGTTTGTGAACTTCTTAACATCATAGATGCATGTCAGGTTACTTTAGACTTGACATTGAATTTTGAATTGACAAAAAACTATCTTGACTTGGTTTTAACATATGTTACACTAATGATATTGTTGTCTCGAGTTGAAGACAGAAAAGCAGTGTTAGGTTTATTTAATGCTGCATATGAATTGCTACAGAATCAAATTGAGAATAGTTTTCCTCGTTTGGGACAGTTGATTGTTGATTATGATGCTCCATTGAAGAAATTGTCTGAAGAATTTGTGCCACATCAAAAAGTACTAGCAAGTGCATTAAATTCTCTATGGCATGTGTATCCAGCTAGAAATCTTTCTGCTGAACATTGGAGATCAGAGCAAAAGCTAAGCTTAGTAAGTAATCCAGCTCAGTTACTGAAACCATCAGAAACAAACACAATGTCTTGTGAATATGTATCATTGGAGTCTTTGGAGAGGTGGGTCATATTTGGTTTTGCACTCTGTCATCAGATGCTCCAGCAGGACCATGCTAATAAAATGTGGGTCAATGCACTAGAGTCAGGATGGGTTGTGGCATTATTTAGAGATGAAGTGATTTACATTCACAGCTATATACAAGGTTTCTTTGACAGCATAAAAGGCTATGGCAAAAGAATATCTGAAGTAAAAGATTGTTACCATCATGCAGTACAGAAAGCAGGATACAAACACAGAGAGAGGAGAAAATTCTTAAGAACAGCTTTGAAAGAACTGGGTCTAATATTGACTGATCAACCAGGATTATTGGGCCCAAAAGCTCTTTTAATTTTCATTGGCCTCTGCTATGCAAGAGATGAAGTATTTTGGCTGTTGCGACATAATGATAACCCACCACAAAAAGTAAAGGGAAAATCTGCAGAAGATTTGGTAGACCGTCAACTTCCTGAACTTTTGTTCCACATGGAAGAATTAAGAGCATTGGTTCGTAAATATAGTCAGGTAATGCAGAGATACTATGTGCAATACCTTTCAGGCTTTGATGCTGTAGCATTGAACATGATGATTCAGAACTTGAAGGTATGTCCTGAAGACGAAAGTATAATATTATCATCTTTATGTACTACTGCAGCAAATTTGAGTGTCAAACAGGTTGAAGAGAATGAGCCATTTGATTTTCGATCTTTCCGTTTAGATTGGTTCAGACTTCAAGCATATACATCTGTTGTCAAAACCCCCTTGAGTCTTGTTGATCAAAGGGAACTGGCTCAGTTTATAGACAAAATGGTATTCCATACTAAAATGGTAGATAACCTTGATGAAATAATGGTTGAAACATCTGATCTGTCAATATTTTGCTTTTACAACAAAATATTTGAAAATCAGTTCCATATGTGTCTTGAGTTCCCTGCACAAAATCGGTATATTATAGCATTCCCGCTTATTTGTAGTCATTTCCAAAATTGTACTCATGAACTATGCCCTGAAGAGAGGCATCACATTCTAGAGAGAAGTTTGTCAGTAGTCAACATATTCTTGGATGAAATGGCAAAAGAAGCAAAAAACATTATCACCACTATATGTGATGAACAGTGTACTATGAGTGACAAATTACTACCCAAACATTGTGCACAAACTATAGCTCATTTAGCTAACAGAAAAAAGAAGGATAAAAATAAGAAAAACACAATTGAAATTGTTAAGCCTGGAGCAGAAAGTTACAGAAAAACCAGAGAAGAATTGACAACCATGGACAAACTTCACATGGCTTTGACAGAATTATGCTATGCTATAAATTATTGTTCCACTGTAAATGTTTGGGAGTATACTTTTGCACCACGAGAGTACTTGCACCAACATTTGGAAACTAGATTCTCTAAGGCCTTGGTTGGCATGGTAATGTTTAACCAAGACACAAGTGAAATTGCTAAGCCTTCTGAGTTGCTTGTTAGTGTTCGTGCATACATGAATGTGCTTCAAACTGTTGAAAATTACGTTCATATTGATATTACACGAGTTTTCAATAATTGTCTTTTACAACAAACTCAAAATATGGATAGTCATAAAGAAAAAACCATTGCATCATTGTATACACAGTGGTACTCTGAGATTTTACTGAGACGGGTCAGTGCTGGTAGTATTTGTTTTTCAATGAGTCAAAAAGCATTTGTTAGTTTGACAGCCGAAGGTGCTATACCCTTTAATGCCGAGGAATATTCTGATATTAATGAGTTAAGGGCATTAGCTGAATTAATTGGGCCCTATGGCATGAAACTGTTAAGTGAAACACTAATGTGGCAAATTGCAAGTCAAGTACAGGAATTGAAGAAACTGGTTGTACAAAATAAAGAGGTGTTGCAGATGCTCAGGACAAATTTTGATAAACCAGAAATTATGAGAGAGCAGTTCAAAAGATTGCAAAATGTGGATAATGTACTACAACGGATGACCATTATTGGAGTCATATTGAGTTTCAGACAAATAGCTCAAGAGTCATTACTAGATGTTTTAGAAAGGCGTATTCCGTTTTTGATAAGTTCCATAAAAGACTTCCAGCAACAGCTGCCGAGTGGTGATCCAATGCGAGTCATTTCAGAAATGTGTTCTGCTGCTGGCCTACCGTGCAAAGTGGATCCAACATTGGCATCAGCTTTACGTCAGCAAAAATCAGAAGTTGAGGAGGAAGAGCATTTAATTGTATGCTTGCTAATGGTGTTTGTTGCTGTGTCTTTGCCTAGACTAGCTCGGAGTGAAGTATCTTTCTATCGACCTTCCCTGGAAGGTCATGCTAACAATATACACTGTATAGCTCCAGCTATCAACCACATATTCGGTGCTTTATTCACTATATGCGGCCAGGGCGATATCGAGGATCGAATGAAAGAATTCTTAGCTTTAGCGTCATCATCTTTGCTTCGTTTAGGGCAAGAAACTGATAAAGAAGCTACTAAGAATAGGGAATCAGTTTACCTTCTATTAGACTTGATAGTGCAGGAGTCACCCTTTCTTACAATGGATTTGTTGGAGTCATGTTTTCCATATGTATTGATACGTAATGCTTATCATGAAGTTTATAAACAAGAGCAGATGCTTCTGCATATGTAA

Protein

MSTLSRSLNISQQKLAEKLIILNDRGIGILTRVYNIKKACGDAKSKPAFLSDKALESSIKHIVRRFPNIDVKGLQAITPIRNEVIKSLSLYYYTFVDLLDFKDNVCELLNIIDACQVTLDLTLNFELTKNYLDLVLTYVTLMILLSRVEDRKAVLGLFNAAYELLQNQIENSFPRLGQLIVDYDAPLKKLSEEFVPHQKVLASALNSLWHVYPARNLSAEHWRSEQKLSLVSNPAQLLKPSETNTMSCEYVSLESLERWVIFGFALCHQMLQQDHANKMWVNALESGWVVALFRDEVIYIHSYIQGFFDSIKGYGKRISEVKDCYHHAVQKAGYKHRERRKFLRTALKELGLILTDQPGLLGPKALLIFIGLCYARDEVFWLLRHNDNPPQKVKGKSAEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDAVALNMMIQNLKVCPEDESIILSSLCTTAANLSVKQVEENEPFDFRSFRLDWFRLQAYTSVVKTPLSLVDQRELAQFIDKMVFHTKMVDNLDEIMVETSDLSIFCFYNKIFENQFHMCLEFPAQNRYIIAFPLICSHFQNCTHELCPEERHHILERSLSVVNIFLDEMAKEAKNIITTICDEQCTMSDKLLPKHCAQTIAHLANRKKKDKNKKNTIEIVKPGAESYRKTREELTTMDKLHMALTELCYAINYCSTVNVWEYTFAPREYLHQHLETRFSKALVGMVMFNQDTSEIAKPSELLVSVRAYMNVLQTVENYVHIDITRVFNNCLLQQTQNMDSHKEKTIASLYTQWYSEILLRRVSAGSICFSMSQKAFVSLTAEGAIPFNAEEYSDINELRALAELIGPYGMKLLSETLMWQIASQVQELKKLVVQNKEVLQMLRTNFDKPEIMREQFKRLQNVDNVLQRMTIIGVILSFRQIAQESLLDVLERRIPFLISSIKDFQQQLPSGDPMRVISEMCSAAGLPCKVDPTLASALRQQKSEVEEEEHLIVCLLMVFVAVSLPRLARSEVSFYRPSLEGHANNIHCIAPAINHIFGALFTICGQGDIEDRMKEFLALASSSLLRLGQETDKEATKNRESVYLLLDLIVQESPFLTMDLLESCFPYVLIRNAYHEVYKQEQMLLHM

Description

Plays a role during growth of the oocyte.

Subunit

Component of the WAVE complex composed of Hem/Kette, Scar/Wave and Sra-1/Cyfip where it binds directly to the C-terminus of Sra-1.

Similarity

Belongs to the heat shock protein 70 family.
Belongs to the HEM-1/HEM-2 family.

Keywords

Cell membrane   Complete proteome   Membrane   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Membrane-associated protein Hem

Uniprot

A0A1E1VYL1   A0A194QBF4   A0A2H1VZQ4   A0A194RME1   A0A212FPB6   A0A0L7KR32   + More
A0A1B6E8D2   A0A2J7RSR7   A0A067R1Z2   A0A0A9YNG5   A0A0C9RHN7   A0A151WUN7   A0A151JZS4   E2C9I5   F4X615   A0A195C7Q6   A0A151IY57   A0A0J7L6I5   E2ALH9   A0A151I1Z4   A0A158NMS9   E9J2G9   A0A2A3E3X8   K7IXQ7   A0A310SQH9   A0A1Y1K2U0   A0A026W2C6   A0A088AFJ6   A0A1W4WP41   A0A154PMQ3   E0W2A8   A0A023F447   A0A0L7QJK1   A0A0V0G7U7   A0A0T6BES9   Q16V64   A0A069DZQ9   A0A1Q3FXH3   A0A0N7Z970   A0A182H761   A0A2C9GQZ7   A0A182TK65   A0A182KNQ8   Q7PPI1   A0A182VI02   A0A182M787   A0A2M4AEB2   A0A182SLJ9   A0A182X2H7   W5J5D3   A0A182QSA6   A0A336LPG5   A0A182YKR9   A0A182WM09   A0A182JBE8   A0A182K4N4   A0A182N1Z7   A0A182P5G5   D7EI65   A0A182RAL7   W8AWC4   A0A0K8UG50   A0A034VHD8   A0A0A1XHY9   B4MND0   A0A0M4F0H1   B3MB43   A0A1A9WSP3   B4KX53   A0A1B0FKC3   A0A1A9XGF2   A0A1B0BZM6   A0A1A9ZKP0   A0A1A9UFU4   P55162   A0A1I8M685   B3NJ37   T1PFW3   A0A3B0JRM4   Q29E13   B4H430   A0A1W4UZ08   B4QKR9   B4LFH9   B4IAZ8   A0A0L0BUH4   B4J304   A0A1J1IGR0   A0A1B6KH25   A0A1I8Q3C5   A0A1J1J7Q4   H9IYU3   U4UE05   N6TSI2   A0A0P5RNZ5   E9FST5   A0A0P5XNV6   A0A0P5LU54   T1JIM6   A0A3R7M9U9  

Pubmed

26354079    22118469    26227816    24845553    25401762    20798317    + More
21719571    21347285    21282665    20075255    28004739    24508170    30249741    20566863    25474469    17510324    26334808    27129103    26483478    20966253    12364791    14747013    17210077    20920257    23761445    25244985    18362917    19820115    24495485    25348373    25830018    17994087    7643388    10731132    12537572    12537569    15385157    25315136    15632085    22936249    26108605    19121390    23537049    21292972   

EMBL

GDQN01011237    GDQN01002207    JAT79817.1    JAT88847.1    KQ459220    KPJ02873.1    + More
ODYU01005387    SOQ46176.1    KQ459984    KPJ18993.1    AGBW02003014    OWR55588.1    JTDY01006954    KOB65570.1    GEDC01003119    JAS34179.1    NEVH01000250    PNF43871.1    KK852808    KDR16018.1    GBHO01009017    JAG34587.1    GBYB01006466    JAG76233.1    KQ982729    KYQ51563.1    KQ981374    KYN42394.1    GL453868    EFN75387.1    GL888761    EGI58109.1    KQ978231    KYM96178.1    KQ980775    KYN13235.1    LBMM01000540    KMQ98104.1    GL440609    EFN65681.1    KQ976560    KYM80593.1    ADTU01020778    GL767845    EFZ12994.1    KZ288422    PBC25956.1    KQ760129    OAD61839.1    GEZM01098871    JAV53696.1    KK107499    QOIP01000007    EZA49751.1    RLU20495.1    KQ434948    KZC12490.1    DS235875    EEB19764.1    GBBI01002466    JAC16246.1    LHQN01029188    KQ414657    KOC58745.1    KOC65739.1    GECL01002743    JAP03381.1    LJIG01001249    KRT85691.1    CH477602    EAT38438.1    GBGD01000210    JAC88679.1    GFDL01002893    JAV32152.1    GDKW01001371    JAI55224.1    JXUM01115630    KQ565901    KXJ70552.1    APCN01004639    AAAB01008948    EAA10373.3    AXCM01003267    GGFK01005731    MBW39052.1    ADMH02002171    ETN58075.1    AXCN02000979    UFQT01000031    SSX18267.1    DS497673    EFA13274.1    GAMC01017512    JAB89043.1    GDHF01026771    JAI25543.1    GAKP01017974    JAC40978.1    GBXI01003720    JAD10572.1    CH963847    EDW72639.1    CP012525    ALC44257.1    CH902618    EDV41344.1    CH933809    EDW19696.1    CCAG010018197    JXJN01023210    X80028    AE014296    AY118579    CH954178    EDV52754.1    KA646783    AFP61412.1    OUUW01000002    SPP76349.1    CH379070    EAL30250.1    CH479208    EDW31145.1    CM000363    CM002912    EDX11484.1    KMZ01168.1    CH940647    EDW70297.1    CH480826    EDW44461.1    JRES01001310    KNC23681.1    CH916366    EDV97174.1    CVRI01000050    CRK99437.1    GEBQ01029258    JAT10719.1    CVRI01000072    CRL07502.1    BABH01010805    BABH01010806    KB632314    ERL92204.1    APGK01053803    KB741235    ENN72215.1    GDIQ01107025    JAL44701.1    GL732524    EFX89764.1    GDIP01081728    LRGB01000890    JAM21987.1    KZS15328.1    GDIQ01165551    JAK86174.1    JH432213    QCYY01002360    ROT70995.1   

Proteomes

UP000053268    UP000053240    UP000007151    UP000037510    UP000235965    UP000027135    + More
UP000075809    UP000078541    UP000008237    UP000007755    UP000078542    UP000078492    UP000036403    UP000000311    UP000078540    UP000005205    UP000242457    UP000002358    UP000053097    UP000279307    UP000005203    UP000192223    UP000076502    UP000009046    UP000053825    UP000008820    UP000069940    UP000249989    UP000075840    UP000075902    UP000075882    UP000007062    UP000075903    UP000075883    UP000075901    UP000076407    UP000000673    UP000075886    UP000076408    UP000075920    UP000075880    UP000075881    UP000075884    UP000075885    UP000007266    UP000075900    UP000007798    UP000092553    UP000007801    UP000091820    UP000009192    UP000092444    UP000092443    UP000092460    UP000092445    UP000078200    UP000000803    UP000095301    UP000008711    UP000268350    UP000001819    UP000008744    UP000192221    UP000000304    UP000008792    UP000001292    UP000037069    UP000001070    UP000183832    UP000095300    UP000005204    UP000030742    UP000019118    UP000000305    UP000076858    UP000283509   

PRIDE

P55162    H9IYU3   

Pfam

PF09735   Nckap1        + More
PF10268   Tmemb_161AB
PF00012   HSP70

Interpro

IPR019137   Nck-associated_protein-1        + More
IPR018181   Heat_shock_70_CS       
IPR029048   HSP70_C_sf       
IPR019395   Transmembrane_161A/B       
IPR013126   Hsp_70_fam       
IPR029047   HSP70_peptide-bd_sf       

SUPFAM

SSF100934   SSF100934        + More
SSF100920   SSF100920       

Gene 3D

1.20.1270.10     2.60.34.10    

ProteinModelPortal

A0A1E1VYL1   A0A194QBF4   A0A2H1VZQ4   A0A194RME1   A0A212FPB6   A0A0L7KR32   + More
A0A1B6E8D2   A0A2J7RSR7   A0A067R1Z2   A0A0A9YNG5   A0A0C9RHN7   A0A151WUN7   A0A151JZS4   E2C9I5   F4X615   A0A195C7Q6   A0A151IY57   A0A0J7L6I5   E2ALH9   A0A151I1Z4   A0A158NMS9   E9J2G9   A0A2A3E3X8   K7IXQ7   A0A310SQH9   A0A1Y1K2U0   A0A026W2C6   A0A088AFJ6   A0A1W4WP41   A0A154PMQ3   E0W2A8   A0A023F447   A0A0L7QJK1   A0A0V0G7U7   A0A0T6BES9   Q16V64   A0A069DZQ9   A0A1Q3FXH3   A0A0N7Z970   A0A182H761   A0A2C9GQZ7   A0A182TK65   A0A182KNQ8   Q7PPI1   A0A182VI02   A0A182M787   A0A2M4AEB2   A0A182SLJ9   A0A182X2H7   W5J5D3   A0A182QSA6   A0A336LPG5   A0A182YKR9   A0A182WM09   A0A182JBE8   A0A182K4N4   A0A182N1Z7   A0A182P5G5   D7EI65   A0A182RAL7   W8AWC4   A0A0K8UG50   A0A034VHD8   A0A0A1XHY9   B4MND0   A0A0M4F0H1   B3MB43   A0A1A9WSP3   B4KX53   A0A1B0FKC3   A0A1A9XGF2   A0A1B0BZM6   A0A1A9ZKP0   A0A1A9UFU4   P55162   A0A1I8M685   B3NJ37   T1PFW3   A0A3B0JRM4   Q29E13   B4H430   A0A1W4UZ08   B4QKR9   B4LFH9   B4IAZ8   A0A0L0BUH4   B4J304   A0A1J1IGR0   A0A1B6KH25   A0A1I8Q3C5   A0A1J1J7Q4   H9IYU3   U4UE05   N6TSI2   A0A0P5RNZ5   E9FST5   A0A0P5XNV6   A0A0P5LU54   T1JIM6   A0A3R7M9U9  

PDB

4N78     E-value=0,     Score=3659

KEGG

101746119    K05750 NCK-associated protein 1 | (RefSeq) membrane-associated protein Hem

GO

GO:0032440   GO:0030031   GO:0016477   GO:0030866   GO:0048812   GO:0031209   GO:0000902   GO:0016021   GO:0005524   GO:0008407   GO:0007409   GO:0007417   GO:0007520   GO:0033627   GO:0008360   GO:0001764   GO:0007528   GO:0030036   GO:0007010   GO:0005886  

PANTHER

PTHR12093  

Subcellular location

Cell membrane  

Length:

1125

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.27054

Exp number, first 60 AAs:

0.00088

Total prob of N-in:

0.00457

outside

1  -  1125

 

 

Pi

224.174433

Theta

211.458761

Tajima's D

0.223451

CLR

0.145437

CSRT

0.428828558572071

Interpretation

Uncertain