Gene

KWMTBOMO05229  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002478

Annotation

methylthioribose-1-phosphate_isomerase_[Bombyx_mori]

Location

Bomo_Chr9(+):11560271-11564281      View in EpiBrowser

Full name

Methylthioribose-1-phosphate isomerase      

Alternative Name

S-methyl-5-thioribose-1-phosphate isomerase
Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein

Location in the cell

Cytoplasmic   Reliability : 1.502 Mitochondrial   Reliability : 1.306

CDS

ATGAGTTTAGAATCCATAAAATATACTAGAGGTAGTCTAGAGATCTTAGATCAATTATTATTGCCTTTACAAACGAGATATATCAAAGTGCGAGGTGTTGAGGATGGTTGGAAAGTAATAAATAAAATGCAGGTCCGTGGAGCACCAGCCATAGCCATAGTGGGTTGCTTATCACTAGCCGTTGAATTATCACCTGACAATGAATCTTCAAAAAAAAACATGAGGCAAGAGATCGAAGGTAAACTTAACTATCTGGTGTCTGCCAGGCCAACAGCTGTAAATATAAAATTGGCAGCTGATGAGCTGATAAATTTGGCAAATACACTTTGTGCTGACGACAGTATTTCAGCTGAAATTTTTAAAGAAAGGTTTATAGGTAGCATAGAGGATATGCTCACTAAAGATATACATGATAACAAAGCAATAGGAAGTTTTGGATGTGAAGCTATATTAAAAAATATAGATGGTGATAGTCCAGTCAGAGTGCTTACACACTGTAATACAGGATCCTTAGCTACAGCCGGATATGGCACTGCTTTAGGAGTTATCAGATCATTACATGCCACTAAAAGATTAGAGCATGTCTTCTGCACTGAGACAAGGCCATATAATCAAGGAGCAAGACTGACTGCGTATGAACTAGTCCACGAGAAAATCCCTTCTACATTAATTGTAGATAGTATGGTCTCTGCTCTTATGCACACCAGGAAAATACATGCAGTCATTGTTGGTGCTGACAGGGTTGCCGCTAATGGGGATACAGCAAATAAAATTGGAACGTATCAAATAGCTATTGTAGCAAAATATCATGATGTACCCTTCTACGTAGCGGCTCCGCTCACATCCATAGACATGTCTTTACCATATGGAGAAAAAATTAAAATTGAAGAACGGCCCGATAGGGAAATGACTCATATCGGAGAACATAGAATAGCTGCACCAGGCATAAATTGCTGGAACCCTTCATTTGACGTAACACCGGCATCTCTAATAGCAGGCATCATAACTGAAAAAGGTGTATTTGCTCCTGACAATCTAAAAAGTGTTAAAACCACGTAA

Protein

MSLESIKYTRGSLEILDQLLLPLQTRYIKVRGVEDGWKVINKMQVRGAPAIAIVGCLSLAVELSPDNESSKKNMRQEIEGKLNYLVSARPTAVNIKLAADELINLANTLCADDSISAEIFKERFIGSIEDMLTKDIHDNKAIGSFGCEAILKNIDGDSPVRVLTHCNTGSLATAGYGTALGVIRSLHATKRLEHVFCTETRPYNQGARLTAYELVHEKIPSTLIVDSMVSALMHTRKIHAVIVGADRVAANGDTANKIGTYQIAIVAKYHDVPFYVAAPLTSIDMSLPYGEKIKIEERPDREMTHIGEHRIAAPGINCWNPSFDVTPASLIAGIITEKGVFAPDNLKSVKTT

Description

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

Catalytic Activity

S-methyl-5-thio-alpha-D-ribose 1-phosphate = 5-methylsulfanyl-D-ribulose 1-phosphate

Similarity

Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Belongs to the eIF-2B alpha/beta/delta subunits family.

Keywords

Amino-acid biosynthesis   Complete proteome   Cytoplasm   Isomerase   Methionine biosynthesis   Nucleus   Reference proteome  

Feature

chain  Methylthioribose-1-phosphate isomerase

Uniprot

H9IYZ3   Q0ZB81   A0A194RNT7   A0A2H1V342   A0A212FPF1   A0A194QHF3   + More
A0A0L0CRS8   A0A336M6Q7   D3TPX8   A0A1A9V7L8   A0A1A9YPY7   A0A1I8MNW6   A0A1I8P818   A0A0K8TZJ1   A0A0A1XPU2   W8ATZ5   B4NG41   A0A3B0JLB6   A0A3S2L2C5   A0A0P9C7L9   B3M098   A0A034WM25   A0A0R1E6U2   B4PNE2   A0A1L8DSB6   A0A0Q9XEZ1   A0A0B4KI38   B4K8A4   Q9V9X4   A0A1L8DSH4   A0A0T6B099   A0A0R3NFW4   B4QSM8   B4I029   Q29BB3   B3P538   B4GYU1   A0A0Q9WFQ3   B4LWZ8   A0A023EPH1   Q16I17   A0A1W4UI24   A0A1B0AA10   B4JRX2   A0A2K7P6D8   J3JU25   A0A0M5J5J5   A0A2J7RE64   U4UMP6   A0A1B0BSJ1   A0A154PE20   A0A088A0V6   A0A067RM30   A0A182GDF3   A0A0L7QTG6   A0A1Q3F2S1   E0VD22   A0A2A3EMN7   A0A1B6E498   T1P8E0   B0X724   A0A0M8ZVG9   A0A2H8TPA2   A0A2S2N645   J9K017   D7EIW4   A0A2P8YD53   A0A2S2R147   A0A1Y1KS96   E2BR69   A0A1B6HUX9   A0A1B6FMN1   A0A182J706   A0A1B6M9X3   A0A084VI63   W5JII4   A0A2J7RE61   A0A182F7K2   A0A182QR25   A0A182NS67   A0A182YAM4   K7J7D2   F4WHD9   A0A182K5C6   A0A182VZ96   A0A232FET0   A0A158NBD7   A0A182R646   A0A195EWW1   A0A151X051   A0A182PGR2   A0A182L9N1   A0A182HLA4   Q7PKS9   A0A026X1N3   A0A151J4I9   A0A182WSF3   A0A195BRR2   A0A182VBY7   A0A1J1J4Z4  

EC Number

5.3.1.23

Pubmed

19121390    26354079    22118469    26108605    20353571    25315136    + More
25830018    24495485    17994087    18057021    25348373    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    15632085    24945155    17510324    22516182    23537049    24845553    26483478    20566863    18362917    19820115    29403074    28004739    20798317    24438588    20920257    23761445    25244985    20075255    21719571    28648823    21347285    20966253    12060762    12364791    24508170   

EMBL

BABH01010796    BABH01010797    DQ645455    KQ459984    KPJ18990.1    ODYU01000448    + More
SOQ35247.1    AGBW02003014    OWR55593.1    KQ459220    KPJ02871.1    JRES01000007    KNC34917.1    UFQS01000635    UFQT01000635    SSX05615.1    SSX25974.1    EZ423480    ADD19756.1    GDHF01032618    GDHF01030048    GDHF01026946    GDHF01023845    GDHF01017108    GDHF01003068    JAI19696.1    JAI22266.1    JAI25368.1    JAI28469.1    JAI35206.1    JAI49246.1    GBXI01016862    GBXI01001320    JAC97429.1    JAD12972.1    GAMC01016873    JAB89682.1    CH964251    OUUW01000005    SPP81132.1    RSAL01000217    RVE44107.1    CH902617    KPU79541.1    GAKP01003273    GAKP01003272    JAC55679.1    CM000160    KRK04735.1    GFDF01004732    JAV09352.1    CH933806    KRG02163.1    AE014297    AGB96523.1    AY060664    GFDF01004733    JAV09351.1    LJIG01022454    KRT80510.1    CM000070    KRS99771.1    CM000364    CH480819    CH954182    CH479198    CH940650    KRF83436.1    GAPW01002211    JAC11387.1    CH478117    CH916373    APGK01039373    BT126737    KB740970    AEE61699.1    ENN76653.1    CP012526    ALC47844.1    NEVH01005277    PNF39120.1    KB632388    ERL94382.1    JXJN01019729    KQ434869    KZC09440.1    KK852427    KDR24083.1    JXUM01242290    KQ635445    KXJ62470.1    KQ414744    KOC61915.1    GFDL01013218    JAV21827.1    DS235070    EEB11278.1    KZ288208    PBC33025.1    GEDC01004532    JAS32766.1    KA644976    AFP59605.1    DS232433    EDS41718.1    KQ435859    KOX70443.1    GFXV01003667    MBW15472.1    GGMR01000025    MBY12644.1    ABLF02031390    KQ971380    EFA12349.2    PYGN01000690    PSN42191.1    GGMS01014548    MBY83751.1    GEZM01075242    GEZM01075241    JAV64184.1    GL449906    EFN81802.1    GECU01029230    JAS78476.1    GECZ01032443    GECZ01018312    JAS37326.1    JAS51457.1    GEBQ01007270    JAT32707.1    ATLV01013301    KE524850    KFB37657.1    ADMH02001150    ETN63911.1    PNF39121.1    AXCN02000267    GL888158    EGI66416.1    NNAY01000374    OXU28807.1    ADTU01010923    KQ981953    KYN32374.1    KQ982622    KYQ53715.1    APCN01000888    AJ439060    AAAB01008987    KK107039    EZA61921.1    KQ980151    KYN17519.1    KQ976417    KYM89705.1    CVRI01000067    CRL06534.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000053268    UP000037069    UP000078200    + More
UP000092443    UP000095301    UP000095300    UP000007798    UP000268350    UP000283053    UP000007801    UP000002282    UP000009192    UP000000803    UP000001819    UP000000304    UP000001292    UP000008711    UP000008744    UP000008792    UP000008820    UP000192221    UP000092445    UP000001070    UP000019118    UP000092553    UP000235965    UP000030742    UP000092460    UP000076502    UP000005203    UP000027135    UP000069940    UP000249989    UP000053825    UP000009046    UP000242457    UP000002320    UP000053105    UP000007819    UP000007266    UP000245037    UP000008237    UP000075880    UP000030765    UP000000673    UP000069272    UP000075886    UP000075884    UP000076408    UP000002358    UP000007755    UP000075881    UP000075920    UP000215335    UP000005205    UP000075900    UP000078541    UP000075809    UP000075885    UP000075882    UP000075840    UP000007062    UP000053097    UP000078492    UP000076407    UP000078540    UP000075903    UP000183832   

PRIDE

H9IYZ3    Q0ZB81    Q9V9X4    Q29BB3    B4GYU1   

Pfam

PF01008   IF-2B        + More
PF01186   Lysyl_oxidase
PF00530   SRCR

Interpro

IPR000649   IF-2B-related        + More
IPR011559   Initiation_fac_2B_a/b/d       
IPR005251   IF-M1Pi       
IPR037171   NagB/RpiA_transferase-like       
IPR027363   M1Pi_N       
IPR019828   Lysyl_oxidase_CS       
IPR017448   SRCR-like_dom       
IPR036772   SRCR-like_dom_sf       
IPR001190   SRCR       
IPR001695   Lysyl_oxidase       

SUPFAM

SSF100950   SSF100950        + More
SSF56487   SSF56487       

Gene 3D

1.20.120.420     3.10.250.10    

ProteinModelPortal

H9IYZ3   Q0ZB81   A0A194RNT7   A0A2H1V342   A0A212FPF1   A0A194QHF3   + More
A0A0L0CRS8   A0A336M6Q7   D3TPX8   A0A1A9V7L8   A0A1A9YPY7   A0A1I8MNW6   A0A1I8P818   A0A0K8TZJ1   A0A0A1XPU2   W8ATZ5   B4NG41   A0A3B0JLB6   A0A3S2L2C5   A0A0P9C7L9   B3M098   A0A034WM25   A0A0R1E6U2   B4PNE2   A0A1L8DSB6   A0A0Q9XEZ1   A0A0B4KI38   B4K8A4   Q9V9X4   A0A1L8DSH4   A0A0T6B099   A0A0R3NFW4   B4QSM8   B4I029   Q29BB3   B3P538   B4GYU1   A0A0Q9WFQ3   B4LWZ8   A0A023EPH1   Q16I17   A0A1W4UI24   A0A1B0AA10   B4JRX2   A0A2K7P6D8   J3JU25   A0A0M5J5J5   A0A2J7RE64   U4UMP6   A0A1B0BSJ1   A0A154PE20   A0A088A0V6   A0A067RM30   A0A182GDF3   A0A0L7QTG6   A0A1Q3F2S1   E0VD22   A0A2A3EMN7   A0A1B6E498   T1P8E0   B0X724   A0A0M8ZVG9   A0A2H8TPA2   A0A2S2N645   J9K017   D7EIW4   A0A2P8YD53   A0A2S2R147   A0A1Y1KS96   E2BR69   A0A1B6HUX9   A0A1B6FMN1   A0A182J706   A0A1B6M9X3   A0A084VI63   W5JII4   A0A2J7RE61   A0A182F7K2   A0A182QR25   A0A182NS67   A0A182YAM4   K7J7D2   F4WHD9   A0A182K5C6   A0A182VZ96   A0A232FET0   A0A158NBD7   A0A182R646   A0A195EWW1   A0A151X051   A0A182PGR2   A0A182L9N1   A0A182HLA4   Q7PKS9   A0A026X1N3   A0A151J4I9   A0A182WSF3   A0A195BRR2   A0A182VBY7   A0A1J1J4Z4  

PDB

4LDQ     E-value=7.48422e-107,     Score=989

KEGG

733082    K08963 methylthioribose-1-phosphate isomerase [EC:5.3.1.23] | (RefSeq) M1Pi; eIF2B-alpha-like protei

PATHWAY

00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0046523   GO:0005634   GO:0019284   GO:0005737   GO:0019509   GO:0003743   GO:0016020   GO:0005044   GO:0005507   GO:0016641   GO:0044249   GO:0044237   GO:0000413   GO:0006772   GO:0003677   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

Subcellular location

Cytoplasm  
Nucleus  

Length:

352

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.54409

Exp number, first 60 AAs:

0.3627

Total prob of N-in:

0.05360

outside

1  -  352

 

 

Pi

221.550894

Theta

186.897087

Tajima's D

0.469108

CLR

0.070148

CSRT

0.501474926253687

Interpretation

Uncertain