SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO05228  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA002429
Annotation
cyclophilin-like_protein_[Bombyx_mori]
Location
Bomo_Chr9(-):11554697-11555960      View in EpiBrowser
Full name
Peptidyl-prolyl cis-trans isomerase      
Alternative Name
Cyclophilin
Cyclosporin A-binding protein
Rotamase
Location in the cell
Cytoplasmic   Reliability : 3.941
 

Sequence

CDS
ATGTCTCTACCACGAGTATTCTTCGACGTCACTGTTGACGATGCCCCACTGGGAAAAATTGTTATTGAGCTGAGAAGTGACGTCACTCCCAAGACGTGTGAAAACTTCCGTGCCCTGTGCACTGGCGAGAAAGGCTTCGGTTACAAGGGCTCCATTTTCCATCGTGTCATCCCCAATTTCATGCTGCAAGGAGGGGACTTCACCAACCATAACGGCACTGGGGGAAAGTCCATCTACGGCAATAAGTTTGAAGACGAGAATTTCACCCTTAAGCACACTGGACCTGGCGTCCTCTCCATGGCTAATGCCGGTGCTGATACTAATGGTTCCCAGTTCTTCATCACCACTGTCAAGACCTCCTGGCTGGATGGCAGACATGTTGTCTTTGGGAATGTTGTTGAAGGCATGGAAGTTGTCAAGCAGATTGAGACCTTTGGCAGCCAGTCTGGGAAGACCTCTAAGAGAATCGTTATCAAAGACTGTGGTCAGATTGCCTAA
Protein
MSLPRVFFDVTVDDAPLGKIVIELRSDVTPKTCENFRALCTGEKGFGYKGSIFHRVIPNFMLQGGDFTNHNGTGGKSIYGNKFEDENFTLKHTGPGVLSMANAGADTNGSQFFITTVKTSWLDGRHVVFGNVVEGMEVVKQIETFGSQSGKTSKRIVIKDCGQIA

Summary

Description
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic Activity
[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
Similarity
Belongs to the cyclophilin-type PPIase family.
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Keywords
Complete proteome   Cytoplasm   Direct protein sequencing   Isomerase   Phosphoprotein   Reference proteome   Rotamase  
Feature
chain  Peptidyl-prolyl cis-trans isomerase
Uniprot
Q5CCL3   H9IYU4   Q56C53   I4DJA1   A0A3G1T1D0   I4DMT7   + More
A0A2H1V328   R4FMV8   A0A194RNK0   A0A0L7KY60   S4PBG4   A0A0K8S607   A0A3S2NCR0   A0A212FPC4   U5EZE6   L7WSJ0   A0A182R0E6   D7RPB5   A0A2M4C0B2   A0A1Y1L1V2   A0A2M4BZN1   A0A1Y1L5L4   Q16P59   A0A2M3YY51   A0A2M4A133   A0A2M4A146   T1PHF9   T1DP12   A0A182IVW0   A0A023EJK1   A2I3U7   Q1HRR9   A0A0K8TQ86   A0A232FLD2   D6WB54   A0A182FMF3   A0A146LID2   A0A0T6AV63   A0A336LQB3   A0A182N180   A0A084VLS9   T1DGZ5   A0A1Z5KXX2   J9JT88   A0A182RHI0   A0A2R5LCA2   C4WRW7   A0A182IAP9   K7IM71   N6UJM4   A0A220XK87   A8C9W3   W5JUI0   B8RJ95   A0A182PFY1   B3GCD7   B3GCD6   A0A3S3SL31   A0A1D6T5K5   Q7PS16   A0A0P6IS29   A0A182LXJ5   A0A087T258   B7Q0J9   A0A2J7RN34   A1KXG2   J3JWH7   A0A1L8DU24   A0A0K8R8H4   A0A2H8TZ61   A0A1B6G2X9   A0A1L8E8G0   A0A1L8EF36   R4UW88   D3TMT7   A0A023FFI9   A0A1L8E917   B4L5M3   A0A291KZD7   K7J0P3   A0A1W7R9W4   A0A182XXS4   A0A1Y2HML4   A0A0M4ENB3   A0A023FXC1   A0A1I8PXH6   A0A1E1X7M1   A0A1L4AAU0   A0A023GF86   A0A139A349   J7HBB0   R4WCQ5   A0A182XDV5   B4IF57   A0A2A3EAB9   V9IIN8   A0A088A8D4   A8E774   P25007   A0A0A0VBV2  
EC Number
5.2.1.8
Pubmed
19121390    22651552    26354079    26227816    23622113    22118469    + More
23326229    28004739    17510324    25315136    24945155    26483478    17204158    26369729    28648823    18362917    19820115    26823975    24438588    24330624    28528879    20075255    23537049    17760985    20920257    23761445    18495616    12364791    14747013    17210077    22516182    20353571    17994087    28982170    25244985    28503490    27895657    25977457    23691247    10731132    12537572    1707759    8500545    18327897    24303891   
EMBL
DQ201183    AB206402    ABA54173.1    BAD90848.1    BABH01010795    AY966877    + More
AAX76988.1    AK401369    KQ459220    BAM17991.1    KPJ02870.1    MG846936    AXY94788.1    AK402605    BAM19227.1    ODYU01000448    SOQ35248.1    GAHY01000813    JAA76697.1    KQ459984    KPJ18989.1    JTDY01004473    KOB68105.1    GAIX01005922    JAA86638.1    GBRD01017243    JAG48584.1    RSAL01000217    RVE44108.1    AGBW02003014    OWR55594.1    GANO01000936    JAB58935.1    KC118982    AGC84404.1    AXCN02002156    HM113489    ADI58372.1    GGFJ01009287    MBW58428.1    GEZM01066883    JAV67669.1    GGFJ01009323    MBW58464.1    GEZM01066882    JAV67670.1    CH477793    EAT36139.1    GGFM01000451    MBW21202.1    GGFK01001141    MBW34462.1    GGFK01001144    MBW34465.1    KA647328    AFP61957.1    GAMD01002370    JAA99220.1    JXUM01086823    GAPW01004438    KQ563593    JAC09160.1    KXJ73620.1    EF070450    ABM55516.1    DQ440025    ABF18058.1    GDAI01001297    JAI16306.1    NNAY01000049    OXU31554.1    KQ971311    EEZ98965.2    GDHC01010788    JAQ07841.1    LJIG01022734    KRT78986.1    UFQT01000054    SSX19061.1    ATLV01014549    KE524974    KFB38923.1    GALA01001471    JAA93381.1    GFJQ02007329    JAV99640.1    ABLF02033823    GGLE01002982    MBY07108.1    AK339947    BAH70637.1    APCN01001299    APGK01021421    KB740322    KB631815    ENN80871.1    ERL86427.1    KY273928    ASL05640.1    EU032341    ABV44708.1    ADMH02000109    ETN67806.1    EZ000520    ACJ64394.1    EU669818    ACD69576.1    EU669817    ACD69575.1    NCKU01000192    RWS16668.1    AAAB01008846    EAA06299.6    GDIQ01002400    JAN92337.1    AXCM01003587    KK113043    KFM59197.1    ABJB010263896    DS832869    EEC12371.1    NEVH01002545    PNF42238.1    AY283280    KM010000    AAP35065.1    AIO08856.1    BT127595    AEE62557.1    GFDF01004141    JAV09943.1    GADI01006427    JAA67381.1    GFXV01007384    MBW19189.1    GECZ01012974    JAS56795.1    GFDG01003906    JAV14893.1    GFDG01001515    JAV17284.1    KC740692    AGM32516.1    EZ422739    ADD19015.1    GBBK01004617    JAC19865.1    GFDG01003700    JAV15099.1    CH933811    EDW06482.2    MF346049    ATI08942.1    GFAH01000450    JAV47939.1    MCFL01000020    ORZ35830.1    CP012526    ALC47077.1    GBBL01001965    JAC25355.1    GFAC01003935    JAT95253.1    KX268378    API65179.1    GBBM01002861    JAC32557.1    KQ965809    KXS11134.1    JX160103    AFP99100.1    AK416924    BAN20139.1    CH480832    EDW46111.1    KZ288325    PBC28011.1    JR049570    AEY61003.1    BT031016    ABV82398.1    AE014298    BT009946    M62398    KF860413    AIW62418.1   
Proteomes
UP000005204    UP000053268    UP000053240    UP000037510    UP000283053    UP000007151    + More
UP000075886    UP000008820    UP000095301    UP000075880    UP000069940    UP000249989    UP000215335    UP000007266    UP000069272    UP000075884    UP000030765    UP000007819    UP000075900    UP000075840    UP000002358    UP000019118    UP000030742    UP000000673    UP000075885    UP000285301    UP000007062    UP000075883    UP000054359    UP000001555    UP000235965    UP000009192    UP000076408    UP000193411    UP000092553    UP000095300    UP000070544    UP000076407    UP000001292    UP000242457    UP000005203    UP000000803   
PRIDE
Q5CCL3    H9IYU4    Q56C53    B3GCD6    B7Q0J9    A1KXG2    + More
A0A088A8D4    A8E774    P25007   
Pfam
PF00160   Pro_isomerase
Interpro
IPR029000   Cyclophilin-like_dom_sf        + More
IPR020892   Cyclophilin-type_PPIase_CS       
IPR024936   Cyclophilin-type_PPIase       
IPR002130   Cyclophilin-type_PPIase_dom       
SUPFAM
SSF50891   SSF50891       
Gene 3D
2.40.100.10    
ProteinModelPortal
Q5CCL3   H9IYU4   Q56C53   I4DJA1   A0A3G1T1D0   I4DMT7   + More
A0A2H1V328   R4FMV8   A0A194RNK0   A0A0L7KY60   S4PBG4   A0A0K8S607   A0A3S2NCR0   A0A212FPC4   U5EZE6   L7WSJ0   A0A182R0E6   D7RPB5   A0A2M4C0B2   A0A1Y1L1V2   A0A2M4BZN1   A0A1Y1L5L4   Q16P59   A0A2M3YY51   A0A2M4A133   A0A2M4A146   T1PHF9   T1DP12   A0A182IVW0   A0A023EJK1   A2I3U7   Q1HRR9   A0A0K8TQ86   A0A232FLD2   D6WB54   A0A182FMF3   A0A146LID2   A0A0T6AV63   A0A336LQB3   A0A182N180   A0A084VLS9   T1DGZ5   A0A1Z5KXX2   J9JT88   A0A182RHI0   A0A2R5LCA2   C4WRW7   A0A182IAP9   K7IM71   N6UJM4   A0A220XK87   A8C9W3   W5JUI0   B8RJ95   A0A182PFY1   B3GCD7   B3GCD6   A0A3S3SL31   A0A1D6T5K5   Q7PS16   A0A0P6IS29   A0A182LXJ5   A0A087T258   B7Q0J9   A0A2J7RN34   A1KXG2   J3JWH7   A0A1L8DU24   A0A0K8R8H4   A0A2H8TZ61   A0A1B6G2X9   A0A1L8E8G0   A0A1L8EF36   R4UW88   D3TMT7   A0A023FFI9   A0A1L8E917   B4L5M3   A0A291KZD7   K7J0P3   A0A1W7R9W4   A0A182XXS4   A0A1Y2HML4   A0A0M4ENB3   A0A023FXC1   A0A1I8PXH6   A0A1E1X7M1   A0A1L4AAU0   A0A023GF86   A0A139A349   J7HBB0   R4WCQ5   A0A182XDV5   B4IF57   A0A2A3EAB9   V9IIN8   A0A088A8D4   A8E774   P25007   A0A0A0VBV2  
PDB
4TOT     E-value=2.04655e-70,     Score=670

Ontologies

KEGG
692737    K09565 peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8] | (RefSeq) Cypa; cyclophilin A
GO
GO:0003755   GO:0006457   GO:0051082   GO:0042026   GO:0016018   GO:0005634   GO:0005737   GO:0005829   GO:0000413   GO:0016020   GO:0006772   GO:0003677   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

Topology

Subcellular location
Cytoplasm  
Length:
165
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00107
Exp number, first 60 AAs:
0.00023
Total prob of N-in:
0.02697
outside
1  -  165
 
 

Population Genetic Test Statistics

Pi
157.401833
Theta
177.258642
Tajima's D
-0.542418
CLR
16.173452
CSRT
0.230688465576721
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Peptides ×
Source Sequence Identity Evalue
28556443 HTGPGVLSMANAGADTNGSQFFITTVK 100.00 6e-13
28556443 HTGPGVLSMANAGADTNGSQFFITTVK 100.00 6e-13
28556443 HTGPGVLSMANAGADTNGSQFFITTVK 100.00 6e-13
28556443 HTGPGVLSMANAGADTNGSQFFITTVK 100.00 6e-13
28556443 HTGPGVLSMANAGADTNGSQFFITTVK 100.00 6e-13
28556443 FMLQGGDFTNHNGTGGK 100.00 6e-13
28556443 FMLQGGDFTNHNGTGGK 100.00 6e-13
26822097 INIPIISDITHSIAK 96.30 2e-12
26280517 HSPISVETDGR 96.30 2e-12
25044914 HTETCEKNPIPTK 96.30 2e-12
24402669 HTEIVSWK 96.30 2e-12
27102218 HVVFGNVVEGMEVVKQIETFGSQSGK 96.30 2e-12
28467696 HTGGIPISAYVVEK 96.30 2e-12
27102218 FEDENFTIK 100.00 3e-11
28556443 VIPNFMLQGGDFTNHNGTGGK 100.00 3e-11
28556443 VIPNFMLQGGDFTNHNGTGGK 100.00 6e-09
28556443 VIPNFMLQGGDFTNHNGTGGK 100.00 6e-09
28556443 VIPNFMLQGGDFTNHNGTGGK 100.00 6e-09
28556443 VIPNFMLQGGDFTNHNGTGGK 100.00 6e-09
28556443 VIPNFMLQGGDFTNHNGTGGK 100.00 6e-09
28556443 VIPNFMLQGGDFTNHNGTGGK 100.00 6e-09
28556443 VIPNFMLQGGDFTNHNGTGGK 100.00 6e-09
28556443 VIPNFMLQGGDFTNHNGTGGK 100.00 6e-09
28556443 VFFDVTVDDAPLGK 100.00 6e-09
28556443 VFFDVTVDDAPLGK 100.00 6e-09
26822097 TCENFR 95.24 1e-08
26280517 VIKETEEIQK 95.24 1e-08
25044914 VIPIEVESIIVR 95.24 1e-08
24402669 VIPGNFFIMDSIR 95.24 1e-08
27102218 IVIKDCGQIA 95.24 1e-08
28467696 VIPIEVESIIVRPTEAFQPMDVEPQTSR 95.24 1e-08
28556443 TSWLDGR 100.00 3e-07
28556443 FMLQGGDFTNHNGTGGK 100.00 9e-06
28556443 FMLQGGDFTNHNGTGGK 100.00 9e-06
28556443 FMLQGGDFTNHNGTGGK 100.00 9e-06
28556443 FEDENFTLK 100.00 9e-06
28556443 FEDENFTLK 100.00 9e-06
28556443 HVVFGNVVEGMEVVKQIETFGSQSGK 100.00 6e-05
28556443 TTILNLQNNK 100.00 2e-04
28556443 QIETFGSQSGK 100.00 3e-04
26822097 SIYGNKFEDENFTIK 100.00 0.002
26280517 GIKGESNVVECAYVK 100.00 0.002
25044914 HVVFGK 100.00 0.002
24402669 HVQCVIK 100.00 0.002
27102218 TCENFR 100.00 0.002
28467696 HVTEAISQIATSENPIIHQYTR 100.00 0.002
28556443 HVVFGNVVEGMEVVK 100.00 0.002
28556443 HVVFGNVVEGMEVVK 100.00 0.002
28556443 HVVFGNVVEGMEVVK 100.00 0.002
28556443 HVVFGNVVEGMEVVK 100.00 0.002
28556443 HVVFGNVVEGMEVVK 100.00 0.002
28556443 HVVFGNVVEGMEVVK 100.00 0.002
28556443 HVVFGNVVEGMEVVK 100.00 0.002
28556443 HVVFGNVVEGMEVVK 100.00 0.002
28556443 HVVFGNVVEGMEVVK 100.00 0.002
28556443 HVVFGNVVEGMEVVK 100.00 0.002
28556443 HTGPGVLSMANAGADTNGSQFFITTVK 100.00 0.002
28556443 HTGPGVLSMANAGADTNGSQFFITTVK 100.00 0.002
28556443 VFFDVTVDDAPLGK 100.00 0.003
28556443 VFFDVTVDDAPLGK 100.00 0.003
28556443 QIETFGSQSGK 100.00 0.003
28556443 SIYGNKFEDENFTLK 100.00 0.003
26280517 SDVDYVIDIDVR 100.00 0.010
28556443 HTGPGVLSMAN 100.00 0.013
20822545 VTHKVSFDMK 100.00 0.023
26822097 HYGAGWISMANAGK 100.00 0.023
25860555 SDTQVVASNECAGIIEIANAR 100.00 0.023
26280517 AGPAIEVIGSAK 100.00 0.023
25044914 DTIYECVNAVIQSSK 100.00 0.023
24093152 DTIYECVNAVIQSSK 100.00 0.023
24402669 DTIYECVNAVIQSSK 100.00 0.023
27102218 TEVVAEPFSVTK 100.00 0.023
28467696 DTIYECVNAVIQSSK 100.00 0.023
29197581 ISPTNQIPNR 100.00 0.023
28556443 DTNGSQFFITTVK 100.00 0.023
28556443 DTNGSQFFITTVK 100.00 0.023
28556443 DTNGSQFFITTVK 100.00 0.023
28556443 DTNGSQFFITTVK 100.00 0.023
28556443 DTNGSQFFITTVK 100.00 0.023
28556443 FEDENFK 100.00 0.023
28556443 DTNGSQFFITTVK 100.00 0.023
28556443 DTNGSQFFITTVK 100.00 0.023
28556443 DTNGSQFFITTVK 100.00 0.023
28556443 DTNGSQFFITTVK 100.00 0.023
28556443 QIETFGSQSGKTSK 100.00 0.023
28556443 AGADTNGSQFFITTVK 100.00 0.023
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