Gene

KWMTBOMO05226

Pre Gene Modal

BGIBMGA002476

Annotation

PREDICTED:_uncharacterized_protein_LOC101745836_[Bombyx_mori]

Location

Bomo_Chr9(+):11467744-11497763      View in EpiBrowser

Full name

E3 ubiquitin-protein ligase      

Location in the cell

Nuclear   Reliability : 4.389

CDS

ATGATGCGGCGTGGGTCAATGGCCCTGATAGGGGCTGGGGAACCTCTCATCGTAGTGGAGGAAAGTGGCGTGGAAGATGCAGAGAGCTCCCCGAAAGCAACAATACCGCTCCGAGGCATATCCATAGACCAGGAGTCTCCTCCGGACCCGTATCATCTGTCACCGTGGCGCGAAACACGCAAGCATTCACTTCCGACACCACAATGCACCTCTGGTCCCACGGCCAGCCAGGTGCGACGACTATCAGAGCGCGGCGAAAGCGCTGCCCGCGAAGCGCGTGAAGCTGCTTTTTTGGCTACACTCAGCCAAGCTCCACCGCAACCTGGAGGTAGAAGACATTCCGTTGTAACCATATCACGGGTGCCCCAAGCATTGTTTGGCCGAGGCCGTCGCGAATCCATAGCCGCATTCCCAGCTCTCGGACGCCGCCGAGATTCTGGCTCTAAAAAAGGTCCCCCTGCCATTGAGACTTTTGGAAGCACTCATAACTTGCAGCTGGATATAATGGACGACATAGTGCAAGCTCGTAAAGTACGTATGCGTCTTTGGAATACATCGAATGAACGGGTCTGCGAGGTTCAACCGCTGGACGAACGTTCTCCTATAAGCGGATCAGTGAGATACACCAACCGGGGACGCCGTCACTCAGACTTCGTAGGATCTCCACTCCCACCGATACCAGCCAGACGTCGTGCTTCCGAGATGCCGCCGCCGCCACCCATTCCTCCTCGAAGTAACACTGGCGTCGTCTGCACAGACACAGATTTACATCTCATGCTTAACGCACTCACTTCATCCGCCACAGAAATTGATCGCTGCGGTAAACCCGAACGTCCAGGAATGAGGCGTCTCTCGGACAACATGCGTTCCAGCAGCTTCGATGCCTCTTCTCTTCGTGAAAAACCCGCAGAATCGGGCACTACATGGTTTGCCCGCCGACATCAGACTCTAGCCACCAAAAATCAAGAAAATGAACCAAAGAAGGCTAAAGTTACTTTTGCAGCGGACTCTAAGCCGGCTCCCGGAGATGTGGCCACTGTTGTATGGGACAAGCCGTCGGGTTCTGTGGTTGACGCCAGTGCACTCGGTAGCGCCATTGAAGTGTTTCTCCGCAAAAGCAGCATTGTCGATTCAGGACCTTCGACTTCAAGTGTGGTAGAAACTAAAGAAATTACAGCTAAGACTAGGGATGTTCCACCAAAAGCACGTGACAAGCCGGGGCCGAGTCGAGCAGCCGAGCGTTGGTACTCCAACAAGCCGGAGGAAGAAGAAGTGTCCGAAAGCTGCGACGCAAGCCTTTGCACCTCTTTGAAAGACCTTTTCGTTTAG

Protein

MMRRGSMALIGAGEPLIVVEESGVEDAESSPKATIPLRGISIDQESPPDPYHLSPWRETRKHSLPTPQCTSGPTASQVRRLSERGESAAREAREAAFLATLSQAPPQPGGRRHSVVTISRVPQALFGRGRRESIAAFPALGRRRDSGSKKGPPAIETFGSTHNLQLDIMDDIVQARKVRMRLWNTSNERVCEVQPLDERSPISGSVRYTNRGRRHSDFVGSPLPPIPARRRASEMPPPPPIPPRSNTGVVCTDTDLHLMLNALTSSATEIDRCGKPERPGMRRLSDNMRSSSFDASSLREKPAESGTTWFARRHQTLATKNQENEPKKAKVTFAADSKPAPGDVATVVWDKPSGSVVDASALGSAIEVFLRKSSIVDSGPSTSSVVETKEITAKTRDVPPKARDKPGPSRAAERWYSNKPEEEEVSESCDASLCTSLKDLFV

Description

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Similarity

Belongs to the SINA (Seven in absentia) family.

Uniprot

H9IYZ1   A0A2H1V333   A0A2A4IW87   A0A194RSE1   A0A3S2TEW5   A0A212F1U1   + More
A0A0L7KKY0   A0A1B0DLS9   A0A1B0CVJ2   A0A139WNH5   N6UQ58   A0A0L0C1N6   A0A1W4WEJ3   A0A2P8Z1S7   A0A1W4WDK7   A0A182LZY2   A0A182W5I7   K7J0P4   A0A182XXS7   A0A1I8PSM7   A0A182XDV2   A0A182VD45   A0A182N183   A0A2C9GPF1   Q5TV37   A0A1S4G8V7   A0A182IQ89   A0A154PLK2   A0A0M9A2Q7   A0A034WCT7   A0A026WXZ4   Q16P58   A0A1B0A5B8   E2BDP5   A0A1I8MCZ0   A0A088A8A5   A0A1A9UPV9   A0A1B0G2Q5   A0A1J1IP28   A0A1A9X834   A0A1B0AUH3   E9IVQ2   W8BER6   A0A023F0K7   A0A1A9X5I1   A0A195EE47   A0A158NN83   T1HMT0   E2AKH9   A0A195AV38   A0A0L7QZG1   W5JH89   A0A182FJI9   A0A195FWS2   A0A084VLS4   A0A067QXT4   A0A310S749   A0A195CRI5   A0A2J7RN30   B4MSN4   E0VI62   A0A0J7L0F6   A0A182TH41  

EC Number

2.3.2.27

Pubmed

19121390    26354079    22118469    26227816    18362917    19820115    + More
23537049    26108605    29403074    20075255    25244985    12364791    25348373    24508170    30249741    17510324    20798317    25315136    21282665    24495485    25474469    21347285    20920257    23761445    24438588    24845553    17994087    20566863   

EMBL

BABH01010782    ODYU01000448    SOQ35250.1    NWSH01006097    PCG63658.1    KQ459984    + More
KPJ18986.1    RSAL01000217    RVE44110.1    AGBW02010803    OWR47696.1    JTDY01009196    KOB63987.1    AJVK01006788    AJWK01030673    KQ971311    KYB29416.1    APGK01021421    KB740322    KB631815    ENN80872.1    ERL86426.1    JRES01001003    KNC26215.1    PYGN01000238    PSN50459.1    AXCM01011838    APCN01001303    AAAB01008846    EAL41204.3    KQ434946    KZC12334.1    KQ435768    KOX75236.1    GAKP01006825    JAC52127.1    KK107085    QOIP01000008    EZA60014.1    RLU19870.1    CH477793    EAT36140.1    GL447678    EFN86207.1    CCAG010000408    CVRI01000057    CRL01991.1    JXJN01003637    GL766328    EFZ15356.1    GAMC01011117    JAB95438.1    GBBI01003695    JAC15017.1    KQ979039    KYN23381.1    ADTU01021143    ADTU01021144    ACPB03003848    GL440281    EFN66030.1    KQ976738    KYM75890.1    KQ414680    KOC64005.1    ADMH02001203    ETN63732.1    KQ981208    KYN44767.1    ATLV01014548    KE524974    KFB38918.1    KK852834    KDR15280.1    KQ766586    OAD53674.1    KQ977372    KYN03245.1    NEVH01002545    PNF42237.1    CH963851    EDW75123.2    DS235184    EEB13068.1    LBMM01001554    KMQ96096.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000283053    UP000007151    UP000037510    + More
UP000092462    UP000092461    UP000007266    UP000019118    UP000030742    UP000037069    UP000192223    UP000245037    UP000075883    UP000075920    UP000002358    UP000076408    UP000095300    UP000076407    UP000075903    UP000075884    UP000075840    UP000007062    UP000075880    UP000076502    UP000053105    UP000053097    UP000279307    UP000008820    UP000092445    UP000008237    UP000095301    UP000005203    UP000078200    UP000092444    UP000183832    UP000092443    UP000092460    UP000091820    UP000078492    UP000005205    UP000015103    UP000000311    UP000078540    UP000053825    UP000000673    UP000069272    UP000078541    UP000030765    UP000027135    UP000078542    UP000235965    UP000007798    UP000009046    UP000036403    UP000075902   

PRIDE

H9IYZ1   

Pfam

PF03145   Sina

Interpro

IPR004162   SINA-like        + More
IPR013083   Znf_RING/FYVE/PHD       
IPR013010   Znf_SIAH       
IPR018121   7-in-absentia-prot_TRAF-dom       
IPR008974   TRAF-like       

SUPFAM

SSF49599   SSF49599       

Gene 3D

3.30.40.10    

ProteinModelPortal

H9IYZ1   A0A2H1V333   A0A2A4IW87   A0A194RSE1   A0A3S2TEW5   A0A212F1U1   + More
A0A0L7KKY0   A0A1B0DLS9   A0A1B0CVJ2   A0A139WNH5   N6UQ58   A0A0L0C1N6   A0A1W4WEJ3   A0A2P8Z1S7   A0A1W4WDK7   A0A182LZY2   A0A182W5I7   K7J0P4   A0A182XXS7   A0A1I8PSM7   A0A182XDV2   A0A182VD45   A0A182N183   A0A2C9GPF1   Q5TV37   A0A1S4G8V7   A0A182IQ89   A0A154PLK2   A0A0M9A2Q7   A0A034WCT7   A0A026WXZ4   Q16P58   A0A1B0A5B8   E2BDP5   A0A1I8MCZ0   A0A088A8A5   A0A1A9UPV9   A0A1B0G2Q5   A0A1J1IP28   A0A1A9X834   A0A1B0AUH3   E9IVQ2   W8BER6   A0A023F0K7   A0A1A9X5I1   A0A195EE47   A0A158NN83   T1HMT0   E2AKH9   A0A195AV38   A0A0L7QZG1   W5JH89   A0A182FJI9   A0A195FWS2   A0A084VLS4   A0A067QXT4   A0A310S749   A0A195CRI5   A0A2J7RN30   B4MSN4   E0VI62   A0A0J7L0F6   A0A182TH41  

KEGG

101745836    no KO assigned | (RefSeq) uncharacterized LOC101745836

GO

GO:0005634   GO:0007275   GO:0016567   GO:0006511   GO:0008270  

PANTHER

PTHR45877  

Length:

442

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00036

Exp number, first 60 AAs:

0.00036

Total prob of N-in:

0.00517

outside

1  -  442

 

 

Pi

218.770016

Theta

177.949685

Tajima's D

0.671222

CLR

0.178543

CSRT

0.56067196640168

Interpretation

Uncertain