Gene

KWMTBOMO05225

Pre Gene Modal

BGIBMGA002475

Annotation

A_disintegrin_and_metalloproteinase_with_thrombospondin_motifs_1_precursor_[Bombyx_mori]

Location

Bomo_Chr9(+):11402654-11434949      View in EpiBrowser

Full name

A disintegrin and metalloproteinase with thrombospondin motifs 3      

Alternative Name

Procollagen II N-proteinase
Procollagen II amino propeptide-processing enzyme

Location in the cell

Extracellular   Reliability : 2.417 Nuclear   Reliability : 2.394

CDS

ATGCCTCACGTGTGCCGGTCAAAGCGAGCGCCGCCTCTCGAGGGAACACCCTGTGGACAAAACCAATGGTGCGTGGATCGTGTCTGCGAGCCGATGCCTGGCCACAGTAAAGAGACTAAGGTTGAAAACAAACATACTCCAGAATGGGGAGATTGGGAGGAGTGGAGCGCATGCAACGCAGATTGTGGTTACGGCCTCAGGACAAGAACACGAAAATGCAAATACAGAGGGTTTGTATCAGAGAGCGCATGTGAGGGTGCTGGATCTCAAGTAGCGACTTGCTGGGCGGGGTCTTCGTGCGCTGCAACCAGAGACATCCGCTCCGACCTCTGCCATCGCCAACAGAGCAGACTCATACCTTATTTACATGCCAACGAGTCCAACCATTGTGAAATTTCGTGTGTGGACTACGCTGGAGGGTCGCCCACCAATTTCGGAGCCCTACCCGACGGAACGCCCTGCAGCTACCTTCGACCCTTCGACGTTTGCTTCCAGGGTACGTGCGTGAAAGGTCAATGCAATTCATCAGATACAACCTGCAACTGGTGCCCAGACGGCTACTGCAACAACAACACTAACACATACACAAGATTACTCGGTAACGGCTGGACTCGCATGACGATGGTGCCGCACGAAGCACGTCAACTGTCCATACACATAGCCACACCGATTCCCCTCCACATTGCACTGCGCGAACGGAAACGGGACAAGCCGATTCTAGAACTTTCTAAGCACTCCAAAAAATTCGACATCAGCTCCCTTCAGGACAACTACTTGAAATACGATCCGAGCGTGCCTCAGAATCTTCAGATCGTGGAAATGGACAGCAACATTTTAGACTTGAAAGAGAGCTTTCGTTATGAAGGCGAGGCGATCACGGCTGGGACTCTCCTGCGCTGGAATCAAACCGACACGGACATTTATATAACGTCAGAATCTAGACTGCAAACTGATTTGATGATAATGGCAATACCAGTTAATCCTACATTAGAAGATGCGGTCAGTGTGGACGTGTCAGTAAACTACAGCACTCCAACTGGACGCACGAGACCATTGGAATACAGGTGGTCGATAGAGCGCGGTCCGTGTTCCGCGTCCTGCGGTGGCGGTGTGCGATTGATAACAGCCCAGTGTCATCGAGATCAGAAATGTCCACCGCCTAGATACGAATCATGCAATACACACAGCTGTGAATTTGTGTGGGCTTCTGACGATTGGGAAGAATGCAGTTCGACATGCGGTAGCAACGGTGTTCAAGAAAGACAATTGTTCTGTGTTCCATCAAACGCAAGCATGTTATCGAGGAGAGAGTTTATCAAACACAGCGTGTCACCAGTCATGTGCTCGTCGTCAAAGCCGCCACATCGCCAGCCCTGCAACCGTATCCCCTGCCCTGTTTACTGGAGGGAGCAACCCTGGACTCCTTGCTCGGCGTCGTGCGGACGCGGCGTGTCCCGGCGTCCGCTCACGTGTCCGGCGTCAGACGAGCTACTATGCGGACCGAAGCCGCGCGAGCGACGCCGGCGCTGCAGACTCCGGCGCTGCCCCTCAGCATTGAGAGTCGCAGTGCAGTGCCCCGAACGCGACCACGCGCACTACTGCGAGCTCTTCACACTGGAACAGCTGCACCGGAACTGCGAGGTGCCGCCGTTCAGGAAATATTGCTGTAACGCTTGCAGGGACGCAGACCGCCGTCAGCACAGACGGTACGGCTGA

Protein

MPHVCRSKRAPPLEGTPCGQNQWCVDRVCEPMPGHSKETKVENKHTPEWGDWEEWSACNADCGYGLRTRTRKCKYRGFVSESACEGAGSQVATCWAGSSCAATRDIRSDLCHRQQSRLIPYLHANESNHCEISCVDYAGGSPTNFGALPDGTPCSYLRPFDVCFQGTCVKGQCNSSDTTCNWCPDGYCNNNTNTYTRLLGNGWTRMTMVPHEARQLSIHIATPIPLHIALRERKRDKPILELSKHSKKFDISSLQDNYLKYDPSVPQNLQIVEMDSNILDLKESFRYEGEAITAGTLLRWNQTDTDIYITSESRLQTDLMIMAIPVNPTLEDAVSVDVSVNYSTPTGRTRPLEYRWSIERGPCSASCGGGVRLITAQCHRDQKCPPPRYESCNTHSCEFVWASDDWEECSSTCGSNGVQERQLFCVPSNASMLSRREFIKHSVSPVMCSSSKPPHRQPCNRIPCPVYWREQPWTPCSASCGRGVSRRPLTCPASDELLCGPKPRERRRRCRLRRCPSALRVAVQCPERDHAHYCELFTLEQLHRNCEVPPFRKYCCNACRDADRRQHRRYG

Cofactor

Zn(2+)

Keywords

Cleavage on pair of basic residues   Complete proteome   Disease mutation   Disulfide bond   Extracellular matrix   Glycoprotein   Heparin-binding   Hydrolase   Metal-binding   Metalloprotease   Polymorphism   Protease   Reference proteome   Repeat   Secreted   Signal   Zinc   Zymogen  

Feature

chain  A disintegrin and metalloproteinase with thrombospondin motifs 3
sequence variant  In dbSNP:rs788908.

Uniprot

Q5W7F4   A0A2H1WAC8   A0A194RNT2   A0A194QHE7   S4NIS8   A0A2P8Z1U4   + More
A0A2J7RN45   A0A067R067   A0A139WNG8   A0A091RHA2   A0A091KXR1   A0A091U841   A0A3B3WMY8   A0A3B3WMY7   A0A087XEN1   A0A2I0MH16   A0A093CHI1   A0A151N535   A0A091PZ28   A0A091P525   G1NCI6   A0A091H105   A0A091SXL7   A0A3Q0G275   A0A091K8M6   R0M107   U3IS63   A0A099ZNV3   A0A3P9PEY9   F1NVD1   A0A091VCW9   A0A091LC65   A0A3Q0EFX4   A0A087R272   D2I440   A0A091J468   G5ANH7   A0A2K5HK83   A0A093CCX3   A0A0N8ETJ2   A0A2U3YAU7   A0A0D9QXR4   G3WCC6   M3XK24   G3T767   A0A093FUL1   A0A2Y9I964   A0A3Q3WLY1   A0A2K6U7Q8   A0A3B3V2H4   A0A2K5YJI7   A0A2K6DXS9   A0A2K5VFV4   F7DSS6   F7A2S0   A0A2U3VE68   G7MT43   A0A3Q0T9Y4   A0A2K6KEF5   H2PDJ7   A0A096MW58   G1R882   A0A3B5QTX8   A0A3Q7Q9K0   A0A2K6PGE9   G3WCC5   M3ZJG0   A0A2J8UTV5   F6ZC90   O15072   M7BEC0   K7FWV3   A0A0A0APK9   A0A096N567   A0A2K5NRE9   A0A2K5NRF3   A0A2R9C2C1   A0A2I3TEV8   G7P5M2   A0A2R9CC15   A0A2K5DSM2   A0A2J8PFD7   A0A384C954   A0A3Q7VXP6   A0A287D421   A0A3B5LAW6   G3QLZ8   A0A2K5RWN8   F7EC85   H3ASK2   A0A3P9N0W4   A0A2Y9DZH5   A0A096MCV0   A0A3Q3ACX3   A0A3Q2PEV4   A0A0S7K3A9  

EC Number

3.4.24.-

Pubmed

15898116    26354079    23622113    29403074    24845553    18362917    + More
19820115    23371554    22293439    20838655    23749191    15592404    20010809    21993625    21709235    9215903    17431167    19892987    22002653    23542700    25362486    15815621    15489334    11408482    9205841    28985353    23624526    17381049    22722832    16136131    24813606    22398555    17495919   

EMBL

AB194270    BAD69559.2    ODYU01007276    SOQ49906.1    KQ459984    KPJ18985.1    + More
KQ459220    KPJ02866.1    GAIX01013944    JAA78616.1    PYGN01000238    PSN50464.1    NEVH01002545    PNF42261.1    KK852834    KDR15277.1    KQ971311    KYB29417.1    KK799877    KFQ27987.1    KK758737    KFP44208.1    KK441088    KFQ70223.1    AYCK01002573    AYCK01002574    AYCK01002575    AYCK01002576    AYCK01002577    AKCR02000013    PKK28972.1    KL244624    KFV13923.1    AKHW03004011    KYO31943.1    KK652494    KFQ02619.1    KK668078    KFQ02695.1    KL448082    KFO80022.1    KK937324    KFQ47943.1    KK549618    KFP33380.1    KB742619    EOB06348.1    ADON01026404    ADON01026405    ADON01026406    KL896449    KGL83506.1    AADN05000017    KL410916    KFR00914.1    KL308792    KFP52695.1    KL226056    KFM07576.1    ACTA01106043    ACTA01114043    ACTA01122043    ACTA01130043    GL194421    EFB28993.1    KK501372    KFP14465.1    JH166213    EHA98587.1    KL458380    KFV10864.1    GEBF01004227    JAN99405.1    AQIB01016336    AQIB01016337    AQIB01016338    AQIB01016339    AQIB01016340    AQIB01016341    AEFK01211420    AEFK01211421    AEFK01211422    AEFK01211423    AEFK01211424    AEFK01211425    AEFK01211426    AEFK01211427    AEFK01211428    AEFK01211429    AFYH01085802    AFYH01085803    AFYH01085804    AFYH01085805    AFYH01085806    AFYH01085807    AFYH01085808    AFYH01085809    AFYH01085810    AFYH01085811    KK635260    KFV58056.1    AQIA01054839    AQIA01054840    AQIA01054841    AQIA01054842    AQIA01054843    AQIA01054844    AQIA01054845    AQIA01054846    AQIA01054847    AQIA01054848    JSUE03033558    JSUE03033559    JSUE03033560    CM001257    EHH25939.1    ABGA01228450    ABGA01228451    ABGA01228452    ABGA01228453    ABGA01368097    ABGA01368098    ABGA01368099    ABGA01368100    ABGA01368101    ABGA01368102    AHZZ02026886    AHZZ02026887    AHZZ02026888    AHZZ02026889    AHZZ02026890    AHZZ02026891    ADFV01029806    ADFV01029807    ADFV01029808    ADFV01029809    ADFV01029810    ADFV01029811    ADFV01029812    ADFV01029813    NDHI03003443    PNJ48693.1    PNJ48694.1    AC093790    AC095056    AC104814    BC130287    BC132735    AF247668    AB002364    KB549684    EMP30488.1    AGCU01102093    AGCU01102094    AGCU01102095    AGCU01102096    AGCU01102097    AGCU01102098    AGCU01102099    AGCU01102100    AGCU01102101    AGCU01102102    KL872293    KGL94995.1    AJFE02062842    AJFE02062843    AJFE02062844    AJFE02062845    AJFE02062846    AJFE02062847    AACZ04033876    AACZ04033877    AACZ04033878    AACZ04033879    AACZ04033880    CM001280    EHH53740.1    NBAG03000215    PNI82723.1    PNI82724.1    AGTP01072028    AGTP01072029    CABD030031336    CABD030031337    CABD030031338    CABD030031339    CABD030031340    CABD030031341    CABD030031342    CABD030031343    CABD030031344    CABD030031345    AYCK01007292    GBYX01223108    JAO71405.1   

Proteomes

UP000053240    UP000053268    UP000245037    UP000235965    UP000027135    UP000007266    + More
UP000261480    UP000028760    UP000053872    UP000050525    UP000001645    UP000053760    UP000189705    UP000016666    UP000053641    UP000242638    UP000000539    UP000053283    UP000189704    UP000053286    UP000008912    UP000053119    UP000006813    UP000233080    UP000245341    UP000029965    UP000007648    UP000008672    UP000007646    UP000248481    UP000261620    UP000233220    UP000261500    UP000233140    UP000233120    UP000233100    UP000006718    UP000002281    UP000245340    UP000261340    UP000233180    UP000001595    UP000028761    UP000001073    UP000002852    UP000286641    UP000233200    UP000005640    UP000031443    UP000007267    UP000053858    UP000233060    UP000240080    UP000002277    UP000009130    UP000233020    UP000261680    UP000291021    UP000286642    UP000005215    UP000261380    UP000001519    UP000233040    UP000002280    UP000248480    UP000264800    UP000265000   

PRIDE

Q5W7F4    O15072   

Pfam

PF00090   TSP_1        + More
PF01562   Pep_M12B_propep
PF01421   Reprolysin
PF17771   ADAM_CR_2
PF05986   ADAM_spacer1

Interpro

IPR001590   Peptidase_M12B        + More
IPR000884   TSP1_rpt       
IPR036383   TSP1_rpt_sf       
IPR041645   ADAM_CR_2       
IPR024079   MetalloPept_cat_dom_sf       
IPR002870   Peptidase_M12B_N       
IPR006586   ADAM_Cys-rich       
IPR013273   ADAMTS/ADAMTS-like       
IPR010909   PLAC       
IPR010294   ADAM_spacer1       

SUPFAM

SSF82895   SSF82895       

Gene 3D

2.20.100.10     3.40.390.10    

ProteinModelPortal

Q5W7F4   A0A2H1WAC8   A0A194RNT2   A0A194QHE7   S4NIS8   A0A2P8Z1U4   + More
A0A2J7RN45   A0A067R067   A0A139WNG8   A0A091RHA2   A0A091KXR1   A0A091U841   A0A3B3WMY8   A0A3B3WMY7   A0A087XEN1   A0A2I0MH16   A0A093CHI1   A0A151N535   A0A091PZ28   A0A091P525   G1NCI6   A0A091H105   A0A091SXL7   A0A3Q0G275   A0A091K8M6   R0M107   U3IS63   A0A099ZNV3   A0A3P9PEY9   F1NVD1   A0A091VCW9   A0A091LC65   A0A3Q0EFX4   A0A087R272   D2I440   A0A091J468   G5ANH7   A0A2K5HK83   A0A093CCX3   A0A0N8ETJ2   A0A2U3YAU7   A0A0D9QXR4   G3WCC6   M3XK24   G3T767   A0A093FUL1   A0A2Y9I964   A0A3Q3WLY1   A0A2K6U7Q8   A0A3B3V2H4   A0A2K5YJI7   A0A2K6DXS9   A0A2K5VFV4   F7DSS6   F7A2S0   A0A2U3VE68   G7MT43   A0A3Q0T9Y4   A0A2K6KEF5   H2PDJ7   A0A096MW58   G1R882   A0A3B5QTX8   A0A3Q7Q9K0   A0A2K6PGE9   G3WCC5   M3ZJG0   A0A2J8UTV5   F6ZC90   O15072   M7BEC0   K7FWV3   A0A0A0APK9   A0A096N567   A0A2K5NRE9   A0A2K5NRF3   A0A2R9C2C1   A0A2I3TEV8   G7P5M2   A0A2R9CC15   A0A2K5DSM2   A0A2J8PFD7   A0A384C954   A0A3Q7VXP6   A0A287D421   A0A3B5LAW6   G3QLZ8   A0A2K5RWN8   F7EC85   H3ASK2   A0A3P9N0W4   A0A2Y9DZH5   A0A096MCV0   A0A3Q3ACX3   A0A3Q2PEV4   A0A0S7K3A9  

PDB

2RJQ     E-value=1.10705e-05,     Score=119

KEGG

692529    K08619 a disintegrin and metalloproteinase with thrombospondin motifs 3 [EC:3.4.24.-] | (RefSeq) Ada

GO

GO:0004222   GO:0007229   GO:1900748   GO:0016485   GO:0010573   GO:0032964   GO:0005615   GO:0030199   GO:0008201   GO:0030574   GO:0031012   GO:0070062   GO:0097435   GO:0008270   GO:0004175   GO:0005576  

Subcellular location

Secreted  
Extracellular space  
Extracellular matrix  

Length:

571

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01106

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00864

outside

1  -  571

 

 

Pi

213.451511

Theta

166.538616

Tajima's D

0.781407

CLR

0.260426

CSRT

0.603869806509674

Interpretation

Uncertain