Gene

KWMTBOMO05215  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002470

Annotation

PREDICTED:_charged_multivesicular_body_protein_5_[Amyelois_transitella]

Location

Bomo_Chr9(+):11260274-11265317      View in EpiBrowser

Full name

Charged multivesicular body protein 5      

Alternative Name

Vacuolar protein-sorting-associated protein 60

Location in the cell

Cytoplasmic   Reliability : 2.145 Nuclear   Reliability : 2.59

CDS

ATGAACAGATTATTTGGAAGAGCGAAACCCAAAGAACCTGGCCCCAGCATTACGGATTGCATTAAAAACGTAGATGGCCGAGCCGATAATATTGAACAGAAAGTCCAGAAACTGGACACAGAACTTAGAAAATACAAGGATCAGATGAGCAAAATGAGGGAGGGTCCTGCTAAAAATTCAGTCAAGCAAAAAGCAATGAGAGTATTGAAACAGAAGAAAATGTATGAACAACAACTTGATAATCTCCGTGCCCAGTCTTTCAACATGGAACAAGCAAATTATGCAACGCAGACATTGAAGGACACTCATACCACAATATCTGCAATGAAGGATGGTGTAACACAAATGAAAAAAGAATTTAAGAAGATTAATATTGATTCCATTGATGATGTAAATGATGAGTTAGCTGATATGATGGAACAAGCTGATGAAGTTCAAGAAGCCCTCGGCAGGCAATATGGTATGCCAGAGATTGATGATGATGAGCTTGCTGCAGAACTTGATGCTCTTGGTGATGAAATTGCTTTAGATGATGATGCTTCTTACCTTGACGATGTTGTGAAGGCTCCAGCAGCTCCAGATAGGGAACCTGGAGCCGACAGCATCCGGAACAAAGATGGTGTTCCCGTGGACGAATTTGGTCTGCCTCAGGTTCCAAGTACACCACAAACACACTGA

Protein

MNRLFGRAKPKEPGPSITDCIKNVDGRADNIEQKVQKLDTELRKYKDQMSKMREGPAKNSVKQKAMRVLKQKKMYEQQLDNLRAQSFNMEQANYATQTLKDTHTTISAMKDGVTQMKKEFKKINIDSIDDVNDELADMMEQADEVQEALGRQYGMPEIDDDELAAELDALGDEIALDDDASYLDDVVKAPAAPDREPGADSIRNKDGVPVDEFGLPQVPSTPQTH

Description

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Specifically down-regulates Notch signaling activity in the germarium, probably by facilitating Notch endocytosis (PubMed:24762813).

Subunit

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III).

Similarity

Belongs to the SNF7 family.

Keywords

Coiled coil   Complete proteome   Endosome   Membrane   Phosphoprotein   Protein transport   Reference proteome   Transport  

Feature

chain  Charged multivesicular body protein 5

Uniprot

H9IYY5   A0A1V0JHU4   A0A2H1VMI4   A0A1E1W8T1   A0A194RNS7   A0A194QBM2   + More
A0A212ESJ1   A0A1B0DMH6   A0A023EK64   Q1HQE2   A0A154PNF8   A0A2A3EI90   A0A088ACS6   E2BKB7   A0A026WAV5   A0A182JFU8   A0A182UNG6   A0A182TID4   A0A182X491   A0A182LBA3   Q7Q9Q8   A0A182HP94   E2AVJ2   A0A182T031   A0A0K8TTJ4   A0A182N897   A0A182RTL9   A0A182YFM5   A0A182P6B0   A0A182WIJ5   A0A182MB39   A0A2M4AH73   W5JVB9   B0XB50   A0A232FDQ3   K7IY65   A0A084W2J3   A0A182Q7T7   B0X7X3   U5EX55   T1DNI7   A0A2M3ZHU1   A0A2M4BYZ9   D6WCX4   A0A1Q3FHL6   A0A182FCF1   A0A1A9WP18   A0A1B0AI28   D3TNV0   A0A0L0C2Q4   A0A067QKH8   A0A1L8DVU0   A0A1A9VYQ7   A0A034VSS6   A0A0L7RHP8   A0A1A9XC91   A0A1B0B596   A0A1W4VSK8   A0A0K8V4E2   A0A1B0CJF1   B4J3J1   A0A0A1XT40   A0A1J1ISZ1   B4PJL2   B3NHT2   B4QNX4   A0A310STT2   A0A336MXA6   M9PCV9   Q9VVI9   A0A0T6ATI7   W8AUJ9   V5GZL1   F4W952   A0A1B6CQK7   E9G1P0   A0A158P084   A0A2J7PP90   T1PDW4   A0A1B6F678   A0A1W4WD55   A0A162T5J7   A0A023EMS9   B4N4D3   A0A0P5W573   A0A0N8BPF9   A0A3B0KI13   B4LEZ3   B3M4S5   A0A0P5EB27   A0A0P5CHR5   A0A1B6LEJ6   A0A1L8EEH2   Q2M0U1   A0A0P4X6B3   B4KZJ4   A0A1Y1M490   A0A1I8Q6U6   A0A0P4WE76   A0A0P5HBT5  

Pubmed

19121390    26354079    22118469    24945155    17204158    17510324    + More
20798317    24508170    30249741    20966253    12364791    14747013    17210077    26369729    25244985    20920257    23761445    28648823    20075255    24438588    18362917    19820115    20353571    26108605    24845553    25348373    17994087    25830018    17550304    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17372656    18327897    24762813    24495485    21719571    21292972    21347285    25315136    15632085    28004739   

EMBL

BABH01010760    KY694523    ARD08864.1    ODYU01003368    SOQ42040.1    GDQN01007695    + More
JAT83359.1    KQ459984    KPJ18980.1    KQ459220    KPJ02862.1    AGBW02012778    OWR44450.1    AJVK01001342    GAPW01004085    JAC09513.1    DQ440502    CH477862    CH477360    ABF18535.1    EAT35527.1    EAT42670.1    KQ434999    KZC13372.1    KZ288234    PBC31437.1    GL448783    EFN83841.1    KK107293    QOIP01000005    EZA53232.1    RLU22570.1    AAAB01008900    EAA09450.2    APCN01002931    GL443122    EFN62543.1    GDAI01000343    JAI17260.1    AXCM01004441    GGFK01006766    MBW40087.1    ADMH02000391    ETN66744.1    DS232614    EDS44103.1    NNAY01000399    OXU28650.1    ATLV01019621    KE525275    KFB44437.1    AXCN02000962    DS232468    EDS42192.1    GANO01001120    JAB58751.1    GAMD01002835    JAA98755.1    GGFM01007330    MBW28081.1    GGFJ01009112    MBW58253.1    KQ971311    EEZ98827.1    GFDL01007989    JAV27056.1    CCAG010009787    EZ423102    ADD19378.1    JRES01001077    KNC25699.1    KK853234    KDR09590.1    GFDF01003536    JAV10548.1    GAKP01013438    JAC45514.1    KQ414590    KOC70390.1    JXJN01008650    GDHF01033214    GDHF01032892    GDHF01018532    GDHF01018174    GDHF01011465    JAI19100.1    JAI19422.1    JAI33782.1    JAI34140.1    JAI40849.1    AJWK01014542    AJWK01014543    CH916366    EDV96193.1    GBXI01011467    GBXI01000187    JAD02825.1    JAD14105.1    CVRI01000057    CRL02222.1    CM000159    EDW94700.1    CH954178    EDV51947.1    CM000363    CM002912    EDX10876.1    KMZ00275.1    KQ760478    OAD60230.1    UFQS01003338    UFQS01004223    UFQT01003338    UFQT01004223    SSX15520.1    SSX16260.1    SSX34886.1    AE014296    AGB94687.1    AY071206    LJIG01022880    KRT78253.1    GAMC01014065    JAB92490.1    GALX01002543    JAB65923.1    GL888002    EGI69234.1    GEDC01021640    GEDC01016924    GEDC01004251    JAS15658.1    JAS20374.1    JAS33047.1    GL732529    EFX86777.1    ADTU01000980    NEVH01023278    PNF18162.1    KA646330    AFP60959.1    GECZ01024000    JAS45769.1    LRGB01000007    KZS21926.1    GAPW01003949    JAC09649.1    CH964095    EDW79007.1    GDIP01091068    JAM12647.1    GDIQ01157787    JAK93938.1    OUUW01000009    SPP84751.1    CH940647    EDW69162.1    CH902618    EDV40499.1    GDIP01144111    JAJ79291.1    GDIP01186053    JAJ37349.1    GEBQ01018053    JAT21924.1    GFDG01001800    JAV16999.1    CH379069    EAL30835.1    GDIP01246363    JAI77038.1    CH933809    EDW17921.1    GEZM01041009    JAV80654.1    GDRN01042492    JAI67043.1    GDIQ01230109    JAK21616.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000092462    UP000008820    + More
UP000076502    UP000242457    UP000005203    UP000008237    UP000053097    UP000279307    UP000075880    UP000075903    UP000075902    UP000076407    UP000075882    UP000007062    UP000075840    UP000000311    UP000075901    UP000075884    UP000075900    UP000076408    UP000075885    UP000075920    UP000075883    UP000000673    UP000002320    UP000215335    UP000002358    UP000030765    UP000075886    UP000007266    UP000069272    UP000091820    UP000092445    UP000092444    UP000037069    UP000027135    UP000078200    UP000053825    UP000092443    UP000092460    UP000192221    UP000092461    UP000001070    UP000183832    UP000002282    UP000008711    UP000000304    UP000000803    UP000007755    UP000000305    UP000005205    UP000235965    UP000095301    UP000192223    UP000076858    UP000007798    UP000268350    UP000008792    UP000007801    UP000001819    UP000009192    UP000095300   

PRIDE

H9IYY5    M9PCV9    Q9VVI9   

Pfam

PF03357   Snf7

Interpro

IPR005024   Snf7_fam       

ProteinModelPortal

H9IYY5   A0A1V0JHU4   A0A2H1VMI4   A0A1E1W8T1   A0A194RNS7   A0A194QBM2   + More
A0A212ESJ1   A0A1B0DMH6   A0A023EK64   Q1HQE2   A0A154PNF8   A0A2A3EI90   A0A088ACS6   E2BKB7   A0A026WAV5   A0A182JFU8   A0A182UNG6   A0A182TID4   A0A182X491   A0A182LBA3   Q7Q9Q8   A0A182HP94   E2AVJ2   A0A182T031   A0A0K8TTJ4   A0A182N897   A0A182RTL9   A0A182YFM5   A0A182P6B0   A0A182WIJ5   A0A182MB39   A0A2M4AH73   W5JVB9   B0XB50   A0A232FDQ3   K7IY65   A0A084W2J3   A0A182Q7T7   B0X7X3   U5EX55   T1DNI7   A0A2M3ZHU1   A0A2M4BYZ9   D6WCX4   A0A1Q3FHL6   A0A182FCF1   A0A1A9WP18   A0A1B0AI28   D3TNV0   A0A0L0C2Q4   A0A067QKH8   A0A1L8DVU0   A0A1A9VYQ7   A0A034VSS6   A0A0L7RHP8   A0A1A9XC91   A0A1B0B596   A0A1W4VSK8   A0A0K8V4E2   A0A1B0CJF1   B4J3J1   A0A0A1XT40   A0A1J1ISZ1   B4PJL2   B3NHT2   B4QNX4   A0A310STT2   A0A336MXA6   M9PCV9   Q9VVI9   A0A0T6ATI7   W8AUJ9   V5GZL1   F4W952   A0A1B6CQK7   E9G1P0   A0A158P084   A0A2J7PP90   T1PDW4   A0A1B6F678   A0A1W4WD55   A0A162T5J7   A0A023EMS9   B4N4D3   A0A0P5W573   A0A0N8BPF9   A0A3B0KI13   B4LEZ3   B3M4S5   A0A0P5EB27   A0A0P5CHR5   A0A1B6LEJ6   A0A1L8EEH2   Q2M0U1   A0A0P4X6B3   B4KZJ4   A0A1Y1M490   A0A1I8Q6U6   A0A0P4WE76   A0A0P5HBT5  

PDB

5FD7     E-value=5.55654e-05,     Score=108

KEGG

101742750    K12198 charged multivesicular body protein 5 | (RefSeq) charged multivesicular body protein 5

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0007034   GO:0000815   GO:0032509   GO:0015031   GO:0005524   GO:0009229   GO:0030975   GO:0006772   GO:0003677   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

Subcellular location

Endosome membrane  

Length:

225

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.06582

outside

1  -  225

 

 

Pi

209.151101

Theta

144.903482

Tajima's D

1.70267

CLR

0.235313

CSRT

0.828758562071896

Interpretation

Uncertain