Gene

KWMTBOMO05212  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002469

Annotation

PREDICTED:_tetratricopeptide_repeat_protein_21B-like_[Bombyx_mori]

Location

Bomo_Chr9(+):11201034-11211850      View in EpiBrowser

Full name

Sodium channel protein      

Location in the cell

Cytoplasmic   Reliability : 1.774 Nuclear   Reliability : 1.095

CDS

ATGTCTGGAATGTTAACAAGAGCTCGCGCTTTCTCCACGGAAGCTCTAAAAGTTGTTAACAATGTTGCTAAGCAACAGTTTGCTGTGTCAATAAAAGGAGAAGATGCTGTGATCAGCTATGAGAAGAAAGGCAAGGGGATAACCTTGATCCATACAAATGTGCCGCAGGCTTTTCAAGGAAAAGGAGTTGGGAAATTATTGGCACAGTATGCCTTTGATCATGCTTTAGAAAACAGGTTGAATAATAATTTAACCATGGATTTGGCTTGGCATAGATGTAATATTCATTATTATTTACGGGAAAAATACTATGGTAATGTTAAGAAAATTTCAAACGAAGCGTTGCAACAAAATCCTAGGAACTCAGAATTTATTTTCTATACTGGAATTGCATTGATATTAGAAGGGCAAGTTCATAAAGGGATTTCTGAACTAACTCCGCTCCAATCAGACAGTGAGATACAATTGGCAGTGATCATTGCTCTAGTTTATGCATACAAAGTTTCTAATTTACCAGAAAAAGAGGTGTTGTTCAATTTAGAATCAAAATTGAAGGAAGAAAAGAAACATGCAAGCATAACTTCATATTACTATTCAGCTTTGTTTTTATCATTAGCAGAAATAAATGAAAAAGCATCTGACTATTTAAATAAAGTATTTAGAAAAGATCCTAATAATTTAGATTCTATAATTCTGAAGGGATGGAATGACCTGGGCTTGAGTCAGGAAAAATCACCGAAATCCACTATAGAATGTTTAGAAGCAGCTATCAGAAAAAGTGATAACAGTATTGAAGCACTGCTTGGGTTGGCAAAATTGAAATATCTAGCAAAGGACTATGATGCATCAAATTTAACATTAGATAGACTGATTATTAACAACTCAGGGCAAGTAGTACCCCTTGTCGAGAAAATGAAAAATGAATTTGCAATGCAGAAATGGGAAGCGGTTTTCGATACATTAGAAAGAATATTTTCTATAGATCCAGATAATGTTGAGGGCTTGAAAATGAGAATATATCTTGCACTTGGTAAACGATCTGATTATATAGAAGCAGCTGATCAATTGAACCGCTTTTTTGGTATACTCGAAATTGAAGAAAGCCATAATGGACATCAGTTTTACTATACTGCTCAAATCTTTTCTAGAATTTGTGGGAGGTCAAGTGCAGTTTTGTCTCAAGCTTATAGATTTGCCCAGTATGCTTCAGAAATGTATTCAAATAATGTTGACTATCTCAGTGAAGTTGGCTACCAGTGTATCCTTCAGGCAAAATATAAAGACGCACTGAGTTTCTTTAGAGCTGCAAGTAAATTGGACAATAATTCCATCACAGCACTCTGTGGATTGACTCTCTGCCAAATGTTAGAGAATGGTCCGACAGACCAAATAACCCAACAAATTGAATTACTTTTTGAGATGCAAGGAACAGAAAAGTTACCACTTCTATACTTGTTGTCTGCCCAACTAAATATCAAGAACTCATCTAATGCAGTACCATTGTTAAACACAGCCTTTGAAACAAAATTAAATTTAGCCTCTCGCAATCCCATGAGTTTAATTTACATTAAGGACTTAGACCCAGATTTTGTTTTAGAAATTTACAAAGAGTACAAAAAGCATTTACCAAAGAAGCCGTTTATTATCATTGGGTATCTGCTTTATTCTCAAGAAGGAAACATCCCTGTTGTAATCCAGTGTTTTAAAATCTTAAATGCTGTTTGTGAAGCTTGCTCAGGTTTGATACCAGGCTTATTTGAATTGGCTAAATTGAAATTTCTTTTCGGATATGCCATTGAAGCTGAAAAAATAGCTCAACAAATCGCTGAGTTGGACAATACACATGCTGGTAGTCAGATTTTACTATCACAAATTTATATACAACAGCAAGAATATGTTAAAGCTGAACAATGTTTAGAAATTTGTCTGAGTTACAATTTCAAAGTCAGAGATAGTGCAATGTACCATTTTATAAATGCAATAGTTTTAAAAAGCAAAGAAAAATTACAAGATGCTTTGTCAAGCTTCTTGACAAGTCTTCAGATAGCAACTAGTAAAAGCAACATGAGCAGAACATTCGATTCAGACTTGAACATTATTGATAAAGCTACTTTGTATCTACAAATCATTGAGATACACACAGCTTTAGGGCAAATTGGGGAAGCGGGCAAAGCCATGCAGGAAGCAATTCAAGAATTTTCATATACATCAGAAGAAACTCGGCTGTTAATATCACGTGCTGACTTGGCTCTGAATCAAGGGGATATTGACAGTGCAATTGACATCTTAAATGAAATAAAGCCCGGACAGCCATATTACTTTCAAGCCCACAGCAAACTGGCTCATATTTATTTGAAAAATAAAAAAGACAGAGCCATGTTCACAACATGTTTTAAAGAGATTGTCAGTAATCATCCAATGACAGATGCCCATACGATGATGGGAGATGCTTTTATGTCGATTCAAGATCCAGCACAAGCGGTGGAGTCATACGAGACCGCCCTGAGAGGCAACCTCGGGGACCTACAGCTCACTAAGAAACTCGGCGCAGCTTTGTTCAAGATGCACGAATACGACAAGGCCGTGCAGCACTATGAGAACGCGATGAAAACGTTCAACGACGACGAACTTAAATTTGAATATCTCGATCTACTCGTCAGATTAAAACAATACGATAAAGCGGACACTACTATATCTTCGGAGCTGAATCAGGTGTACAATAAAGAGAAAGACATCGGAACACTGAGGCGCCGTGTCCGATTGCTACTTAAGCAGGCGAAATGTAGAGAACTGAAAACTCCGACTCCGGGAAACGTCAATTTAATATTAGCCGAAGCAAAAGAATTGCAGTTATCGATCGTCAAAAGACTAGAGATAGACTCGAAGACGGATCTGCAGGAGGAGAGGAGGCAGCTTTCGAACATATTGTGCGCTTTGGCGAAGTTCAAAAGCATGAGGGAGCCGGCTGTCGCGGCTAATTTGTATTCTGAGGCCCTAATTCATACTCCCCGCGAGCCGAGCACGCTGCTGGCCCTAGCTAAGCTGTACGCGCAGATGAATAATCCAGAAAAGTGCGAGCAAACTTGTGCAGTTTTATTGAACGCAGATCCGAATAATGAATCTGCGGCAGTCATGATGGCAGACCTGGCGTTTCGTAAGGTGGATCTAGAAACAGCCCAACGGCATCTGAACCAGATCTTATCGGTGAAGCCGACGAGCTGGGAGGCTCTCGCGCAGCTTGTCGAGGTGCAGTGGAGACGCGGGAAACTCAGCGAAGCCGAACAGGCCTTGGAACTCGCCAAGCAACACCTCGACGATCCGGACGACCCGGGCTACAAGTACTGCGCGGGCGTGTGCGCGGCGTACGGCGGCAAGTGCAACGCGGCGCTGCGGGCGCTGAACGCGGCGCGCGGGGGGGCGCGGTGGGGGGCCGCGGCCGCCGCGCGCATGGTGCTGCTGTGCCTGTCGCAGCACGCGCCGCTGCCGCCGCCGGATAACCTCACCGCCTCCGCTGATGACGCTGATACGCGTCTACTAGCTTTACGGACCGCCGAAAAGCTTCTCGTCGAAGTGAATCCAGCTGAACGGAAACCTCTGCAGGCGCTCCTCCAGCTGGCGACCAAGAACAAGGGCCAGGCGGAGCGGGTGCTGCAAGACTTGCTACCCCTGGTCACCGAGGACGGCTACCAGGACGACCCTTACGTCGTGCTGGCCATCGCTAATGCATACAATATAACAAAACAGCCGACGCGCGCGAAGAACATCCTCAAAAGAACTATTTCGTCCATCGTGTGGTCGCCGGAGAAGGCCGATGGACTCGAAAGATGCTGGCTGGAAGTGGCTGAGGGACAGATAAGTTCCGGAAGGACGGACGCTGCCAAAGAACTGCTCACGAAAATCTTAAACCACAACAACTCTTGTGCTAGAGCCTACCAATATCTAGGTCAAATAGCGGAGAAGGAGCAGAATTACAAGAGCGCGGCGCACAACTACGACAACGCGTGGAGCCACGCCGGCCGCGGCGACCTGTCCGTCGGCTACAAGCTGGCGCATTGTTATTTGAAACTCAAGAAGTACCCGGAATGTATAATCGTATCGCGATACATACTGAAGGTGCATCCCGACTATCCGAAGATCAAGAAGGAGATTTTAGAGAAAGCTAAAGCGAATTTGAGGACGTGA

Protein

MSGMLTRARAFSTEALKVVNNVAKQQFAVSIKGEDAVISYEKKGKGITLIHTNVPQAFQGKGVGKLLAQYAFDHALENRLNNNLTMDLAWHRCNIHYYLREKYYGNVKKISNEALQQNPRNSEFIFYTGIALILEGQVHKGISELTPLQSDSEIQLAVIIALVYAYKVSNLPEKEVLFNLESKLKEEKKHASITSYYYSALFLSLAEINEKASDYLNKVFRKDPNNLDSIILKGWNDLGLSQEKSPKSTIECLEAAIRKSDNSIEALLGLAKLKYLAKDYDASNLTLDRLIINNSGQVVPLVEKMKNEFAMQKWEAVFDTLERIFSIDPDNVEGLKMRIYLALGKRSDYIEAADQLNRFFGILEIEESHNGHQFYYTAQIFSRICGRSSAVLSQAYRFAQYASEMYSNNVDYLSEVGYQCILQAKYKDALSFFRAASKLDNNSITALCGLTLCQMLENGPTDQITQQIELLFEMQGTEKLPLLYLLSAQLNIKNSSNAVPLLNTAFETKLNLASRNPMSLIYIKDLDPDFVLEIYKEYKKHLPKKPFIIIGYLLYSQEGNIPVVIQCFKILNAVCEACSGLIPGLFELAKLKFLFGYAIEAEKIAQQIAELDNTHAGSQILLSQIYIQQQEYVKAEQCLEICLSYNFKVRDSAMYHFINAIVLKSKEKLQDALSSFLTSLQIATSKSNMSRTFDSDLNIIDKATLYLQIIEIHTALGQIGEAGKAMQEAIQEFSYTSEETRLLISRADLALNQGDIDSAIDILNEIKPGQPYYFQAHSKLAHIYLKNKKDRAMFTTCFKEIVSNHPMTDAHTMMGDAFMSIQDPAQAVESYETALRGNLGDLQLTKKLGAALFKMHEYDKAVQHYENAMKTFNDDELKFEYLDLLVRLKQYDKADTTISSELNQVYNKEKDIGTLRRRVRLLLKQAKCRELKTPTPGNVNLILAEAKELQLSIVKRLEIDSKTDLQEERRQLSNILCALAKFKSMREPAVAANLYSEALIHTPREPSTLLALAKLYAQMNNPEKCEQTCAVLLNADPNNESAAVMMADLAFRKVDLETAQRHLNQILSVKPTSWEALAQLVEVQWRRGKLSEAEQALELAKQHLDDPDDPGYKYCAGVCAAYGGKCNAALRALNAARGGARWGAAAAARMVLLCLSQHAPLPPPDNLTASADDADTRLLALRTAEKLLVEVNPAERKPLQALLQLATKNKGQAERVLQDLLPLVTEDGYQDDPYVVLAIANAYNITKQPTRAKNILKRTISSIVWSPEKADGLERCWLEVAEGQISSGRTDAAKELLTKILNHNNSCARAYQYLGQIAEKEQNYKSAAHNYDNAWSHAGRGDLSVGYKLAHCYLKLKKYPECIIVSRYILKVHPDYPKIKKEILEKAKANLRT

Description

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

Similarity

Belongs to the sodium channel (TC 1.A.1.10) family.

Uniprot

H9IYY4   A0A3S2P7P3   A0A2H1VZJ3   A0A194QBR4   A0A194RN87   A0A212ESH8   + More
A0A2J7PP87   Q16N31   A0A1S4FVA3   A0A1L8DDD7   A0A182G9P2   B0WWU5   A0A067QXT2   A0A336M386   A0A084VV01   A0A182SMF2   A0A182W438   A0A182FMD7   A0A182LVY1   A0A182YR90   A0A182PUA3   A0A182RL52   A0A1J1IH00   A0A182Q0B7   A0A182JDX0   Q7QET0   A0A0P4W164   W5JQB5   A0A182NAG6   A0A182WY98   A0A310SF76   E0VDU1   A0A0M8ZT09   A0A1L8EW56   A0A0Q3NN39   A0A2T7PR73   A0A2A3ELH2   S4RS46   F6VQ95   A0A3S1B7K1   A0A087ZQS7   K7FZF7   A0A210QRV3   B0R0W1   A0A0L7RC52   A0A3P4R7C3   A0A0C9PW60   L5JZ99   A0A3B3R5I6   F7EKI1   A0A1S3IUI9   A0A2I0UTR5   A0A1D5P6C2   A0A3Q7MMD4   A0A3Q7MR24   A0A2Y9SKT9   A0A2Y9SHT7   A0A1S3HYF2   A0A384A7E7   A0A3Q7S2D0   A0A2U3VPM3   A0A384A7P2   A0A2Y9I4I8   A0A2Y9KHV3   A0A384A7F6   A0A1A9YT09   G3T4U0   A0A2Y9MUQ0   F1PDE7   A0A151M074   W5KSZ3   M3XNN0   A0A1Y1JW15   A0A2U4ACI5   A0A232EYK3   G3WF32   H0XF97   A0A0T6B5W0   A0A3Q2I0E6   M3W8I9   V3ZQE9   G3UPS4   A0A3Q2GVP2   A0A340WR56   W5UBA7   G1NE60   A0A2D0R7J2   A0A1W4Z8S6   K7J0A3   A0A384BT08   A0A1S3GAR7   A0A0D9RSF2   F1RPM9   A0A2K5SGV7   A0A3Q7UJ01   A0A2K5ZJI4   A0A2K5LFJ5   W5P4N3  

Pubmed

19121390    26354079    22118469    17510324    26483478    24845553    + More
24438588    25244985    12364791    14747013    17210077    20920257    23761445    20566863    27762356    20431018    17381049    28812685    23594743    23258410    29240929    17495919    15592404    16341006    22293439    25329095    28004739    28648823    21709235    19892987    17975172    23254933    20838655    23127152    20075255    30723633    20809919   

EMBL

BABH01010754    BABH01010755    BABH01010756    BABH01010757    RSAL01000231    RVE43847.1    + More
ODYU01005407    SOQ46213.1    KQ459220    KPJ02859.1    KQ459984    KPJ18977.1    AGBW02012778    OWR44453.1    NEVH01023278    PNF18160.1    CH477841    EAT35755.1    GFDF01009760    JAV04324.1    JXUM01049614    KQ561613    KXJ78001.1    DS232152    EDS36206.1    KK853234    KDR09588.1    UFQT01000488    SSX24712.1    ATLV01017139    KE525157    KFB41795.1    AXCM01000646    CVRI01000048    CRK98820.1    AXCN02002022    AAAB01008846    EAA06388.5    GDRN01080754    JAI62146.1    ADMH02000831    ETN64929.1    KQ769179    OAD52955.1    DS235088    EEB11547.1    KQ435911    KOX68929.1    CM004482    OCT63545.1    LMAW01000636    KQK96063.1    PZQS01000002    PVD35924.1    KZ288226    PBC31871.1    AAMC01061984    AAMC01061985    AAMC01061986    RQTK01000545    RUS77887.1    AGCU01098810    AGCU01098811    AGCU01098812    AGCU01098813    AGCU01098814    AGCU01098815    AGCU01098816    AGCU01098817    AGCU01098818    AGCU01098819    NEDP02002253    OWF51460.1    AL929294    KQ414616    KOC68419.1    CYRY02039205    VCX30787.1    GBYB01005722    GBYB01005723    JAG75489.1    JAG75490.1    KB031068    ELK04660.1    KZ505638    PKU49451.1    AADN05000350    AAEX03017731    AAEX03017732    AKHW03006853    KYO17908.1    AEYP01014821    AEYP01014822    AEYP01014823    AEYP01014824    GEZM01102120    JAV51950.1    NNAY01001613    OXU23425.1    AEFK01111842    AEFK01111843    AEFK01111844    AEFK01111845    AAQR03118360    AAQR03118361    LJIG01009639    KRT82678.1    AANG04001482    KB201891    ESO93623.1    JT409868    AHH38854.1    AQIB01012439    AQIB01012440    AQIB01012441    AQIB01012442    AQIB01012443    AQIB01012444    AQIB01012445    AQIB01012446    AQIB01012447    AQIB01012448    AEMK02000100    DQIR01316794    HDC72268.1    AMGL01052917    AMGL01052918    AMGL01052919    AMGL01052920   

Proteomes

UP000005204    UP000283053    UP000053268    UP000053240    UP000007151    UP000235965    + More
UP000008820    UP000069940    UP000249989    UP000002320    UP000027135    UP000030765    UP000075901    UP000075920    UP000069272    UP000075883    UP000076408    UP000075885    UP000075900    UP000183832    UP000075886    UP000075880    UP000007062    UP000000673    UP000075884    UP000076407    UP000009046    UP000053105    UP000186698    UP000051836    UP000245119    UP000242457    UP000245300    UP000008143    UP000271974    UP000005203    UP000007267    UP000242188    UP000000437    UP000053825    UP000010552    UP000261540    UP000002280    UP000085678    UP000000539    UP000286641    UP000248484    UP000261681    UP000286640    UP000245340    UP000248481    UP000248482    UP000092443    UP000007646    UP000248483    UP000002254    UP000050525    UP000018467    UP000000715    UP000245320    UP000215335    UP000007648    UP000005225    UP000002281    UP000011712    UP000030746    UP000001645    UP000265300    UP000221080    UP000192224    UP000002358    UP000261680    UP000081671    UP000029965    UP000008227    UP000233040    UP000286642    UP000233140    UP000233060    UP000002356   

PRIDE

H9IYY4    F1RPM9   

Pfam

PF14542   Acetyltransf_CG        + More
PF07719   TPR_2
PF13181   TPR_8
PF13174   TPR_6
PF01433   Peptidase_M1
PF11838   ERAP1_C
PF07721   TPR_4
PF00595   PDZ
PF00373   FERM_M
PF09976   TPR_21
PF02866   Ldh_1_C
PF13176   TPR_7
PF00515   TPR_1
PF06512   Na_trans_assoc
PF00520   Ion_trans
PF11933   Na_trans_cytopl

Interpro

IPR040364   TTC21A/TTC21B        + More
IPR013026   TPR-contain_dom       
IPR011990   TPR-like_helical_dom_sf       
IPR019734   TPR_repeat       
IPR016181   Acyl_CoA_acyltransferase       
IPR031165   GNAT_YJDJ       
IPR013105   TPR_2       
IPR042097   Aminopeptidase_N-like_N       
IPR014782   Peptidase_M1_dom       
IPR024571   ERAP1-like_C_dom       
IPR011717   TPR-4       
IPR019747   FERM_CS       
IPR019748   FERM_central       
IPR036034   PDZ_sf       
IPR001478   PDZ       
IPR018980   FERM_PH-like_C       
IPR000299   FERM_domain       
IPR029071   Ubiquitin-like_domsf       
IPR014352   FERM/acyl-CoA-bd_prot_sf       
IPR019749   Band_41_domain       
IPR035963   FERM_2       
IPR018704   TPR_21       
IPR036291   NAD(P)-bd_dom_sf       
IPR022383   Lactate/malate_DH_C       
IPR015955   Lactate_DH/Glyco_Ohase_4_C       
IPR001440   TPR_1       
IPR010526   Na_trans_assoc       
IPR024583   Na_trans_cytopl       
IPR027359   Volt_channel_dom_sf       
IPR001696   Na_channel_asu       
IPR005821   Ion_trans_dom       

SUPFAM

SSF48452   SSF48452        + More
SSF55729   SSF55729       
SSF50156   SSF50156       
SSF54236   SSF54236       
SSF47031   SSF47031       
SSF56327   SSF56327       
SSF51735   SSF51735       

Gene 3D

1.25.40.10     2.60.40.1730     1.20.80.10     3.90.110.10     1.20.120.350    

CDD

cd14473  FERM_B-lobe

ProteinModelPortal

H9IYY4   A0A3S2P7P3   A0A2H1VZJ3   A0A194QBR4   A0A194RN87   A0A212ESH8   + More
A0A2J7PP87   Q16N31   A0A1S4FVA3   A0A1L8DDD7   A0A182G9P2   B0WWU5   A0A067QXT2   A0A336M386   A0A084VV01   A0A182SMF2   A0A182W438   A0A182FMD7   A0A182LVY1   A0A182YR90   A0A182PUA3   A0A182RL52   A0A1J1IH00   A0A182Q0B7   A0A182JDX0   Q7QET0   A0A0P4W164   W5JQB5   A0A182NAG6   A0A182WY98   A0A310SF76   E0VDU1   A0A0M8ZT09   A0A1L8EW56   A0A0Q3NN39   A0A2T7PR73   A0A2A3ELH2   S4RS46   F6VQ95   A0A3S1B7K1   A0A087ZQS7   K7FZF7   A0A210QRV3   B0R0W1   A0A0L7RC52   A0A3P4R7C3   A0A0C9PW60   L5JZ99   A0A3B3R5I6   F7EKI1   A0A1S3IUI9   A0A2I0UTR5   A0A1D5P6C2   A0A3Q7MMD4   A0A3Q7MR24   A0A2Y9SKT9   A0A2Y9SHT7   A0A1S3HYF2   A0A384A7E7   A0A3Q7S2D0   A0A2U3VPM3   A0A384A7P2   A0A2Y9I4I8   A0A2Y9KHV3   A0A384A7F6   A0A1A9YT09   G3T4U0   A0A2Y9MUQ0   F1PDE7   A0A151M074   W5KSZ3   M3XNN0   A0A1Y1JW15   A0A2U4ACI5   A0A232EYK3   G3WF32   H0XF97   A0A0T6B5W0   A0A3Q2I0E6   M3W8I9   V3ZQE9   G3UPS4   A0A3Q2GVP2   A0A340WR56   W5UBA7   G1NE60   A0A2D0R7J2   A0A1W4Z8S6   K7J0A3   A0A384BT08   A0A1S3GAR7   A0A0D9RSF2   F1RPM9   A0A2K5SGV7   A0A3Q7UJ01   A0A2K5ZJI4   A0A2K5LFJ5   W5P4N3  

PDB

3VTY     E-value=0.0119862,     Score=96

KEGG

101745397    K19673 tetratricopeptide repeat protein 21B | (RefSeq) tetratricopeptide repeat protein 21B-like

GO

GO:0008237   GO:0016021   GO:0008270   GO:0035721   GO:0030991   GO:0061512   GO:0005929   GO:0042802   GO:0005856   GO:0016616   GO:0005975   GO:0007369   GO:0006357   GO:0008589   GO:0007224   GO:0021798   GO:1905799   GO:0021591   GO:0000790   GO:0001518   GO:0005248   GO:0005244   GO:0034765   GO:0005515   GO:0005549   GO:0007608   GO:0016020   GO:0006355   GO:0003677   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

PANTHER

PTHR14699  

Subcellular location

Cell membrane  

Length:

1393

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01624

Exp number, first 60 AAs:

0.00012

Total prob of N-in:

0.00074

outside

1  -  1393

 

 

Pi

351.60259

Theta

180.393257

Tajima's D

3.788647

CLR

0.372906

CSRT

0.997600119994

Interpretation

Uncertain