Gene

KWMTBOMO05206

Pre Gene Modal

BGIBMGA002463

Annotation

nuclear_factor_NF-kappa-B_p110_subunit_isoform_2_[Bombyx_mori]

Location

Bomo_Chr9(+):10919345-10938979      View in EpiBrowser

Full name

Nuclear factor NF-kappa-B p110 subunit      

Alternative Name

Rel-p110
Relish protein

Transcription factor

RHD

Location in the cell

Nuclear   Reliability : 4.25

CDS

ATGTCTACAACTGCCAGTGATCAGGATAGTGATTCTTCCAGCAGATCCCCACAATCTTATTATAGTTATTGTTCACCCTCTCAACAAGTACCTCAGTTGACTCCAGATTTGAACAACCTAATATATCTAGACAATGGCTCAAAGAGAAACAGACCGTTTCTTCGCATAATTGAACAGCCACAGGACTACTTTAGATTTCGCTATGCTAGTGAAATGGCTGGAACACATGGATGTTTGCTCGGAAAGTCATCTTCAACAAACAAGAACAAAGTTCACCCTACAGTTGAGCTTGTAAACTACACTGGCCAGGCTGTAATAAAATGTCAGTTGGCCCAACATAAGACACCTGAGGAGCATCCACACAAGCTATTCGAAGAAGAACAAGATAATGATGACAGAGAAGTCAGCTGCATTGTTCCTAAACAAGGCATTTACAAAGTCGGGTTCGGTGGAATGGGTATCATACACACAGCAAAAAAAAACGTACCAGGCTTACTGTTCCAGAAGTATGCAGAGAAGTGTAAGAACATCAGCAACAAAGAGCTCAAAATCCAATGCGAGAATATGGCTAAAAGCATAGATCTCAACATTGTGCGTTTGAAGTTCAGCGCTCACGACATCAGCACCGATCGTGAGATATGCAAGCCTGTTTTCTCTGAACCGATACACAACTTAAAAAGTGCTGCTTCGAACGATCTGAAGATATGTCGCATCAGTCGTTGTTCCGGGCGTCCAGTTGGAGGAGAAGACGTGTACATTTTCGTCGAGAAAGTTAACAAAAAAAATATACAGATACGCTTCTTCGAATTGGACGAGAATGGCCACCGCGTGTGGACGGCTAACGGGAGTTTCATGCCTGGCGATGTTCACCACCAGTACGCCATAATCTTCAGGACCCCGGCCTACAAGGATACGAAGATATCAAAGAACGTGAACGTGTATATAGAACTGGCGCGGCCCTCGGACGGTCGCACGAGCGAACCTAAGGAGTTCAAGTACATCGCCGAGCCCATATACTCGAACAGCAAGAAGAGAAGGATGAATGCCTCATGTTCTACTTCCCCTGCTTCGTCTGGGTCGTTGAAGAGTATCAGCGATCTGCCCGCCCTTGTGACTCTCAATAACAATTTCAACGATGAAAACAACATTGAAATGCCGAAAACTGAGGTACTTGATCCATTGACTTATGTATTATAA

Protein

MSTTASDQDSDSSSRSPQSYYSYCSPSQQVPQLTPDLNNLIYLDNGSKRNRPFLRIIEQPQDYFRFRYASEMAGTHGCLLGKSSSTNKNKVHPTVELVNYTGQAVIKCQLAQHKTPEEHPHKLFEEEQDNDDREVSCIVPKQGIYKVGFGGMGIIHTAKKNVPGLLFQKYAEKCKNISNKELKIQCENMAKSIDLNIVRLKFSAHDISTDREICKPVFSEPIHNLKSAASNDLKICRISRCSGRPVGGEDVYIFVEKVNKKNIQIRFFELDENGHRVWTANGSFMPGDVHHQYAIIFRTPAYKDTKISKNVNVYIELARPSDGRTSEPKEFKYIAEPIYSNSKKRRMNASCSTSPASSGSLKSISDLPALVTLNNNFNDENNIEMPKTEVLDPLTYVL

Description

Plays a key role in the humoral immune response (PubMed:8816802, PubMed:10619029, PubMed:11269501, PubMed:11872802, PubMed:22022271). Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes (PubMed:11269501). I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation (PubMed:11872802, PubMed:11018014). Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition (PubMed:25477468). May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system (PubMed:18000549). Possibly post-transcriptionally regulates the neuron-specific genes sc and ase, by promoting the rapid turnover of their transcripts in the wing imaginal disk (PubMed:18000549).

Subunit

Rel-p68 subunit interacts with Dredd (PubMed:11269502). Interacts with DMAP1 (PubMed:24947515). Interacts with akirin; interaction is immune stimulation-dependent; activates selected rel target gene promoters (PubMed:25180232).

Keywords

Activator   Alternative splicing   ANK repeat   Complete proteome   Cytoplasm   Direct protein sequencing   Immunity   Innate immunity   Nucleus   Phosphoprotein   Reference proteome   Repeat   Transcription   Transcription regulation  

Feature

chain  Nuclear factor NF-kappa-B p110 subunit
splice variant  In isoform Maternal.

Uniprot

A7BJ66   A7BJ65   A0A1E1WML5   A0A2H1W203   A0A059XSW9   A0A059XNQ1   + More
G9BRX4   G3LF45   E2GK02   E2GK03   A0A345CI06   A0A194RSC1   A0A194QHC6   A0A212ESP0   A0A0L7L833   Q2N406   Q2N408   Q2N409   Q2N403   Q2N404   Q2N401   Q2N407   Q2N402   Q2N400   Q2N3Z9   Q2N405   A0A2J7Q2V8   A0A2J7Q2X5   A0A2J7Q2W5   D6X3U8   Q2N3Z8   A0A1L8DSX3   A0A1L8DSW9   A0A1Y1N3B2   Q8MV45   A0A2Z0LP10   A0A2M4AIV0   Q171I8   Q8MV44   A0A1S4FH15   A0A1B0DRJ1   A0A026W8J6   A0A2A3ETK9   A0A2M4AE10   A0A2M4AE14   A0A2M4AE46   A0A2Z5FM13   W8C6E6   A0A182GU76   A0A2M3ZGZ8   E2B900   A0A087ZPI1   A0A182JBP2   A0A2U9Q5H3   A0A3L8DJT8   A0A182TKA6   Q294I3   A0A1W4W384   B3P1U0   B4HKI3   A5YCD6   Q94527-2   A0A3B0KCT7   A5YCE6   Q9U444   Q9U442   Q9U441   Q9TVT4   Q9U443   Q9U434   Q94527   A0A182QGU8   E2AYS4   A0A182FI36   B3M1Z7   D0QWP1   B4PTZ8   A5YCF0   A5YCF3   A5YCE9   A5YCF1   A0A3F2YW05   A0A2M4BC07   A0A1I8MHC1   T1PJB1   B4QXA6   F4WF21   A0A2M4BAT5   A0A0A1WZ86   A0A1Q3FFU3   A0A0L0CE32   A0A195DYG0   A5YCE2   A0A2M4CPK7   A0A2M4CP56   A0A1Q3FFN3   B0WY04   A0A2M4CYK8   U5EVW4   W5JN07  

Pubmed

17714806    26847920    26354079    22118469    26227816    16221893    + More
18362917    19820115    28004739    12119421    25632977    17510324    24508170    24495485    26483478    20798317    30249741    15632085    17994087    8816802    10619029    10731132    12537572    12537569    10757765    11269501    11269502    11018014    11872802    18000549    18327897    22022271    25180232    24947515    25477468    19859648    17550304    25315136    21719571    25830018    26108605    20920257    23761445   

EMBL

AB298442    BAF74126.1    AB298441    BAF74125.1    GDQN01002810    JAT88244.1    + More
ODYU01005802    SOQ47057.1    KJ576789    AIA24468.1    KJ576790    AIA24469.1    HQ680461    AEW24431.1    JN315690    AEO51739.1    HM363513    ADK39023.1    HM363514    ADK39024.1    MF797867    AXF67445.1    KQ459984    KPJ18966.1    KQ459220    KPJ02846.1    AGBW02012778    OWR44464.1    JTDY01002386    KOB71525.1    DQ058901    AAZ08471.1    DQ058899    AAZ08469.1    DQ058898    AAZ08468.1    DQ058904    AAZ08474.1    DQ058903    AAZ08473.1    DQ058906    AAZ08476.1    DQ058900    AAZ08470.1    DQ058905    AAZ08475.1    DQ058907    AAZ08477.1    DQ058908    AAZ08478.1    DQ058902    AAZ08472.1    NEVH01019075    PNF22925.1    PNF22923.1    PNF22924.1    KQ971326    EEZ97717.1    DQ058909    AAZ08479.1    GFDF01004521    JAV09563.1    GFDF01004522    JAV09562.1    GEZM01013723    GEZM01013722    JAV92342.1    AF498104    AAM97894.1    KM034779    AJG05484.1    GGFK01007382    MBW40703.1    CH477453    EAT40659.1    AF498105    AAM97895.1    AJVK01001957    AJVK01001958    AJVK01001959    AJVK01001960    AJVK01001961    AJVK01001962    KK107347    EZA52293.1    KZ288186    PBC34834.1    GGFK01005705    MBW39026.1    GGFK01005706    MBW39027.1    GGFK01005699    MBW39020.1    MF770717    AXC07421.1    GAMC01004309    JAC02247.1    JXUM01089109    JXUM01089110    JXUM01089111    KQ563746    KXJ73392.1    GGFM01007042    MBW27793.1    GL446405    EFN87834.1    AXCP01007903    MH370859    AWT86617.1    QOIP01000007    RLU20433.1    CM000070    EAL28981.2    CH954181    EDV49828.1    CH480815    EDW42933.1    EF494521    ABQ65730.1    U62005    AF186073    AF186077    AF186078    AE014297    AY058264    AF204284    AF204285    AF204286    AF204287    AF204288    AF204289    AAL13493.1    OUUW01000008    SPP84019.1    EF494531    ABQ65740.1    AF204277    AAF18094.1    AF204281    AAF18098.1    AF204283    AAF18100.1    AF204278    AF204280    AF204282    AAF18099.1    AF204279    AAF18096.1    AF204290    AAF20138.1    AXCN02000579    GL443983    EFN61437.1    CH902617    EDV43321.1    FJ821033    ACN94740.1    CM000160    EDW96609.1    EF494535    ABQ65744.1    EF494538    ABQ65747.1    EF494534    ABQ65743.1    EF494536    ABQ65745.1    GGFJ01001419    MBW50560.1    KA647988    AFP62617.1    CM000364    EDX13677.1    GL888115    EGI67072.1    GGFJ01001024    MBW50165.1    GBXI01010502    JAD03790.1    GFDL01008619    JAV26426.1    JRES01000519    KNC30457.1    KQ980066    KYN17918.1    EF494527    ABQ65736.1    GGFL01002943    MBW67121.1    GGFL01002944    MBW67122.1    GFDL01008680    JAV26365.1    DS232178    EDS36814.1    GGFL01006181    MBW70359.1    GANO01003227    JAB56644.1    ADMH02000632    ETN65501.1   

Proteomes

UP000053240    UP000053268    UP000007151    UP000037510    UP000235965    UP000007266    + More
UP000008820    UP000092462    UP000053097    UP000242457    UP000069940    UP000249989    UP000008237    UP000005203    UP000075880    UP000279307    UP000075902    UP000001819    UP000192221    UP000008711    UP000001292    UP000000803    UP000268350    UP000075886    UP000000311    UP000069272    UP000007801    UP000002282    UP000075884    UP000095301    UP000000304    UP000007755    UP000037069    UP000078492    UP000002320    UP000000673   

PRIDE

A7BJ66    A7BJ65    Q94527   

Pfam

PF00554   RHD_DNA_bind        + More
PF16179   RHD_dimer
PF00023   Ank
PF12796   Ank_2
PF00531   Death
PF13606   Ank_3
PF02882   THF_DHG_CYH_C
PF00763   THF_DHG_CYH

Interpro

IPR002909   IPT_dom        + More
IPR014756   Ig_E-set       
IPR011539   RHD_DNA_bind_dom       
IPR000451   NFkB/Dor       
IPR013783   Ig-like_fold       
IPR033926   IPT_NFkappaB       
IPR008967   p53-like_TF_DNA-bd       
IPR037059   RHD_DNA_bind_dom_sf       
IPR032397   RHD_dimer       
IPR036770   Ankyrin_rpt-contain_sf       
IPR020683   Ankyrin_rpt-contain_dom       
IPR002110   Ankyrin_rpt       
IPR011029   DEATH-like_dom_sf       
IPR000488   Death_domain       
IPR016024   ARM-type_fold       
IPR020631   THF_DH/CycHdrlase_NAD-bd_dom       
IPR020867   THF_DH/CycHdrlase_CS       
IPR020630   THF_DH/CycHdrlase_cat_dom       
IPR000672   THF_DH/CycHdrlase       
IPR036291   NAD(P)-bd_dom_sf       

SUPFAM

SSF49417   SSF49417        + More
SSF81296   SSF81296       
SSF48403   SSF48403       
SSF47986   SSF47986       
SSF48371   SSF48371       
SSF51735   SSF51735       

Gene 3D

2.60.40.10     2.60.40.340     1.25.40.20    

CDD

cd01177  IPT_NFkappaB
cd00204  ANK
cd01080  NAD_bind_m-THF_DH_Cyclohyd

ProteinModelPortal

A7BJ66   A7BJ65   A0A1E1WML5   A0A2H1W203   A0A059XSW9   A0A059XNQ1   + More
G9BRX4   G3LF45   E2GK02   E2GK03   A0A345CI06   A0A194RSC1   A0A194QHC6   A0A212ESP0   A0A0L7L833   Q2N406   Q2N408   Q2N409   Q2N403   Q2N404   Q2N401   Q2N407   Q2N402   Q2N400   Q2N3Z9   Q2N405   A0A2J7Q2V8   A0A2J7Q2X5   A0A2J7Q2W5   D6X3U8   Q2N3Z8   A0A1L8DSX3   A0A1L8DSW9   A0A1Y1N3B2   Q8MV45   A0A2Z0LP10   A0A2M4AIV0   Q171I8   Q8MV44   A0A1S4FH15   A0A1B0DRJ1   A0A026W8J6   A0A2A3ETK9   A0A2M4AE10   A0A2M4AE14   A0A2M4AE46   A0A2Z5FM13   W8C6E6   A0A182GU76   A0A2M3ZGZ8   E2B900   A0A087ZPI1   A0A182JBP2   A0A2U9Q5H3   A0A3L8DJT8   A0A182TKA6   Q294I3   A0A1W4W384   B3P1U0   B4HKI3   A5YCD6   Q94527-2   A0A3B0KCT7   A5YCE6   Q9U444   Q9U442   Q9U441   Q9TVT4   Q9U443   Q9U434   Q94527   A0A182QGU8   E2AYS4   A0A182FI36   B3M1Z7   D0QWP1   B4PTZ8   A5YCF0   A5YCF3   A5YCE9   A5YCF1   A0A3F2YW05   A0A2M4BC07   A0A1I8MHC1   T1PJB1   B4QXA6   F4WF21   A0A2M4BAT5   A0A0A1WZ86   A0A1Q3FFU3   A0A0L0CE32   A0A195DYG0   A5YCE2   A0A2M4CPK7   A0A2M4CP56   A0A1Q3FFN3   B0WY04   A0A2M4CYK8   U5EVW4   W5JN07  

PDB

5ZMC     E-value=3.95415e-49,     Score=492

KEGG

100124425    K02580 nuclear factor NF-kappa-B p105 subunit | (RefSeq) Rel, BmRelish, BmRelish2, Bmrelish1, relish

GO

GO:0003700   GO:0005634   GO:0005737   GO:0003677   GO:0000502   GO:0007165   GO:0050766   GO:0006964   GO:0034198   GO:2000647   GO:0005719   GO:0045429   GO:0051607   GO:0006974   GO:0061057   GO:0002230   GO:0061059   GO:0043565   GO:0048935   GO:0048813   GO:0050829   GO:0001228   GO:1901224   GO:0006967   GO:0005829   GO:0045089   GO:0006955   GO:0000981   GO:0009617   GO:0006963   GO:0045944   GO:0042802   GO:0042742   GO:0005654   GO:0045087   GO:0010628   GO:0045088   GO:0004488   GO:0005515   GO:0006355   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

PANTHER

PTHR24169  

Subcellular location

Nucleus  
Cytoplasm  

Length:

398

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00589999999999998

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01804

outside

1  -  398

 

 

Pi

175.177358

Theta

161.469439

Tajima's D

0.616916

CLR

0.21564

CSRT

0.541722913854307

Interpretation

Uncertain