Gene

KWMTBOMO05198

Pre Gene Modal

BGIBMGA002458

Annotation

neuropeptide_receptor_A22_[Bombyx_mori]

Location

Bomo_Chr9(+):10737686-10740381      View in EpiBrowser

Full name

RYamide receptor      

Alternative Name

Neuropeptide Y-like receptor

Location in the cell

PlasmaMembrane   Reliability : 4.954

CDS

ATGTATAGCGCAGTGTTTTTAGTTGCGCTTTTGGGAAATGGATTAGTGTGTTTCATTGTTCACACATCTCCTCGTATGAAGACGGTCACGAATTATTTTATAGTGAACCTGGCAGTCGGAGATATCCTGATGACGTTGTTCTGTGTGCCGTTTTCTTTCGTGTCAATGCTTGTACTGCGGTATTGGCCCTTTGGTGCGGTTATGTGCAAAGTTGTCAACTTCTCACAAGCGGTTTCGGTACTAGTCAGCGCATACACGCTACTCGCCATATCCATTGACAGATACATAGTTATAATGCGGCCATTAAAGCCTCGACTTGGGAAAGGTGCAGCTAAAATGGTCGTCGCTGCTGTTTGGGGAGGAGCCATTATAACGGCAGCGCCGATTCCTATAGTTTCTCAGCTACAGCGACCTTCGCCTTGGCATGAGGCTTGTAAAGTTGACATCTGCAGCGAACAGTGGGCCGATGGAAAACAAAGCGAGCATTATACGTTTGCTTTATTGACACTGCAATTTACTTTGCCATTGACCGCTCTCGTTTACACGTACGGGCGAATAGCGCATTTTGTATGGGGCGGTCGACCACCTGGAGAAGCAGAAAGCGGTCGGGACTCGCGGCTGCAACTCTCCAAAAGGAAAATGATCAAAATGATGGTCACAGTAGTGGCGGTGTTTGTAGTTTGCTGGTTACCGCTCAATATCTTTATTGTAAGTAGCATTTGTTTCTTAATTGTACTAGTATAG

Protein

MYSAVFLVALLGNGLVCFIVHTSPRMKTVTNYFIVNLAVGDILMTLFCVPFSFVSMLVLRYWPFGAVMCKVVNFSQAVSVLVSAYTLLAISIDRYIVIMRPLKPRLGKGAAKMVVAAVWGGAIITAAPIPIVSQLQRPSPWHEACKVDICSEQWADGKQSEHYTFALLTLQFTLPLTALVYTYGRIAHFVWGGRPPGEAESGRDSRLQLSKRKMIKMMVTVVAVFVVCWLPLNIFIVSSICFLIVLV

Description

Receptor for the neuropeptides RYamide-1 and RYamide-2 (PubMed:21843505, PubMed:21704020). The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system (PubMed:21843505, PubMed:21704020). RYamide signaling may suppress feeding behavior (PubMed:21704020).

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Cell membrane   Complete proteome   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  RYamide receptor

Uniprot

B3XXN5   A0A2H1V2X5   A0A0S1YDM6   B3XXN2   A0A0S1YD83   A0A2H1VQ84   + More
A0A0L7L8U4   A0A194RNG8   W8BKX0   W8C5P9   U3U7M9   A0A194PN54   B4N8F0   B3MT11   A0A336M9A8   A0A1B6GV51   A0A0R3NME0   I5ANE3   A0A0U1SQQ4   B4K9P0   B4M121   A0A1B6HNX7   U5N1G6   U3U4E6   Q7PS45   A0A0R3NFZ1   A0A3B0K4J6   A0A1B6KQU8   A0A1W4UIN3   A0A154PPP1   A0A310SGV6   A0A1W4U5X8   A0A2A3E4P5   A0A0B4LIR4   P25931   A0A0L0BKK6   A0A1A9ZQ06   A0A1A9UTI4   A0A1A9YGR4   A0A0B4LHT6   A0A1B0BK89   A0A087ZXB1   A0A1B0GFC2   J9HFI0   A0A1B0GI77   A0A1J1HKG2   H9IYV7   A0A2S2NKP8   B4JHG9   A0A1A9VZB2   A0A1I8M4W6   A0A182M6Y6   A0A182RQ76   A0A0L7QUK8   A0A2H8TU58   A0A2P8YU82   A0A182PT96   A0A182IB01   A0A182N0R3   A0A182U9Y7   B4G2E6   W5JI13   A0A182WW95   A0A1I8PP13   A0A182QZJ5   A0A182YF15   A0A182VFB5   A0A182W592   A0A182J901   J9JLB3   B0XGN8   U5N1H5   A0A182FIQ5   Q2QKU5   U5N4G7   B4PRW5   Q16Z67   B3P871   A0A1B6DRF1   B4IC28   E9G455   Q69DS4   B4QXD4   T1KC18   A0A087UNN0   A0A0P5YRX6   A0A0N8A9E0   A0A2J7PUG3   A0A0P6G3P1   A0A0M5J4H1   Q1DGY7   E0VRZ1   A0A2P6KHF5   A0A1L1VXI0   A0A147BFV4   A0A164Z7G7   A0A2U9PFU7   A0A0P6HZ76   A0A0P5L1Z5  

Pubmed

18725956    26227816    26354079    24495485    23932938    17994087    + More
18057021    15632085    24130914    12364791    14747013    17210077    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    21843505    1370455    21704020    26108605    17510324    19121390    25315136    29403074    20920257    23761445    25244985    17550304    21292972    20566863    29652888   

EMBL

AB330443    BAG68421.1    ODYU01000259    SOQ34722.1    KT031020    ALM88318.1    + More
AB330440    BAG68418.1    KT031017    ALM88315.1    ODYU01003776    SOQ42958.1    JTDY01002261    KOB71780.1    KQ459984    KPJ18959.1    GAMC01008932    JAB97623.1    GAMC01008931    JAB97624.1    AB817303    BAO01070.1    KQ459597    KPI94747.1    CH964232    EDW81401.2    CH902623    EDV30401.2    KPU72827.1    UFQS01000647    UFQT01000567    UFQT01000647    SSX05744.1    SSX25373.1    GECZ01003504    JAS66265.1    CM000070    KRT00006.1    EIM52478.1    JQ433061    AFJ42283.1    CH933806    EDW14515.1    CH940650    EDW67432.2    GECU01031343    JAS76363.1    KC439535    AGX85003.1    AB817304    BAO01071.1    AAAB01008846    EAA06194.6    KRT00007.1    OUUW01000005    SPP80546.1    GEBQ01031640    GEBQ01026161    JAT08337.1    JAT13816.1    KQ435012    KZC13832.1    KQ760123    OAD61850.1    KZ288376    PBC26670.1    AE014297    AHN57552.1    JN234381    BT015303    M81490    AAT94531.1    JRES01001712    KNC20611.1    AHN57551.1    JXJN01015848    CCAG010006669    CH477341    EJY57582.1    AJWK01013567    CVRI01000006    CRK88026.1    BABH01010701    GGMR01005151    MBY17770.1    CH916369    EDV92796.1    AXCM01000048    KQ414734    KOC62323.1    GFXV01005684    MBW17489.1    PYGN01000356    PSN47797.1    APCN01001400    CH479179    EDW23991.1    ADMH02001126    ETN64027.1    AXCN02001397    ABLF02032190    ABLF02032192    DS233047    EDS27732.1    KC439538    AGX85006.1    DQ005188    AAY46405.1    KC439537    AGX85005.1    CM000160    EDW98558.1    CH477497    EAT39936.1    CH954182    EDV53475.1    GEDC01021184    GEDC01009041    JAS16114.1    JAS28257.1    CH480828    EDW45186.1    GL732531    EFX85694.1    AH013422    AY347941    AY347942    AY347944    AY347945    AAR28374.1    CM000364    EDX14620.1    CAEY01001957    KK120754    KFM78969.1    GDIP01053955    JAM49760.1    GDIP01244017    GDIP01169617    JAJ53785.1    NEVH01021198    PNF19968.1    GDIQ01049951    JAN44786.1    CP012526    ALC45594.1    CH900018    EAT32417.2    DS235639    EEB16147.1    MWRG01011857    PRD25747.1    KF309026    AHE76193.1    GEGO01005714    JAR89690.1    LRGB01000770    KZS16035.1    MG550209    AWT50643.1    GDIQ01013001    JAN81736.1    GDIQ01201287    JAK50438.1   

Proteomes

UP000037510    UP000053240    UP000053268    UP000007798    UP000007801    UP000001819    + More
UP000009192    UP000008792    UP000007062    UP000268350    UP000192221    UP000076502    UP000242457    UP000000803    UP000037069    UP000092445    UP000078200    UP000092443    UP000092460    UP000005203    UP000092444    UP000008820    UP000092461    UP000183832    UP000005204    UP000001070    UP000091820    UP000095301    UP000075883    UP000075900    UP000053825    UP000245037    UP000075885    UP000075840    UP000075884    UP000075902    UP000008744    UP000000673    UP000076407    UP000095300    UP000075886    UP000076408    UP000075903    UP000075920    UP000075880    UP000007819    UP000002320    UP000069272    UP000002282    UP000008711    UP000001292    UP000000305    UP000000304    UP000015104    UP000054359    UP000235965    UP000092553    UP000009046    UP000076858   

PRIDE

B3XXN5    B3XXN2    P25931    H9IYV7   

Pfam

PF00001   7tm_1        + More
PF06585   JHBP
PF03103   DUF243

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR000611   NPY_rcpt       
IPR017452   GPCR_Rhodpsn_7TM       
IPR010562   Haemolymph_juvenile_hormone-bd       
IPR038606   To_sf       
IPR001681   Neurokn_rcpt       
IPR005395   NPFF_rcpt       
IPR004145   DUF243       

Gene 3D

3.15.10.30    

ProteinModelPortal

B3XXN5   A0A2H1V2X5   A0A0S1YDM6   B3XXN2   A0A0S1YD83   A0A2H1VQ84   + More
A0A0L7L8U4   A0A194RNG8   W8BKX0   W8C5P9   U3U7M9   A0A194PN54   B4N8F0   B3MT11   A0A336M9A8   A0A1B6GV51   A0A0R3NME0   I5ANE3   A0A0U1SQQ4   B4K9P0   B4M121   A0A1B6HNX7   U5N1G6   U3U4E6   Q7PS45   A0A0R3NFZ1   A0A3B0K4J6   A0A1B6KQU8   A0A1W4UIN3   A0A154PPP1   A0A310SGV6   A0A1W4U5X8   A0A2A3E4P5   A0A0B4LIR4   P25931   A0A0L0BKK6   A0A1A9ZQ06   A0A1A9UTI4   A0A1A9YGR4   A0A0B4LHT6   A0A1B0BK89   A0A087ZXB1   A0A1B0GFC2   J9HFI0   A0A1B0GI77   A0A1J1HKG2   H9IYV7   A0A2S2NKP8   B4JHG9   A0A1A9VZB2   A0A1I8M4W6   A0A182M6Y6   A0A182RQ76   A0A0L7QUK8   A0A2H8TU58   A0A2P8YU82   A0A182PT96   A0A182IB01   A0A182N0R3   A0A182U9Y7   B4G2E6   W5JI13   A0A182WW95   A0A1I8PP13   A0A182QZJ5   A0A182YF15   A0A182VFB5   A0A182W592   A0A182J901   J9JLB3   B0XGN8   U5N1H5   A0A182FIQ5   Q2QKU5   U5N4G7   B4PRW5   Q16Z67   B3P871   A0A1B6DRF1   B4IC28   E9G455   Q69DS4   B4QXD4   T1KC18   A0A087UNN0   A0A0P5YRX6   A0A0N8A9E0   A0A2J7PUG3   A0A0P6G3P1   A0A0M5J4H1   Q1DGY7   E0VRZ1   A0A2P6KHF5   A0A1L1VXI0   A0A147BFV4   A0A164Z7G7   A0A2U9PFU7   A0A0P6HZ76   A0A0P5L1Z5  

PDB

5ZBQ     E-value=1.37911e-20,     Score=243

KEGG

100174933    K14072 RYamide receptor | (RefSeq) NGR-A22, BNGR-A22; neuropeptide receptor A22

GO

GO:0004983   GO:0016021   GO:0004930   GO:0001653   GO:0005886   GO:0007166   GO:0007186   GO:0008188   GO:0004995   GO:0050254   GO:0031683   GO:0007165   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

Subcellular location

Cell membrane  

Length:

247

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

129.92288

Exp number, first 60 AAs:

41.38705

Total prob of N-in:

0.02522

POSSIBLE N-term signal

sequence

outside

1  -  3

TMhelix

4  -  21

inside

22  -  33

TMhelix

34  -  56

outside

57  -  75

TMhelix

76  -  98

inside

99  -  109

TMhelix

110  -  132

outside

133  -  161

TMhelix

162  -  184

inside

185  -  220

TMhelix

221  -  243

outside

244  -  247

 

 

Pi

257.014715

Theta

140.032803

Tajima's D

2.647077

CLR

0.171765

CSRT

0.95785210739463

Interpretation

Uncertain