Gene

KWMTBOMO05196  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002457

Annotation

PREDICTED:_retinal_dehydrogenase_1-like_[Amyelois_transitella]

Location

Bomo_Chr9(+):10699026-10713235      View in EpiBrowser

Full name

Retinal dehydrogenase 1       + More
Aldehyde dehydrogenase, cytosolic 1      

Alternative Name

Aldehyde dehydrogenase, cytosolic
ALDH class 1
ALDH-E1
ALHDII
Aldehyde dehydrogenase family 1 member A7
Aldehyde dehydrogenase phenobarbital-inducible

Location in the cell

Cytoplasmic   Reliability : 2.667

CDS

ATGGTCCCGGAAATTAAATACACCAAGTTGTTCATTGACAACGAATGGGTTGATGCGAAAGATGGCGAAACATTTGATACATTCAGTCCACACGACGGATCAGTCATCGCTAAAGTAGCCAAAGGACAAAAGGCTGATATTGACGCCGCAGTGGCAGCGGCGAAGCGTGCGTTCCAACGTAACTCAGAATGGCGGTTGGCGGATGCCTCGCAGCGCGGAAAACTACTTTACAAGTTCGCAGATCTTATTGAACGCGACTTCGAATATCTTGCGAAACTCGAGTCATATGACAATGGCATGGTTTATAAAAATTGCCTTAGAATACTTTCAGGAATTCCTGACAGTGTAAGATACCTAGGCAGTCTGGCGGACAAAATCCAAGGCGACACAATACCAACTGATGGCGATTCATTCAGTTACACATTGAAACAACCCGTTGGAGTGTGTGGTCTCATTTTACCCTGGAACGTTCCCATCCTGATGTTTCTGAACAAGGTCGTAACTGCCTTAGCAGCAGGATGTACAGTGGTAGTGAAGCCGGCAGAACAAACTCCATTAACTGCTTTGGCATTGGCCGCACTGTTGAAAGAAGCTGGCATACCTAAGGGTGTAGTCAACATCGTGCCAGGATTCGGAGAAGATGCAGGAGTGGCGCTCACACATCACCCTGATGTTGCCAAAATTTCCTTTACAGGATCTTTGGAGGTAGGCAAACTGATCCAAAAGGCAGCTGGAACAAACAATTTGAAGCGTGTCACTCTCGAACTCGGAGGCAAGAGTCCACTAATCATAATGAATGACGCCGATTTAAATTTAGCCATCCCTTATGCTGGCAGCGGTGTATTTTTCCACCAAGGACAAATTTGCGTGGCTGCTTCCCGCTTGTACGTCCAGTCGGGTATTTACGACAAATTCGTGAAGGGGGCCGTTGAATATGCAAAAGCTATCCGGGTCGGCAATCCTTTTGACGAATCAACTGTAAACGGACCACAGATTGACGAGTCTATGATGAATAAAGTTTTGGGCTTAATAGAGACCGGAAAAAAAGAAGGAGCGAACCTACTGGCAGGTGGAGAACGTATTGGTACCGCCGGATATTATATCCAGCCTACTGTGTTTGCAGATGTTAATGATGATATGACTATTGCTAAGGAAGAGATTTTCGGTCCAGTCCAGAGCATTCTAAAGTTCGATACGTTGGAAGAAGTGATCGATCGCGCCAACAATACAAATTACGGTCTTGCAGCTGGAATCTTCACTACAAACCTTAACAACGCATTGCAGTTTAGTAAGCATGTCGAGGCCGGAACAGTTTGGGTGAATAACTACCTGACAATGGCACATCAAGCACCTTTCGGAGGATTCAAGGACTCAGGAATTGGCCGTGAAAATGGTATCAAAGCAGTTGAAGCATATTTGGAAGAGAAGACTGTCATCATTTCTCTCCCTAAAAAGCTTTGA

Protein

MVPEIKYTKLFIDNEWVDAKDGETFDTFSPHDGSVIAKVAKGQKADIDAAVAAAKRAFQRNSEWRLADASQRGKLLYKFADLIERDFEYLAKLESYDNGMVYKNCLRILSGIPDSVRYLGSLADKIQGDTIPTDGDSFSYTLKQPVGVCGLILPWNVPILMFLNKVVTALAAGCTVVVKPAEQTPLTALALAALLKEAGIPKGVVNIVPGFGEDAGVALTHHPDVAKISFTGSLEVGKLIQKAAGTNNLKRVTLELGGKSPLIIMNDADLNLAIPYAGSGVFFHQGQICVAASRLYVQSGIYDKFVKGAVEYAKAIRVGNPFDESTVNGPQIDESMMNKVLGLIETGKKEGANLLAGGERIGTAGYYIQPTVFADVNDDMTIAKEEIFGPVQSILKFDTLEEVIDRANNTNYGLAAGIFTTNLNNALQFSKHVEAGTVWVNNYLTMAHQAPFGGFKDSGIGRENGIKAVEAYLEEKTVIISLPKKL

Description

Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity).
Can oxidize benzaldehyde, propionaldehyde and acetaldehyde. No detectable activity with retinal.

Catalytic Activity

all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH
9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH
11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH
an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH

Biophysicochemical Properties

2.4 mM for acetaldehyde
1.6 mM for propionaldehyde
4.7 uM for benzaldehyde

Subunit

Homotetramer.

Similarity

Belongs to the aldehyde dehydrogenase family.

Keywords

Acetylation   Complete proteome   Cytoplasm   Direct protein sequencing   NAD   Oxidoreductase   Phosphoprotein   Reference proteome  

Feature

chain  Retinal dehydrogenase 1

Uniprot

H9IYX2   A0A3S2KZ33   A0A194PUD1   A0A3S2NX34   A0A194RS96   A0A2H1VZJ0   + More
A0A194PJZ7   A0A194RNN6   A0A2H1W5M3   A0A194PPT3   A0A2H1VS14   A0A194PP34   A0A212FDV0   A0A194RSB1   A0A0L7L392   A0A2A4J2H6   A0A2A4J196   A0A2A4JJH0   B0X5Q3   A0A3B0E4Q5   A0A1Q3FGB5   A0A182QSK4   Q16UC5   A0A182JIV1   A0A182GPP9   A0A023EVW3   A0A1S4H2G8   A0A1S4FNU3   A0A182XHT7   T1DF46   A0A2M4AEX2   A0A2M4AF40   A0A182HRD9   A0A2R5LM52   A0A182KYZ4   W5JT01   A0A182Y6E2   A0A182U026   A0A182F3L2   A0A182VIA5   A0A067QMD6   A0A084VWF2   A0A182NAW2   A0A182W8W6   A0A182PG53   A0A3S3P5E3   A0A1W7R9T2   A0A182MWM4   A0A147BAA5   Q7Q165   K7J1A8   A0A182RRC2   A0A293MT25   A0A194PHE0   A0A2H1VID4   A0A3S3NWG2   A0A212EPE8   A0A232EVC3   A0A3S3NN32   A0A0L7LH99   A0A1J1HJ07   A0A0A9WG19   A0A0K8SBS2   A0A2J7Q305   A0A2H1VRY1   A0A3L7HYV8   A0A1Z5LI79   K7FVP6   A0A3G5ANS0   A0A194R140   A0A2I0UI03   A0A0B8RTZ3   D6X3U7   A0A1D1W8T6   A0A1U7QDB4   A0A3G5AQ09   A0A2J7Q301   P86886   A0A1S3FCC6   A0A286X885   G3WEY3   A0A2J7Q307   Q2F5Y9   A0A286XZF8   T1DLI5   A0A0F7ZBD8   A0A1Y1KPZ3   A0A2H1VX41   A0A023ET21   Q6DFL9   G1KMC0   Q9PWJ3   A0A1Q3FCD3   A0A023GKS1   Q6DE83   Q16HB6   P13601   Q9YGY2   A0A286XMJ1   A0A3Q0CHQ7  

EC Number

1.2.1.-
1.2.1.36
1.2.1.3

Pubmed

19121390    26354079    22118469    26227816    17510324    26483478    + More
24945155    12364791    20966253    20920257    23761445    25244985    24845553    24438588    20075255    28648823    25401762    29704459    28528879    17381049    25476704    18362917    19820115    27649274    21993624    21709235    23758969    28004739    10085078    2753900    10998257    10091603    28071753   

EMBL

BABH01010692    BABH01010693    BABH01010694    BABH01010695    BABH01010696    RSAL01000402    + More
RVE41911.1    KQ459597    KPI94745.1    RSAL01000037    RVE51196.1    KQ459984    KPJ18941.1    ODYU01005422    SOQ46251.1    KQ459606    KPI91415.1    KPJ18940.1    ODYU01006360    SOQ48142.1    KPI94744.1    ODYU01004072    SOQ43566.1    KPI94743.1    AGBW02008996    OWR51929.1    KPJ18956.1    JTDY01003290    KOB69791.1    NWSH01003948    PCG65640.1    PCG65639.1    NWSH01001358    PCG71550.1    DS232392    EDS41034.1    RBVL01000220    RKO10496.1    GFDL01008464    JAV26581.1    AXCN02000654    CH477625    EAT38124.1    JXUM01078869    KQ563093    KXJ74487.1    GAPW01001149    JAC12449.1    AAAB01008980    GAMD01003251    JAA98339.1    GGFK01006020    MBW39341.1    GGFK01006088    MBW39409.1    APCN01001694    GGLE01006443    MBY10569.1    ADMH02000539    ETN66060.1    KK853170    KDR10336.1    ATLV01017583    KE525174    KFB42296.1    NCKU01001310    RWS12467.1    GFAH01000487    JAV47902.1    AXCM01004965    GEIB01000036    JAR87698.1    EAA14068.3    GFWV01019295    MAA44023.1    KQ459603    KPI92727.1    ODYU01002733    SOQ40599.1    NCKU01002086    RWS10468.1    AGBW02013494    OWR43337.1    NNAY01002022    OXU22287.1    NCKU01007299    RWS02740.1    JTDY01001120    KOB74817.1    CVRI01000006    CRK88023.1    GBHO01036212    JAG07392.1    GBRD01015069    JAG50757.1    NEVH01019075    PNF22959.1    ODYU01004073    SOQ43567.1    RAZU01000133    RLQ71138.1    GFJQ02000226    JAW06744.1    AGCU01194510    AGCU01194511    AGCU01194512    AGCU01194513    AGCU01194514    AGCU01194515    AGCU01194516    AGCU01194517    AGCU01194518    MH990439    AYV88986.1    KQ460883    KPJ11229.1    KZ505748    PKU45677.1    GBSH01002235    JAG66791.1    KQ971326    EEZ97369.1    BDGG01000018    GAV08728.1    MH979760    AYV89215.1    PNF22957.1    AAKN02026169    AAKN02026170    AAKN02026171    AAKN02026172    AAKN02026173    AEFK01077107    AEFK01077108    AEFK01077109    AEFK01077110    AEFK01077111    AEFK01077112    AEFK01077113    AEFK01077114    AEFK01077115    AEFK01077116    PNF22956.1    BABH01005570    BABH01005571    BABH01005572    BABH01005573    DQ311283    ABD36228.1    GAAZ01002032    JAA95911.1    GBEX01002791    JAI11769.1    GEZM01076997    JAV63479.1    ODYU01004657    SOQ44774.1    GAPW01001148    JAC12450.1    BC076716    AAH76716.1    AB016718    BAA76412.1    GFDL01009835    JAV25210.1    GBBM01000946    JAC34472.1    BC077256    AAH77256.1    CH478186    EAT33638.1    M23995    AF061833    AAC69552.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000053240    UP000007151    UP000037510    + More
UP000218220    UP000002320    UP000276569    UP000075886    UP000008820    UP000075880    UP000069940    UP000249989    UP000076407    UP000075840    UP000075882    UP000000673    UP000076408    UP000075902    UP000069272    UP000075903    UP000027135    UP000030765    UP000075884    UP000075920    UP000075885    UP000285301    UP000075883    UP000007062    UP000002358    UP000075900    UP000215335    UP000183832    UP000235965    UP000273346    UP000007267    UP000007266    UP000186922    UP000189706    UP000081671    UP000005447    UP000007648    UP000001646    UP000002494   

PRIDE

H9IYX2    P86886    Q2F5Y9    P13601   

Pfam

PF00171   Aldedh

Interpro

IPR016161   Ald_DH/histidinol_DH        + More
IPR016163   Ald_DH_C       
IPR016160   Ald_DH_CS_CYS       
IPR029510   Ald_DH_CS_GLU       
IPR016162   Ald_DH_N       
IPR015590   Aldehyde_DH_dom       
IPR011407   10_FTHF_DH       

SUPFAM

SSF53720   SSF53720       

Gene 3D

3.40.309.10     3.40.605.10    

ProteinModelPortal

H9IYX2   A0A3S2KZ33   A0A194PUD1   A0A3S2NX34   A0A194RS96   A0A2H1VZJ0   + More
A0A194PJZ7   A0A194RNN6   A0A2H1W5M3   A0A194PPT3   A0A2H1VS14   A0A194PP34   A0A212FDV0   A0A194RSB1   A0A0L7L392   A0A2A4J2H6   A0A2A4J196   A0A2A4JJH0   B0X5Q3   A0A3B0E4Q5   A0A1Q3FGB5   A0A182QSK4   Q16UC5   A0A182JIV1   A0A182GPP9   A0A023EVW3   A0A1S4H2G8   A0A1S4FNU3   A0A182XHT7   T1DF46   A0A2M4AEX2   A0A2M4AF40   A0A182HRD9   A0A2R5LM52   A0A182KYZ4   W5JT01   A0A182Y6E2   A0A182U026   A0A182F3L2   A0A182VIA5   A0A067QMD6   A0A084VWF2   A0A182NAW2   A0A182W8W6   A0A182PG53   A0A3S3P5E3   A0A1W7R9T2   A0A182MWM4   A0A147BAA5   Q7Q165   K7J1A8   A0A182RRC2   A0A293MT25   A0A194PHE0   A0A2H1VID4   A0A3S3NWG2   A0A212EPE8   A0A232EVC3   A0A3S3NN32   A0A0L7LH99   A0A1J1HJ07   A0A0A9WG19   A0A0K8SBS2   A0A2J7Q305   A0A2H1VRY1   A0A3L7HYV8   A0A1Z5LI79   K7FVP6   A0A3G5ANS0   A0A194R140   A0A2I0UI03   A0A0B8RTZ3   D6X3U7   A0A1D1W8T6   A0A1U7QDB4   A0A3G5AQ09   A0A2J7Q301   P86886   A0A1S3FCC6   A0A286X885   G3WEY3   A0A2J7Q307   Q2F5Y9   A0A286XZF8   T1DLI5   A0A0F7ZBD8   A0A1Y1KPZ3   A0A2H1VX41   A0A023ET21   Q6DFL9   G1KMC0   Q9PWJ3   A0A1Q3FCD3   A0A023GKS1   Q6DE83   Q16HB6   P13601   Q9YGY2   A0A286XMJ1   A0A3Q0CHQ7  

PDB

5L2O     E-value=7.28088e-148,     Score=1344

KEGG

101740694    K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] | (RefSeq) retinal dehydrogenase 1-like

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00071    Fatty acid degradation - Bombyx mori (domestic silkworm)
00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
00310    Lysine degradation - Bombyx mori (domestic silkworm)
00330    Arginine and proline metabolism - Bombyx mori (domestic silkworm)
00340    Histidine metabolism - Bombyx mori (domestic silkworm)
00380    Tryptophan metabolism - Bombyx mori (domestic silkworm)
00410    beta-Alanine metabolism - Bombyx mori (domestic silkworm)
00561    Glycerolipid metabolism - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016620   GO:0016491   GO:0009258   GO:0005737   GO:0006730   GO:0016155   GO:0004029   GO:0005829   GO:0001758   GO:0001523   GO:0055114   GO:0042572   GO:0018479   GO:0043878   GO:0051289   GO:0042802   GO:0051287   GO:0006068   GO:0035106   GO:0004028   GO:0008152   GO:0007264   GO:0031683   GO:0007165   GO:0001664   GO:0005525   GO:0003824  

Subcellular location

  
Cytoplasm  

Length:

486

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.26137

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01364

outside

1  -  486

 

 

Pi

171.746592

Theta

143.64057

Tajima's D

0.586666

CLR

0

CSRT

0.538823058847058

Interpretation

Uncertain