Gene

KWMTBOMO05179  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012488

Annotation

PREDICTED:_uncharacterized_protein_LOC101740358_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr9(-):9868751-9890187      View in EpiBrowser

Full name

Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1       + More
Cubilin      
CUB and sushi domain-containing protein 1      
CUB and sushi domain-containing protein 3      
Probable cubilin      

Alternative Name

CCP module-containing protein 22
Polydom
Selectin-like osteoblast-derived protein
Serologically defined breast cancer antigen NY-BR-38
460 kDa receptor
Glycoprotein 280
Intrinsic factor-cobalamin receptor
Intrinsic factor-vitamin B12 receptor
Intestinal intrinsic factor receptor
CUB and sushi multiple domains protein 1
CUB and sushi multiple domains protein 3

Location in the cell

Extracellular   Reliability : 2.992

CDS

ATGGTGCCGGCTAGTCCTAGTAATAACCATTACTGGCTCGGGCTTGCCTCAGTTGATGATCTTCGAACGAATACACTTGAATCTGCTGCCGGTGGATTAGTTTCACAATACGCTGGATTCTGGGACTTAAAACAGCCAAACCCAAAAGAAGGCGAATGCGTAGATGTTCTTGTCACATCGGATAGTCAATCTTGGGAGCTAACAACTTGCGAAACATTATTGCCCTTCATGTGCAAAGCCAACGCCTGTCCAGCCGGAACCTTCCATTGTTCTAACGGAAGATGTATCAACGCAGCCTTCAAATGTGACAAACAAGATGATTGCGGTGATGCATCAGACGAAATGGACTGCGCTTCTGAGTGTCACTTTTATATGGCGAGCAGTGGAGATGTAGTGGAATCCCCTAATTATCCACACAAATATCCATCATTTAGCGAATGCAAATGGACTCTTGAAGGGCCTCAAGGACAAAATATTCTTTTACAATTCCAAGAGTTTGAAACAGAAAAATCCTTTGATACAGTCCAAATTCTTGTCGGCGATGGTTCTGTAGAAAAGAAGGGATTCAGGGCATCATGGAAAACAGAATCTTCTAATTGTGGTGGTGTCCTTCGAGCTACACCTCAAGGCCAAGTTTTGACGTCACCGGGCTATCCAAATGGGTACCCAGGTGGCTTAGAATGCATGTATATAATCGAAGCCCAACCGGGCCGAATTGTTTCATTAGAGATTGAAGATTTAGAACTAGGAATGAACAGAGATTACATCGTTGTAAAAGACGGTAATACCCCTTCCAGTCCAGTGTTGGCCAGATTGACGGGTCCTGGTGAAGACAATGAAAAAGTTGTGATTTCGACAACAAATCATCTTTACTTGTACTTTAGAACAAGCCTGGGAGATTCTAAAAAGGGATTTAATATGCGATATTCGCAAGGCTGCAAGGCTACCATTATTGCGGCTAATGGTACATTCACATCTCCGGCATACGGTCTAACAAATTATCCCAACAACCAGGAATGTCTCTACAGAATTAAGAATCCTACCGGAGGTCCGCTTTCGTTGAAGTTTGATGAATTTAATATTCATTCTTCTGATGTAGTACAAGTTTTCGACGGCTCGAGTACAAATGGACTCAGGTTACATTCTGAAAATGGATTTACTATAAAACCTAGAATAACTTTGACTGCTTCCAGTGGTGAAATGTTAATACGATTCGTATCTGATGCATTGCATAATGGAAAAGGATGGAAGGCGACGTTTTCTGCAGATTGCCCACCACTAAAATCTGGCATAGGAGCACTAGCATCAAATAGAGATACTGCTTTCGGAACAGTCATAACGTTCTCTTGTCCAATTGGTCAGGAATTTGCTACAGGAAAACCCAGACTTACAACTAAATGCTTGGACGGTGGAAATTGGTCAACGATGTACATACCTAGCTGTCAAGAGGTATATTGTGGTCCAGTGCCGCAAATTGACAATGGTTTTTCAATCGGTTCCACAAACGTGACATATCGTGGTGTTGCCACTTATCAATGTTATGCAGGTTTTGCTTTTCCAACTGGTCAACCAATTGAAAGAATATCATGTTTATCCGACGGACGATGGGAACGAACCCCCACTTGTTTGGCTTCTCAGTGCGTAGCCTTGCCTGACGTACCGCACGCGAATGTAACGATTCTTAACGGTGGCGGTCGTAGCTACGGTACAATCGTCCGTTACGAATGCGAACCAGGCTATGTTAGATCTGGTCAACCAGTACTTCTCTGTATGAGCAACGGCACGTGGTCTGGAGACGTACCAACCTGTACAAAAACCATATGTTCTAAATTTCCCGAAATAAAAAACGGTTATATCGTAGATCAGAGCAGAACTTACATGTTTGGCGACGAAGCACGCGCGCAGTGTTTTAAAGGTTACAAATTAAATGGACCTAGCATACTAAGATGTGGGGCAAACCAAGAATTTGATCAAGCACCAACATGTGAAGATATAAATGAGTGCTTGAGTTCGCAATGCGACTCAGTCTCAACTGAATGTAAAAACACTCAAGGAGGATTCTTCTGTCCCTGTCGAACTGGTTTTGCACCCAGCTTAGATTGTAGACCTGTTGGCGATTTAGGACTTATAAACGGAGCAATCCCTGACGAGTCAATCTCGACATCAACACCAGAACCAGGATATAACAGTGGTATGGTGCGCCTTAACAACGGAGGTGGATGGTGTGGTAACAATCTCGAAGCCGGCGCGAATTGGATTTTAATCGATTTGAGAGCTCCAACAATTGTCCGAGGATTTAGAACGATGAGTGTAATGCGAGCTGATGGCAATATTGCATTTACTTCTGCCATACGCATACAGTACACAAATGATCTTACCGATGTTTTCAAAGATTACACTAATCCTGACGGGACTGCTGTAGAATTCCGTATTTTAGAACCAACTCTATCTGTACTTAATCTCCCAGTACCTATAGAAGCACAATACGTCAAGTTCAAAATTCAAGATTATGTTGGAGCACCATGTTTGAAATTAGAAGTTATGGGATGTGCGAGATTAGACTGTTTAGATATTAATGAATGCAGCGAAAACAACGGAGGATGTGAGCAAAAGTGCTTAAACACGCCCGGCAACTTTTCATGCGCGTGTAATCTTGGATTTGAATTATATTCTTCCAATGGAACAGCAGGTTTCTCAATTGAACTATCTGAAACCGGTGAAAGAGACGGAGATACATATCAAAGGAATAAATCTTGCGTACCGGTCATGTGCCCCCCACTTGCACCACCTGAAAACGGACAACTTTTATCGACAAAAAAATCTTATCACTTCGGTGATACAGTTCATTTCCAATGTGACTTTGGATATGTAATGTCAGGATTTTCGACATTACAATGCACCTCAAGTGGAACTTGGAATGGAACTGCTCCTGAATGTCAATATGCTCGATGTGTAACTTTATCTGACGACAAAAACGATGGCTTAAGAGTCATAAGGGATGATCCTGAAAGTGTTTTAGTACCATACAGAGACAATGTTACAATAACCTGCACTTCTCCTGGGAGACACCTGAGAAATACTCTCACATCTTCTTTTAGACAGTGTGTTTACGATCCTAAGCCTGGTCTTCCTGATTATTGGTTTTCTGGGGCACAACCACAATGTCCAAGACAAGACTGCGGTATCCCAATGCCAACACCTGGTGCAGAATATGGGCAATATCTTGATACTAAATATCAAAGCTCCTTTTTCTTTGGTTGCCAAAACACTTTCAAACTTGCTGGGCAGACAAGTAAACACGATAACGTTGTAAGATGTCAGGCAAATGGCATATGGGACTTCGGAGATTTGAGATGCGAAGGACCAGTTTGTGAAGACCCAGGTAGACCTGCTGACGGCTACCAAATTGCAAGAAGCTATGAACAAGGATCTGAAGTGCTATTCGGTTGTTCAAGACCTGGCTATATCCTAATAAATCCGAGACCTATAACATGCATGCGTGAACCGGAATGTAAAGTTATCAAACCTCTGGGTCTTGCTTCGGGTAGAATACCCGACTCCGCTATCAATGCTACATCAGAAAGACCTAACTATGAAGCTAAAAATATTCGACTCAATTCGGTTACGGGTTGGTGTGGTAAGCAAGAAGCTTTTACGTATGTGAGTGTAGATCTTGGTAAAGTTTACAGAGTCAAAGCTATCCTTGTAAAGGGTGTAGTAACCTCCGATATTGTGGGACGTCCTACTGAAATAAGATTTTTCTACAAACAAGCCGAAAACGAAAACTATGTTGTGTATTTCCCGAATTTCAATTTAACCATGAGGGATCCCGGAAACTATGGAGAACTAGCAATGATTACATTGCCAAAATTTGTCCAAGCAAGGTTTGTAATTTTGGGCATAGTCAGTTTCATGGACAACGCTTGTCTCAAATTTGAAGTAATGGGATGTGAAGAACCAAGCACAGAACCCTTATTGGGTTACGACTATGGTTATTCTCCTTGTGTCGATAATGAACCACCAGTGTTCCAGAACTGCCCTCAACAACCGATTGTAGTCCAAACCGATGTTAATGGTGGCTTACTTGCTGTAAACTTCACTGAACCTACTGCAATTGACAATTCTGGTGCAATAGCTCGATTAGAAGTTACACCCCAGCATTTTAAAACACCAATTCAAGTATTCCATAATATGGTAGTTCGATATGTGGCTTTCGATTTTGATGGAAATGTTGCAATTTGTGAAGTAAACATTACTGTACCTGATTACACCCCTCCTAAATTAAGCTGCCCTCAAAGCTATGTTATAGAACTGGTGGATAAACAAGACAGTTACGCTGTTAATTTCAACGAAACGAGAAGAAGAATCAACGCAACTGATTCATCCGGAGAAGTTTACTTGAAGTTCATTCCTGAAAGAGCAGTTATTCCCATTCGAGGATACGAAAACGTCACAGTTATCGCCTCAGACAAATATGGCAACAAAGCTCAATGTCACTTCCAAGTATCAGTGCAAGCTACTCCGTGCGTAGATTGGGAACTAATGCCTCCAGCAAACGGCGCAATGAATTGTATTCCGGGTGACAGGGGTATACAGTGTATAGCCACTTGCAGTCCAGGTTTTAGATTCACAGATGGAGAGCCTGTCAAGACTTTTGTCTGCGAAACGAAACGTCAATGGGTCCCATCTGCTGTTGTTCCAGATTGCGTTTCTGAAAACACTCAACAAGCTGCTTATCACGTCGTAGCCGGTGTACAGTACAGAGCTCTGGGTGCAGTTTCAAGTGCTTGTTTACCTCAATACAAAGATCTACTAGCACAATATGATAACATTCTAAACGAAAGGCTGTCACAACGTTGCTCAGCAGTTAATGTTAACATTAACGTAACTTTCGTTAAAGCTATGCCAAGTTTATTAGATGAAAATGTGGTCAAAATGGACTTTGTCTTGGCCATTACACCAGCCATTAGACAAACTCAGCTATATGATTTGTGTGGCTCAACACTAAATCTCATCTTTGATCTGTCTGTTCCATACGCAAGTGCACTTATTGAACCAGTACTAAATGTTTCATCCATCGGAAATCAATGTCCACCACTGAGAGCCATCAGAAGCTCAATAACAAGAGGATTTACTTGCAGTGTTGGAGAAGTATTAAATATGGATACAAACGACGTACCTAGATGTCTACATTGTCCTGCTGGTACTTCCGCTGGAGAAAAGCAAAAGACGTGCACAATGTGTCCACTAGGATATTTCCAGAATCAAGCACGTCAAGGTTCGTGTTTGAAATGTCCTCAAGGTACATTTACTCGAGAAGAAGGCTCAAAAGATATTTCTGATTGCATACCGGTCTGCGGTTACGGTACATACTCACCAACTGGACTGGTTCCTTGCTTAGAGTGTCCCAGAAACAGTTACACTGCCGAACCTCCAGTCGGAGGCTTCAAAGACTGTCAAGCATGTCCGATAAACACATTTACCTATCAACCAGCAGCGCCAGGTCGTGACAAGTGTAGAGCAAAGTGTGCTCCAGGAACAGGTGCAACAGGATTAGAAGAATGCATCCCTGTTGAATGTTCGAACAGCGCTTGCCAGCATGGAGGTCTATGTGTGCCGAAAGGACACGGTGTCCAATGCTACTGCCCAGCTGGATTTTCTGGACGCAGATGTGAAGTTGATATCGATGAATGTGCCAGTCAACCCTGTTACAACGGCGGTACCTGTACTGATTTGCCTCAAGGATACAGGTGCTCGTGTCCCACTGGTTACGGTGGAGTTAACTGTCAAGAAGAAAAATCTGATTGTAGAAATGATACGTGCCCAGAACGAGCTATGTGCAAAGACGAACCTGGATTCGATAACTATACTTGTTTGTGTAGATCTGGATATACTGGAATTGATTGTGATATCACAATCGATCCATGCACTGCTAACGGAAATCCTTGCTCAAACGGTGCTAGTTGTATTGCATTACAACAAGGGCGCTTCAAGTGTGAGTGCTTACCAGGATGGGAAGGACAACTTTGTGACATTAATACAGATGATTGTATCGAAAAGCCTTGTCTTCTTGGTGCACCTTGTACGGACTTAGTTAATGACTTTAGCTGCTCATGTCCACCAGGATTCACGGGAAAACGTTGTCATGAAAAAATAGATCTCTGCTCAAGCGAACCATGCAAACATGGAATATGTGTAGATAAACTCTTCGTTCATCAATGTATATGTGACCCTGGTTGGTCAGGACCATCGTGTGATATTAACATTAATGAATGTGTGATATCACCATGTGAGAACGGAGGTCAATGTATGGACGGTATCGACGATTTCAATTGCGTATGTGAAACTGGTTTTACAGGAAAGAAATGTCAACACACCATCGATGATTGTTTATCAAATCCTTGTCAAAACGGTGCAACATGTATGGATCAAATCGAAGGATTTGTTTGCAAATGCCGACCTGGATTCGTAGGTCTTCAATGCGAAACGGCCATTGATGAATGTTTGACCGAGCCATGCAACCCTACGGGAACCGAACGCTGTATAGATTTAGACAACAAATACCAATGCGTCTGTCGTGAAGGTTTCACAGGAAAAATGTGTGAAACAAACGTTGATGACTGCGCTTCAAATCCTTGCTTTAATGGTGGATCGTGCACAGACGAAGTCGGCGGATACAAATGCGCCTGTCATCCAGGATGGACTGGCAAGAGATGCGAAAAAGACATCGGTAATTGCGTAAACCAACCCTGCCAAAATCATGCTAAATGTATTGACCTATTCCAAGATTATTTCTGTGTGTGTCCTAGTGGAACTGATGGAAAACAATGTGAAACGGCCCCGGAAAGATGTATTGGAAGCCCATGTATGCACGGCGGAAAGTGTCAAGACTTTGGATCAGGCCTTAATTGCACATGTTCATCTGATTACACTGGCATTGGCTGTCAATATGAATTTGATGCCTGCGAAGCTGGTTTGTGCCAAAATGGAGCAACGTGCATCGACGAAGGCGAAGGATACCGTTGTATTTGCGCTCCTGGATTTAAAGGACAAAATTGCGACGAAGACATTATCGATTGTAAAGAAAACTCTTGTCCACCTTCGGCAACATGCATTGACCTTCCAGGGAGATTCTACTGTCAATGTCCATTTAATCTAACGGGAGATGACTGTAGAAAAACAATCAGTGTTGATTACGATATGTACTTCAGTGATCCCTTAAGGTCAAGCGCAGCCCAAGTGGTACCGTTTGATACCAATTCAGCAGATAGCTTAACTATAGCCATGTGGGTACAATACACACAACAAGACGAAGGCGGTGTCTTCTTCACAGCATATAGCGTAAGCAATTCCCACATTGCGCTTAACAGAAGACAAGTCATACAAGCACATTCAAATGGAGTTCAGGTGTCTCTATTCTCTGAACTACAAGATGTATACCTCAGTTTCGGAGAATTCGCTACGGTCAACGATGGACAATGGCACCATGTTGCGTTGGTGTGGGATGGTAGCAATGGCGGCGAACTCACATTAATCACTGAAGGACTGATTGCCAGCAAACTCGCTGGTTATGGCAGCGGTCGAACCTTGCCACGATACATCTGGGTAACATTGGGTAAGCCGCAGTCCGATAATCCAAAGGCGTATACCGAAGCCGGATTCCAAGGACATCTTACCAAGGTACAAGTCTGGAATCGAGCACTAGACGTCACTAATGAAGTTCAAAAACAAGTCCGTGACTGCAGAACGGAGCCTGTCCTTTACAGTGGTTTAACTTTGACCTGGGCTGGATATGATGACATAATTGGTGGAGTAGAACGAATCGTACCATCACATTGTGGACAAAGGGTTTGCCCTAATGGCTACAATGGTCAAAAATGTCAACAATTAGAAGTCGATAAAGAACCACCAAGAGTAGATAGATGCCCTGGTGACTTATGGGTGATTGCTAAGAATGGATCATCTATTGTCAACTGGGATGCACCTGTATTTAGCGACAATGTTGGAGTGGCAAAAGTAGTAGAAAAATCTGGACATAAGCCAGGAGAGAACCTTGCTTGGGGAGCATATGACATAGCCTACATTGCATATGACGCCGTGGGTAATGCAGCGACATGCACATTTAAGATTACAGTATTATCGGAATTCTGTCCACCTTTACCGGATCCTCTGGGTGGTTATCAATCTTGTCGCGATTGGGGCGCAGGAGGTCAATTCAAGGTCTGCGAGATTGCTTGTCGCGATGGCTTGCGATTCTCACAGCCCGTACCTCCGTTCTTTACATGCGGCGCAGAAGGCTTTTGGAGACCAACAACTGATCCAAGTTTGCCACTAATATATCCTGCTTGCTCACCTGCTTCACCTGCTCAACGTGTCTTCAAAGTATCTATGTTGTTCCCGAGTTCTGTTCTCTGCAACGACGCTGGCCAAGCCGTACTTCGACAAAAAGTACGCAGCGCTATCAATCAACTCAATAGAGATTGGAACTTCTGCTCTTACGCAATTGATGGTACTCGAGAATGCAAAGAATTGGATATTAATGTGAAATGCGATCACCGCGCCAACAGGCAGACTAGACAAGTGTCGTCCCCTCCCACAGTAACAGCTGAAGATACCTATGTTTTGGACGCTATAATTCCTGTCGAAGAGACACGAAGCAGTAGGGAGGGTCGACAAATTGGCGATACGTACAGCGTTGAAATATCTTTCCCGGCTGTCAACGACCCAGTAATCCACGGCGGTAATAACGAAAGATCGACTGTGCAACGATTACTGGAGAAATTAATTCTCGAAGACGAACAATTCGACGTTAGGAATATCCTTCCGAATACCGTACCTGATCCCGCGAGCTTGGTGCTTGCTTCTGATTACGCCTGCCCTACTGGACAGGTCGTAATGGCTCCTGACTGTGTGGCATGCGCTGTCGGTACCTTCTTAGATTCGGCCACCGACTCGTGCAAGCCGTGCCCCATGGGAAGCTACCAATCAGAAGCTGGACAATTACAGTGTATCTCCTGCCCAACGATAGCTGGCCAACCTGGAGTTACCCAAACAACAGGAGCTCGAAGCGCTGCTGACTGTAAAGAGAAGTGTGCCGCTGGTAAATACTTTGACGCTGAGGCGGAACTTTGCCGTCCATGCGGTCACGGTTCCTATCAACCAAGAGAGGGCGCCTTCTCCTGTATCTCCTGTCCCAGAGGTCAAACCACTCGAGCCACAGAAGCGGTATCTGCTGCCGAATGCAGAGACGATTGTCCTTCAGGAGAACAGTTAGGCACTGATGGAGGTTGTGAACCTTGTCCTCGAGGTACATGGCGCGCGACAGGCGCGGGAGCCGCGTGCGCGCCGTGCCCTCCTGGGACTACCACACCGCAAACAGGCGCTTCCTCTGCAGATCAATGTTCTTTGCCCGTTTGTAGACCTGGGTCATACCTCAACGTGACACTGAACACGTGCATTCAATGCAGAAAGGGTACCTACCAGTCGGAAGCACAACAGACAATATGCGTACCTTGTCCTATAAACACGAGTACCAGAGGACCGGGCGCGACCTCAGAGTCAGACTGCACAAATCCTTGCGAGATGAGCGGTCCTGAGATGCACTGCGATGTCAATGCATACTGCCTTTTGATGCCGGAGACAAGCGAATTCAAATGTCAGTGCAAACCTGGATTCAACGGCACTGGAAAAGTTTGCATAGACGTGTGCCTTGACTACTGCGACAATGGAGGCGAATGCATAAAGGACGCTAGAGGCGAACCTTCGTGCAGATGCACGGGTTCGTTCACCGGAAGACACTGCAGGGACAAGAGCGAGTTCGCATACATTGCGAGCGGTGTCGCCGGTGGAGTCATCTTTATTATATTCTTGGTCCTGCTTGTATGGATGATTTGCGCCAGGTCAACCAAGAGGAAAGAACCAAAGAAGACACTCACCCCAGCTATCGACCAAAACGGTTCCCAAGTGAACTTCTACTACGGAGCTCACACACCTTACGCGGAATCAATAGCGCCCTCGCATCATTCAACATACGCTCATTACTACGACGACGAGGAAGACGGCTGGGAGATGCCGAACTTTTACAACGAGACTTACATGAAGGAGAGTTTGCATAATGGTATGAATGGTAAAATGAACAGCTTGGCGAGGTCAAACGCCAGCATCTATGGAACGAAGGAGGATCTTTACGATAGGTTGAAGAGACACGCGTACCCGGAGAAGAGTGATAGCGACAGTGAAGGTCAATAG

Protein

MVPASPSNNHYWLGLASVDDLRTNTLESAAGGLVSQYAGFWDLKQPNPKEGECVDVLVTSDSQSWELTTCETLLPFMCKANACPAGTFHCSNGRCINAAFKCDKQDDCGDASDEMDCASECHFYMASSGDVVESPNYPHKYPSFSECKWTLEGPQGQNILLQFQEFETEKSFDTVQILVGDGSVEKKGFRASWKTESSNCGGVLRATPQGQVLTSPGYPNGYPGGLECMYIIEAQPGRIVSLEIEDLELGMNRDYIVVKDGNTPSSPVLARLTGPGEDNEKVVISTTNHLYLYFRTSLGDSKKGFNMRYSQGCKATIIAANGTFTSPAYGLTNYPNNQECLYRIKNPTGGPLSLKFDEFNIHSSDVVQVFDGSSTNGLRLHSENGFTIKPRITLTASSGEMLIRFVSDALHNGKGWKATFSADCPPLKSGIGALASNRDTAFGTVITFSCPIGQEFATGKPRLTTKCLDGGNWSTMYIPSCQEVYCGPVPQIDNGFSIGSTNVTYRGVATYQCYAGFAFPTGQPIERISCLSDGRWERTPTCLASQCVALPDVPHANVTILNGGGRSYGTIVRYECEPGYVRSGQPVLLCMSNGTWSGDVPTCTKTICSKFPEIKNGYIVDQSRTYMFGDEARAQCFKGYKLNGPSILRCGANQEFDQAPTCEDINECLSSQCDSVSTECKNTQGGFFCPCRTGFAPSLDCRPVGDLGLINGAIPDESISTSTPEPGYNSGMVRLNNGGGWCGNNLEAGANWILIDLRAPTIVRGFRTMSVMRADGNIAFTSAIRIQYTNDLTDVFKDYTNPDGTAVEFRILEPTLSVLNLPVPIEAQYVKFKIQDYVGAPCLKLEVMGCARLDCLDINECSENNGGCEQKCLNTPGNFSCACNLGFELYSSNGTAGFSIELSETGERDGDTYQRNKSCVPVMCPPLAPPENGQLLSTKKSYHFGDTVHFQCDFGYVMSGFSTLQCTSSGTWNGTAPECQYARCVTLSDDKNDGLRVIRDDPESVLVPYRDNVTITCTSPGRHLRNTLTSSFRQCVYDPKPGLPDYWFSGAQPQCPRQDCGIPMPTPGAEYGQYLDTKYQSSFFFGCQNTFKLAGQTSKHDNVVRCQANGIWDFGDLRCEGPVCEDPGRPADGYQIARSYEQGSEVLFGCSRPGYILINPRPITCMREPECKVIKPLGLASGRIPDSAINATSERPNYEAKNIRLNSVTGWCGKQEAFTYVSVDLGKVYRVKAILVKGVVTSDIVGRPTEIRFFYKQAENENYVVYFPNFNLTMRDPGNYGELAMITLPKFVQARFVILGIVSFMDNACLKFEVMGCEEPSTEPLLGYDYGYSPCVDNEPPVFQNCPQQPIVVQTDVNGGLLAVNFTEPTAIDNSGAIARLEVTPQHFKTPIQVFHNMVVRYVAFDFDGNVAICEVNITVPDYTPPKLSCPQSYVIELVDKQDSYAVNFNETRRRINATDSSGEVYLKFIPERAVIPIRGYENVTVIASDKYGNKAQCHFQVSVQATPCVDWELMPPANGAMNCIPGDRGIQCIATCSPGFRFTDGEPVKTFVCETKRQWVPSAVVPDCVSENTQQAAYHVVAGVQYRALGAVSSACLPQYKDLLAQYDNILNERLSQRCSAVNVNINVTFVKAMPSLLDENVVKMDFVLAITPAIRQTQLYDLCGSTLNLIFDLSVPYASALIEPVLNVSSIGNQCPPLRAIRSSITRGFTCSVGEVLNMDTNDVPRCLHCPAGTSAGEKQKTCTMCPLGYFQNQARQGSCLKCPQGTFTREEGSKDISDCIPVCGYGTYSPTGLVPCLECPRNSYTAEPPVGGFKDCQACPINTFTYQPAAPGRDKCRAKCAPGTGATGLEECIPVECSNSACQHGGLCVPKGHGVQCYCPAGFSGRRCEVDIDECASQPCYNGGTCTDLPQGYRCSCPTGYGGVNCQEEKSDCRNDTCPERAMCKDEPGFDNYTCLCRSGYTGIDCDITIDPCTANGNPCSNGASCIALQQGRFKCECLPGWEGQLCDINTDDCIEKPCLLGAPCTDLVNDFSCSCPPGFTGKRCHEKIDLCSSEPCKHGICVDKLFVHQCICDPGWSGPSCDININECVISPCENGGQCMDGIDDFNCVCETGFTGKKCQHTIDDCLSNPCQNGATCMDQIEGFVCKCRPGFVGLQCETAIDECLTEPCNPTGTERCIDLDNKYQCVCREGFTGKMCETNVDDCASNPCFNGGSCTDEVGGYKCACHPGWTGKRCEKDIGNCVNQPCQNHAKCIDLFQDYFCVCPSGTDGKQCETAPERCIGSPCMHGGKCQDFGSGLNCTCSSDYTGIGCQYEFDACEAGLCQNGATCIDEGEGYRCICAPGFKGQNCDEDIIDCKENSCPPSATCIDLPGRFYCQCPFNLTGDDCRKTISVDYDMYFSDPLRSSAAQVVPFDTNSADSLTIAMWVQYTQQDEGGVFFTAYSVSNSHIALNRRQVIQAHSNGVQVSLFSELQDVYLSFGEFATVNDGQWHHVALVWDGSNGGELTLITEGLIASKLAGYGSGRTLPRYIWVTLGKPQSDNPKAYTEAGFQGHLTKVQVWNRALDVTNEVQKQVRDCRTEPVLYSGLTLTWAGYDDIIGGVERIVPSHCGQRVCPNGYNGQKCQQLEVDKEPPRVDRCPGDLWVIAKNGSSIVNWDAPVFSDNVGVAKVVEKSGHKPGENLAWGAYDIAYIAYDAVGNAATCTFKITVLSEFCPPLPDPLGGYQSCRDWGAGGQFKVCEIACRDGLRFSQPVPPFFTCGAEGFWRPTTDPSLPLIYPACSPASPAQRVFKVSMLFPSSVLCNDAGQAVLRQKVRSAINQLNRDWNFCSYAIDGTRECKELDINVKCDHRANRQTRQVSSPPTVTAEDTYVLDAIIPVEETRSSREGRQIGDTYSVEISFPAVNDPVIHGGNNERSTVQRLLEKLILEDEQFDVRNILPNTVPDPASLVLASDYACPTGQVVMAPDCVACAVGTFLDSATDSCKPCPMGSYQSEAGQLQCISCPTIAGQPGVTQTTGARSAADCKEKCAAGKYFDAEAELCRPCGHGSYQPREGAFSCISCPRGQTTRATEAVSAAECRDDCPSGEQLGTDGGCEPCPRGTWRATGAGAACAPCPPGTTTPQTGASSADQCSLPVCRPGSYLNVTLNTCIQCRKGTYQSEAQQTICVPCPINTSTRGPGATSESDCTNPCEMSGPEMHCDVNAYCLLMPETSEFKCQCKPGFNGTGKVCIDVCLDYCDNGGECIKDARGEPSCRCTGSFTGRHCRDKSEFAYIASGVAGGVIFIIFLVLLVWMICARSTKRKEPKKTLTPAIDQNGSQVNFYYGAHTPYAESIAPSHHSTYAHYYDDEEDGWEMPNFYNETYMKESLHNGMNGKMNSLARSNASIYGTKEDLYDRLKRHAYPEKSDSDSEGQ

Description

May play a role in the cell attachment process.
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface (By similarity).
Involved in dendrite development.
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake.

Subunit

Component of the cubam complex composed of CUBN and AMN (By similarity). The cubam complex can oligomerize and form cubam trimers. Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner. Found in a complex with PID1/PCLI1, LRP1 and CUBNI (By similarity). Interacts with LRP1 and PID1/PCLI1 (By similarity).
Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner (By similarity). Component of the cubam complex composed of CUBN and AMN. The cubam complex can oligomerize and form cubam trimers. Found in a complex with PID1/PCLI1, LRP1 and CUBNI (By similarity). Interacts with LRP1 and PID1/PCLI1 (By similarity).
Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner. Component of the cubam complex composed of CUBN and AMN. The cubam complex can oligomerize and form cubam trimers. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and PID1/PCLI1 (By similarity).
Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner. Component of the cubam complex composed of CUBN and AMN. The cubam complex can oligomerize and form cubam trimers. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and PID1/PCLI1.

Miscellaneous

CSMD1 may be a candidate for oral and oropharyngeal squamous cell carcinomas (OSCCs). PubMed:12696061 and PubMed:14506705 are however in disagreement: while PubMed:14506705 considers CSMD1 as a strong candidate for OSCCs, PubMed:12696061 thinks it is not.

Similarity

Belongs to the CSMD family.

Keywords

Alternative splicing   Calcium   Cell adhesion   Complete proteome   Cytoplasm   Disulfide bond   EGF-like domain   Glycoprotein   Membrane   Polymorphism   Reference proteome   Repeat   Secreted   Signal   Sushi   Cholesterol metabolism   Cleavage on pair of basic residues   Cobalamin   Cobalt   Direct protein sequencing   Endosome   Lipid metabolism   Lysosome   Metal-binding   Phosphoprotein   Protein transport   Steroid metabolism   Sterol metabolism   Transport   Cell membrane   Coated pit   3D-structure   Disease mutation   Endocytosis   Receptor   Transmembrane   Transmembrane helix  

Feature

chain  Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
splice variant  In isoform 3.
sequence variant  In dbSNP:rs3818764.
propeptide  Removed in mature form

Uniprot

Q4LDE5.3   P0C6B8.1   O70244.2   Q9JLB4.3   Q9TU53.1   O60494.5   + More
Q923L3.2   Q96PZ7.3   Q80T79.3   Q20911.4   Q7Z407.3  

Pubmed

16206243    14702039    15164053    15489334    17974005    12747765    + More
11062057    22171320    15057822    17139625    9478979    9153271    9691015    10400683    10811843    11805171    12724130    15616221    16641100    20237569    19468303    11856751    10766831    11278724    14983511    15342463    19349973    21183079    10552972    9572993    15164054    10371504    11717447    11606717    14576052    17124247    10080186    10887099    16959974    21355061    21248752    23114252    11472063    16141072    15815621    16751668    12975309    11572484    12696061    14506705    26566883    12693553    27033969    9851916    12754521    17761667    12906867    12943675   

EMBL

AJ619977    AY916667    AK023591    AK075235    AK027870    AL158158    + More
AL354982    AL592463    BC030816    BX537918    BX538049    AF308289    AABR03040659    AABR03041327    AABR03041522    AABR03042206    AABR03044351    AABR03044745    AABR03045322    AF022247    AL773538    AL928807    AF197159    AF137068    AF034611    EF444970    AC067747    AL365215    AL596445    AL731551    AY017475    AK038679    AK082377    AC101229    AC122323    AC122839    AC122911    AC123819    AC123866    AC123984    AC124351    AC125132    AC125354    AC132578    AC144939    AC154107    AF333704    AC021523    AC023296    AC087692    AC026991    AC135324    AY017307    DQ384438    DQ384439    DQ384440    DQ384441    DQ384442    KF458667    KF458665    KF458666    AY358174    AB067477    AK126936    AK140264    AK015672    AC099596    AC099600    AC099711    AC101706    AC101771    AC129189    AC130669    AC137905    AC154881    AC157584    AC158907    AK122567    Z74046    Z74473    AY210419    AB114604    AB114605    AB067481    AK126252   

Proteomes

UP000005640    UP000002494    UP000000589    UP000002254    UP000001940   

PRIDE

Q4LDE5    P0C6B8    O70244    Q9JLB4    Q9TU53    O60494    + More
Q923L3    Q96PZ7    Q80T79    Q20911    Q7Z407   

Pfam

PF07645   EGF_CA        + More
PF12661   hEGF
PF00008   EGF
PF07699   Ephrin_rec_like
PF00084   Sushi
PF02494   HYR
PF00354   Pentaxin
PF00092   VWA
PF12947   EGF_3
PF00431   CUB

Interpro

IPR009030   Growth_fac_rcpt_cys_sf        + More
IPR001881   EGF-like_Ca-bd_dom       
IPR035976   Sushi/SCR/CCP_sf       
IPR036465   vWFA_dom_sf       
IPR013320   ConA-like_dom_sf       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR001759   Pentraxin-related       
IPR011641   Tyr-kin_ephrin_A/B_rcpt-like       
IPR003410   HYR_dom       
IPR002035   VWF_A       
IPR013032   EGF-like_CS       
IPR018097   EGF_Ca-bd_CS       
IPR000742   EGF-like_dom       
IPR000436   Sushi_SCR_CCP_dom       
IPR000859   CUB_dom       
IPR035914   Sperma_CUB_dom_sf       
IPR024731   EGF_dom       

SUPFAM

SSF57535   SSF57535        + More
SSF49899   SSF49899       
SSF57184   SSF57184       
SSF53300   SSF53300       
SSF49854   SSF49854       

Gene 3D

3.40.50.410     2.60.120.290    

CDD

cd00033  CCP
cd00152  PTX
cd00041  CUB

ProteinModelPortal

Q4LDE5.3   P0C6B8.1   O70244.2   Q9JLB4.3   Q9TU53.1   O60494.5   + More
Q923L3.2   Q96PZ7.3   Q80T79.3   Q20911.4   Q7Z407.3  

PDB

4XBM     E-value=3.21297e-59,     Score=587

KEGG

101740358    no KO assigned | (RefSeq) uncharacterized LOC101740358

GO

GO:0007155   GO:0005737   GO:0005509   GO:0005576   GO:0003682   GO:0016020   GO:0006766   GO:0020028   GO:0010008   GO:0001701   GO:0032991   GO:0030492   GO:0016324   GO:0006898   GO:0038024   GO:0070207   GO:0007584   GO:0005905   GO:0008203   GO:0031526   GO:0005765   GO:0043202   GO:0031419   GO:0042802   GO:0030666   GO:0008144   GO:0005798   GO:0015889   GO:0030135   GO:0042366   GO:0005886   GO:0038023   GO:0045177   GO:0042953   GO:0005794   GO:0005768   GO:0030139   GO:0009617   GO:0070062   GO:0005783   GO:0042803   GO:0005903   GO:0015031   GO:0009235   GO:0031232   GO:0001894   GO:0005829   GO:0034384   GO:0042359   GO:0042593   GO:0016021   GO:0001964   GO:0050773   GO:0006629   GO:0005515   GO:0003824   GO:0019001   GO:0031683   GO:0007165   GO:0001664   GO:0005525   GO:0016491  

Subcellular location

Secreted  
Cytoplasm  
Membrane  
Endosome membrane  
Lysosome membrane  
Apical cell membrane   Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells.   With evidence from 1 publications.
Cell membrane   Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells.   With evidence from 1 publications.
Coated pit   Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells.   With evidence from 1 publications.
Endosome   Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells.   With evidence from 1 publications.

Length:

3415

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.86951

Exp number, first 60 AAs:

0.00057

Total prob of N-in:

0.00012

outside

1  -  3272

TMhelix

3273  -  3295

inside

3296  -  3415

 

 

Pi

231.405845

Theta

189.663755

Tajima's D

0.595603

CLR

0.854302

CSRT

0.544972751362432

Interpretation

Uncertain