Gene

KWMTBOMO05167  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012478

Annotation

PREDICTED:_trypsin_delta/gamma-like_[Bombyx_mori]

Location

Bomo_Chr9(+):9536620-9538899      View in EpiBrowser

Full name

Trypsin-4       + More
Trypsin-1      
Trypsin-2      
Trypsin-3      
Trypsin 5G1      
Trypsin-7      

Alternative Name

Antryp1
Antryp2

Location in the cell

Extracellular   Reliability : 2.73

CDS

ATGAAGTCAAATATTTGTGCCGCTTTTGTTTTTTTCACTTTCTCGACTACTGCTTCAGCATTGCCAACATCTGCAACTTCAAGTGATCTACCATCAAGAATAGTGAATGGTTTTCCGATTGATATAACTGAAATTCCGTACCAAGCTTCCTTGAGACGGAGCGTGGCGTCAGGATGGGCACATTCCTGTGGAGCTGTGATCATTAGCAACAATGCGGTATTGACGGCTGCACACTGTGTTGATTCCTATGTCTTAAATCCTTCAGTTTTAAAAGTAGTCGTTGGAACATCGTACCGACTTTCAGGAGGACAATCCTATGCGATATCGAGAATCATTCCTCACGAACAGTATTTACAATCTACTTTAGAAAATGACATTGCTGTTGTAGGAACATCTAAAACAATGACTTTCAGTGCAAGTGTTAATTCCGTTGCTATTGCTTCATCAACTTTATCTTTACCGATCGGATCTGAAGCACTTGTATCTGGATATGGGACAACATCATACGAAGGCACCACATCATCTGTCCTTCAAGCTGCTAAAGTCAAAGTTATCGCTCAAGAAACGTGTGCTCGGGCGTATTTGCGGATTACCCCGATTACCTCTGGAATGTTATGTGCCAACGCTACCCAGCCTCCAAGGGATGCCTGCCAAGGGGACTCGGGTGGTCCTTTAGTAGCAGACAACGTTCTAATCGGTGTCGTGTCCTGGGGTGAAGGCTGCGCTGATGCTTTATACCCAGGAGTCTACACAAGGGTTTCTGAATATAATTCATGGATTGTGCGCAATGTTGGACTTTTATAA

Protein

MKSNICAAFVFFTFSTTASALPTSATSSDLPSRIVNGFPIDITEIPYQASLRRSVASGWAHSCGAVIISNNAVLTAAHCVDSYVLNPSVLKVVVGTSYRLSGGQSYAISRIIPHEQYLQSTLENDIAVVGTSKTMTFSASVNSVAIASSTLSLPIGSEALVSGYGTTSYEGTTSSVLQAAKVKVIAQETCARAYLRITPITSGMLCANATQPPRDACQGDSGGPLVADNVLIGVVSWGEGCADALYPGVYTRVSEYNSWIVRNVGLL

Description

Constitutive trypsin that is expressed 2 days after emergence, coinciding with host seeking behavior of the female.
Major function may be to aid in digestion of the blood meal.

Catalytic Activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Similarity

Belongs to the peptidase S1 family.

Keywords

Complete proteome   Digestion   Disulfide bond   Hydrolase   Protease   Reference proteome   Secreted   Serine protease   Signal   Zymogen  

Feature

propeptide  Activation peptide
chain  Trypsin-4

Uniprot

H9JSG7   A0A194PFC6   A0A194RN29   A0A2H1VE79   A0A0M3T9F2   G9F9I9   + More
A0A3S2TPW3   A0A212EYY4   A0A0L7L3B0   O16133   A0A182T724   A0A1Y9J0S1   A0A1Y9IS50   A0A2C9GTS6   A0A1Y9GLA7   A0A1Y9HES5   P35038   P35035   A0A240PM69   A0A1Y9J180   A0A1Y9GKV0   A0A1Y9J0J4   P35036   A0A182VGJ0   A0A182U9U3   A0A2C9GTQ1   U5EZ49   A0A2C9GTY9   A0A182G8J0   A0A182MJH4   A0A182TKI7   A0A182M8Z6   U5EZJ4   A0A1Y9GKU7   Q16TL8   A0A182VG56   A0A2K7P6D6   A0A240PL34   A0A182KHH7   C8CGF6   A0A182Y3F4   Q16ID8   A0A240PL37   A0A182T760   Q16TM1   Q0IF85   B8XY09   A0A1Y9J184   A0A1Y9GLX5   A0A182TJQ8   P35037   A0A1S4GXU9   A0A084VY04   E1ZYQ4   A0A084VY03   A0A1B0CUP1   B5AKB2   P29787   A0A240PKC7   A0A182F4C2   A0A1L8DQH5   A0A1L8DQU1   B4LJ08   C5IBF3   A0A084VY00   A4UCN4   A0A1A9XJL9   T1DN08   A0A084VY02   A0A1A9WKF8   A0A182V8D5   A0A1L8DQE6   U5EGR6   A0A1L8DQQ8   A0A1B0BCW7   A0A182F5Y2   A0A1I8PQ52   Q17086   A0A1Q3FP18   G9B5H8   B0WDC9   A0A182TVG7   B0WBW0   A0A1A9VW11   G9B5H7   A0A182GET6   G9B5I4   A0A182GAC9   G9B5J3   G9B5H5   A0A2C9GTS0   B0WF77   G9B5I2   Q16ID4   A0A182F2A5   A0A182L0V6   A0A182XL71   T1DEY9   G9B5H9   P35041  

EC Number

3.4.21.4

Pubmed

19121390    26354079    22432944    22118469    26227816    11016929    + More
20966253    7498434    12364791    8335004    26483478    17510324    20100490    25244985    24438588    20798317    9087545    17994087    19204376    17879236    22727120   

EMBL

BABH01027869    KQ459606    KPI91399.1    KQ459984    KPJ18922.1    ODYU01002080    + More
SOQ39135.1    KR024670    ALE15212.1    JN033734    JN315759    AEW46887.1    AFK64823.1    RSAL01000027    RVE51908.1    AGBW02011440    OWR46654.1    JTDY01003207    KOB69947.1    AF012809    AAB66878.1    APCN01000798    Z22930    AAAB01008964    Z18889    Z18890    GANO01001434    JAB58437.1    JXUM01047815    KQ561534    KXJ78237.1    AXCM01007963    AXCM01021675    GANO01000688    JAB59183.1    CH477645    EAT37859.1    GQ398048    ACV07665.1    GQ398049    CH478086    ACV07666.1    EAT34028.1    EAT37856.1    CH477389    EAT42001.1    FJ458410    ACL37992.1    ATLV01018235    KE525226    KFB42848.1    GL435242    EFN73594.1    KFB42847.1    AJWK01029481    EU855138    ACF72874.2    X64363    GFDF01005368    JAV08716.1    GFDF01005369    JAV08715.1    CH940648    EDW60458.2    FJ839343    ACR61324.1    ATLV01018234    KFB42844.1    EF011106    ABM26904.1    GAMD01003270    JAA98320.1    KFB42846.1    GFDF01005398    JAV08686.1    GANO01003334    JAB56537.1    GFDF01005370    JAV08714.1    JXJN01012155    U52359    AAA97479.1    GFDL01005706    JAV29339.1    HM480738    AEI58584.1    DS231896    EDS44442.1    DS231882    EDS42890.1    HM480737    AEI58583.1    JXUM01058527    KQ562007    KXJ76926.1    HM480744    AEI58590.1    JXUM01008849    KQ560270    KXJ83415.1    HM480753    AEI58599.1    HM480735    AEI58581.1    DS231915    EDS26053.1    EDS26054.1    HM480736    HM480742    AEI58588.1    EAT34032.1    GAMD01003326    JAA98264.1    HM480739    AEI58585.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000283053    UP000007151    UP000037510    + More
UP000075901    UP000076407    UP000075903    UP000075882    UP000075840    UP000075900    UP000007062    UP000075885    UP000075902    UP000069940    UP000249989    UP000075883    UP000008820    UP000075881    UP000076408    UP000030765    UP000000311    UP000092461    UP000069272    UP000008792    UP000092443    UP000091820    UP000092460    UP000095300    UP000002320    UP000078200   

PRIDE

H9JSG7    P35035    P35036    P29787    P35041   

Pfam

PF00089   Trypsin

Interpro

IPR018114   TRYPSIN_HIS        + More
IPR001314   Peptidase_S1A       
IPR009003   Peptidase_S1_PA       
IPR001254   Trypsin_dom       
IPR033116   TRYPSIN_SER       

SUPFAM

SSF50494   SSF50494       

CDD

cd00190  Tryp_SPc

ProteinModelPortal

H9JSG7   A0A194PFC6   A0A194RN29   A0A2H1VE79   A0A0M3T9F2   G9F9I9   + More
A0A3S2TPW3   A0A212EYY4   A0A0L7L3B0   O16133   A0A182T724   A0A1Y9J0S1   A0A1Y9IS50   A0A2C9GTS6   A0A1Y9GLA7   A0A1Y9HES5   P35038   P35035   A0A240PM69   A0A1Y9J180   A0A1Y9GKV0   A0A1Y9J0J4   P35036   A0A182VGJ0   A0A182U9U3   A0A2C9GTQ1   U5EZ49   A0A2C9GTY9   A0A182G8J0   A0A182MJH4   A0A182TKI7   A0A182M8Z6   U5EZJ4   A0A1Y9GKU7   Q16TL8   A0A182VG56   A0A2K7P6D6   A0A240PL34   A0A182KHH7   C8CGF6   A0A182Y3F4   Q16ID8   A0A240PL37   A0A182T760   Q16TM1   Q0IF85   B8XY09   A0A1Y9J184   A0A1Y9GLX5   A0A182TJQ8   P35037   A0A1S4GXU9   A0A084VY04   E1ZYQ4   A0A084VY03   A0A1B0CUP1   B5AKB2   P29787   A0A240PKC7   A0A182F4C2   A0A1L8DQH5   A0A1L8DQU1   B4LJ08   C5IBF3   A0A084VY00   A4UCN4   A0A1A9XJL9   T1DN08   A0A084VY02   A0A1A9WKF8   A0A182V8D5   A0A1L8DQE6   U5EGR6   A0A1L8DQQ8   A0A1B0BCW7   A0A182F5Y2   A0A1I8PQ52   Q17086   A0A1Q3FP18   G9B5H8   B0WDC9   A0A182TVG7   B0WBW0   A0A1A9VW11   G9B5H7   A0A182GET6   G9B5I4   A0A182GAC9   G9B5J3   G9B5H5   A0A2C9GTS0   B0WF77   G9B5I2   Q16ID4   A0A182F2A5   A0A182L0V6   A0A182XL71   T1DEY9   G9B5H9   P35041  

PDB

1A5I     E-value=6.65216e-29,     Score=315

KEGG

101735316    K01312 trypsin [EC:3.4.21.4] | (RefSeq) trypsin delta/gamma-like

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0004252   GO:0008236   GO:0005576   GO:0007586   GO:0005615   GO:0006508   GO:0007186   GO:0019001   GO:0031683   GO:0007165   GO:0001664   GO:0005525   GO:0016491   GO:0003824  

Subcellular location

Secreted  
  

SignalP

Position:   1 - 20,         Likelihood:  0.982043

 

 

Length:

267

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

9.81276999999999

Exp number, first 60 AAs:

9.46894

Total prob of N-in:

0.48170

outside

1  -  267

 

 

Pi

201.695388

Theta

144.718641

Tajima's D

0.559807

CLR

0.699122

CSRT

0.533173341332933

Interpretation

Uncertain