SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO05158
Pre Gene Modal
BGIBMGA012476
Annotation
insulin-like_precursor_polypeptide_2_[Spodoptera_littoralis]
Full name
Bombyxin B-12       + More
Bombyxin B-3      
Bombyxin A-2 homolog      
Bombyxin G-1      
Bombyxin B      
Bombyxin B-2      
Bombyxin B-6      
Bombyxin B-4      
Bombyxin B-1      
Bombyxin A-1 homolog      
Bombyxin B-7      
Bombyxin B-10      
Bombyxin B-9      
Bombyxin B-5      
Bombyxin B-2 homolog      
Bombyxin A      
Bombyxin A-6      
Bombyxin A-3      
Bombyxin A-3 homolog      
Bombyxin B-1 homolog      
Bombyxin A-7      
Bombyxin A-1      
Bombyxin A-4      
Bombyxin A-8      
Bombyxin A-2      
Bombyxin-related peptide A      
Bombyxin B-11      
Bombyxin A-9      
Bombyxin B-8      
Insulin-related peptide 4      
Insulin-related peptide 2      
Bombyxin F-1      
Con-Ins Im2      
Bombyxin C-1      
Bombyxin E-1      
Bombyxin A-5      
Bombyxin D-1      
Alternative Name
4K-prothoracicotropic hormone
Bombyxin-II
ABRP
Insulin 2
4K-prothoracicotropic hormone IV
Bombyxin IV
Location in the cell
Extracellular   Reliability : 3.681
 

Sequence

CDS
ATGAAATTCACGGTGATGATAGTGCTGATGGCGTTAGCTTACGTCTCAGCGCACAAGGAAGCAGTCACTCTGTGTGGACGGAACCTTGCAAACGCAAGGGTTGCAGTGTGTTATGGAGCAGAATACGTTGATAAACGGACATCGGGAAACACATTATTCGATGATTTCGAAGATGTAGACCTGCACGGCGATTGGCCGTGGACTGGCCGTCGAGGCGCCCTCTCCGCTGACTGGACCCGCTACAAGCGCCAAGGAATCGTCAACGAATGCTGTTTCAAACCATGCACCACCGACGTACTCTTGAAATATTGTTAA
Protein
MKFTVMIVLMALAYVSAHKEAVTLCGRNLANARVAVCYGAEYVDKRTSGNTLFDDFEDVDLHGDWPWTGRRGALSADWTRYKRQGIVNECCFKPCTTDVLLKYC

Summary

Description
Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.
This venom insulin facilitates prey capture by rapidly inducing hypoglycemic shock. Intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin. In vivo, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency.
Subunit
Heterodimer of a B chain and an A chain linked by two disulfide bonds.
Miscellaneous
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.
Similarity
Belongs to the insulin family.
Keywords
Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Hormone   Reference proteome   Secreted   Signal   3D-structure   Direct protein sequencing   Pyrrolidone carboxylic acid   Amidation   Neuropeptide   Carbohydrate metabolism   Gamma-carboxyglutamic acid   Glucose metabolism   Toxin  
Feature
peptide  Bombyxin B-12 B chain
propeptide  C peptide like
chain  Bombyxin B
EMBL
HQ451073    AEE43937.1    NWSH01001540    PCG70919.1    ODYU01000348    SOQ34957.1    + More
RSAL01000529    RVE41449.1    D00789    D00778    KQ459606    KPI91080.1    JTDY01002420    KOB71447.1    KQ461198    KPJ06073.1    D13924    AB010380    AB010381    CAQQ02093058    AGBW02014744    OWR41114.1    BABH01042454    M26069    D00781    BABH01028595    BABH01042456    D00779    M26068    D13923    D00782    D00783    D00787    D00785    KC340940    AGH25572.1    AGBW02011334    OWR46809.1    D00786    BAA00682.1    D00780    CH933809    EDW18097.1    KQ460211    KPJ16548.1    CH902618    EDV39079.1    D00771    KPJ16546.1    D13925    AGBW02013861    AGBW02010668    OWR42608.1    OWR48079.1    D00772    D00773    D00340    D00769    AB661462    BAK57501.1    BABH01006963    D00774    D00775    KQ459324    KPJ01447.1    MH028092    AXY04261.1    J04727    BABH01028594    KQ971338    EFA02796.2    D63147    D63146    D00788    ODYU01010158    SOQ55081.1    GGMS01005107    MBY74310.1    KPJ16545.1    D00776    D00784    HQ451072    AEE43936.1    KT005974    ALM30325.1    RSAL01000039    RVE51045.1    KC340942    AGH25574.1    NWSH01001233    PCG72023.1    MH028098    AXY04267.1    AB001049    AB001050    KP268612    AJD85825.1    ODYU01012871    SOQ59389.1    OUUW01000012    SPP87457.1    KQ459583    KPI98658.1    BABH01028597    GBYB01006609    JAG76376.1    D00790    D00791    J04728    KU881654    ANC47992.1    GBYB01006610    GBYB01006611    JAG76377.1    JAG76378.1    MF765470    AXF48190.1    GAIX01011802    JAA80758.1    KPJ16543.1    MH360346    AXL95395.1    KPI98656.1    D78138    D00770    GCVH01000114    JAI17779.1    GCVM01000088    JAI17901.1    KB202619    ESO89360.1    CH480815    EDW40930.1    KC340941    AGH25573.1    FR751157    HE654180    CM000363    CM002912    CBY85567.1    CCF74202.1    EDX09913.1    KMY98773.1    KPJ16544.1    D00797    AB003905    ODYU01009526    SOQ54023.1    BABH01016939    ABLF02024498    ODYU01007848    SOQ50980.1   
Pfam
PF00049   Insulin        + More
PF04756   OST3_OST6
Interpro
IPR036438   Insulin-like_sf        + More
IPR022352   Insulin_family       
IPR022353   Insulin_CS       
IPR016179   Insulin-like       
IPR040228   Insulin-relat-peptide_inver       
IPR016724   Insulin-rel_pep       
IPR027285   Bombyxin_B       
IPR017097   Bombyxin       
IPR021149   OligosaccharylTrfase_OST3/OST6       
IPR036249   Thioredoxin-like_sf       
IPR030680   Bombyxin_A       
SUPFAM
SSF56994   SSF56994        + More
SSF52833   SSF52833       
PDB
1BON     E-value=0.0159853,     Score=83

Ontologies

Topology

Subcellular location
Secreted  
SignalP
Position:   1 - 17,         Likelihood:  0.998741
 
 
Length:
104
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.20366
Exp number, first 60 AAs:
0.20366
Total prob of N-in:
0.16912
outside
1  -  104
 
 

Population Genetic Test Statistics

Pi
214.285984
Theta
152.981506
Tajima's D
1.2432
CLR
0.033711
CSRT
0.729013549322534
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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