Gene

KWMTBOMO05158

Pre Gene Modal

BGIBMGA012476

Annotation

insulin-like_precursor_polypeptide_2_[Spodoptera_littoralis]

Location

Bomo_Chr9(+):9228198-9230552      View in EpiBrowser

Full name

Bombyxin B-12       + More
Bombyxin B-3      
Bombyxin A-2 homolog      
Bombyxin G-1      
Bombyxin B      
Bombyxin B-2      
Bombyxin B-6      
Bombyxin B-4      
Bombyxin B-1      
Bombyxin A-1 homolog      
Bombyxin B-7      
Bombyxin B-10      
Bombyxin B-9      
Bombyxin B-5      
Bombyxin B-2 homolog      
Bombyxin A      
Bombyxin A-6      
Bombyxin A-3      
Bombyxin A-3 homolog      
Bombyxin B-1 homolog      
Bombyxin A-7      
Bombyxin A-1      
Bombyxin A-4      
Bombyxin A-8      
Bombyxin A-2      
Bombyxin-related peptide A      
Bombyxin B-11      
Bombyxin A-9      
Bombyxin B-8      
Insulin-related peptide 4      
Insulin-related peptide 2      
Bombyxin F-1      
Con-Ins Im2      
Bombyxin C-1      
Bombyxin E-1      
Bombyxin A-5      
Bombyxin D-1      

Alternative Name

4K-prothoracicotropic hormone
Bombyxin-II
ABRP
Insulin 2
4K-prothoracicotropic hormone IV
Bombyxin IV

Location in the cell

Extracellular   Reliability : 3.681

CDS

ATGAAATTCACGGTGATGATAGTGCTGATGGCGTTAGCTTACGTCTCAGCGCACAAGGAAGCAGTCACTCTGTGTGGACGGAACCTTGCAAACGCAAGGGTTGCAGTGTGTTATGGAGCAGAATACGTTGATAAACGGACATCGGGAAACACATTATTCGATGATTTCGAAGATGTAGACCTGCACGGCGATTGGCCGTGGACTGGCCGTCGAGGCGCCCTCTCCGCTGACTGGACCCGCTACAAGCGCCAAGGAATCGTCAACGAATGCTGTTTCAAACCATGCACCACCGACGTACTCTTGAAATATTGTTAA

Protein

MKFTVMIVLMALAYVSAHKEAVTLCGRNLANARVAVCYGAEYVDKRTSGNTLFDDFEDVDLHGDWPWTGRRGALSADWTRYKRQGIVNECCFKPCTTDVLLKYC

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.
This venom insulin facilitates prey capture by rapidly inducing hypoglycemic shock. Intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin. In vivo, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Hormone   Reference proteome   Secreted   Signal   3D-structure   Direct protein sequencing   Pyrrolidone carboxylic acid   Amidation   Neuropeptide   Carbohydrate metabolism   Gamma-carboxyglutamic acid   Glucose metabolism   Toxin  

Feature

peptide  Bombyxin B-12 B chain
propeptide  C peptide like
chain  Bombyxin B

Uniprot

F6KMX3   A0A2A4JGH3   A0A2H1V286   A0A3S2NJC1   P29519   P26737   + More
A0A194PJ20   A0A0L7L7G8   A0A194QKH9   P33719   O61271   T1GAC2   A0A212EI08   H9JY77   P26734   P26740   H9JR12   H9JY78   P26738   P26733   P33718   P26741   Q17194   P26743   M4QC54   A0A212EZ83   Q53X51   P26739   B4L0M0   A0A194RFE4   B3MA65   P33722   H9JQX3   P26729   P26726   A0A194RKP6   P33720   A0A212F2W7   P33721   P26730   Q17192   P26727   F8WTP8   H9ITT7   P26731   A0A194Q7C8   A0A385H8W6   P15411   H9JR11   D2A2M7   O09209   Q17196   A0A2H1WPS9   A0A2S2Q9T5   A0A194RGU3   P26732   P26742   F6KMX2   C0HKS5   H9JY76   A0A0S1U0R4   C0HKS4   A0A3S2M4A9   M4QEN0   A0A2A4JKR2   A0A385H8W5   P91896   H9JQX4   A0A0B5A8P8   A0A1I8PH91   A0A2H1X245   A0A3B0JZE9   A0A194Q039   H9JQX2   A0A0C9QS78   P15410   A0A168L4Y5   A0A0C9RE29   A0A345BED8   S4NYE8   A0A194RFD7   A0A346CIJ6   A0A194PZA6   P21808   P26728   A0A0K8TTI4   A0A0K8TUG5   V4A388   B4HLB1   M4QNU1   B4QNP6   A0A1I8PLE9   A0A194RGH1   P26736   A0A2H1WLR7   H9JRY4   J9M6G9   A0A2H1WD29  

Pubmed

17559850    8683595    26354079    26227816    1601275    9732555    + More
22118469    19121390    2674935    17994087    16593744    7473749    30171635    2708384    18362917    19820115    8673077    29466015    9401466    25605914    23622113    30060147    9253178    1515030    23254933    22936249   

EMBL

HQ451073    AEE43937.1    NWSH01001540    PCG70919.1    ODYU01000348    SOQ34957.1    + More
RSAL01000529    RVE41449.1    D00789    D00778    KQ459606    KPI91080.1    JTDY01002420    KOB71447.1    KQ461198    KPJ06073.1    D13924    AB010380    AB010381    CAQQ02093058    AGBW02014744    OWR41114.1    BABH01042454    M26069    D00781    BABH01028595    BABH01042456    D00779    M26068    D13923    D00782    D00783    D00787    D00785    KC340940    AGH25572.1    AGBW02011334    OWR46809.1    D00786    BAA00682.1    D00780    CH933809    EDW18097.1    KQ460211    KPJ16548.1    CH902618    EDV39079.1    D00771    KPJ16546.1    D13925    AGBW02013861    AGBW02010668    OWR42608.1    OWR48079.1    D00772    D00773    D00340    D00769    AB661462    BAK57501.1    BABH01006963    D00774    D00775    KQ459324    KPJ01447.1    MH028092    AXY04261.1    J04727    BABH01028594    KQ971338    EFA02796.2    D63147    D63146    D00788    ODYU01010158    SOQ55081.1    GGMS01005107    MBY74310.1    KPJ16545.1    D00776    D00784    HQ451072    AEE43936.1    KT005974    ALM30325.1    RSAL01000039    RVE51045.1    KC340942    AGH25574.1    NWSH01001233    PCG72023.1    MH028098    AXY04267.1    AB001049    AB001050    KP268612    AJD85825.1    ODYU01012871    SOQ59389.1    OUUW01000012    SPP87457.1    KQ459583    KPI98658.1    BABH01028597    GBYB01006609    JAG76376.1    D00790    D00791    J04728    KU881654    ANC47992.1    GBYB01006610    GBYB01006611    JAG76377.1    JAG76378.1    MF765470    AXF48190.1    GAIX01011802    JAA80758.1    KPJ16543.1    MH360346    AXL95395.1    KPI98656.1    D78138    D00770    GCVH01000114    JAI17779.1    GCVM01000088    JAI17901.1    KB202619    ESO89360.1    CH480815    EDW40930.1    KC340941    AGH25573.1    FR751157    HE654180    CM000363    CM002912    CBY85567.1    CCF74202.1    EDX09913.1    KMY98773.1    KPJ16544.1    D00797    AB003905    ODYU01009526    SOQ54023.1    BABH01016939    ABLF02024498    ODYU01007848    SOQ50980.1   

Proteomes

UP000218220    UP000283053    UP000005204    UP000053268    UP000037510    UP000053240    + More
UP000015102    UP000007151    UP000009192    UP000007801    UP000007266    UP000095300    UP000268350    UP000030746    UP000001292    UP000000304    UP000007819   

PRIDE

P29519    P26737    P33719    O61271    H9JY77    P26734    + More
P26740    H9JR12    H9JY78    P26738    P26733    P26741    Q17194    P26743    P26739    H9JQX3    P26729    P26726    P26730    P26727    F8WTP8    H9ITT7    P26731    P15411    H9JR11    Q17196    P26732    P26742    H9JY76    P91896    H9JQX4    H9JQX2    P15410    P21808    P26728    P26736    H9JRY4   

Pfam

PF00049   Insulin        + More
PF04756   OST3_OST6

Interpro

IPR036438   Insulin-like_sf        + More
IPR022352   Insulin_family       
IPR022353   Insulin_CS       
IPR016179   Insulin-like       
IPR040228   Insulin-relat-peptide_inver       
IPR016724   Insulin-rel_pep       
IPR027285   Bombyxin_B       
IPR017097   Bombyxin       
IPR021149   OligosaccharylTrfase_OST3/OST6       
IPR036249   Thioredoxin-like_sf       
IPR030680   Bombyxin_A       

SUPFAM

SSF56994   SSF56994        + More
SSF52833   SSF52833       

ProteinModelPortal

F6KMX3   A0A2A4JGH3   A0A2H1V286   A0A3S2NJC1   P29519   P26737   + More
A0A194PJ20   A0A0L7L7G8   A0A194QKH9   P33719   O61271   T1GAC2   A0A212EI08   H9JY77   P26734   P26740   H9JR12   H9JY78   P26738   P26733   P33718   P26741   Q17194   P26743   M4QC54   A0A212EZ83   Q53X51   P26739   B4L0M0   A0A194RFE4   B3MA65   P33722   H9JQX3   P26729   P26726   A0A194RKP6   P33720   A0A212F2W7   P33721   P26730   Q17192   P26727   F8WTP8   H9ITT7   P26731   A0A194Q7C8   A0A385H8W6   P15411   H9JR11   D2A2M7   O09209   Q17196   A0A2H1WPS9   A0A2S2Q9T5   A0A194RGU3   P26732   P26742   F6KMX2   C0HKS5   H9JY76   A0A0S1U0R4   C0HKS4   A0A3S2M4A9   M4QEN0   A0A2A4JKR2   A0A385H8W5   P91896   H9JQX4   A0A0B5A8P8   A0A1I8PH91   A0A2H1X245   A0A3B0JZE9   A0A194Q039   H9JQX2   A0A0C9QS78   P15410   A0A168L4Y5   A0A0C9RE29   A0A345BED8   S4NYE8   A0A194RFD7   A0A346CIJ6   A0A194PZA6   P21808   P26728   A0A0K8TTI4   A0A0K8TUG5   V4A388   B4HLB1   M4QNU1   B4QNP6   A0A1I8PLE9   A0A194RGH1   P26736   A0A2H1WLR7   H9JRY4   J9M6G9   A0A2H1WD29  

PDB

1BON     E-value=0.0159853,     Score=83

KEGG

NA   

GO

GO:0005179   GO:0005576   GO:0008083   GO:0005615   GO:0016021   GO:0061964   GO:0045475   GO:0030431   GO:0060180   GO:0008286   GO:0009743   GO:0032008   GO:0018445   GO:0007218   GO:0006006   GO:0090729  

PANTHER

PTHR13647   PTHR12692  

Subcellular location

Secreted  

SignalP

Position:   1 - 17,         Likelihood:  0.998741

 

 

Length:

104

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.20366

Exp number, first 60 AAs:

0.20366

Total prob of N-in:

0.16912

outside

1  -  104

 

 

Pi

214.285984

Theta

152.981506

Tajima's D

1.2432

CLR

0.033711

CSRT

0.729013549322534

Interpretation

Uncertain