Gene

KWMTBOMO05152

Pre Gene Modal

BGIBMGA012495

Annotation

PREDICTED:_speckle-type_POZ_protein_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr9(-):9064509-9105157      View in EpiBrowser

Full name

Protein roadkill      

Alternative Name

Hh-induced MATH and BTB domain-containing protein

Location in the cell

Nuclear   Reliability : 1.874

CDS

ATGGCCTTAGCCAGGTATAATCAGCAAACCGCGCGCTCCTCTTGGTTGAAGCTCGGTTCGGGCAGCGAGTGCGTTGGCGGGTCGGGCGGCGGCGCGCCCTCTCCGCAGTCGGCGCGCGTCTCTTCGAACGGCGCTGGCGGGATGGCGGTGAGCCGCGTGCCCAGCCCGTTGCACGACGGAAACACGCCCGTCGCAGAAAACTGGTGCTTCACACAAGTCAAAGTGGTGAAATTCAGTTACATGTGGACAATAAACAATTTTAGTTTTTGTAGAGAAGAAATGGGTGAAGTGTTAAAATCATCGACTTTCTCAGCTGGTGCTAGTGATAAATTAAAATGGTGTCTTCGCGTCAATCCAAAAGGACTCGATGAAGAGAGCAAAGACTATTTATCGTTATACTTATTATTAGTCTCGTGTAATAAATCAGAAGTGCGGGCAAAGTTTAAATTTTCAATATTAAATGCTAAAAGAGAAGAAACTAAAGCAATGGAATCGCAACGGGCGTACAGATTCGTGCAAGGAAAAGACTGGGGATTCAAAAAGTTTATCAGAAGAGATTTCCTGCTCGACGAGGCCAATGGTTTATTACCCGAAGATAAACTGACGATATTCTGCGAAGTGTCAGTTGTAGCGGATAGCATCAACATCAGCGGGCAGAGCAACGTGGTTCAGTTCAAAGTGCCTGAGTGCAGATTGTCAGACGATTTAGGAGCTCTCTTTGATAACGAAAGATTCTCTGATGTCACGCTAGCCGTGGGCGGCAGGGAGTTTCAAGCGCATAAAGCTATATTAGCAGCGCGGAGTCCTGTGTTCGCTGCGATGTTCGAACACGAAATGGAAGAGAGGAAGAGGAATAGAGTCGACATAACGGACGTCGATCATGAAGTATTAAGAGAAATGTTACGTTTCATATATACGGGCAGAGCGCCCAATTTGGATAAGATGGCCGACGATCTGCTAGCTGCGGCCGATAAGTATGCATTGGAGCGGCTAAAAGTGATGTGCGAAGAGGCGCTGTGCTTGAGTCTCTCGGTGGAGACTGCCGCAGACACGCTCATACTCGCAGACCTGCACTCCGCCGACCAGCTCAAAGCGCAGACCATAGATTTCATTAACACGAGCCACGCGACGGACGTGATGGACACGGCCGGCTGGAAGAACATGATCTCGTCGCACCCGCACCTCATCGCGGAGGCGTTCCGCGCGCTCGCGACCCAGCAGCAGCAGATCCCGCCCATCGGGCCGCCACGGAAACGTGTGAAGCAGGCCTAG

Protein

MALARYNQQTARSSWLKLGSGSECVGGSGGGAPSPQSARVSSNGAGGMAVSRVPSPLHDGNTPVAENWCFTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSAGASDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPEDKLTIFCEVSVVADSINISGQSNVVQFKVPECRLSDDLGALFDNERFSDVTLAVGGREFQAHKAILAARSPVFAAMFEHEMEERKRNRVDITDVDHEVLREMLRFIYTGRAPNLDKMADDLLAAADKYALERLKVMCEEALCLSLSVETAADTLILADLHSADQLKAQTIDFINTSHATDVMDTAGWKNMISSHPHLIAEAFRALATQQQQIPPIGPPRKRVKQA

Description

Involved in segment polarity. In complex with gft/CUL3, promotes ubiquitination of ci and its subsequent degradation by the proteasome, which results in hh signaling attenuation. This regulation may be important during eye formation for proper packing of ommatidia into a hexagonal array.

Subunit

Interacts with ci and gft/CUL3.

Similarity

Belongs to the Tdpoz family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Nucleus   Reference proteome   Segmentation polarity protein   Ubl conjugation pathway  

Feature

chain  Protein roadkill
splice variant  In isoform 2.

Uniprot

A0A1E1W5S0   A0A2H1VJN0   A0A212F9Z7   A0A1E1WJF8   A0A194PFB6   A0A1E1VZR2   + More
A0A194RS66   Q179U2   A0A1J1J0U8   A0A1I8MAR9   A0A1I8Q4G3   A0A2M4CV23   A0A2M4CV51   A0A2M3ZG88   A0A2M4A8E1   T1DCX9   A0A2M3Z1Q4   A0A2M4A8M8   A0A084VI71   A0A1L8DMC3   A0A1L8DM31   A0A1I8JT83   A0A1I8JT76   A0A0K8TMR4   B3LYT1   A0A0A1XH08   A0A336KF12   A0A3B0K1J1   B4NFQ5   Q298W3   A0A2M4A8F9   W8BQW6   F5HK16   A0A1I8MAS0   Q9VFP2-4   Q9VFP2-3   A0A1W4V5V8   A0A1W4USH7   B4R0J2   A0A0R3NH15   I5ANU6   C7LAF6   B4G4S2   A0A0R1E4C9   B4PTD9   A0A0P8YGX7   B4HF69   B3P0K1   Q9VFP2   A0A1W4V4U8   A0A1I8Q4H2   B4MB81   B4JSB8   A0A1A9WJT9   Q7PGC0   B4KC14   A0A0Q9VZH1   A0A139WMR0   A0A0K8V0W6   A0A1Y1NHB6   W8B3B6   A0A0A1WVQ7   A0A1B6DLG6   Q9VFP2-2   A0A1W4US38   I5ANU5   A0A0R1E3Q2   A0A0P8Y1H1   A0A1I8Q4I6   A0A0M3QY84   A0A1B6LAQ1   A0A1B6L6U9   A0A0Q9VZH9   N6U5F7   A0A224XR50   A0A0K8SF32   A0A1B6GH68   A0A023FB09   R4G7P9   A0A0A9Z6U1   A0A0A9Y6H6   A0A0A9Z0Y4   A0A0A9Y1Z4   A0A154PL41   A0A0A9YWX0   V9IDF5   T1JG19   A0A0P6J6Y5   E2C6Z1   A0A151IYV4   A0A0C9RMN6   A0A151WPY5   A0A2A3EEX6   A0A0P5XV92   A0A0C9R9M6   A0A0C9RQU0   A0A158NMX7   A0A224YZW1   A0A131YNK4   A0A3S3PIL6  

Pubmed

22118469    26354079    17510324    25315136    24330624    24438588    + More
26369729    17994087    25830018    15632085    24495485    12364791    14747013    17210077    16651542    10731132    12537572    12537569    16740475    17550304    18362917    19820115    28004739    23537049    25474469    25401762    20798317    21347285    28797301    26830274   

EMBL

GDQN01008738    JAT82316.1    ODYU01002932    SOQ41049.1    AGBW02009539    OWR50554.1    + More
GDQN01003932    JAT87122.1    KQ459606    KPI91389.1    GDQN01011347    GDQN01010836    JAT79707.1    JAT80218.1    KQ459984    KPJ18911.1    CH477345    EAT43021.1    CVRI01000066    CRL05960.1    GGFL01005014    MBW69192.1    GGFL01004971    MBW69149.1    GGFM01006778    MBW27529.1    GGFK01003752    MBW37073.1    GALA01001652    JAA93200.1    GGFM01001684    MBW22435.1    GGFK01003771    MBW37092.1    ATLV01013303    ATLV01013304    ATLV01013305    ATLV01013306    KE524850    KFB37665.1    GFDF01006567    JAV07517.1    GFDF01006566    JAV07518.1    APCN01002208    GDAI01001961    JAI15642.1    CH902617    EDV44047.1    GBXI01004077    JAD10215.1    UFQS01000350    UFQT01000350    SSX03077.1    SSX23443.1    OUUW01000013    SPP88104.1    CH964251    EDW83122.2    CM000070    EAL27842.2    GGFK01003765    MBW37086.1    GAMC01010934    JAB95621.1    AAAB01008851    EGK96627.1    DQ507278    AE014297    AY121682    BT012443    BT021321    CM000364    EDX13007.1    KRT00308.1    EIM52631.1    BT099706    ACV53070.1    CH479179    EDW24588.1    CM000160    KRK03871.1    EDW97638.1    KPU80594.1    CH480815    EDW42243.1    CH954181    EDV48827.1    CH940656    EDW58352.1    CH916373    EDV94658.1    EAA44989.5    CH933806    EDW16887.2    KRF78249.1    KQ971312    KYB29174.1    GDHF01026604    GDHF01019881    GDHF01017641    GDHF01013322    GDHF01012301    JAI25710.1    JAI32433.1    JAI34673.1    JAI38992.1    JAI40013.1    GEZM01002479    JAV97231.1    GAMC01010935    JAB95620.1    GBXI01013583    GBXI01011687    JAD00709.1    JAD02605.1    GEDC01010791    JAS26507.1    EIM52630.1    KRK03872.1    KPU80595.1    CP012526    ALC47233.1    GEBQ01019231    JAT20746.1    GEBQ01020538    JAT19439.1    KRF78250.1    APGK01048489    KB741112    KB632184    ENN73807.1    ERL89641.1    GFTR01005803    JAW10623.1    GBRD01013929    JAG51897.1    GECZ01007987    JAS61782.1    GBBI01000503    JAC18209.1    ACPB03014368    GAHY01002342    JAA75168.1    GBHO01006079    GBRD01013931    JAG37525.1    JAG51895.1    GBHO01018504    JAG25100.1    GBHO01006078    JAG37526.1    GBHO01018501    GBRD01013930    JAG25103.1    JAG51896.1    KQ434948    KZC12467.1    GBHO01006082    JAG37522.1    JR038652    AEY58359.1    JH432192    GDIQ01022320    JAN72417.1    GL453255    EFN76263.1    KQ980745    KYN13677.1    GBYB01009625    JAG79392.1    KQ982850    KYQ49926.1    KZ288266    PBC30270.1    GDIP01079332    JAM24383.1    GBYB01009627    JAG79394.1    GBYB01009624    GBYB01009626    GBYB01009628    JAG79391.1    JAG79393.1    JAG79395.1    ADTU01020833    ADTU01020834    ADTU01020835    GFPF01012000    MAA23146.1    GEDV01008881    JAP79676.1    NCKU01000330    RWS15969.1   

Proteomes

UP000007151    UP000053268    UP000053240    UP000008820    UP000183832    UP000095301    + More
UP000095300    UP000030765    UP000075840    UP000007801    UP000268350    UP000007798    UP000001819    UP000007062    UP000000803    UP000192221    UP000000304    UP000008744    UP000002282    UP000001292    UP000008711    UP000008792    UP000001070    UP000091820    UP000009192    UP000007266    UP000092553    UP000019118    UP000030742    UP000015103    UP000076502    UP000008237    UP000078492    UP000075809    UP000242457    UP000005205    UP000285301   

PRIDE

Q9VFP2   

Pfam

PF00917   MATH        + More
PF00651   BTB
PF04084   ORC2

Interpro

IPR000210   BTB/POZ_dom        + More
IPR011333   SKP1/BTB/POZ_sf       
IPR034089   SPOP_C       
IPR002083   MATH/TRAF_dom       
IPR008974   TRAF-like       
IPR007220   ORC2       

SUPFAM

SSF54695   SSF54695        + More
SSF49599   SSF49599       

Gene 3D

2.60.210.10    

CDD

cd14734  SPOP_C

ProteinModelPortal

A0A1E1W5S0   A0A2H1VJN0   A0A212F9Z7   A0A1E1WJF8   A0A194PFB6   A0A1E1VZR2   + More
A0A194RS66   Q179U2   A0A1J1J0U8   A0A1I8MAR9   A0A1I8Q4G3   A0A2M4CV23   A0A2M4CV51   A0A2M3ZG88   A0A2M4A8E1   T1DCX9   A0A2M3Z1Q4   A0A2M4A8M8   A0A084VI71   A0A1L8DMC3   A0A1L8DM31   A0A1I8JT83   A0A1I8JT76   A0A0K8TMR4   B3LYT1   A0A0A1XH08   A0A336KF12   A0A3B0K1J1   B4NFQ5   Q298W3   A0A2M4A8F9   W8BQW6   F5HK16   A0A1I8MAS0   Q9VFP2-4   Q9VFP2-3   A0A1W4V5V8   A0A1W4USH7   B4R0J2   A0A0R3NH15   I5ANU6   C7LAF6   B4G4S2   A0A0R1E4C9   B4PTD9   A0A0P8YGX7   B4HF69   B3P0K1   Q9VFP2   A0A1W4V4U8   A0A1I8Q4H2   B4MB81   B4JSB8   A0A1A9WJT9   Q7PGC0   B4KC14   A0A0Q9VZH1   A0A139WMR0   A0A0K8V0W6   A0A1Y1NHB6   W8B3B6   A0A0A1WVQ7   A0A1B6DLG6   Q9VFP2-2   A0A1W4US38   I5ANU5   A0A0R1E3Q2   A0A0P8Y1H1   A0A1I8Q4I6   A0A0M3QY84   A0A1B6LAQ1   A0A1B6L6U9   A0A0Q9VZH9   N6U5F7   A0A224XR50   A0A0K8SF32   A0A1B6GH68   A0A023FB09   R4G7P9   A0A0A9Z6U1   A0A0A9Y6H6   A0A0A9Z0Y4   A0A0A9Y1Z4   A0A154PL41   A0A0A9YWX0   V9IDF5   T1JG19   A0A0P6J6Y5   E2C6Z1   A0A151IYV4   A0A0C9RMN6   A0A151WPY5   A0A2A3EEX6   A0A0P5XV92   A0A0C9R9M6   A0A0C9RQU0   A0A158NMX7   A0A224YZW1   A0A131YNK4   A0A3S3PIL6  

PDB

3HU6     E-value=2.14913e-130,     Score=1193

KEGG

101742384    K10523 speckle-type POZ protein | (RefSeq) protein roadkill

PATHWAY

04341    Hedgehog signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0006511   GO:0043161   GO:0030162   GO:0031625   GO:0005634   GO:0005737   GO:0007367   GO:0051865   GO:0042308   GO:0042802   GO:0043065   GO:0042803   GO:0042067   GO:1901044   GO:0005654   GO:0031648   GO:0046330   GO:0045879   GO:0048592   GO:0016567   GO:0001654   GO:0000808   GO:0006260   GO:0005515   GO:0016020   GO:0030170   GO:0007166   GO:0016616   GO:0046168   GO:0016491   GO:0003824  

Subcellular location

Nucleus  

Length:

423

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00614999999999997

Exp number, first 60 AAs:

0.00398

Total prob of N-in:

0.03767

outside

1  -  423

 

 

Pi

218.16571

Theta

183.515188

Tajima's D

0.504474

CLR

0.854007

CSRT

0.512324383780811

Interpretation

Uncertain