Gene

KWMTBOMO05134

Pre Gene Modal

BGIBMGA012468

Annotation

PREDICTED:_centrosomal_protein_of_290_kDa-like_[Bombyx_mori]

Location

Bomo_Chr9(+):8734833-8744020      View in EpiBrowser

Full name

Centrosomal protein of 290 kDa      

Alternative Name

Bardet-Biedl syndrome 14 protein homolog
Nephrocystin-6

Location in the cell

Nuclear   Reliability : 3.459

CDS

ATGAATACAGCCATGCAACTGGAGAATGAGATTGCTATAAAAAATAAACACATTAAAAAGCTTCTAGCTGACGTTAAGGTCTTAGAAGAAGACAATCTTACATTCAAAGGAAAAGTTTCCATTTTGAAAGATAAACTAATCGAAGCTACACAGATTATAGATAATTTGACCGAACAATTACTTTCGATGAAGAATGAGACTGCGCGCTTAAAAGAAATATTGGGAAAATCAGAGCAAATAAAATCGCAACAGTCAGCTGAAATCGAAGTGCTGAAACAAAATTCTGAACGAGATGCTTATTCGCATAAGTGCACTATTCCGGAAGAAATTAAATTAAAAATTAAGCATTGGAAGGATATGGCTCGTTCCAAAAAGATCGAATTAGATATGATAGCTCTCGAAAACGTGAAACTAAAAGAACAACTTTCTAAAACCTATCAGCTACCCCCAACACACGATGAAGGCAGATCTTCTCGTGAATTTGAAATAAAAATAAAAGAGCTACAAGAAAAATTGCATGAAGCTACAAATGAAATCGAACGTTCTGCTATAATAATTAATACACTAAAGGCAGAAATACGTCAATTAAAAAGTGTTATAGAAGAAACACCCGATCCAGTTTCTGAAGTGAGAAATGAAAGTGACGACGGGAAGCAAAGAGCAATCATAAGACGATTGAGGAAAAAAAACATAGATTTAATAGCTTCTCTCCATGGGGCAGATGAGGTTCTTATCGCACGTGAAAAGGAGTTATCAGAAGTTACCGCGCAATTACAGTTAATTCAATCTGAAGAAGGTGTAAGTGTCTTGATCGAAGGATTGAAAAATAAAAAGAATCAGCTTAAAATTAAAGACGAAGGTATCAAAAGTCTAGTTCAAGAGGTTAATACTTTACATCAATTGGTGACTGATCTGCAGTTAGAAAATGAAACTCTAAGACAAAAATATAACATTCCTTTTGATGAAAGAGTTTGTACAAAAGGCATTCTAAAAAAATACCGAGATATGGAGCTACTCAATGCTAAAATGAAAAACGAACTAAAACACGTGGAAAACAAAATAATCGATTTGGAACTAAACGAAAGATGTATGTCTTCAAAAATTATAAAACTAAAAAAAATATTAACTTTGCAAGGGTATAATGTTGATGACGCCTATTTGAACGCTGAAGATGATGAATATAATGAGGAAATTTTAAGTGGTGCAAAAGAATCTTTGGCGATTGATCAATCTATAAATTTAGTACAGCATGTGAAGAGTAGCAATGAAACTGAAAATATACAGGCAATAATCGACGAAAACGAAGGATTAAGAAAAGCACTTCAAGAGCTCTTAGATTTTTTAAAAGACAACAGTTCCACTTCCTCGGGAGTATTGGCGTTACAGTGTCCAAGTCTTGAGTCAATTTTACAAAAAATGGGAATCAGACACGCAGCCGGCTGGTTTTCACCACACATGTCTACTTTTATGGAATTAGAAGCGGCACGTGGAGGAAAAGAAGCATTGCTTTTAGCGCTTCACGAAGCCAGGAAAGAAACATTCAATTTAATGAAGAACTTATCTCATCAATCAAAAATAAATGAAGATCTTCAAAAAAAAGTTAACGAATTAGAGTCTCAGAGTGTACAAAATTTTGATCTCGAAGATAACTTGTTCGAATTTGGTTCATGGGTAACAGAGGAAGAAATCAATTCTGTTGACTTTTATGACAAAGAACAATTACAAGACAGTGTGCATATTAAAAGTCAATTGATGTATGAAAATACATTGAAAAAGGTACTAAAACATTTCCATGATCAGTTTAAAGTTCTATACGACAAAATGAATTCACTAGCCATAGAACATATAGATAAAAACAATCATTGGTTAATTCAAGAAGAACGGTACAAAGCCGAAATTGAAAATTTAAAGATTCGTTTACAGCAAAATGAAGATGAAGACTTTAGTAATGCATCACCTGGTCTTTTACCTACATCGAATACTTCTATGCTTGAAAGAAGATGTTCATATTTAGAAGATTCTTACAAAGACATTAGGAACATAAACGAAAACTTAAGAAATGAAAATATAGAATGTAAAAGAGAAAAAACGTTAGTGGTCTCAGAAAACGAAATTAAAACGCAGAAGCTATTGCTACTTATTTGTGACATTACTGATAAGCTGCGTTCTTCAATAGCCCTTGACTTGTTTTGGGACCAAAACAGACTTCTCAACGAAGTAACATTAAAATATAGAAAAATTGCTGAAAATACTTTTAAAGATAAAAATAAAACCATGGACATGTTAAAGTGTCTTGAAGAAAGTAAATCGGAAATTATTAATTACGTTCAAAAACAACTGTGTGAAAATGTAGGCGATGCCGATAGACGTCAAATACTTAATGAAGTGGAACAATTAGCAATAGAAAAACAATTGCGACAATCAATAACAGAATTAGAAAAGAGAGAAAAAGAAATCAATTTGTTGGAATCCAAATATATGGAACTAAATCAACTGCAAGCAGGCCTTATCGATGATTCTTTACGCTCGGTAAATACAGAAGAAATTAATTTTATGAAATCCCAGATTTCTAATCTTTCTGCGGAACGGAAAATACTCAAAGAACAATATCAATCCACTAAAGATCAATTAGAGGTTACAATATTGCAGTTGCAAGAATTCCAACAGCGTCAAATGTGCAAAGAAATCGAAGTAAATATTCTAAGGCATCAAATACTAGATTTACAATCAACTGGAAATAATAAAGCAGTCGTTGCAAGGCTGAGTAGTGAATTATTAGTGACACATTTACAAGCTTCAGAGTATAATAGAAAAATTCAAGAGTTGACCACAGCTCTGAATAAGGAAAAGGAAATGAGAGCAGATATCGAAGATATTTTGTCTACCAGGCAAAAAGTTTTTGACCTTTATACACGTAGATACGACTCAAAATTCAAACATATTCACACGGTATTGAATATTATGCGGCTCCAATACCAAGGAAGTTTGCCTTTGACGTCAATAGAAAATTTTGTCTCCAAATTGGAAGATCTTTCTCGTAAAAATCATGCAATTAATCAACAACTAACTGAAGTTGACGAGCTGCGGACCAGTTTAGTGACAAAACATGCTGTATTCGATCAAATACTCGACGTTTCTAAAGATAAATGCTTACTTCAAGAAGATGACTGTCCACACAAATTAAAAAGTTTTATTATGGATGCAACGCATGCCCGAGAGATGGATAATATGAAGAAGAAAATTAAAATATCTGAACAAGTACGTGAAGAACTTTTAAGTCAATGTACTAACTTAGAAAAGACTTTGGCATATATTAATCAAGGTTATGAAAAATACACCTCCGTTGAGTTGAAGCACAAGCTGAAGGAAGTACAAAATGATGAAGCCATAAATTTAGAGGATCTGGTATCAGACGAAGAGCCAGATTCCAGAAGTAGTCGAATAGCTAAATCTCAAATACTCAAACCTACAACACATACCAAAGCAACTGTAACTGATATTAATAACGAACACCTTCAAGAAAATTTATTTGGTTCCCCGGCGAAGAAATTACCAGTGACACAACTCAAGCCAAAGGTAGCCAATGTTTTTGTACAAACAGACCAGTTGACACTATGCAAAAGTGAAAAAAACATTCAAACCGAAGAAGACGCTCTCATTATTGACATGAAATATTCTATTGAAAGTGCTAGAAATGATATAAAAATTAAAATGCGAGAACTTGATGAAGCTCTCTTGGTAGCTAAGAAACGTACGGAAGAAATGTTGATAATGGAATCAGAAAAAATAGATATACAATCGAAAATAAAAAATCTTCATCATACAATTAAGGAAAAGGATAATTTGAATAATCAGTTACAAAAAACTTTGTCTGAATTAAGAAAACAAGTAGAAGTTTCTCAGAATTTACAAATTGAAGAAATAGATAAGATTAAGCACTTAGAAAATGAAGAGACTAAAAAACTGTTATCGGCCTTGAAAGAATTAGAAAACGACAAAAATAAAATAATTGAGGAATACAAACAGCTACTGTATAACGAAAGAGAAGAATACACAAAAGCTATGAAGGAATTGCAAGTGAAATTATTTGAATTACAAACCAAGCTAGACAGGTACATACACAAATGGAATAAAGCTTTCTTTGAAGTAGCTTGA

Protein

MNTAMQLENEIAIKNKHIKKLLADVKVLEEDNLTFKGKVSILKDKLIEATQIIDNLTEQLLSMKNETARLKEILGKSEQIKSQQSAEIEVLKQNSERDAYSHKCTIPEEIKLKIKHWKDMARSKKIELDMIALENVKLKEQLSKTYQLPPTHDEGRSSREFEIKIKELQEKLHEATNEIERSAIIINTLKAEIRQLKSVIEETPDPVSEVRNESDDGKQRAIIRRLRKKNIDLIASLHGADEVLIAREKELSEVTAQLQLIQSEEGVSVLIEGLKNKKNQLKIKDEGIKSLVQEVNTLHQLVTDLQLENETLRQKYNIPFDERVCTKGILKKYRDMELLNAKMKNELKHVENKIIDLELNERCMSSKIIKLKKILTLQGYNVDDAYLNAEDDEYNEEILSGAKESLAIDQSINLVQHVKSSNETENIQAIIDENEGLRKALQELLDFLKDNSSTSSGVLALQCPSLESILQKMGIRHAAGWFSPHMSTFMELEAARGGKEALLLALHEARKETFNLMKNLSHQSKINEDLQKKVNELESQSVQNFDLEDNLFEFGSWVTEEEINSVDFYDKEQLQDSVHIKSQLMYENTLKKVLKHFHDQFKVLYDKMNSLAIEHIDKNNHWLIQEERYKAEIENLKIRLQQNEDEDFSNASPGLLPTSNTSMLERRCSYLEDSYKDIRNINENLRNENIECKREKTLVVSENEIKTQKLLLLICDITDKLRSSIALDLFWDQNRLLNEVTLKYRKIAENTFKDKNKTMDMLKCLEESKSEIINYVQKQLCENVGDADRRQILNEVEQLAIEKQLRQSITELEKREKEINLLESKYMELNQLQAGLIDDSLRSVNTEEINFMKSQISNLSAERKILKEQYQSTKDQLEVTILQLQEFQQRQMCKEIEVNILRHQILDLQSTGNNKAVVARLSSELLVTHLQASEYNRKIQELTTALNKEKEMRADIEDILSTRQKVFDLYTRRYDSKFKHIHTVLNIMRLQYQGSLPLTSIENFVSKLEDLSRKNHAINQQLTEVDELRTSLVTKHAVFDQILDVSKDKCLLQEDDCPHKLKSFIMDATHAREMDNMKKKIKISEQVREELLSQCTNLEKTLAYINQGYEKYTSVELKHKLKEVQNDEAINLEDLVSDEEPDSRSSRIAKSQILKPTTHTKATVTDINNEHLQENLFGSPAKKLPVTQLKPKVANVFVQTDQLTLCKSEKNIQTEEDALIIDMKYSIESARNDIKIKMRELDEALLVAKKRTEEMLIMESEKIDIQSKIKNLHHTIKEKDNLNNQLQKTLSELRKQVEVSQNLQIEEIDKIKHLENEETKKLLSALKELENDKNKIIEEYKQLLYNEREEYTKAMKELQVKLFELQTKLDRYIHKWNKAFFEVA

Description

Involved in early and late steps in cilia formation (PubMed:21565611). Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (By similarity). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (By similarity). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (PubMed:16632484). Required for efficient recruitment of RAB8A to primary cilium (By similarity). In the ciliary transition zone is part of the tectonic-like complex (also named B9 complex) which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (PubMed:21725307). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (By similarity). Activates ATF4-mediated transcription (By similarity).

Subunit

Part of the tectonic-like complex (also named B9 complex) (PubMed:21725307). Interacts with ATF4 via its N-terminal region (By similarity). Associates with the BBSome complex, interacting (via N-terminus) with BBS4 (By similarity). Interacts with IQCB1/NPHP5; IQCB1 and CEP290/NPHP6 are proposed to form a functional NPHP5-6 module localized to the centrosome. Interacts with NPHP4; the interaction likely requires additional interactors (PubMed:21565611). Interacts with ZNF423, FAM161A, CEP162, CEP162, CEP131, TALPID3, CCDC13, CC2D2A, RPGRIP1 (By similarity). Can self-associate (homo- or heteromeric) (By similarity). Interacts with CCP110; required for suppressing cilia formation (By similarity). Interacts with RPGR (PubMed:16632484). Associates (via C-terminus) with microtubules; association to microtubule is reduced in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling (By similarity). Interacts with FAM161A (By similarity). Interacts with PCM1 (PubMed:17705300). Interacts with CCDC66 (By similarity).

Keywords

Activator   Alternative splicing   Cell projection   Cilium   Coiled coil   Complete proteome   Cytoplasm   Cytoplasmic vesicle   Cytoskeleton   Nucleus   Protein transport   Reference proteome   Transcription   Transcription regulation   Transport   Ubl conjugation  

Feature

chain  Centrosomal protein of 290 kDa
splice variant  In isoform 2.

Uniprot

A0A2W1BW57   A0A2H1W0J9   A0A437BNC2   A0A0L7LM02   A0A194PF99   A0A212FGJ7   + More
A0A194RS51   E9Q9M0   Q6A078   A0A2Y9LM76   A0A341CS29   A0A3Q2H4M9   A0A2U4CRH8   A0A3Q2I5W6   A0A3L7IH85   A0A2U4CR73   F6WFW1   A0A2U4CR74   A0A3Q2HX45   M3Y8A8   A0A383YSX7   A0A2Y9T4Y3   A0A452RRN3   A0A2J8SW40   A0A2J8SW60   H2NI74   A0A2Y9IR29   G1T822   W5Q1V1  

Pubmed

28756777    26227816    26354079    22118469    19468303    21183079    + More
16141072    15368895    16632484    16682970    16682973    17705300    21565611    21725307    21623382    23807208    23943788    19892987    29704459    21993624    20809919   

EMBL

KZ149974    PZC75983.1    ODYU01005309    SOQ46034.1    RSAL01000027    RVE51932.1    + More
JTDY01000637    KOB76384.1    KQ459606    KPI91374.1    AGBW02008651    OWR52871.1    KQ459984    KPJ18896.1    AC153501    AK029960    AK172940    BAC26700.1    BAD32218.1    RAZU01000062    RLQ76702.1    AEYP01024829    AEYP01024830    AEYP01024831    AEYP01024832    AEYP01024833    NDHI03003538    PNJ24994.1    PNJ24997.1    ABGA01200231    ABGA01200232    ABGA01200233    ABGA01200234    ABGA01200235    AAGW02034526    AAGW02034527    AAGW02034528    AMGL01079901    AMGL01079902    AMGL01079903    AMGL01079904    AMGL01079905   

Proteomes

UP000283053    UP000037510    UP000053268    UP000007151    UP000053240    UP000000589    + More
UP000248483    UP000252040    UP000002281    UP000245320    UP000273346    UP000000715    UP000261681    UP000248484    UP000291022    UP000001595    UP000248482    UP000001811    UP000002356   

PRIDE

Q6A078   

Pfam

PF16574   CEP209_CC5

Interpro

IPR026201   Cep290        + More
IPR032321   Cep209_CC5       

ProteinModelPortal

A0A2W1BW57   A0A2H1W0J9   A0A437BNC2   A0A0L7LM02   A0A194PF99   A0A212FGJ7   + More
A0A194RS51   E9Q9M0   Q6A078   A0A2Y9LM76   A0A341CS29   A0A3Q2H4M9   A0A2U4CRH8   A0A3Q2I5W6   A0A3L7IH85   A0A2U4CR73   F6WFW1   A0A2U4CR74   A0A3Q2HX45   M3Y8A8   A0A383YSX7   A0A2Y9T4Y3   A0A452RRN3   A0A2J8SW40   A0A2J8SW60   H2NI74   A0A2Y9IR29   G1T822   W5Q1V1  

KEGG

101736262    no KO assigned | (RefSeq) centromere-associated protein E-like

GO

GO:0060271   GO:0005634   GO:0005813   GO:0035869   GO:0042802   GO:0090316   GO:0000930   GO:0034451   GO:0036064   GO:0045893   GO:0005814   GO:0005829   GO:0048793   GO:0007163   GO:0032991   GO:0030916   GO:0070201   GO:0036038   GO:0031410   GO:0032391   GO:0005737   GO:0007507   GO:0060041   GO:0001750   GO:0042462   GO:0007368   GO:0030902   GO:0015031   GO:0045494   GO:1905515  

PANTHER

PTHR18879  

Subcellular location

Cytoplasm   Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Found in the connecting cilium of photoreceptor cells (PubMed:16632484, PubMed:23943788), base of cilium in kidney intramedullary collecting duct cells (PubMed:16682970). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:21725307). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (By similarity).   With evidence from 2 publications.
Cytoskeleton   Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Found in the connecting cilium of photoreceptor cells (PubMed:16632484, PubMed:23943788), base of cilium in kidney intramedullary collecting duct cells (PubMed:16682970). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:21725307). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (By similarity).   With evidence from 2 publications.
Microtubule organizing center   Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Found in the connecting cilium of photoreceptor cells (PubMed:16632484, PubMed:23943788), base of cilium in kidney intramedullary collecting duct cells (PubMed:16682970). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:21725307). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (By similarity).   With evidence from 2 publications.
Centrosome   Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Found in the connecting cilium of photoreceptor cells (PubMed:16632484, PubMed:23943788), base of cilium in kidney intramedullary collecting duct cells (PubMed:16682970). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:21725307). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (By similarity).   With evidence from 2 publications.
Centriolar satellite   Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Found in the connecting cilium of photoreceptor cells (PubMed:16632484, PubMed:23943788), base of cilium in kidney intramedullary collecting duct cells (PubMed:16682970). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:21725307). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (By similarity).   With evidence from 2 publications.
Nucleus   Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Found in the connecting cilium of photoreceptor cells (PubMed:16632484, PubMed:23943788), base of cilium in kidney intramedullary collecting duct cells (PubMed:16682970). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:21725307). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (By similarity).   With evidence from 2 publications.
Centriole   Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Found in the connecting cilium of photoreceptor cells (PubMed:16632484, PubMed:23943788), base of cilium in kidney intramedullary collecting duct cells (PubMed:16682970). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:21725307). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (By similarity).   With evidence from 2 publications.
Cell projection   Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Found in the connecting cilium of photoreceptor cells (PubMed:16632484, PubMed:23943788), base of cilium in kidney intramedullary collecting duct cells (PubMed:16682970). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:21725307). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (By similarity).   With evidence from 2 publications.
Cilium   Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Found in the connecting cilium of photoreceptor cells (PubMed:16632484, PubMed:23943788), base of cilium in kidney intramedullary collecting duct cells (PubMed:16682970). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:21725307). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (By similarity).   With evidence from 2 publications.
Cilium basal body   Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Found in the connecting cilium of photoreceptor cells (PubMed:16632484, PubMed:23943788), base of cilium in kidney intramedullary collecting duct cells (PubMed:16682970). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:21725307). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (By similarity).   With evidence from 2 publications.
Cytoplasmic vesicle   Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By similarity). Found in the connecting cilium of photoreceptor cells (PubMed:16632484, PubMed:23943788), base of cilium in kidney intramedullary collecting duct cells (PubMed:16682970). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:21725307). Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent (By similarity).   With evidence from 2 publications.

Length:

1384

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00000

outside

1  -  1384

 

 

Pi

25.469812

Theta

200.870322

Tajima's D

-1.81374

CLR

3.211423

CSRT

0.0277986100694965

Interpretation

Uncertain