Gene
KWMTBOMO05127
Pre Gene Modal
BGIBMGA012463
Annotation
PREDICTED:_ras-related_protein_Rab-27A_isoform_X1_[Bombyx_mori]
Full name
Ras-related protein Rab-27A
Alternative Name
GTP-binding protein Ram
Ram p25
Ram p25
Location in the cell
Nuclear Reliability : 2.033
Sequence
CDS
ATGGATTACGATTATCTTATAAAATTGCTGTGTGTCGGGGATTCAGGAGTAGGAAAAACTAGTTTTTTATACAAGTACACCGATGGGGTGTTTCATACACAGTTCATATCAACAGTTGGAATTGATTTCAGGGAAAAAACTGTGATTTATCAGCAAAACGGAAGGCAGCATCGCATACATCTACAGCTTTGGGATACTGCAGGCCAAGAAAGGTTTAGAAGTTTAACAACAGCCTTTTACAGAGATGCCATGGGTTTTCTATTACTGTTTGACTTGACCAATGAGGCTTCATTTCTTGAAGTACGCAATTGGATTGAACAATTGAAGACACACAGCTTAAGTGATGATCCAGATATCGTCCTTTGTGGCCACAAGTGTGACTTGCAAGAGAAAAGGCTCGTGAACCAGAATCGTGCCAGAGAATTTGCCAAGAACCACAACTTGGCATATTTAGAAACTAGTGCCAAAACAGGACAAAATATTGATAGAGCAATAGATATATTGCTAGATAGAGTTATGTATAGAATGGAGCATTCTGTGGAATACGCTATGCTTTGTGCGTCAGGACGTCGCCGGCAATCTCTACAGAAACTACAAGCCAGACAGGAGAGAAAAATATGCACATGCTAG
Protein
MDYDYLIKLLCVGDSGVGKTSFLYKYTDGVFHTQFISTVGIDFREKTVIYQQNGRQHRIHLQLWDTAGQERFRSLTTAFYRDAMGFLLLFDLTNEASFLEVRNWIEQLKTHSLSDDPDIVLCGHKCDLQEKRLVNQNRAREFAKNHNLAYLETSAKTGQNIDRAIDILLDRVMYRMEHSVEYAMLCASGRRRQSLQKLQARQERKICTC
Summary
Description
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse (By similarity).
Subunit
Binds SYTL1, SYTL2, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5. Interacts with RPH3A and RPH3A. Binds MLPH. Interacts with UNC13D. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4) (By similarity).
Binds SYTL1, SYTL2, SLAC2B, MYRIP, SYTL3, SYTL4, SYTL5 and MLPH. Interacts with UNC13D. Interacts with RPH3A and RPH3A. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4) (By similarity).
Binds SYTL1, SYTL2, SLAC2B, MYRIP, SYTL3, SYTL4, SYTL5 and MLPH. Interacts with UNC13D. Interacts with RPH3A and RPH3A. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4) (By similarity).
Similarity
Belongs to the small GTPase superfamily. Rab family.
Keywords
Acetylation
Complete proteome
Disulfide bond
Endosome
Exocytosis
GTP-binding
Lipoprotein
Lysosome
Membrane
Methylation
Nucleotide-binding
Phosphoprotein
Prenylation
Reference proteome
3D-structure
Feature
chain Ras-related protein Rab-27A
Uniprot
A0A194PEB3
A0A194RN96
A0A3S2LED4
A0A212FC92
A0A2H1VA17
A0A2P8XN81
+ More
A0A195BDJ3 A0A158NDM6 A0A151WEU1 A0A195C1D3 F4WEC5 A0A195FGW9 A0A151JNZ2 V9IKY8 A0A088AS49 E2A190 D6WBK8 A0A0L7RH55 A0A3L8DZ73 A0A154P867 N6UEM8 A0A067RA14 A0A2J7QDK0 A0A0L0C8V5 A0A1Y1MZ87 A0A1Y1MW93 E0V9Q4 A0A2A3EKV8 A0A3M7RGZ6 A0A023EJR8 A0A023EMF1 A0A0N8E224 A0A0P5HDT4 A0A0P6DWL4 A0A0P4XWW8 A0A023EK55 A0A1B0D0T5 A0A3M7PEI5 E2BAI8 A0A1I8MAM0 A0A182H3Y2 A0A023EIZ5 A0A1I8PCP0 A0A034WQP2 A0A0P7WYI6 A0A0P5GHJ4 B4MB22 A0A0K8USL0 T1JG14 R7VP16 E9GRW0 A0A1A9X1D2 A0A1A9YQ87 A0A1B0BZ05 A0A3B3ZF01 A0A1U7Q9G6 K7J4W4 B4L750 A0A087X7M4 A0A3B3VRE1 A0A0B4UDF7 C3YKE6 A0A3Q3SV41 H0X2L8 G3GRJ8 A0A3B5RA98 A0A1A9ULN0 G3SUQ5 A0A1B6LEK1 A0A3L8SKF3 A0A218V875 H0Z802 A0A1B0FAH6 A0A1W2WH91 A0A1B0A0A7 P23640 A0A3B4D6D4 A0A3Q1HEQ0 W5N7H3 H2LXV1 A0A2I4CTG4 W5LPK0 H2YKM9 Q544U7 G1ST33 Q9ERI2 A0A2D0QU66 F6XND0 A0A0P4WII1 A0A315VE41 A0A1S3KUY6 A0A0P5BKQ1 A0A3P8T433 A0A3Q1AUX7 A0A2I2UDJ9 A0A3Q2FQ70 A0A3Q3A564 A0A060W9H9 F7D6A3 A0A1S3PVN7
A0A195BDJ3 A0A158NDM6 A0A151WEU1 A0A195C1D3 F4WEC5 A0A195FGW9 A0A151JNZ2 V9IKY8 A0A088AS49 E2A190 D6WBK8 A0A0L7RH55 A0A3L8DZ73 A0A154P867 N6UEM8 A0A067RA14 A0A2J7QDK0 A0A0L0C8V5 A0A1Y1MZ87 A0A1Y1MW93 E0V9Q4 A0A2A3EKV8 A0A3M7RGZ6 A0A023EJR8 A0A023EMF1 A0A0N8E224 A0A0P5HDT4 A0A0P6DWL4 A0A0P4XWW8 A0A023EK55 A0A1B0D0T5 A0A3M7PEI5 E2BAI8 A0A1I8MAM0 A0A182H3Y2 A0A023EIZ5 A0A1I8PCP0 A0A034WQP2 A0A0P7WYI6 A0A0P5GHJ4 B4MB22 A0A0K8USL0 T1JG14 R7VP16 E9GRW0 A0A1A9X1D2 A0A1A9YQ87 A0A1B0BZ05 A0A3B3ZF01 A0A1U7Q9G6 K7J4W4 B4L750 A0A087X7M4 A0A3B3VRE1 A0A0B4UDF7 C3YKE6 A0A3Q3SV41 H0X2L8 G3GRJ8 A0A3B5RA98 A0A1A9ULN0 G3SUQ5 A0A1B6LEK1 A0A3L8SKF3 A0A218V875 H0Z802 A0A1B0FAH6 A0A1W2WH91 A0A1B0A0A7 P23640 A0A3B4D6D4 A0A3Q1HEQ0 W5N7H3 H2LXV1 A0A2I4CTG4 W5LPK0 H2YKM9 Q544U7 G1ST33 Q9ERI2 A0A2D0QU66 F6XND0 A0A0P4WII1 A0A315VE41 A0A1S3KUY6 A0A0P5BKQ1 A0A3P8T433 A0A3Q1AUX7 A0A2I2UDJ9 A0A3Q2FQ70 A0A3Q3A564 A0A060W9H9 F7D6A3 A0A1S3PVN7
Pubmed
26354079
22118469
29403074
21347285
21719571
20798317
+ More
18362917 19820115 30249741 23537049 24845553 26108605 28004739 20566863 30375419 24945155 25315136 26483478 25348373 17994087 23371554 21292972 25463417 20075255 25542378 18563158 21804562 23542700 30282656 20360741 2124544 15489334 1527078 17554307 25329095 10349636 11042159 11076861 11217851 11773082 11856727 12466851 12040188 12578829 16141073 16923123 21183079 21993624 10859366 16141072 12051743 11887186 16716193 18354201 18266782 18940603 12481130 15114417 29703783 17975172 24755649 17495919
18362917 19820115 30249741 23537049 24845553 26108605 28004739 20566863 30375419 24945155 25315136 26483478 25348373 17994087 23371554 21292972 25463417 20075255 25542378 18563158 21804562 23542700 30282656 20360741 2124544 15489334 1527078 17554307 25329095 10349636 11042159 11076861 11217851 11773082 11856727 12466851 12040188 12578829 16141073 16923123 21183079 21993624 10859366 16141072 12051743 11887186 16716193 18354201 18266782 18940603 12481130 15114417 29703783 17975172 24755649 17495919
EMBL
KQ459606
KPI91368.1
KQ459984
KPJ18889.1
RSAL01000027
RVE51934.1
+ More
AGBW02009211 OWR51338.1 ODYU01001457 SOQ37679.1 PYGN01001670 PSN33467.1 KQ976509 KYM82628.1 ADTU01000165 KQ983238 KYQ46305.1 KQ978350 KYM94652.1 GL888102 EGI67563.1 KQ981606 KYN39633.1 KQ978779 KYN28502.1 JR052820 AEY61798.1 GL435730 EFN72784.1 KQ971311 EEZ98999.1 KQ414590 KOC70307.1 QOIP01000002 RLU25523.1 KQ434839 KZC08041.1 APGK01025022 KB740570 KB632375 ENN80210.1 ERL93892.1 KK852598 KDR20555.1 NEVH01015820 PNF26662.1 JRES01000755 KNC28667.1 GEZM01019106 JAV89870.1 GEZM01019102 JAV89873.1 DS234995 EEB10089.1 KZ288218 PBC32357.1 REGN01003412 RNA22714.1 GAPW01004287 JAC09311.1 GAPW01004104 JAC09494.1 GDIP01233703 GDIQ01069476 LRGB01002674 JAI89698.1 JAN25261.1 KZS06587.1 GDIQ01228316 JAK23409.1 GDIP01231201 GDIQ01071174 JAI92200.1 JAN23563.1 GDIP01245463 JAI77938.1 GAPW01004103 JAC09495.1 AJVK01010043 REGN01011611 RMZ97134.1 GL446759 EFN87282.1 JXUM01108936 JXUM01108937 JXUM01108938 KQ565276 KXJ71141.1 GAPW01004939 JAC08659.1 GAKP01001051 JAC57901.1 JARO02004029 KPP69283.1 GDIQ01246708 JAK05017.1 CH940655 EDW66431.1 GDHF01022816 JAI29498.1 JH432192 KB375890 AKCR02000019 EMC80103.1 PKK27596.1 PKK27597.1 GL732560 EFX77850.1 JXJN01022928 AAZX01000454 CH933812 EDW06196.1 AYCK01016310 KP216764 AJC97121.1 GG666522 EEN59190.1 AAQR03025074 AAQR03025075 AAQR03025076 JH000003 EGV99874.1 GEBQ01017848 JAT22129.1 QUSF01000015 RLW03682.1 MUZQ01000030 OWK62139.1 ABQF01017103 CCAG010006943 D17352 BC098667 AHAT01024879 AK030529 AB120511 AB232622 CH466522 BAC27005.1 BAC87831.1 BAF02884.1 EDL26285.1 AAGW02024888 AAGW02024889 AAGW02024890 AAGW02024891 AF304376 AB046693 AK010373 BC008173 BC009656 EAAA01001945 EAAA01001946 GDRN01087476 GDRN01087474 JAI61033.1 NHOQ01002371 PWA17291.1 GDIP01187356 JAJ36046.1 AANG04001761 FR904391 CDQ61904.1
AGBW02009211 OWR51338.1 ODYU01001457 SOQ37679.1 PYGN01001670 PSN33467.1 KQ976509 KYM82628.1 ADTU01000165 KQ983238 KYQ46305.1 KQ978350 KYM94652.1 GL888102 EGI67563.1 KQ981606 KYN39633.1 KQ978779 KYN28502.1 JR052820 AEY61798.1 GL435730 EFN72784.1 KQ971311 EEZ98999.1 KQ414590 KOC70307.1 QOIP01000002 RLU25523.1 KQ434839 KZC08041.1 APGK01025022 KB740570 KB632375 ENN80210.1 ERL93892.1 KK852598 KDR20555.1 NEVH01015820 PNF26662.1 JRES01000755 KNC28667.1 GEZM01019106 JAV89870.1 GEZM01019102 JAV89873.1 DS234995 EEB10089.1 KZ288218 PBC32357.1 REGN01003412 RNA22714.1 GAPW01004287 JAC09311.1 GAPW01004104 JAC09494.1 GDIP01233703 GDIQ01069476 LRGB01002674 JAI89698.1 JAN25261.1 KZS06587.1 GDIQ01228316 JAK23409.1 GDIP01231201 GDIQ01071174 JAI92200.1 JAN23563.1 GDIP01245463 JAI77938.1 GAPW01004103 JAC09495.1 AJVK01010043 REGN01011611 RMZ97134.1 GL446759 EFN87282.1 JXUM01108936 JXUM01108937 JXUM01108938 KQ565276 KXJ71141.1 GAPW01004939 JAC08659.1 GAKP01001051 JAC57901.1 JARO02004029 KPP69283.1 GDIQ01246708 JAK05017.1 CH940655 EDW66431.1 GDHF01022816 JAI29498.1 JH432192 KB375890 AKCR02000019 EMC80103.1 PKK27596.1 PKK27597.1 GL732560 EFX77850.1 JXJN01022928 AAZX01000454 CH933812 EDW06196.1 AYCK01016310 KP216764 AJC97121.1 GG666522 EEN59190.1 AAQR03025074 AAQR03025075 AAQR03025076 JH000003 EGV99874.1 GEBQ01017848 JAT22129.1 QUSF01000015 RLW03682.1 MUZQ01000030 OWK62139.1 ABQF01017103 CCAG010006943 D17352 BC098667 AHAT01024879 AK030529 AB120511 AB232622 CH466522 BAC27005.1 BAC87831.1 BAF02884.1 EDL26285.1 AAGW02024888 AAGW02024889 AAGW02024890 AAGW02024891 AF304376 AB046693 AK010373 BC008173 BC009656 EAAA01001945 EAAA01001946 GDRN01087476 GDRN01087474 JAI61033.1 NHOQ01002371 PWA17291.1 GDIP01187356 JAJ36046.1 AANG04001761 FR904391 CDQ61904.1
Proteomes
UP000053268
UP000053240
UP000283053
UP000007151
UP000245037
UP000078540
+ More
UP000005205 UP000075809 UP000078542 UP000007755 UP000078541 UP000078492 UP000005203 UP000000311 UP000007266 UP000053825 UP000279307 UP000076502 UP000019118 UP000030742 UP000027135 UP000235965 UP000037069 UP000009046 UP000242457 UP000276133 UP000076858 UP000092462 UP000008237 UP000095301 UP000069940 UP000249989 UP000095300 UP000034805 UP000192224 UP000008792 UP000053872 UP000000305 UP000091820 UP000092443 UP000092460 UP000261520 UP000189706 UP000002358 UP000009192 UP000028760 UP000261500 UP000001554 UP000261640 UP000005225 UP000001075 UP000002852 UP000078200 UP000007646 UP000276834 UP000197619 UP000007754 UP000092444 UP000092445 UP000002494 UP000261440 UP000265040 UP000018468 UP000001038 UP000192220 UP000018467 UP000007875 UP000001811 UP000000589 UP000221080 UP000008144 UP000087266 UP000265080 UP000257160 UP000011712 UP000265020 UP000264800 UP000193380 UP000002280
UP000005205 UP000075809 UP000078542 UP000007755 UP000078541 UP000078492 UP000005203 UP000000311 UP000007266 UP000053825 UP000279307 UP000076502 UP000019118 UP000030742 UP000027135 UP000235965 UP000037069 UP000009046 UP000242457 UP000276133 UP000076858 UP000092462 UP000008237 UP000095301 UP000069940 UP000249989 UP000095300 UP000034805 UP000192224 UP000008792 UP000053872 UP000000305 UP000091820 UP000092443 UP000092460 UP000261520 UP000189706 UP000002358 UP000009192 UP000028760 UP000261500 UP000001554 UP000261640 UP000005225 UP000001075 UP000002852 UP000078200 UP000007646 UP000276834 UP000197619 UP000007754 UP000092444 UP000092445 UP000002494 UP000261440 UP000265040 UP000018468 UP000001038 UP000192220 UP000018467 UP000007875 UP000001811 UP000000589 UP000221080 UP000008144 UP000087266 UP000265080 UP000257160 UP000011712 UP000265020 UP000264800 UP000193380 UP000002280
Pfam
PF00071 Ras
Interpro
SUPFAM
SSF52540
SSF52540
CDD
ProteinModelPortal
A0A194PEB3
A0A194RN96
A0A3S2LED4
A0A212FC92
A0A2H1VA17
A0A2P8XN81
+ More
A0A195BDJ3 A0A158NDM6 A0A151WEU1 A0A195C1D3 F4WEC5 A0A195FGW9 A0A151JNZ2 V9IKY8 A0A088AS49 E2A190 D6WBK8 A0A0L7RH55 A0A3L8DZ73 A0A154P867 N6UEM8 A0A067RA14 A0A2J7QDK0 A0A0L0C8V5 A0A1Y1MZ87 A0A1Y1MW93 E0V9Q4 A0A2A3EKV8 A0A3M7RGZ6 A0A023EJR8 A0A023EMF1 A0A0N8E224 A0A0P5HDT4 A0A0P6DWL4 A0A0P4XWW8 A0A023EK55 A0A1B0D0T5 A0A3M7PEI5 E2BAI8 A0A1I8MAM0 A0A182H3Y2 A0A023EIZ5 A0A1I8PCP0 A0A034WQP2 A0A0P7WYI6 A0A0P5GHJ4 B4MB22 A0A0K8USL0 T1JG14 R7VP16 E9GRW0 A0A1A9X1D2 A0A1A9YQ87 A0A1B0BZ05 A0A3B3ZF01 A0A1U7Q9G6 K7J4W4 B4L750 A0A087X7M4 A0A3B3VRE1 A0A0B4UDF7 C3YKE6 A0A3Q3SV41 H0X2L8 G3GRJ8 A0A3B5RA98 A0A1A9ULN0 G3SUQ5 A0A1B6LEK1 A0A3L8SKF3 A0A218V875 H0Z802 A0A1B0FAH6 A0A1W2WH91 A0A1B0A0A7 P23640 A0A3B4D6D4 A0A3Q1HEQ0 W5N7H3 H2LXV1 A0A2I4CTG4 W5LPK0 H2YKM9 Q544U7 G1ST33 Q9ERI2 A0A2D0QU66 F6XND0 A0A0P4WII1 A0A315VE41 A0A1S3KUY6 A0A0P5BKQ1 A0A3P8T433 A0A3Q1AUX7 A0A2I2UDJ9 A0A3Q2FQ70 A0A3Q3A564 A0A060W9H9 F7D6A3 A0A1S3PVN7
A0A195BDJ3 A0A158NDM6 A0A151WEU1 A0A195C1D3 F4WEC5 A0A195FGW9 A0A151JNZ2 V9IKY8 A0A088AS49 E2A190 D6WBK8 A0A0L7RH55 A0A3L8DZ73 A0A154P867 N6UEM8 A0A067RA14 A0A2J7QDK0 A0A0L0C8V5 A0A1Y1MZ87 A0A1Y1MW93 E0V9Q4 A0A2A3EKV8 A0A3M7RGZ6 A0A023EJR8 A0A023EMF1 A0A0N8E224 A0A0P5HDT4 A0A0P6DWL4 A0A0P4XWW8 A0A023EK55 A0A1B0D0T5 A0A3M7PEI5 E2BAI8 A0A1I8MAM0 A0A182H3Y2 A0A023EIZ5 A0A1I8PCP0 A0A034WQP2 A0A0P7WYI6 A0A0P5GHJ4 B4MB22 A0A0K8USL0 T1JG14 R7VP16 E9GRW0 A0A1A9X1D2 A0A1A9YQ87 A0A1B0BZ05 A0A3B3ZF01 A0A1U7Q9G6 K7J4W4 B4L750 A0A087X7M4 A0A3B3VRE1 A0A0B4UDF7 C3YKE6 A0A3Q3SV41 H0X2L8 G3GRJ8 A0A3B5RA98 A0A1A9ULN0 G3SUQ5 A0A1B6LEK1 A0A3L8SKF3 A0A218V875 H0Z802 A0A1B0FAH6 A0A1W2WH91 A0A1B0A0A7 P23640 A0A3B4D6D4 A0A3Q1HEQ0 W5N7H3 H2LXV1 A0A2I4CTG4 W5LPK0 H2YKM9 Q544U7 G1ST33 Q9ERI2 A0A2D0QU66 F6XND0 A0A0P4WII1 A0A315VE41 A0A1S3KUY6 A0A0P5BKQ1 A0A3P8T433 A0A3Q1AUX7 A0A2I2UDJ9 A0A3Q2FQ70 A0A3Q3A564 A0A060W9H9 F7D6A3 A0A1S3PVN7
PDB
3BC1
E-value=5.0114e-68,
Score=651
Ontologies
GO
GO:0005525
GO:0003924
GO:0042470
GO:0030141
GO:0045921
GO:0006886
GO:0032402
GO:0032482
GO:1990182
GO:0032585
GO:0043316
GO:0005794
GO:0007596
GO:0010628
GO:0031489
GO:0005764
GO:0070382
GO:0030318
GO:0030425
GO:0006605
GO:0019003
GO:0050766
GO:0043320
GO:1903435
GO:0097278
GO:1903428
GO:0036257
GO:1903307
GO:0001750
GO:0071985
GO:0019882
GO:0032400
GO:0016324
GO:0019904
GO:0033093
GO:0006887
GO:0030667
GO:0016021
GO:0051904
GO:0005770
GO:0016192
GO:0051875
GO:0043473
GO:0007264
GO:0008265
GO:0030151
GO:0030170
GO:0007166
GO:0016616
GO:0046168
GO:0016491
GO:0003824
Topology
Subcellular location
Membrane
Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. With evidence from 2 publications.
Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. With evidence from 2 publications.
Late endosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. With evidence from 2 publications.
Lysosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. With evidence from 2 publications.
Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. With evidence from 2 publications.
Late endosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. With evidence from 2 publications.
Lysosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. With evidence from 2 publications.
Length:
209
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.02924
Exp number, first 60 AAs:
0.01579
Total prob of N-in:
0.05168
outside
1 - 209
Population Genetic Test Statistics
Pi
201.870206
Theta
159.657944
Tajima's D
0.623855
CLR
0.000362
CSRT
0.548522573871306
Interpretation
Uncertain
