Silkworm Genome Informatics Database

Gene

KWMTBOMO05125 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012462

Annotation

Molybdenum_cofactor_sulfurase_[Papilio_machaon]

Location

Bomo_Chr9(+):8549663-8554351 View in EpiBrowser

Full name

Molybdenum cofactor sulfurase + More
Molybdenum cofactor sulfurase 2

Alternative Name

Molybdenum cofactor sulfurtransferase
Protein maroon-like
Molybdenum cofactor sulfurtransferase 2
Protein maroon-like 2

Location in the cell

Nuclear Reliability : 2.953

CDS

ATGACCGTGCTAAGTCAAATAATAAAGCCCGATGATATGATAAAAATTACATCAGAGTTTGCAAGACTGGGAGACAGATGTTATTTGGACAATGCCGGTGCTACTTTATACCCAAAAAGTTTGATTACGTCCATAAATGAAGACTTATTAAAAAATGTTTATATGAATCCTCATACAGATAAAAATACAAAAGATTACATAGAACAAATTAGATGTCTCATACTAAAACATTTCAATACAGATCCTTCAACATATACGTTGATTTTCACATCTGGAACCACTCAAGCCTTGAAATTAGTTATTGAATCATTTCAATTTATGAAGAATGAAGATGATGATTTAAATTGTGGTTCCTTTGTTTACCTAGAAGATAATCACACATCTGTTGTTGGCTTAAGAGAACTTGCAGTAGACAAAGATGCAGAAGTAGTCCACATAGCCCATGAAGATTTCTTAAATGTCATAAACACGAAAGCCAAACAAACAAGCAAATACACAAATGGTGGTAACAGTCTTGTTGCTTATCCTGCTCAGAGTAATTTCAATGGTTTTAAATACCCTTTAAACTGCATAGAGAATATAAAAAATGGATGTCTGAACAATCACTTGAAAAAGCATTTATGTGAGATAAACAGTGACTGGTACGTTCTGTTAGATGCTGCTGCATATGTTGCTACCAGTAAATTGGATCTCACAAAAGTGCAACCAGATTTTGTATCTTTATCGTTTTATAAGATTTTTGGTTTCCCAACTGGATTGGGAGCTTTATTAGTTAAAAAATCTAGTGAGAATGTTTTAAGCCAAAAAAGGTATTTTGGTGGAGGCACTGTTGATGCATTATTGAGTAATGAGCACTATCATATCAAAAGGGAAATCTTTCATGAAAGATTTGAAGATGGATCTCTATCTTTCTTATCCATAATTTCTTTAAAACAATGTCTGGATACAATGTACAGAATCATACCAAGAATAATACATGACGATATTATGGAAACAATATCTTACCATACGTTTTATTTAGCAAAAGATTTGTATTGTCAGCTATTAGATTTACGACATCGAAACGGCACAAAGGCTATCAAATTCTATTTAGATTCAGATTTTAGTGACATTACAAAGCAAGGGGGCGTTTTAACTTTTAATCTGGTGAGAGAAGATGGAACTTACATTGGTTTTTCTGAGTTCCAACACATGGCAGACTTATTTAACATAAGTGTCAGAACAGGATGTTTTTGTAATTCTGGATCATGTCAAAGACATTTGCACATGTCAAACAAGGATATGAAAGATATGTATAATGCTGGTCACAGATGTGGAGATGAAGTAGATTTAATTAATGGAAAGCCCACAGGTTGGAACATAGGTCCAAAAGGTTTTGAATACGACCGAGAATGGATGATAGTTAAAGACAATGGAGTGTGTCTCACACAGAAACAGAATACACGTATGTGCATGATTCGCCCACAAATCGATCTCAAACTAAAAGTAATGATATTAAATTTCCCAGGTAAAACTCCCATATCCATACCCTTGGAAAATTCTATAAACGAGGTACAGAAAAATGGATCACTCTGTCATAGTAAAGTCTGTACAGATATGATTAAGGGCATTGATTGTGGTGATGAAGTTGCAGACTGGATATCTGAAGCTCTTGAAGTGTCATTCCTTCGTTTAATACGACAATCTAGCAACGACAACAGATCTCTAAAGAAGAAGAAAGATGAAGATAAAAAATTATTGTCGCTTAGCAATCAGGCTCAATATCTTCTAATTAATAAAGCAACAGTTAAATGGCTTAGTGAAAAGATCAAAGATCCTCTCTTTACTGATGATTTAAATCATTTAACAGACCGATTTAGAGGGAATCTCATTATAGAAATGGAACAAGAATTGTTGGAACGTGAATGGCACAGTGTTATAATTGGAAATCACGAGTTTAAGGTGGAAGGGCAGTGCCCCAGGTGTCAAATGGTATGCATAGATCAACAAACTGGCGAGAAAACTGTAGAGCCCCTTAGGACAATAGCAGAACAATTTGGAGGGAAACTTCGATTTGGTATTTACTTGAGTTATGTTGGCACAGTGAATAAATCTGACGACAGAACTTTGAAAACTTATTCTCCAATTAAAGCAATACTAAATGATGACAACATCAGTAGATGA

Protein

MTVLSQIIKPDDMIKITSEFARLGDRCYLDNAGATLYPKSLITSINEDLLKNVYMNPHTDKNTKDYIEQIRCLILKHFNTDPSTYTLIFTSGTTQALKLVIESFQFMKNEDDDLNCGSFVYLEDNHTSVVGLRELAVDKDAEVVHIAHEDFLNVINTKAKQTSKYTNGGNSLVAYPAQSNFNGFKYPLNCIENIKNGCLNNHLKKHLCEINSDWYVLLDAAAYVATSKLDLTKVQPDFVSLSFYKIFGFPTGLGALLVKKSSENVLSQKRYFGGGTVDALLSNEHYHIKREIFHERFEDGSLSFLSIISLKQCLDTMYRIIPRIIHDDIMETISYHTFYLAKDLYCQLLDLRHRNGTKAIKFYLDSDFSDITKQGGVLTFNLVREDGTYIGFSEFQHMADLFNISVRTGCFCNSGSCQRHLHMSNKDMKDMYNAGHRCGDEVDLINGKPTGWNIGPKGFEYDREWMIVKDNGVCLTQKQNTRMCMIRPQIDLKLKVMILNFPGKTPISIPLENSINEVQKNGSLCHSKVCTDMIKGIDCGDEVADWISEALEVSFLRLIRQSSNDNRSLKKKKDEDKKLLSLSNQAQYLLINKATVKWLSEKIKDPLFTDDLNHLTDRFRGNLIIEMEQELLEREWHSVIIGNHEFKVEGQCPRCQMVCIDQQTGEKTVEPLRTIAEQFGGKLRFGIYLSYVGTVNKSDDRTLKTYSPIKAILNDDNISR

Description

Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

Catalytic Activity

AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin

Cofactor

pyridoxal 5'-phosphate

Similarity

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.

Keywords

Complete proteome Molybdenum cofactor biosynthesis Pyridoxal phosphate Reference proteome Transferase Phosphoprotein

Feature

chain Molybdenum cofactor sulfurase 2

Uniprot

A0A0N1PI14 E2A192 F4WEC3 F4WEC2 A0A1B0GLL1 A0A1W4YP56 + More
A0A2K7P6C6 Q16P87 A0A1Y1MFR2 B3MZN7 L9KTU6 A0A1S4ES76

EC Number

2.8.1.9

Pubmed

26354079 20798317 21719571 17510324 28004739 17994087 + More
23385571

EMBL

KQ461012 KPJ10000.1 GL435730 EFN72786.1 GL888102 EGI67561.1 + More
EGI67560.1 AJWK01035663 CH477791 GEZM01034279 GEZM01034276 JAV83838.1 CH902635 KB320722 ELW64587.1

Proteomes

UP000053240 UP000000311 UP000007755 UP000092461 UP000192224 UP000008820 + More
UP000007801 UP000011518 UP000079169

PRIDE

Q16P87

Pfam

PF03473   MOSC        + More
PF00266   Aminotran_5
PF03476   MOSC_N

Interpro

IPR015422   PyrdxlP-dep_Trfase_dom1        + More
IPR005302   MoCF_Sase_C
IPR015424   PyrdxlP-dep_Trfase
IPR011037   Pyrv_Knase-like_insert_dom_sf
IPR000192   Aminotrans_V_dom
IPR015421   PyrdxlP-dep_Trfase_major
IPR028886   MoCo_sulfurase
IPR005303   MOSC_N

SUPFAM

SSF50800 SSF50800 + More
SSF53383 SSF53383

Gene 3D

3.40.640.10 3.90.1150.10

ProteinModelPortal

A0A0N1PI14 E2A192 F4WEC3 F4WEC2 A0A1B0GLL1 A0A1W4YP56 + More
A0A2K7P6C6 Q16P87 A0A1Y1MFR2 B3MZN7 L9KTU6 A0A1S4ES76

PDB

5VPR E-value=4.55525e-11, Score=166

KEGG

100134930 K15631 molybdenum cofactor sulfurtransferase [EC:2.8.1.9] | (RefSeq) mal, MCS, Og; molybdenum cofact

PATHWAY

00790 Folate biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0003824 GO:0030151 GO:0030170 GO:0006777 GO:0102867 GO:0008265 GO:0016829 GO:0043545 GO:0007166 GO:0016616 GO:0046168 GO:0016491

Length:

720

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0369100000000001

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.00169

outside

1 - 720

Pi

243.725271

Theta

221.265932

Tajima's D

0.288613

CLR

0.001795

CSRT

0.455027248637568

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics