Gene

KWMTBOMO05113  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012505

Annotation

Thioredoxin_domain-containing_protein_[Papilio_xuthus]

Location

Bomo_Chr9(-):8184071-8187513      View in EpiBrowser

Full name

MICOS complex subunit MIC60      

Alternative Name

Mitofilin

Location in the cell

Cytoplasmic   Reliability : 1.157 PlasmaMembrane   Reliability : 1.673

CDS

ATGAATTTTGTAATACCGTTTGTATCCCTTTTACTTTGGTGTAATAATGTAAGATCTCAAAGTTTGCTCAATGTAAGTGATGATGAACTTTTGGAACTTATAAGAGAAAAAGAAAAGCTTATTGTCTTATTCACTAAGCAAAATTGTGAGACATGTAAGAAATTGGAACAGCATGTAGAAAGTTTACAAGAAGACTTTAAGAAACACTTAAATGCTATGAGCGTTAAGACTGTAAATAGTCATTTAGCTAGACTTTACAATCCTTCAAAAGAACCAGCACTTATATTTTATCGACATGGTGTTGCACTTTTATACAGTGGTGAGGCTGATGAAAATGAAATCTATGGCTTTTTTGAGAAGAATCAAACACCAGCTGTAAAAGAGCTAACAGATAAAATATTTGAGCATTTGACACAAGCAGCTACTGGTGCAACAACAGGAGATTGGTTTGTCATGTTTTATGGGGCAGCTTGTGTTGAATGCCAAAGGCTACATGCTGTTTGGGAAAGTGTTGGAGCAACATTAAAGAGCAGAATAAATGTTGCTCGCATTGATGCAAGTTTAGCTGGTGTCAACACTGCTAAAAGATTTCATGTTGGAAAATTGCCAGCATTCCTTCTGTTTCGCCTTGGCAAAGTGTACAGATATGACTTGCCAAAAAATGATGTGAAATCTTTTGTTGCATTTGCTCAAGATTGGTATAAAAACTCTAAAGGAGAACCTGTTGCAGTTCTTGCCTCACCATTTGATGATGTGGTGAATTGGTGTGTAGAAATGCTGAAATGGGGAATAGCATTCGGTCTCAATATACTCACAGAACACCCATGGATATGGCAAATAGGAATAGCTGGTTTTGGATTGGTAGCTTTGACAGCTTTAATTGCAATTATTAAAGCAGGAAGATCAAAGCCACTAAAGGAAACAAAAAAAGATAAGAAACGTAAATAA

Protein

MNFVIPFVSLLLWCNNVRSQSLLNVSDDELLELIREKEKLIVLFTKQNCETCKKLEQHVESLQEDFKKHLNAMSVKTVNSHLARLYNPSKEPALIFYRHGVALLYSGEADENEIYGFFEKNQTPAVKELTDKIFEHLTQAATGATTGDWFVMFYGAACVECQRLHAVWESVGATLKSRINVARIDASLAGVNTAKRFHVGKLPAFLLFRLGKVYRYDLPKNDVKSFVAFAQDWYKNSKGEPVAVLASPFDDVVNWCVEMLKWGIAFGLNILTEHPWIWQIGIAGFGLVALTALIAIIKAGRSKPLKETKKDKKRK

Description

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Subunit

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.

Similarity

Belongs to the MICOS complex subunit Mic60 family.

Uniprot

H9JSJ4   A0A1E1WLZ4   S4NU44   A0A194PDE6   A0A194RN86   A0A212ESH4   + More
A0A2H1VG39   A0A2H1VHS5   A0A067RHR2   U5ES44   A0A1B0D1V2   A0A2J7QNU4   K7J4V9   A0A1L8DTZ9   A0A1L8DTY5   A0A182Y790   Q16U72   A0A182PA35   V9II76   A0A182VLR5   A0A088AS52   Q7QBY5   A0A224XNV2   A0A182MKP4   A0A2C9GR61   A0A232EP61   A0A154P768   A0A182JYI8   A0A1W7R7Z4   A0A182ISY0   R4ULE3   A0A084VJQ2   A0A0L7RHG7   A0A1Y1MJM3   A0A023EQR3   A0A1B6FW40   A0A182TD19   A0A2M3Z8F5   A0A2M3Z8C8   A0A182Q7Z4   A0A2M4ANY2   A0A2M4AP03   A0A1B6CJN6   A0A2R7WCI0   A0A2M4BUG4   A0A0P4VK18   R4G8E4   A0A1W4WE73   R4WCS0   W5JRR4   J3JV32   N6TX51   A0A1B6KMU8   A0A1Q3F8X1   A0A2M4AQY0   A0A0T6BF18   A0A2A3EU74   A0A146KPQ4   E2BMX2   E2APT1   A0A182XIC1   D6W9A7   A0A2M4ASF0   A0A026WI64   A0A182F6G5   A0A182VQA2   A0A182RCX1   E9IHM1   A0A0M9A2W4   A0A336MJM0   A0A226CXT6   A0A151WES8   E0VB17   A0A151IZE4   A0A1D2N4R9   A0A195FG00   A0A195BEM8   A0A158NF59   A0A1L8EDB3   A0A1L8ED50   B4NJV7   F4X3A6   B3P6T6   B4IJE2   A0A1W4V881   A0A0B4KHU4   B4PUZ1   B4LUV0   A0A1W4VKD2   A0A1A9VM11   A0A0P8XY41   B3M1X8   Q8SWX6   B4JQQ5   A0A1B0C4E7   A0A2S2QL25  

Pubmed

19121390    23622113    26354079    22118469    24845553    20075255    + More
25244985    17510324    12364791    14747013    17210077    28648823    24438588    28004739    24945155    27129103    23691247    20920257    23761445    22516182    23537049    26823975    20798317    18362917    19820115    24508170    30249741    21282665    20566863    27289101    21347285    17994087    21719571    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17550304    26109357    26109356   

EMBL

BABH01027982    GDQN01003015    JAT88039.1    GAIX01011956    JAA80604.1    KQ459606    + More
KPI91361.1    KQ459984    KPJ18879.1    AGBW02012813    OWR44404.1    ODYU01002391    SOQ39823.1    ODYU01002392    SOQ39824.1    KK852630    KDR19858.1    GANO01003421    JAB56450.1    AJVK01022393    NEVH01012562    PNF30252.1    AAZX01007340    GFDF01004153    JAV09931.1    GFDF01004168    JAV09916.1    CH477631    EAT38061.1    JR047201    AEY60352.1    AAAB01008859    EAA07456.4    GFTR01004928    JAW11498.1    AXCM01005074    APCN01000432    NNAY01003008    OXU20131.1    KQ434829    KZC07712.1    GEHC01000374    JAV47271.1    KC741175    AGM32999.1    ATLV01013846    KE524905    KFB38196.1    KQ414590    KOC70315.1    GEZM01031774    JAV84840.1    GAPW01002649    JAC10949.1    GECZ01015410    JAS54359.1    GGFM01004030    MBW24781.1    GGFM01004032    MBW24783.1    AXCN02000055    GGFK01009175    MBW42496.1    GGFK01009195    MBW42516.1    GEDC01023604    JAS13694.1    KK854624    PTY17394.1    GGFJ01007502    MBW56643.1    GDKW01001224    JAI55371.1    ACPB03015130    GAHY01001117    JAA76393.1    AK417113    BAN20328.1    ADMH02000291    ETN67102.1    BT127098    AEE62060.1    APGK01051641    KB741198    KB632313    ENN72971.1    ERL92167.1    GEBQ01027192    JAT12785.1    GFDL01011082    JAV23963.1    GGFK01009875    MBW43196.1    LJIG01001010    KRT85930.1    KZ288186    PBC34822.1    GDHC01020135    JAP98493.1    GL449377    EFN82954.1    GL441581    EFN64557.1    KQ971312    EEZ98470.1    GGFK01010383    MBW43704.1    KK107193    QOIP01000002    EZA55700.1    RLU26069.1    GL763289    EFZ19921.1    KQ435753    KOX76117.1    UFQT01001337    SSX30095.1    LNIX01000060    OXA37297.1    KQ983238    KYQ46291.1    DS235021    EEB10573.1    KQ980731    KYN13974.1    LJIJ01000236    ODN00055.1    KQ981606    KYN39620.1    KQ976509    KYM82642.1    ADTU01000254    GFDG01002236    JAV16563.1    GFDG01002225    JAV16574.1    CH964272    EDW83959.1    GL888609    EGI59087.1    CH954182    EDV53756.1    CH480848    EDW51133.1    AE014297    AGB96324.1    CM000160    EDW98840.1    CH940649    EDW64277.1    CH902617    KPU79621.1    EDV42238.1    AY095006    AAF56385.2    AAM11334.1    CH916372    EDV99235.1    JXJN01025433    GGMS01009266    MBY78469.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000027135    UP000092462    + More
UP000235965    UP000002358    UP000076408    UP000008820    UP000075885    UP000075903    UP000005203    UP000007062    UP000075883    UP000075840    UP000215335    UP000076502    UP000075881    UP000075880    UP000030765    UP000053825    UP000075902    UP000075886    UP000015103    UP000192223    UP000000673    UP000019118    UP000030742    UP000242457    UP000008237    UP000000311    UP000076407    UP000007266    UP000053097    UP000279307    UP000069272    UP000075920    UP000075900    UP000053105    UP000198287    UP000075809    UP000009046    UP000078492    UP000094527    UP000078541    UP000078540    UP000005205    UP000007798    UP000007755    UP000008711    UP000001292    UP000192221    UP000000803    UP000002282    UP000008792    UP000078200    UP000007801    UP000001070    UP000092460   

PRIDE

H9JSJ4    Q8SWX6   

Pfam

PF00085   Thioredoxin        + More
PF05768   DUF836
PF07449   HyaE
PF01918   Alba
PF09731   Mitofilin

Interpro

IPR036249   Thioredoxin-like_sf        + More
IPR013766   Thioredoxin_domain       
IPR017937   Thioredoxin_CS       
IPR008554   Glutaredoxin-like       
IPR013087   Znf_C2H2_type       
IPR036236   Znf_C2H2_sf       
IPR010893   NiFe-hyd_mat_HyaE       
IPR002775   DNA/RNA-bd_Alba-like       
IPR036882   Alba-like_dom_sf       
IPR019133   Mt-IM_prot_Mitofilin       
IPR011992   EF-hand-dom_pair       

SUPFAM

SSF52833   SSF52833        + More
SSF57667   SSF57667       
SSF82704   SSF82704       
SSF47473   SSF47473       

Gene 3D

3.30.110.20    

ProteinModelPortal

H9JSJ4   A0A1E1WLZ4   S4NU44   A0A194PDE6   A0A194RN86   A0A212ESH4   + More
A0A2H1VG39   A0A2H1VHS5   A0A067RHR2   U5ES44   A0A1B0D1V2   A0A2J7QNU4   K7J4V9   A0A1L8DTZ9   A0A1L8DTY5   A0A182Y790   Q16U72   A0A182PA35   V9II76   A0A182VLR5   A0A088AS52   Q7QBY5   A0A224XNV2   A0A182MKP4   A0A2C9GR61   A0A232EP61   A0A154P768   A0A182JYI8   A0A1W7R7Z4   A0A182ISY0   R4ULE3   A0A084VJQ2   A0A0L7RHG7   A0A1Y1MJM3   A0A023EQR3   A0A1B6FW40   A0A182TD19   A0A2M3Z8F5   A0A2M3Z8C8   A0A182Q7Z4   A0A2M4ANY2   A0A2M4AP03   A0A1B6CJN6   A0A2R7WCI0   A0A2M4BUG4   A0A0P4VK18   R4G8E4   A0A1W4WE73   R4WCS0   W5JRR4   J3JV32   N6TX51   A0A1B6KMU8   A0A1Q3F8X1   A0A2M4AQY0   A0A0T6BF18   A0A2A3EU74   A0A146KPQ4   E2BMX2   E2APT1   A0A182XIC1   D6W9A7   A0A2M4ASF0   A0A026WI64   A0A182F6G5   A0A182VQA2   A0A182RCX1   E9IHM1   A0A0M9A2W4   A0A336MJM0   A0A226CXT6   A0A151WES8   E0VB17   A0A151IZE4   A0A1D2N4R9   A0A195FG00   A0A195BEM8   A0A158NF59   A0A1L8EDB3   A0A1L8ED50   B4NJV7   F4X3A6   B3P6T6   B4IJE2   A0A1W4V881   A0A0B4KHU4   B4PUZ1   B4LUV0   A0A1W4VKD2   A0A1A9VM11   A0A0P8XY41   B3M1X8   Q8SWX6   B4JQQ5   A0A1B0C4E7   A0A2S2QL25  

PDB

3IDV     E-value=2.30975e-07,     Score=130

KEGG

101744785    no KO assigned | (RefSeq) thioredoxin domain-containing protein

GO

GO:0045454   GO:0005623   GO:0016021   GO:0003676   GO:0016853   GO:0005743   GO:0003756   GO:0012505   GO:0009116   GO:0008484   GO:0016020   GO:0004888   GO:0007166   GO:0016616   GO:0046168   GO:0016491   GO:0003824  

PANTHER

PTHR15415  

Subcellular location

Mitochondrion inner membrane  

SignalP

Position:   1 - 19,         Likelihood:  0.987028

 

 

Length:

315

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.74913

Exp number, first 60 AAs:

0.001

Total prob of N-in:

0.00059

outside

1  -  274

TMhelix

275  -  297

inside

298  -  315

 

 

Pi

264.287208

Theta

200.42501

Tajima's D

1.089802

CLR

0.007623

CSRT

0.689115544222789

Interpretation

Uncertain